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Chemopreventive and metabolic effects of inulin on colon cancer development
Emília Hijová,Viktória Szabadosova,Jana Štofilová,Gabriela Hrčková 대한수의학회 2013 Journal of Veterinary Science Vol.14 No.4
Prebiotics modulate microbial composition and ensure a healthy gastrointestinal tract environment that can prevent colon cancer development. These natural dietary compounds are therefore potential chemopreventive agents. Thirty Sprague-Dawley rats (4 months old) were experimentally treated with procarcinogen dimethylhydrazine to induce colon cancer development. The rats were randomly assigned to three groups: a control group (CG), a group treated with dimethylhydrazine (DMH), and a group given DMH and inulin, a prebiotic (DMH+PRE). The effects of inulin on the activities of bacterial glycolytic enzymes, short-chain fatty acids, coliform and lactobacilli counts, cytokine levels, and cyclooxygenase-2 (COX-2) and transcription nuclear factor kappa beta (NFκB) immunoreactivity were measured. Inulin significantly decreased coliform counts (p < 0.01), increased lactobacilli counts (p < 0.001), and decreased the activity of β-glucuronidase (p < 0.01). Butyric and propionic concentrations were decreased in the DMH group. Inulin increased its concentration that had been reduced by DMH. Inulin decreased the numbers of COX-2- and NFκB-positive cells in the tunica mucosae and tela submucosae of the colon. The expression of IL-2, TNFα, and IL-10 was also diminished. This 28-week study showed that dietary intake of inulin prevents preneoplastic changes and inflammation that promote colon cancer development. Prebiotics modulate microbial composition and ensure a healthy gastrointestinal tract environment that can prevent colon cancer development. These natural dietary compounds are therefore potential chemopreventive agents. Thirty Sprague-Dawley rats (4 months old) were experimentally treated with procarcinogen dimethylhydrazine to induce colon cancer development. The rats were randomly assigned to three groups: a control group (CG), a group treated with dimethylhydrazine (DMH), and a group given DMH and inulin, a prebiotic (DMH+PRE). The effects of inulin on the activities of bacterial glycolytic enzymes, short-chain fatty acids, coliform and lactobacilli counts, cytokine levels, and cyclooxygenase-2 (COX-2) and transcription nuclear factor kappa beta (NFκB) immunoreactivity were measured. Inulin significantly decreased coliform counts (p < 0.01), increased lactobacilli counts (p < 0.001), and decreased the activity of β-glucuronidase (p < 0.01). Butyric and propionic concentrations were decreased in the DMH group. Inulin increased its concentration that had been reduced by DMH. Inulin decreased the numbers of COX-2- and NFκB-positive cells in the tunica mucosae and tela submucosae of the colon. The expression of IL-2, TNFα, and IL-10 was also diminished. This 28-week study showed that dietary intake of inulin prevents preneoplastic changes and inflammation that promote colon cancer development.
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김흥로(HR Kim),김평국(PK Kim),하병욱(BW Ha),김태균(TK Kim),곽정상(JS Kwak),곽태로(TR Gwag) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.8
Implantation of a blastocyst within the endocervical canal is termed a“cervical pregn-ancy”, which is one of the most dangerous forms of ectopic pregnancy. It is even less common, but the incidence appear to be increasing, in part due to newer forms of assisted reproduction. Proper management is indicated as soon as the diagnosis is suspected. Hemorrhage may be massive and sometimes fatal. In the past, hysterectomy was often the only choice available because of profuse hemorrhage that accompanied attempts at removal of the cerv- ical pregnancy. We report two cases of cervical pregnancy treated conservatively without hysterect- omy. Hemorrhage from the implantation site was controlled by intracervical placement of a Foley catheter balloon without hemostatic cervical sutures at 3 and 9 o clock. Immediate insertion of a Foley catheter into the cervical canal and inflation of the catheter bulb after endocervical suction curettage appears to be a simple and effective technique of managing cervical pregnancy in a patient who wishes to maintain childbearing capacity.
