Evolution and recovery of original total organic carbon for muddy source rocks with different total organic carbon in the Western Sichuan Depression, Sichuan Basin, China

Zhipeng Huo,Yan Gao,Yi Zhao,Tianyu Zheng,Jinchuan Zhang,Jianghui Ding 한국지질과학협의회 2019 Geosciences Journal Vol.23 No.1

According to the new quantitative model for original total organic carbon (TOCo) evolution and recovery of source rocks, The TOCo evolution of muddy source rocks with different TOCs (MSRDTOC) (0.5% < TOC ≤ 1.5%, 2.5% < TOC ≤ 3.5% and 4.0% < TOC ≤ 6.0%, and their average values were 1.0%, 3.0% and 5.0%, respectively) and type III kerogen were investigated in the Western Sichuan Depression (WSD) of Sichuan Basin, China, finally recovery coefficients of TOCo were calculated. Studies showed that TOCo evolution of the MSRDTOC have similarities and differences. The similarities reveal that with the increase of thermal evolution level, varied TOC all reduce gradually and the sharp reduction occurs at the stage of a large number of hydrocarbon generation and expulsion (0.7% ≤ vitrinite reflectance (VR) ≤ 1.3%). The differences indicate that the starting time and decrease range for varied TOC are different. For TOCo = 1.0%, 3.0% and 5.0%, their starting time of TOC reduction are VR = 1.05%, 0.80% and 0.60%, respectively. When VR reaches to 3.0%, their TOC decrease ranges are 30.54%, 38.52% and 44.00% and their recovery coefficients are 1.44, 1.63 and 1.79, respectively. The higher the TOC is, the earlier the starting time of TOC reduction is, the bigger the range of TOC reduction and recovery coefficient are. It must restore TOCo when we evaluate source rocks at high-over mature stage and predict oil and gas resources. The MSRDTOC and their TOCo recovery should be evaluated, respectively.

Facility Performance Indexes and Rapid Test Feasibility Evaluation Method of Shaking Tables

Wei Guo,Zhipeng Zhai,Zhiwu Yu,Yan Long 대한토목학회 2019 KSCE Journal of Civil Engineering Vol.23 No.7

Shaking table test is widely used as the main experimental approach to evaluate seismic performance of structures, and it usually consumes huge funds and labors. To ensure success of the tests, it is essential to evaluate the feasibility and accuracy before the test is conducted. However, research on test feasibility has rarely been reported. In recent years, complexity of shaking table tests has increased significantly due to the increasing demand of testing facility performance. Hence, feasibility evaluation becomes more and more important. In this paper, main performance indexes of the shaking table facility are expounded. According to the performance indexes of actuator parameters, a rapid feasibility evaluation method is then proposed based on the equilibrium between the facility capacity and the table output demand. Subsequently, applicability of the evaluation method is validated by evaluating the practical tests. The results show that the maximum acceleration targets in horizontal and vertical direction are mutually restrained under threedimensional excitations. For the feasibility evaluation of large-scale model tests, the eccentric and overturning moment of specimen are the main performance control indexes due to their adverse influences on the facility. And the overturn-resistance of shaking table will be enhanced significantly by vertical actuators during the absence of vertical excitations. In the shaking table array test, millimeter-scale relative displacement between tables may lead to accidental damage of the test specimen or not working of the facility when the reinforced concrete foundation crosses the shaking tables. Therefore, attentions should be paid to the design of the test scheme.

Primordial Drivers of Diabetes Heart Disease: Comprehensive Insights into Insulin Resistance

Yajie Fan,Zhipeng Yan,Tingting Li,Aolin Li,Xinbiao Fan,Zhongwen Qi,Junping Zhang 대한당뇨병학회 2024 Diabetes and Metabolism Journal Vol.48 No.1

Insulin resistance has been regarded as a hallmark of diabetes heart disease (DHD). Numerous studies have shown that insulin resistance can affect blood circulation and myocardium, which indirectly cause cardiac hypertrophy and ventricular remodeling, participating in the pathogenesis of DHD. Meanwhile, hyperinsulinemia, hyperglycemia, and hyperlipidemia associated with insulin resistance can directly impair the metabolism and function of the heart. Targeting insulin resistance is a potential therapeutic strategy for the prevention of DHD. Currently, the role of insulin resistance in the pathogenic development of DHD is still under active research, as the pathological roles involved are complex and not yet fully understood, and the related therapeutic approaches are not well developed. In this review, we describe insulin resistance and add recent advances in the major pathological and physiological changes and underlying mechanisms by which insulin resistance leads to myocardial remodeling and dysfunction in the diabetic heart, including exosomal dysfunction, ferroptosis, and epigenetic factors. In addition, we discuss potential therapeutic approaches to improve insulin resistance and accelerate the development of cardiovascular protection drugs.

