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Kupperman's index로 평가된 급성 갱년기 장애 치험 1례
정민영,손영주 대한한방부인과학회 2004 大韓韓方婦人科學會誌 Vol.17 No.2
Purpose : The climacteric disturbance has biological, social and psychologycal character. It's very difficult that treatment's effect of climacteric symptoms by Traditional Korean Medicine(TKM) is appeared objectively. We want to propose that the climacteric symptom be measured objectively and diagnosed definitely by climacteric index. Treatment by TKM of the climacteric symptom can be valued by climacteric index. Method : We measured each climacteric symptom by Kupperman's index and summed up each climacteric index. Then, We compared climacteric disturbance before treatment with one after treatment by Kupperman's index. Result : We treated her who had haven acute climacteric symptoms with herb medication, accupucture, and moxibustion during short term admission. During the admission, her climateric symtoms were improved. The sum of patient's climacteric index was rapidly decreased(from 48 to 20). Conculsion : The treatment by TKM which improves climacteric symptoms is very effective. It would be valid to measure by Kupperman's index for treatment's effect of climacteric symptoms.
갱년기 증상의 척도로서의 심박 변이도의 활용에 관한 연구
안수정 ( Soo Jeong Ahn ),황재호 ( Jae Ho Hwang ),최정은 ( Jung Eun Choi ),조정훈 ( Jung Hoon Cho ),장준복 ( Jun Bock Jang ),이경섭 ( Kyung Sub Lee ) 대한한방부인과학회 2005 大韓韓方婦人科學會誌 Vol.18 No.3
Purpose: To investigate relation between Heart rate variability(HRV) and Kupperman`s index. Methods: From 2004, 3, 15 to 2004, 4, 10, a total 18 female patients(age 40-61) was recruited. but 2 patients was excluded. one was under hormone raplacement therapy, the other was under drug treatment. We measured patient`s HRV by SA-2000E(Medicore Co., Ltd., Korea), and they fulfilled kupperman`s index and qustionnaire. Results: The mean age of patient was 50.13±5.78 years. 6 of 16 patients was menopause, 12 of 16 patients had menstruation. half of 16 patients had a understanding about climacteric syndrome. Investigating relation between HRV and kupperman`s index, kupperman`s index had positive correlation with heart rate significantly. Kupperman`s index had negative correlation with SDNN significantly. Kupperman`s index had negative correlation with RMS-SD significantly. Conclusion: In this study, we presented relation between HRV and kupperman`s index. Furthermore, large scale study is required.
인삼양영탕(人蔘養榮湯) 투여로 호전된 갱년기장애(更年期障碍) 15예(例)에 대한 임상고찰
조성희,양승정,박경미,조현정,정지예,반혜란,Jo, Seung-Hee,Yang, Seung-Jung,Park, Gyeong-Mi,Jo, Hyeon-Jeong,Jeong, Ji-Ye,Ban, Hye-Ran 대한한방체열의학회 2006 대한한방체열의학회지 Vol.5 No.1
Objective: The purpose of this study is to evaluate the effects of Insamyang-yeongtang on menopausal disorder patients Methods : We surveyed 15 menopausal disorder patients who had been administered Insamyang-yeongtang. The patients of menopausal disorder had been estimated twice with Kupperman's index. Result : When patients had been not administered Insamyang-yeongtang. the mean of Kupperman's index score are $42.73(SD{\pm}19.16)$. When administered Insamyang-yeongtang, the mean of kupperman's index score are $25.87(SD{\pm}19.16)$. The difference mean of first and last score are 16.87(p-value 0.001). Conclusion : This study suggests that Insamyang-yeongtang is significantly effective on menopausal disorder patients.
가미귀비환 투여로 호전된 갱년기장애 환자 21례에 대한 증례보고
조성희 ( Seong Hee Cho ) 대한한방부인과학회 2014 大韓韓方婦人科學會誌 Vol.27 No.4
Objectives: The purpose of this study is to evaluate the effects of Kamikubi-hwan on menopausal disorder patients. Methods: We surveyed 21 menopausal disorder patients was administered Kamikubi-hwan. The patients of menopausal disorder was estimated twice with Kupperman``s index (KI) and Stress response inventory (SRI). Results: After treatment, the mean of KI and SRI score were decreased. Symptoms of menopausal disorder were decreased. Conclusions: This study shows that Kamikubi-hwan is significantly effective on menopausal disorder patients.
