Pathological angiogenesis and inflammation in tissues

Ji‑Hak Jeong,Uttam Ojha,이유미 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.1

The role of angiogenesis in the growth of organsand tumors is widely recognized. Vascular–organ interactionis a key mechanism and a concept that enables an understandingof all biological phenomena and normal physiologythat is essential for human survival under pathologicalconditions. Recently, vascular endothelial cells have beenclassified as a type of innate immune cells that are dependenton the pathological situations. Moreover, inflammatorycytokines and signaling regulators activated upon exposureto infection or various stresses play crucial roles in the pathologicalfunction of parenchymal cells, peripheral immunecells, stromal cells, and cancer cells in tissues. Therefore,vascular–organ interactions as a vascular microenvironmentor tissue microenvironment under physiological and pathologicalconditions are gaining popularity as an interestingresearch topic. Here, we review vascular contribution as amajor factor in microenvironment homeostasis in the pathogenesisof normal as well as cancerous tissues. Furthermore,we suggest that the normalization strategy of pathologicalangiogenesis could be a promising therapeutic target forvarious diseases, including cancer.

The Usefulness of 3D-CT Angiography as a Screening Tool for Vascular Abnormalities in Spontaneous ICH Patients

Lee, Ho-Jin,Kong, Min-Ho,Hong, Hyun-Jong,Kang, Dong-Soo,Song, Kwan-Young The Korean Neurosurgical Society 2007 Journal of Korean neurosurgical society Vol.41 No.4

Objective : We investigated the incidence of the vascular abnormalities associated with spontaneous intracerebral hemorrhage [ICH] using three-dimensional computed tomographic angiography [3D-CTA]. Methods : We prospectively assessed consecutive 76 patients with spontaneous intracerebral hemorrhage [ICH] who underwent 3D-CTA between June 2003 and May 2005. The patients with a recent history of trauma or mainly subarachnoid hemorrhage were excluded. We investigated relationship between vascular abnormality and ICH location. The findings of 3D-CTA were classified as one of three patterns with ICH; type A [without evidence of vascular abnormality], type B [with no vascular abnormality as the source of hemorrhage, but with incidental vascular abnormality], and type C [presence of a vascular abnormality as the source of hemorrhage]. Results : Sites of ICH were lobar 26, basal ganglia 23, thalamus 17, posterior fossa 6 and dominant intraventricular hemorrhage [IVH] 4. Among 76 patients, sixteen [21.1%] vascular abnormalities were noted excluding 13 cases of stenoocclusive disease. Sixteen cases included 6 cases of cerebral aneurysms [7.9%], 5 moyamoya diseases [6.6%], 4 arteriovenous malformations [5.3%] and 1 dural sinus thrombosis [1.3%]. Lobar ICH [30.8%] had a higher vascular abnormalities than other types, and younger age [<40] group had a higher incidence of vascular abnormalities than old age group. The patterns of 3D-CTA include sixty cases [79.0%] of type A, 6 cases [7.8%] of type Band 10 cases [13.2%] of type C. The vascular abnormalities were found in 8 [13.5%] of 59 hypertensive patients and 8 [47.0%] of 17 non-hypertensive patients [p=0.006]. Conclusion : 3D-CT angiography is considered a useful screening tool for ICH patients with suspected cerebrovascular abnormalities and should be considered in such clinical settings, especially in lobar type and in non-hypertensive younger patients.

A Review of the Current State and Future Directions for Management of Scalp and Facial Vascular Malformations

Emma Hartman,Daniel M. Balkin,Alfred Pokmeng See 대한신경외과학회 2024 Journal of Korean neurosurgical society Vol.67 No.3

Vascular malformations are structural abnormalities that are thought to result from errors in vasculogenesis and angiogenesis during embryogenesis. Vascular malformations of the scalp present unique management challenges due to aesthetic and functional implications. This review examines the pathophysiology, clinical presentation, and management techniques for six common types of vascular malformations of the face and scalp : infantile hemangioma, capillary malformations, venous malformations, lymphatic malformations, arteriovenous malformations, and arteriovenous fistulas. These lesions range from common to rare, and have very different natural histories and management paradigms. There has been increasing understanding of the molecular pathways that are altered in association with these vascular lesions and these molecular targets may represent novel strategies of treating lesions that have historically been approached from a structural perspective only.

