Mirror Image Gerbode or Partial Atrioventricular Canal Defect?

Cem Ariturk, Ass.Prof.,Ahmet Umit Gullu, Ass.Prof.,Sahin Senay, Ass.Prof.,Eyup Murat Okten, M.D.,Fevzi Toraman,E. Hasan Karabulut, Prof.,Letisya Melengic, M.S.,Cem Alhan, Prof. 대한흉부외과학회 2015 Journal of Chest Surgery (J Chest Surg) Vol.48 No.6

Gebode defect, that can accurately be treated surgical repair, is defined as a true communication between left ventricle and right atrium. A 74-year-old woman with a worsening history of ortophnea and peripheral edema was hospitalised. A communication between right atrium and left ventricle was diagnosed using transeusophageal echocardiography. The defect was repaired and mitral valve was replaced with a biologic valve. It would be beter to tailor surgical strategy for each case with atrioventricular canal defect after preoperative transeusophageal echocardiography and peroperative direct sight.

Long-term outcomes of cervical cancer patients with complete metabolic response after definitive chemoradiotherapy

Cem Onal,Ozan Cem Guler,Mehmet Reyhan,Ali Fuat Yapar 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.5

Objective: We investigated the importance of metabolic parameters measured with18 F-fluorodeoxyglucose positron-emission tomography integrated with computed tomography (FDG-PET/CT) for predicting progression-free survival (PFS) and overall survival (OS) in cervical cancer with complete metabolic response (CMR) after chemoradiotherapy (ChRT). Methods: The clinical data and PET parameters including standardized uptake value (SUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of 122 patients having CMR in post-treatment 18F-FDG-PET/CT delivered a median of 3.9 months after ChRT completion were analyzed. Results: With a median follow-up of 8.4 years, 55 patients (45%) presented with disease a median of 19.7 months after ChRT. For SUVp, MTVp, TLGp, SUVln, MTVln, and TLGp, the cut- off values for OS determined by receiver operating curve analysis were 15.8, 48.7 cm3, 552.3, 8.7, 7.0 cm3, respectively. All metabolic PET parameters were significant prognostic factors for OS and PFS in univariate analysis. International Federation of Gynecology and Obstetrics (FIGO) stage was predictive of both OS and PFS, while pelvic and/or para-aortic lymph node metastasis were predictive of OS only. In multivariate analysis, FIGO stage ≥IIB, MTVp ≥49.8 cm3, and TLGp ≥597.4 were predictive of worse OS. Advanced stage, presence of lymph node metastasis, higher TLGp, and larger MTVln were significant factors for poor PFS rates. Conclusion: We found that advanced stage and higher TLGp values were significant predictors for poor survival and higher progression rates. Volumetric PET parameters could be used to predict treatment outcomes in patients with CMR after definitive ChRT.

A multi-institutional analysis of sequential versus ‘sandwich’ adjuvant chemotherapy and radiotherapy for stage IIIC endometrial carcinoma

Cem Onal,Sezin Yuce Sari,Berna Akkus Yildirim,Guler Yavas,Melis Gultekin,Ozan Cem Guler,Serap Akyurek,Ferah Yildiz 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.3

Objective: To analyze the outcomes of sequential or sandwich chemotherapy (ChT) and radiotherapy (RT) in patients with node-positive endometrial cancer (EC). Methods: Data from 4 centers were collected retrospectively for 179 patients with stage IIIC EC treated with postoperative RT and ChT (paclitaxel and carboplatin). Patients were either treated with 6 cycles of ChT followed by RT (sequential arm; 96 patients) or with 3 cycles of ChT, RT, and an additional 3 cycles of ChT (sandwich arm; 83 patients). Prognostic factors affecting overall survival (OS) and progression-free survival (PFS) were analyzed. Results: The 5-year OS and PFS rates were 64% and 59%, respectively, with a median followup of 41 months (range, 5–167 months). The 5-year OS rates were significantly higher in the sandwich than sequential arms (74% vs. 56%; p=0.03) and the difference for 5-year PFS rates was nearly significant (65% vs. 54%; p=0.05). In univariate analysis, treatment strategy, age, International Federation of Gynecology and Obstetrics (FIGO) stage, pathology, rate of myometrial invasion, and grade were prognostic factors for OS and PFS. In multivariate analysis, non-endometrioid histology, advanced FIGO stage, and adjuvant sequential ChT and RT were negative predictors for OS, whereas only non-endometrioid histology was a prognostic factor for PFS. Conclusion: Postoperative adjuvant ChT and RT for stage IIIC EC patients, either given sequentially or sandwiched, offers excellent clinical efficacy and acceptably low toxicity. Our data support the superiority of the sandwich regimen compared to the sequential strategy in stage IIIC EC patients for OS.

