The Blood Neutrophil-to-lymphocyte Ratio Predicts Survival in Patients with Advanced Hepatocellular Carcinoma Receiving Sorafenib

Zheng, You-Bing,Zhao, Wei,Liu, Bing,Lu, Li-Gong,He, Xu,Huang, Jian-Wen,Li, Yong,Hu, Bao-Shan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9

Background and Aim: Increasing evidence correlates the presence of systemic inflammation with poor survival in patients with hepatocellular carcinoma (HCC). The aim of this study was to investigate the prognostic significance of the blood neutrophil-to-lymphocyte ratio (NLR) in patients with advanced HCC who received sorafenib monotherapy. Methods: A total of sixty-five patients with advanced HCC, not eligible for locoregional therapy, treated with sorafenib were enrolled. Potential prognostic factors such as age, gender, tumoral characteristics, performance status and NLR were analyzed. Results: Median OS and TTP for the entire cohort were 10.0 months (95%CI, 7.6-12.3 months) and 4.5 months (95% CI, 4.0-4.9 months). The mean NLR at baseline was 2.89. The median OS of patients with a high NLR (>4) was 6.5 months (95%CI, 5.2-7.7 months) compared with 12.5 months (95%CI, 9.9-15.0) for patients with a normal NLR (${\leq}4$) (P=0.01). Age ${\leq}65$, NLR>4, extrahepatic metastases and vascular invasion were all predictors of poorer overall survival. Multivariate analysis showed that NLR > 4, vascular invasion and extrahepatic metastases were independent predictors of poorer overall survival. The median TTP of patients with a high NLR was 2.5 months (95%CI, 1.4-3.6 months) compared with 4.5 months (95%CI, 3.9-5.1 months) for patients with a normal NLR (P=0.012). Conclusions: High baseline NLR was associated with worse OS and TTP for patients with advanced HCC treated with sorafenib.

Highly enhancing photoelectrochemical performance of facilely-fabricated Bi-induced (002)-oriented WO₃ film with intermittent short-time negative polarization

Zheng, Jin You,Pawar, Amol Uttam,Kim, Chang Woo,Kim, Yong Joo,Kang, Young Soo Elsevier 2018 Applied catalysis. B, Environmental Vol.233 No.-

<P><B>Abstract</B></P> <P>WO<SUB>3</SUB> photoelectrode should have high photoactivity and stability for application in solar water splitting. By introducing Bi<SUP>3+</SUP> ions, a highly ordered (002)-oriented WO<SUB>3</SUB> film with a high photocurrent was easily prepared on FTO glass by spin coating a simple Bi-doped peroxotungstic acid (PTA) gel followed by calcination. In situ XRD, pole figures, and HR-TEM were performed to elucidate the formation process and epitaxial properties. The flat Bi-WO<SUB>3</SUB> film achieved a remarkable photocurrent density of 2.06 mA cm<SUP>−2</SUP> at 1.5 V vs. Ag/AgCl. By introducing intermittent short-time negative polarization (ISNP) into the process of PEC water splitting, the O<SUB>2</SUB> gas product yield is enhanced by ca. 75% with high faradaic efficiency, as ISNP can efficiently eliminate peroxo species on the surface of the WO<SUB>3</SUB> film. This demonstrates that ISNP can enhance the photostability and photoactivity of WO<SUB>3</SUB> films.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Stable Bi-doped peroxotungstic acid gel is prepared without any organic stabilizer. </LI> <LI> (002)-oriented Bi-doped WO<SUB>3</SUB> films is easily fabricated on FTO by spin-coating technique. </LI> <LI> The Bi-WO<SUB>3</SUB> film exhibits remarkable photoelectrochemical properties. </LI> <LI> Intermittent short-time negative polarization enhances the photostability and photoactivity of the Bi-WO<SUB>3</SUB> film. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Fabrication of (001)-oriented monoclinic WO3 films on FTO substrates.

