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민창호,민영실,이상준,손의동 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.6
It has been reported that several aminoglycosideantibiotics have a potential of prolonging the action of nondepolarizingmuscle relaxants by drug interactions actingpre-synaptically to inhibit acetylcholine release, butantibiotics itself also have a strong effect on relaxing thesmooth muscle. In this study, four antibiotics of aminoglycosidessuch as gentamicin, streptomycin, kanamycinand neomycin were compared with skeletal muscle relaxantsbaclofen, tubocurarine, pancuronium and succinylcholine,and a smooth muscle relaxant, papaverine. Themuscle strips isolated from the rat bladder were stimulatedwith pulse trains of 40 V in amplitude and 10 s in duration,with pulse duration of 1 ms at the frequency of 1–8 Hz, at1, 2, 4, 6, 8 Hz respectively. To test the effect of fourantibiotics on bladder smooth muscle relaxation, each ofthem was treated cumulatively from 1 lM to 0.1 mM withan interval of 5 min. Among the four antibiotics, gentamicinand neomycin inhibited the EFS response. The skeletalmuscle relaxants (baclofen, tubocurarine, pancuronium andsuccinylcholine) and inhibitory neurotransmitters (GABAand glycine) did not show any significant effect. However,papaverine, had a significant effect in the relaxation of thesmooth muscle. It was suggested that the aminoglycosideantibiotics have inhibitory effect on the bladder smoothmuscle.
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