Video-Assisted Thoracoscopic Division of Vascular Rings

이정희,양지혁,전태국 대한흉부외과학회 2015 Journal of Chest Surgery (J Chest Surg) Vol.48 No.1

This study reports our early experience with thoracoscopic division of vascular rings. Three patients were reviewed;their ages at surgery were 25 months, 4 years, and 57 years. All patients were suffering from complete vascularrings involving combinations of the right aortic arch, left ligamentum arteriosum, Kommerell’s diverticulum, and retroesophagealleft subclavian artery. The median surgical time was 180.5 minutes, and the patients showed immediaterecovery. Three complications, namely chylothorax, transient supraventricular tachycardia, and left vocal cord palsy,were observed. Our early experience indicates that thoracoscopic division of a vascular ring may provide early recoveryand could be a promising operative choice.

Isoprocarb induces acute toxicity in developing zebrafish embryos through vascular malformation

Hahyun Park,Gwonhwa Song,Whasun Lim 한국동물생명공학회(구 한국동물번식학회) 2021 Journal of Animal Reproduction and Biotechnology Vol.36 No.1

In this study, the potential toxicity of isoprocarb was demonstrated using zebrafish embryos. We treated isoprocarb (0, 29, and 58 mg/L) to the zebrafish embryos for 72 h then, we estimated morphological changes and apoptotic cell numbers. The increasing extent of apoptosis from the anterior to posterior region of developing zebrafish larvae was correlated with toxicity in the overall development process, including growth and normal organ formation. The appearance of abnormalities in the isoprocarb-treated groups in comparison to normal developing zebrafish larvae was verified using quantitative image analysis based on ImageJ software program. The vascular system comprising a complex interconnection of blood vessels was visualized in vessel-fluorescent transgenic zebrafish (fli1:eGFP). The main vasculature was malformed on isoprocarb treatment, and this was also related to cardiac defects. Taken together, normal embryonic development in zebrafish was interrupted owing to the acute toxicity of isoprocarb.

Isoprocarb induces acute toxicity in developing zebrafish embryos through vascular malformation

Park, Hahyun,Song, Gwonhwa,Lim, Whasun The Korean Society of Animal Reproduction and Biot 2021 한국동물생명공학회지 Vol.36 No.1

In this study, the potential toxicity of isoprocarb was demonstrated using zebrafish embryos. We treated isoprocarb (0, 29, and 58 mg/L) to the zebrafish embryos for 72 h then, we estimated morphological changes and apoptotic cell numbers. The increasing extent of apoptosis from the anterior to posterior region of developing zebrafish larvae was correlated with toxicity in the overall development process, including growth and normal organ formation. The appearance of abnormalities in the isoprocarb-treated groups in comparison to normal developing zebrafish larvae was verified using quantitative image analysis based on ImageJ software program. The vascular system comprising a complex interconnection of blood vessels was visualized in vessel-fluorescent transgenic zebrafish (fli1:eGFP). The main vasculature was malformed on isoprocarb treatment, and this was also related to cardiac defects. Taken together, normal embryonic development in zebrafish was interrupted owing to the acute toxicity of isoprocarb.

노인 우울증

김도훈(Do Hoon Kim) 대한노인정신의학회 2004 노인정신의학 Vol.8 No.2

Geriatric depression is a major public health problem. There has been significant progress in our understanding of the nature, clinical course, and treatment of geriatric depression. Important new findings have emerged in a number of areas directly affecting clinical care and have, in turn, stimulated further research. These findings include the association of geriatric depression with brain abnormality and vascular disease;clinical importance of subsyndromal depression;the possible role of sex hormone;the clinical utility of new antidepressant treatments:and clear relationship between depression and suicide. These new findings in various area of geriatric depression were discussed in the present article.