시호가용골모려탕(柴胡加龍骨牡蠣湯)으로 호전된 갱년기증후군 환자 치험 5례
이용현 ( Yong Hyun Lee ) 대한한방부인과학회 2013 大韓韓方婦人科學會誌 Vol.26 No.1
Objectives: The purpose of this study is to evaluate the effects of Shihogayonggolmoryo-tang on climacteric symptoms. Methods: We studied 5 climacteric symptoms patients who visited Oriental Hospital of OO University from March 2012 to September 2012. We treated them with Shihogayonggolmoryo-tang, acupuncture and moxibustion. The patients of climacteric symptoms had been estimated with Kupperman`s index. Results: After treatment, climacteric symptoms were improved and mean score of Kupperman`s index was reduced (the first case reduce from 82 to 13 during 3 months, the second case reduce from 81 to 19 during 2 months, the third case reduce from 80 to 21 during 2 months, the fouth case reduce from 50 to 9 during 2 months, the fifth case reduce from 66 to 17 during 1 month). Conclusions: This study suggests that Shihogayonggolmoryo-tang is significantly effective on climacteric symptoms patients.
천연소재 MS-10의 에스트로겐 수용체 조절을 통한 여성건강 증진
노유헌(Yoo-Hun Noh),이지원(Ji Won Lee),박지애(Jiae Park),이상형(Sang Hyung Lee),이준영(Jun Young Lee),김성수(Sung-Su Kim),박광균(Kwang-Kyun Park),김태진(Tae Jin Kim),명순철(Soon-Chul Myung),정윤화(Yoonhwa Jeong) 한국식품영양과학회 2016 한국식품영양과학회지 Vol.45 No.6
엉겅퀴와 타임의 복합추출물인 MS-10이 여성호르몬 수용체를 가역적으로 활성화해 여성갱년기에 감소하는 에스트로겐이 효율적으로 사용될 수 있도록 작용한다는 것이 확인되었다. 12주간의 인체적용시험에서 MS-10은 안면홍조 및 야한증, 감각마비, 수면장애, 신경과민, 우울, 현기증, 피로, 관절 및 근육통, 두통, 가슴 두근거림(심계항진), 그리고 질건조 등의 여성갱년기 증상이 개선되었음이 확인되었다. 이러한 MS-10의 여성갱년기 증상 개선은 MS-10에 의한 insulin-like growth factor-1의 개선에 기인한 것으로 판단된다. MS-10은 여성갱년기 증상을 개선하는 천연소재 건강기능식품으로 사용될 수 있다. In this study, the expression level of estrogen receptor in an ovariectomized rat model was effectively enhanced by MS-10, Cirsium japonicum and Thymus vulgaris extract complex, in a reversible manner. MS-10 plays a positive role in enhancing estrogen activity at low concentrations, leading to improved women"s health. In order to determine whether or not MS-10 improves menopausal symptoms clinically, a randomized, double-blinded, and placebo-controlled clinical study was carried out on 62 middle-aged women treated with 500 mg of MS-10 or placebo daily for 12 weeks. Clinical menopausal symptoms were evaluated by Kupperman"s index (KI) detecting various menopausal symptoms, including hot flushes, parenthesis, insomnia, nervousness, melancholia, dizziness, fatigue, rheumatic pain, palpitations, formication, and headaches. Total KI score decreased significantly by about 18% upon ingestion of MS-10. Colpoxerosis, a main symptom of menopause, was significantly reduced by about 21% upon ingestion of MS-10 in contrast to placebo. In addition, reduction of insulin-like growth factor-1 with age was improved by over 10% upon ingestion of MS-10, whereas there were no significant difference with placebo. No side effects appeared after treatment with MS-10. Thus, MS-10 can be suggested as a plausible natural substance for improving women"s health.