Preparation of ultra-homogeneous mullite precursor and evaluation of mullite formation

Cem ÖZGÜR,Remzi GÖREN 한양대학교 세라믹연구소 2015 Journal of Ceramic Processing Research Vol.16 No.3

The objective of this study is to present firstly the preparation of atomically ultra-homogeneous mullite precursors by ultrasonic spray pyrolysis technique and then to investigate the evaluation of mullite formation via calcination temperature and soaking time. At a temperature of as low as 500 o C for 15 days, the temperature was very close to the formation temperature of mullite (477 o C) is energetically possible; the structure of the precursor has been preserved as amorphous. It is possible to obtain single phase of mullite crystals at a temperature of 1000 o C without soaking time, while the crystallization required a temperature of 900 o C for 12 hours.

The effect of web-based portfolio use on academic achievement and retention

Cem Oktay Gu¨ zeller 서울대학교 교육연구소 2012 Asia Pacific Education Review Vol.13 No.3

The web-based portfolio emerged as a result of the influence of technological developments on educational practices. In this study, the effect of the web-based portfolio building process on academic achievement and retention is explored. For this purpose, a study platform known as a computer-assisted personal development portfolio was designed for 30 Turkish students who participated in a web-based portfolio process. The academic achievements of the students were examined through an experimental design in which participants were divided into an experimental group and a control group and given a pre-test and a post-test. The results of the study revealed that the levels of both academic achievement and retention in the experimental group were significantly higher than those in the control group. Similar practices can be applied to the teaching of medicine, economics, physical sciences, humanities and other subjects in order to extend students' performance and achievement levels.

Electrohydrodynamic Printing of Silk Fibroin

Cem Bayram,Zeeshan Ahmad,Emir B. Denkbas,ELEANOR STRIDE,Mohan J. Edirisinghe 한국고분자학회 2013 Macromolecular Research Vol.21 No.4

Understanding Hydrogen-Induced Strain Localization in Super Duplex Stainless Steel Using Digital Image Correlation Technique

Cem Örnek,Bilgehan M. Şeşen,Mustafa K. Ürgen 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.2

This paper provides a mechanistic understanding of hydrogen-microstructure-strain interactions in a finely-grained 25Cr–7Nisuper duplex stainless steel subjected to dynamic tensile loading. Miniature-sized tensile specimens were hydrogen-chargedfor up to nine days, and the microstructure was imaged, in-situ, during mechanical tensile testing. Digital image correlationanalysis of the recorded images revealed that the austenite phase underwent softening while the ferrite phase hardened due touptaken hydrogen. Severe strain localization occurred due to dissolved hydrogen in the microstructure resulting in hydrogeninducedcracks. Mobile hydrogen atoms caused softening of the microstructure while trapped hydrogen reasoned hardening. The austenite’s hydrogen absorption capacity is decisive for the susceptibility to hydrogen embrittlement.