아토피 피부염의 비정상적 피부혈관반응에 관한 연구

유재명(Jae Myung Yoo),김홍직(Hong Jig Kim),황규왕(Kyu Wang Whang) 대한피부과학회 1991 大韓皮膚科學會誌 Vol.29 No.1

The delayed blanch is one of the most discussed but undecided facets of atopic dermatitis as yet. At present, they favor the theory that delayed blanch is due to vasoconstriction, but it is not obvious whether this is due to true vasoconstriction or to the blood vessels being narrowed by the surrounding exudative edema, resulted from vasodilatation and increased capillary per meability. We compared cutaneous response of severe atopic dermatitis with that of age matched non-atopic individuals after intradermal injection of acetylcholine by means of naked eye and laser Doppler flowmeter examination, control group showed flare and wheals while at,opy group resulted in delayed blanch in addition to flare and whealing. The results of laser Doppler flowmeter examination revealed that, as compared to baseline, atopy group showed statistically significantly increase in spite of delayed blanch. We suggested that the delayed blanch may be not due ta va.soconstriction but due to the vasadilatation and aceumulation of edema fluid. (Kor J Dermatol 29(1): 26 31, 1991)

Arterial stiffness in young women with Turner syndrome using cardio-ankle vascular index

You Jung Heo,정혜운,이영아,Choong Ho Shin,Sei Won Yang 대한소아내분비학회 2019 Annals of Pediatirc Endocrinology & Metabolism Vol.24 No.3

Purpose: Patients with Turner syndrome (TS) have increased risk of morbidities and mortality related to cardiovascular complications. Cardio-ankle vascular index (CAVI) is a novel method of evaluating arterial stiffness independent of changes in blood pressure. We compared arterial stiffness using CAVI between TS patients and healthy control subjects. Methods: Nineteen young women with TS (mean, 26.8 years; range, 20.0–35.1 years) and 23 healthy women matched for age and body mass index (BMI) were recruited for CAVI measurements at Seoul National University Hospital between 2010 and 2013. Anthropometric parameters, fasting blood testing and measurements of CAVI were compared between the 2 groups. Results: TS patients were significantly shorter (mean: 150.1 cm vs. 160.7 cm, P<0.001) and had lower body weight (mean: 47.0 kg vs. 55.5 kg, P=0.014) than healthy controls, without difference in BMI. CAVI (6.5±0.6 vs. 6.1±0.6, P=0.039) was significantly higher in TS patients compared to healthy controls. Age was positively associated with CAVI (r=0.403, P=0.008) in univariate analysis. After adjusting for age, TS was associated with CAVI (P=0.006). Conclusion: Young women with TS showed increased arterial stiffness measured by CAVI compared to healthy women after adjusting for age, suggesting inherent vasculopathy in TS patients.

Interrupted Inferior Vena Cava with Hemiazygos Continuation in an Adult with a Persistent Left Superior Vena Cava and Left Single Coronary Artery: A Case Report

김여진,권세환,안성은,김수중,신종수,오주형 대한영상의학회 2016 대한영상의학회지 Vol.74 No.6

A 50-year-old woman was referred to our institution for medical screening due to an incidental finding on abdominal ultrasonography. She underwent chest, abdomen and cardiac multi-detector computed tomography (MDCT). Her MDCT revealed absence of the hepatic segment of the inferior vena cava (IVC), with hemiazygos continuation and a left single coronary artery. The dilated hemiazygos vein drained directly into the persistent left superior vena cava (SVC). Herein, we reported a very rare case combining an incidentally found interrupted IVC with hemiazygos vein continuation, persistent left SVC and a left single coronary artery diagnosed by MDCT.