Poster Session 4 : Immunology ; LIGHT induces TR2-mediated Ca(2+) signaling in human monocytes

( Ha Na Paek ),( Seong A Ju ),( Sang Chul Lee ),( Byung Sam Kim ) 한국생화학분자생물학회 (구 한국생화학회) 2003 생화학분자생물학회 춘계학술발표논문집 Vol.2003 No.-

Improved performance of flexible perovskite light-emitting diodes with modified PEDOT:PSS hole transport layer

Haesook Kim,Ha Na Ra,Ji Sun Kim,Sang-Hyon Paek,Jongwook Park,Young Chul Kim 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.90 No.-

We demonstrated the improved device performance offlexible perovskite light-emitting diodes (PeLEDs)on indium-tin oxide coated poly(ethylene terephthalate) (ITO/PET) substrates by using modified poly(3,4-ethylene dioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) as a hole transport layer (HTL). Solvent modification and dopant modification of the PEDOT:PSS solution were carried out by addingisopropyl alcohol (IPA) and poly(sodium 4-styrenesulfonate) (PSS-Na), respectively, to the pristinesolution. Devices with the modified HTLs, PEDOT:PSS + IPA and PEDOT:PSS + PSS-Na, exhibited asignificant enhancement in both luminance and efficiency. The work function of HTL was improved toreduce the energy barrier against the perovskite layer and facilitate hole transport. The perovskitefilmsdeposited on the modified PEDOT:PSS layers showed a uniformly covered surface morphology withoutany defects, resulting in an increased PL intensity. In particular, the perovskitefilm coated on the dopantmodified HTL showed a better crystallinity and reduced luminescence quenching. The PeLED device withthe PEDOT:PSS + PSS-Na HTL exhibited a maximum luminance of 3900 cd/m2, a maximum currentefficiency of 25.1 cd/A, and a maximum external quantum efficiency of 5.9%.

VDT작업자에서 업무로 인한 정신사회적 스트레스에 대한 인지가 근골격계장애에 미치는 영향

백남종,하미나,조수헌,강대희,백도명,주영수,윤덕로,권호장 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.3

업무에 의한 정신사회적 스트레스가 근골격계 질환의 유병에 미치는 영향을 파악하기 위하여 전화안내원을 대상으로 단면적 조사연구를 수행하였다. 연구 결과 나이, 교육정도, 근무연한, 가사부담 등의 인구학적 변수는 근골격계질환의 유병에 영향을 미치지 않는 것으로 분석되었다. 정신사회적 스트레스 중 업무요구도가 높다고 느끼는 집단에서 그렇지 않은 집단에 비해 근골격계 질환의 유병률이 통계적으로 유의하게 높게 나타났으나 업무재량도나 사회적지지도는 근골격계질환과 유의한 상관관계를 발견할 수 없었다. 그러나 업무요구도는 높고 업무재량도는 낮다고 느끼는 '근무긴장도가 가장 높은 군'은 업무요구도는 낮고 업무재량도는 높다고 느끼는 '근무긴장도가 낮은 군'에 비해 근골격계 질환의 발생위험이 통계적으로 유의하게 높은 것으로 나타났다. 본 연구의 결과는 업무로 인한 정신사회적 스트레스에 대한 인지 정도에 따라 근골격계질환의 유병률이 달라짐을 시사하고 있다. 따라서 작업관련성 근골격계질환의 예방을 위해서는 기존의 인간공학적 접근 이외에 스트레스를 감소시키려는 노력이 동시에 진행되어야 할 것으로 생각한다. A cross-sectional study was conducted to assess the association between perceived occupational psychosocial stress at work and the work-related musculoskeletal disorder(WRMSD) among employees using video display terminals. The study included 111 female telecommunication employees from three companies at ChungBuk province. Cases of WRMSD were defined using symptom questionnaire and physical examination conducted by rehabilitation specialist. Information on demographics, individual factors, and perceived psychosocial stress, were obtained by self-administered questionnaire. For assessing perceived psychosocial stress, we used variables from 'job strain model' proposed by Karasek. Associations between perceived psychosocial stress and WRMSD were assessed by multiple logistic regression models. Forty nine(44% to the total) subjects met our operational definition for WRMSD. Age, seniority, housing load were not associated with WRMSD. Perceived psychosocial stress was associated with WRMSD[odds ratio=3.28, 95% confidence interval: 1.05-10.19]. This study suggests that perceived occupational psychosocial stress is related to the prevalence of WRMSD.

Pure large neuroendocrine carcinoma of the endometrium: A case report

( Tae Wook Kong ),( Ji Sun Lee ),( Ha Na Cho ),( Ji Heum Paek ),( Suk Joon Chang ),( Yong Hee Lee ),( Hee Sug Ryu ) 대한산부인과학회 2015 대한산부인과학회 학술대회 Vol.101 No.-

Increased risk of thyroid cancer in female residents nearby nuclear power plants in Korea: was it due to detection bias?