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김해룡(HR Kim),윤헌식(HS Yoon) 대한산부인과학회 1960 Obstetrics & Gynecology Science Vol.3 No.1
원래 불임증에 대한 고찰은 그 원인과 성인이 다종임에 감하여 그 임상관찰 자체가 복잡하고 또한 장시일을 요함은 제언에서 서술한 바 있거니와 이러한 복잡성에 비추어 외래에서 많은 환자를 다루는 중 특히, 한 Section을 만들지 않는 한 정확하고 계통적인 기록을 남기기는 대단히 곤란한 문제이기는 하나 우선 본교실외래에서 92년도 1년간의 외래환자 총수 2,899명중 원발성불임 177예 속발성불임 196예 계 373예에 대한 일차적인 통계를 하여 다음과 같은 성적을 보았다. 1. 불임환자의 빈도는 1년간을 통하여 12.86%이고 원발성 6.10%, 속발성 6.76%이다. 2. 불임환자 수진년령은 32.1±4.5로서 원발성의 도수분포에 있어서의 Mode는 27세 속발성은 35세이다. 3. 불임기간은 원발성의 도수분포에 있어서의 Mode는 5년 속발성은 6년이며, 공히 불임기간이 길수록 감수하는 경향을 보였다. 4. 초경연령과의 관계는 원발성 속발성 공히 통계학적인 유의차는 없고 각각 평균 15.80±1.72, 15.69±1.44이다. 5. 부인과적질병과의 관계는 원발성군에서는 성기발육부전 및 기능부전이 고율로 29.88% 이며 성기염증이 자궁 21.64%, 부속기 15.46%이다. 속발성군에서는 성기염증이 고율로서 70.36%이다. 6. 난관소통과의 관계 양측폐쇄는 원발성군 36.11%, 속발성군 37.50%로서 유의차는 없고, 양측소통은 전자 55.55% 후자 36.66%이다. 폐쇄부위는 양군 공히 난관채부가 많았다. 외래진단과의 관계에서는 성기염증이 난관폐쇄환자에서 가장 많이 볼 수가 있었다. The patients whose chief complaint is the sterility were investigated at our-patient clinic in the course of one year in 1959, and this result revealed as follows; 1. Frequency of sterile patient at out-patient clinic is 12.86% and among them primary affection is 6.10% and secondary affection is 6.76% respectively. 2. Average age of the first medical consultation is 32.1 4.5 3. Average age of manarche in primary affection is 15.80±1.72 and in secondary affection is 15.69±1.44 4. Relationship withgynecological disease: Under-development of genital organs and dysfunction are the highest figure of 29.88% in primary affection and inflamation of genital organs is the highest figure of 70.36% in secondary affection respectively. 5. Findings in hysterosalpingography: In bilateral obliteration, it showed 36.11% in the group of the primary affection and 37.5% in the group of the secondary affection respectively and the predominent site of obliteration is Fimbrae of the tube.
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윤혜양(HR Youn),임경희(KH Rim) 대한산부인과학회 1966 Obstetrics & Gynecology Science Vol.9 No.4
A case of absence of rectum and anus with ompholecele and defects of colon on ileocercal region and bladder was presented. And a review of literature was made briefly.
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윤혜량(HR Youn),최영욱(YW Choi),송영록(YL Song) 대한산부인과학회 1979 Obstetrics & Gynecology Science Vol.22 No.4
25세의 미혼여성에 발생한 난소미분화 배세포종의 1례를 경험하였기에 문헌적 고찰과 아울러 보고하는 바이다. A case of left ovarian dysgerminoma is 25 years old unmarried women is presented, and its literatures is briefly reviewed.
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3-stage 운전에 의한 3상 DCM컨버터의 입력역률개선
최해룡(HR Choi),구영모(YM Goo),김응진(EJ Kim),목형수(HS Mok),최규하(GH Choe),김규식(KS Kim),원충연(C.Y Won) 전력전자학회 1999 전력전자학술대회 논문집 Vol.1999 No.7
As utility pollution take a growing Interest, ac/dc converter optimizing utility condition has been vigorously studied m decades, In this paper three phase DCM converter is analyzed and equations for average input currents are presented, Also relationships of voltage gam & duty according to angular velocity are presented and variable frequency controller is Implemented using reset integrator which is designed m detail In result power factor and The characteristics of 3-stage and 4-stage operation are compared respectively,
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윤혜량(HR Youn),임경희(KH Rim) 대한산부인과학회 1966 Obstetrics & Gynecology Science Vol.9 No.6
This was presented a case of chorionepithelioma which had had no typical, clinical course, but we evaluated the history, clinical course, operative and pathological findings of the patient.
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