http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Jeong Jong Heon,Hyun Gyu Hwan,Park Yu Jeong,Kwon Sung Won,Lee Ai-Young 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.6
Etretinate, an acitretin metabolite, has a long retention duration in adipose tissues with a teratogenic potential. FDA advises a contraceptive period of at least three years after discontinuing acitretin. However, the effect of accumulated etretinate in adipose tissues on fetus is unknown. Although the teratogenic threshold for serum concentration of etretinate has been presented as higher than 2 ng/mL, that of acitretin is unknown. To examine factors affecting body retention of acitretin and etretinate, effects of acitretin dosage, acitretin-taking duration, elapsed time after stopping acitretin, age, sex, concomitant alcohol consumption, and foods and supplements rich in vitamin A intake on serum concentrations of acitretin and etretinate were analyzed in 14 acitretintaken patients and 58 controls without taking acitretin or etretinate. Serum concentrations of acitretin, but not etretinate, tended to be inversely related to the discontinuation duration. They were also related to old age. Different from a published result that alcohol consumption could promote the metabolism of acitretin into etretinate, alcohol intake did not affect serum concentrations of etretinate. Unexpectedly, more frequent intake of vitamin A or provitamin A-rich food and supplements was associated with higher serum acitretin, whereas less frequent intake of vitamin A or provitamin A-rich food and supplements was associated with higher serum levels of etretinate in acitretin-taken patients. Despite preliminary data, inter-individual variations in serum retention of etretinate suggest the necessity of further research before applying the same guidelines to everyone to minimize unnecessary contraception.
건선에서 acitretin과 etretinate의 치료 효과 비교
문상은(Sang Eun Moon),김방순(Bang Soon Kim),윤재일(Jai Il Youn),이유신(Yoo Shin Lee) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.3
Etretinate, an effective retinoid in the treatment of pustular, erythrodermic and chronic plaque type psoriasis, has the disadvantage of a long terminal elimination half-life. On the other hand, acitretin, the active metabolite of etretinate, has much shorter terminal elimination half-life and is being reported as an agent with good antipsoriatic activity by several authors. To evaluate the clinical efficacy of acitret.in in comparison with etretinate, we treated 10 patients wit,h acitretin at a dose of 30mg per day and 11 patients with etretinate at a same dose for 12 weeks. The PASI score at 12 week was significantly reduced in each group as compared with baseline PASI score. In the acitretin treated group the initial PASI score of 14.5 reduced to 3.9, while the etretinate group PASI score reduced from 12.0 to 3.1. The PASI score differ ences between the acitretin and etretinate groups at each time during therapy and the end of therapy were not statistically significant. The severity of adverse reactions with acitretin was similar to those with etretinate but their incidence was higher. The change in laboratory parameters in the acitretin group was simlar to that of the etretinate group. In view of these results and the known pharmacokinetic advantage of acitretin, that is the short terminal elimination half-life, it is conceivable that acitretin may be a useful alternative to etretinate in the treatment of psoriasis. (Kor J Dermatol 1992; 30(3): 354-361)
Etretinate와 Tretinoin Cream을 병용 치료하여 빠른 호전을 보인 Darier병
허광회 ( Kwang Hoi Hur ),김희옥 ( Hee Ok Kim ),박시룡 ( See Ryong Park ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.4
We report a case of Dariers disease which showed a more effective result using a combined treatment with oral etretinate and topical tretinoin cream than treatment with oral etretinate alone in a 17-year old male patient. Oral etretinate 40mg was given daily and topical therapy with tretinoin cream was applied to lesions of neck and face. Two weeks later, lesions of neck and face showed good improvement compared with the not applied lesions. Topical therapy was then extended to other lesions. Six weeks after treatment, there was a marked improvement. Three months after treatment, most of lesions were nearly gon. (Kor J Denllatol 1995;33(4): 764 768)
Etretinate로 치료한 영아에서 발생된 범발성 농포성 건선
이건복(Kun Bock Lee),이상배(Sang Bae Lee),조백기(Baik Kee Cho),허원(Won Houh) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.3
We present herein a case of generalized pustular psoriasis in a 17-month-old female infant, who showed good response to etretinate therapy. The baby showed generalized pustular eruptions with high fever and marked leukocytosis preceded by annular scaly erythematous and annular pustular lesions. Etretinate was given in a dose of 10mg(0.75mg/kg/day) for 10 days, and then tapered to 7mg, 5mg, and 4mg in every 10 to 13 days. Clinical improvement was noted after 7 days' treatment and almost all of the skin lesions including erythroderma were cleared after 6 weeks' treatment. She is now maintained with 3mg of etretinate without recurrence.
Etretinate로 치료한 소아에서의 호저피상 어린선
김명남(Myeung Nam Kim),전인기(In Gi Chun),노병인(Byung In Ro),장진요(Chin Yo Chang) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.1
A 4-year-old boy have had widespread, multiple, dark brownish, verrucous ]papular plaques on the neck, left chest, right side of abdomen, back and penile skin since birth. Clinical features and light and electron microscopic findings were consistent with ichthyosis hystrix. The patient was successfully treated with systemic administration of etretinate and vitamin E.
정승호,김영근,조문균,정현 순천향대학교 1993 논문집 Vol.16 No.2
Lichen amyloidosis is a most common form of cutaneous amyloidosis and is characterized by the appearance of paroxysmally itch lichenoid papules, typically on the shins, with intense pruritus. Amyloid deposits arise as a result of focal epidermal damage, with subsequent conversion of degenerated epidermal cells into amyloid in the papillary body in lichen amyloidosis. A 52-year old male patient had a large number of brown colored, lichenoid, rice-grain sized, intense pruritic papules on both shin areas of 5 year duration. Diagnosis was made by characteristic clinical and histopathologic findings. He had been treated with systemic use of etretinate.
Darier-White病 1例 : 經口 Etretinate의 使用 經驗 Treated wiht Oral Aromatic Retinoid
成好錫,崔英子,王翰英 인제대학교 1984 仁濟醫學 Vol.5 No.2
Decrier-White病은 遺傳性 丘疹鱗屑性疾患으로 아직도 滿足스러운 治療法이 없으나 最近 새로이 合成된 經口用 retinoids의 導入이 많은 關心과 期待를 모으고 있다. 著者等은 23歲의 男子 例에서 經口用 aromatic retinoid인 etretinate(Tigason)를 使用하여 좋은 效果를 보았다. Darier-White disease is a rare autosomal dominant hereditary disease with characteristic clinical & histological features. There is still no satisfactory treatment for this disease, but recently in some cases dramatic improvement has been reported following the oral administration of newly synthesized aromatic retinoids. We report a case of 23 year-old man who developed characteristic skin lesions of dirty brownish verrucous papules & plaques and typical histological findings of dyskeratotic changes. Treatment with oral etretinate was started at a dose of 50mg daily. After 15 days treatment when the skin lesions improved the dose reduced to 25mg daily and continued for subsequent 25 days. After total 40 days treatment the patient was nearly completely free of disease.