Bong-Kyu Kim,Jung-Min Kim,Myoung-Hee Kim,Do-Myung Paek,Seung-Sik Hwang,Mi-Na Ha,Young-Su Ju 대한직업환경의학회 2018 대한직업환경의학회지 Vol.30 No.-

Background: The Korea Radiation Effect & Epidemiology Cohort - The resident cohort (KREEC-R) study concluded that there is no epidemiological or causal evidence supporting any increase in cancer risks resulting from radiation from Korean nuclear power plants (NPPs). But the risks of thyroid cancer in women were significantly higher in residents living near NPPs than control. Debate about the cause of the pattern of thyroid cancer incidence in women is ongoing and some researchers argue that detection bias influenced the result of KREEC-R study. Therefore there was a need to investigate whether residents living near NPPs who were assessed in the KREEC-R were actually tested more often for thyroid cancer. We evaluated the possibility of detection bias in the finding of the KREEC-R study based on materials available at this time. Methods: Using the KREEC-R raw data, we calculated age standardized rates (ASRs) of female thyroid cancer and re-analyzed the results of survey on the use of medical services. We also marked the administrative districts of residents who received the Radiation Health Research Institute (RHRI) health examinations and those in which thyroid cancer case occurred as per the Chonnam National University Research Institute of Medical Sciences (RIMS) final report on maps where the locations of NPPs and 5 km-radii around them were also indicated. And we compared the incidence rates of Radiation-induced cancer measured between the first period when RHRI health examinations were not yet implemented, and the second period when the RHRI health examinations were implemented. Results: The ASR for the far-distance group, which comprised residents living in areas outside the 30 km radius of the NPPs, increased rapidly after 2000; however, that of the exposed group, which comprised residents living within a 5 km radius of the NPPs, started to increase rapidly even before 1995. The frequencies of the use of medical services were significantly higher in the intermediate proximate group, which comprised residents living within a 5-30 km radius of the NPPs, than in the exposed group in women. In case of female thyroid cancer, the second period ASR was higher than the first period ASR, but in case of female liver cancer and female stomach cancer no significant difference were observed between the periods. On map, many administrative districts of residents who received RHRI health examinations and most administrative districts in which thyroid cancer case occurred on RIMS final report were outside 5 km-radii around NPPs. Conclusions: We could not find any evidence supporting the assertion that detection bias influenced the increased risks of female thyroid cancer observed in the exposed group of the KREEC-R study, as opposed to the control group.

Immunity to melanoma mediated by 4‐1BB is associated with enhanced activity of tumour‐infiltrating lymphocytes

Ju, Seong‐,A,Lee, Sang‐,Chul,Kwon, Tae‐,Hyoung,Heo, Sook‐,Kyoung,Park, Sang‐,Min,Paek, Ha‐,Na,Suh, Jae‐,Hee,Cho, Hong Rae,Kwon, Byungsuk,Kwon, Byoung S,Kim, B Nature Publishing Group 2005 Immunology and Cell Biology Vol.83 No.4

<P>4‐1BB costimulates T cells to carry out effector functions such as eradication of established tumours. 4‐1BB (CD137) is a member of the TNF receptor family, and its triggering by either 4‐1BB ligand or antibody ligation induces T‐cell activation and growth. We analysed tumour‐infiltrating lymphocytes (TIL) in the experimental B16F10 melanoma model to determine the mechanisms involved in 4‐1BB‐mediated tumour suppression. 4‐1BB<SUP>+/+</SUP> mice survived longer than 4‐1BB<SUP>–/–</SUP> mice, and survival was further prolonged by triggering 4‐1BB with an agonistic mAb. The number of metastatic B16F10 colonies in the lung was much greater in 4‐1BB<SUP>–/–</SUP> mice than in their 4‐1BB<SUP>+/+</SUP> littermates. Administration of agonistic anti‐4‐1BB mAb increased the number of TIL in the tumour masses in the lungs of 4‐1BB<SUP>+/+</SUP> mice. The numbers of CD4<SUP>+</SUP> T, CD8<SUP>+</SUP> T and CD11b<SUP>+</SUP> TIL increased in these mice. Anti‐4‐1BB mAb induced not only CD8<SUP>+</SUP> 4‐1BB<SUP>+</SUP> T cells but also a CD8<SUP>+</SUP> IFN‐γ<SUP>+</SUP> T‐cell population. B16F10 cells from the lungs of anti‐4‐1BB‐treated mice showed enhanced expression of MHC class Ι and II antigens compared with the same cells from control IgG‐treated mice. Thus, the increase in number of CD8<SUP>+</SUP> T cells and enhanced MHC Ι and II expression in B16F10 cells that result from augmented IFN‐γ production in response to anti‐4‐1BB mAb may lead to suppression of tumour growth and metastasis.</P>