Integrative applications of network pharmacology and molecular docking: An herbal formula ameliorates H9c2 cells injury through pyroptosis

Zhongwen Qi,Zhipeng Yan,Yueyao Wang,Nan Ji,Xiaoya Yang,Ao Zhang,Meng Li,Fengqin Xu,Junping Zhang The Korean Society of Ginseng 2023 Journal of Ginseng Research Vol.47 No.2

Background: QiShen YiQi pills (QSYQ) is a Traditional Chinese Medicine (TCM) formula, which has a significant effect on the treatment of patients with myocardial infarction (MI) in clinical practice. However, the molecular mechanism of QSYQ regulation pyroptosis after MI is still not fully known. Hence, this study was designed to reveal the mechanism of the active ingredient in QSYQ. Methods: Integrated approach of network pharmacology and molecular docking, were conducted to screen active components and corresponding common target genes of QSYQ in intervening pyroptosis after MI. Subsequently, STRING and Cytoscape were applied to construct a PPI network, and obtain candidate active compounds. Molecular docking was performed to verify the binding ability of candidate components to pyroptosis proteins and oxygen-glucose deprivation (OGD) induced cardiomyocytes injuries were applied to explore the protective effect and mechanism of the candidate drug. Results: Two drug-likeness compounds were preliminarily selected, and the binding capacity between Ginsenoside Rh2 (Rh2) and key target High Mobility Group Box 1 (HMGB1)was validated in the form of hydrogen bonding. 2 μM Rh2 prevented OGD-induced H9c2 death and reduced IL-18 and IL-1β levels, possibly by decreasing the activation of the NLRP3 inflammasome, inhibiting the expression of p12-caspase1, and attenuating the level of pyroptosis executive protein GSDMD-N. Conclusions: We propose that Rh2 of QSYQ can protect myocardial cells partially by ameliorating pyroptosis, which seems to have a new insight regarding the therapeutic potential for MI.

Protective strategy for the caudate lobe bile duct during left hemihepatectomy based on imaging data analysis

Zhengyi Wu*,Liang Sun*,Ke Ning,Zhendong Chen,Zhipeng Wu,Hanqing Yang,Jinlong Yan*,Xiangbao Yin* 대한외과학회 2023 Annals of Surgical Treatment and Research(ASRT) Vol.105 No.6

Purpose: This study was performed to analyze the rule of confluence of the caudate lobe bile duct (CLD) into the left hepatic duct (LHD) and to discuss the protective strategy during left hemihepatectomy. Methods: MRI of 400 patients and T-tube angiography images of 100 patients were collected, and the imaging rules of the confluence of the CLD into the LHD were summarized. The clinical data of 33 patients who underwent left hemihepatectomy using the protective strategy were analyzed. Results: MRI and T-tube angiography images showed that the length from the confluence point of the CLD into the LHD to the confluence of the left and right hepatic ducts was 1.19 ± 0.40 cm and 1.26 ± 0.39 cm, respectively. The average angle between the longitudinal axis of the 2 bile ducts was 68.27° ± 22.59° and 66.58 ± 22.88°, respectively. Coronal and cross-sectional images showed that inflow from the foot side to the cranial side was noted in 79.8% and 82.0% of patients, respectively, and inflow from the dorsal to the ventral side was observed in 84.5% and 88.0%, respectively. Based on these imaging rules, the safe transection length and plane were summarized, and the CLD was effectively protected in 33 cases of left hemihepatectomy. Conclusion: In left hemihepatectomy, the LHD should be transected at least 1.5 cm away from the confluence of the left and right hepatic ducts, and the plane of transection should be oblique to the dorsal side at an angle of 45° with the LHD, these parameters represent an effective strategy to protect the CLD.