Are Mannan-binding Lectine Serin Protease-2 and Alpha-1-microglobulin and Bukinin Precursor the Potential Biomarkers of Manic Episode? A Study via Urinary Proetomic Analysis

Cem Cerit,Mehmet Sarıhan,Ö,mer Nart,Murat Kasap,Hilmi Yaş,ar,Gü,rler Akpınar 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.2

Objective: Investigating the molecular basis of bipolar disorder (BD) is crucial in terms of developing effective treatment strategies as well as objective laboratory-based diagnostic tools for the disease. Methods: We examined the urine samples of BD patients both in manic episode and after remission and compared their urinary protein profiles with the controls. Twelve patients and twelve controls (C group) included to the study. Urinary samples of patients were first collected during manic episode (M group) and then after remission (R group). Two-dimensional gel electrophoresis (2-DE) coupled to MALDI-TOF/TOF massspectrometry approach and Western blot analysis were used. Results: Alpha-1-microglobulin and bukinin precursor (AMBP), Mannan-binding lectine serin protease-2 (MASP-2), and Ig gamma-1-chain displayed significant increases in their abundance in the urine protein pool of M group in comparison to the C and R groups. Alpha-1B glycoprotein and prostaglandin-H2 D-isomerase (PGD2) levels were significantly higher in the urine protein pool of the M and R groups in comparison to the C group. Annexin A1 was downregulated sig-nificantly in the urine protein pool of the M group in comparison to the C group. Conclusion: Intensities of MASP-2 and AMBP proteins discriminated manic episode from remission period and healthy controls indicating that these proteins may be candidate biomarkers for manic episode. The decrease in Annexin A1 and increase in Ig gamma-1 chain levels appeared to be associated with “Manic Episode” while the increase in PGD2 and alpha-1B glycoprotein levels appeared to be associated with “Bipolar Disorder”.

Correlation between microleakage and screw loosening at implantabutment connection

Cem Sahin,Simel Ayyildiz 대한치과보철학회 2014 The Journal of Advanced Prosthodontics Vol.6 No.1

PURPOSE. This study aimed to evaluate the correlation between microleakage and screw loosening at different types of implant-abutment connections and/or geometries measuring the torque values before and after the leakage tests. MATERIALS AND METHODS. Three different abutment types (Intenal hex titanium, internal hex zirconium, morse tapered titaniuım) with different geometries were connected to its own implant fixture. All the abutments were tightened with a standard torque value then the composition was connected to the modified fluid filtration system. After the measurements of leakage removal torque values were re-measured. Kruskal-wallis test was performed for non-parametric and one-way ANOVA was performed for parametric data. The correlation was evaluated using Spearman Correlation Test (α=0.05). RESULTS. Significantly higher microleakage was found at the connection of implant-internal hex zirconium abutment. Observed mean torque value loss was also significantly higher than other connection geometries. Spearman tests revealed a significant correlation between microleakage and screw loosening. CONCLUSION. Microleakage may provoke screw loosening. Removing torque values rationally decrease with the increase of microleakage.

Protective Effect of All-Trans Retinoic Acid in Cisplatin-Induced Testicular Damage in Rats

Cem Yucel,Fatma Demet Arslan,Sumeyye Ekmekci,Volkan Ulker,Erdem Kisa,Elcin Erdogan Yucel,Murat Ucar,Yusuf Ozlem Ilbey,Orcun Celik,Banu Isbilen Basok,Zafer Kozacioglu 대한남성과학회 2019 The World Journal of Men's Health Vol.37 No.2

Purpose: To investigate the effects of all-trans retinoic acid (ATRA) in cisplatin (CP)-induced testicular damage in rats. Materials and Methods: Twenty-eight male Wistar rats were divided into four groups: Control, ATRA alone, ATRA+CP, and CP alone. Body weight, testicular weight, sperm count, sperm motility, percentage of abnormal sperm, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) in testicular tissue, and testicular histopathology were compared among groups. Results: The sperm count and motility significantly decreased and the percentage of abnormal sperm significantly increased in the CP group compared to the control and ATRA groups. CP+ATRA administration significantly increased the sperm count and motility, but reduced the abnormal sperm count. CP administration significantly increased TOS and OSI compared to the control group and the other groups. Administering CP+ATRA significantly decreased TOS and the OSI in testicular tissue and reduced spermatogenesis, but increased the Johnsen score. Conclusions: The destructive effects of CP treatment on testicular tissue and spermatogenesis were reduced by administering ATRA.