Zheng, Jin You,Song, Guang,Kim, Chang Woo,Kang, Young Soo RSC Pub 2013 Nanoscale Vol.5 No.12

<P>(001)-oriented monoclinic nanorod and microplate WO3 films are fabricated on commercial FTO-coated glass substrates by a rubbing seed layer and a spin-coating seed layer assisted by hydrothermal reactions. The nanorod film obtained by the rubbing seed layer assisted by hydrothermal reactions is more regular and perpendicular to the substrate.</P>

Review : Production and Characterization of Monoclonal and Recombinant Antibodies Against Antimicrobial Sulfamethazine

( Zheng You Yang ),( Won Bo Shim ),( Min Gon Kim ),( Kyu Ho Lee ),( Keun Sung Kim ),( Kwang Yup Kim ),( Cheol Ho Kim ),( Sang Do Ha ),( Duck Hwa Chung ) 한국미생물 · 생명공학회 2007 Journal of microbiology and biotechnology Vol.17 No.4

Vertical cobalt dendrite array films: electrochemical deposition and characterization, glucose oxidation and magnetic properties

Zheng, Jin You,Quan, Zhen Lan,Song, Guang,Kim, Chang Woo,Cha, Hyun Gil,Kim, Tae Wan,Shin, Woonsup,Lee, Kyu Joon,Jung, Myung Hwa,Kang, Young Soo The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.24

<P>Vertically and laterally oriented cobalt dendrite films with or without dendritic structures were synthesized by cathodic electrodeposition under different experimental conditions. The morphology of Co deposits was varied significantly depending on deposition conditions such as applied potential, precursor concentration and especially pH value. Co dendritic crystal growth along the [110] direction is preferred. The possible growth mechanism is discussed by supposing differing concentration areas. Results of glucose electrooxidation demonstrate that vertical Co dendrite films are promising materials as carbohydrate sensors with high sensitivity and fast response. In addition, magnetic measurements on cobalt samples under parallel and perpendicular direction of the applied magnetic field show that they exhibit a ferromagnetic behavior with different saturation magnetizations and coercivities.</P> <P>Graphic Abstract</P><P>Vertically and laterally oriented ferromagnetic cobalt films with or without dendritic structures were synthesized by electrodeposition under different deposition conditions (NF: nanoflowers, NS: nanosheets). <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm30300k'> </P>

A novel design method for improving collapse resistances of multi-story steel frames with unequal spans using steel braces

Zheng Tan,Wei-hui Zhong,Bao Meng,Shi-chao Duan,Hong-chen Wang3,Xing-You Yao,Yu-hui Zheng 국제구조공학회 2023 Steel and Composite Structures, An International J Vol.47 No.2

The bearing capacities resisted by the two-bay beams of multi-story planar frames with unequal spans under column removal scenarios differ considerably owing to the asymmetric stress on the left and right beams connected to the failed column and cause the potential for beams with larger span-to-depth ratios to be unable to exert effectively, which is disadvantageous for resisting the vertical load in unequal-span frame structures. To address this problem, the structural measure of adding braces to the weak bays of multi-story unequal-span frames was proposed, with the objective of achieving a coordinated stress state in two-bay beams with unequal spans, thereby improving the collapse resistance of unequal-span frame structures. Before conducting the numerical simulation, the modeling methods were verified by previous experimental results of two multi-story planar frames with and without steel braces. Thereafter, the effects of the tensile and compressive braces on the collapse behavior of the frame structures were elucidated. Then, based on the mechanical action laws of the braces throughout the collapse process, a detailed design method for improving the collapse resistance of unequal-span frame structures was proposed. Finally, the proposed design method was verified by using sufficient example models, and the results demonstrated that the design method has good application prospects and high practical value.

Endophytic fungi harbored in Panax notoginseng: diversity and potential as biological control agents against host plant pathogens of root-rot disease

Zheng, You-Kun,Miao, Cui-Ping,Chen, Hua-Hong,Huang, Fang-Fang,Xia, Yu-Mei,Chen, You-Wei,Zhao, Li-Xing The Korean Society of Ginseng 2017 Journal of Ginseng Research Vol.41 No.3

Background: Endophytic fungi play an important role in balancing the ecosystem and boosting host growth. In the present study, we investigated the endophytic fungal diversity of healthy Panax notoginseng and evaluated its potential antimicrobial activity against five major phytopathogens causing root-rot of P. notoginseng. Methods: A culture-dependent technique, combining morphological and molecular methods, was used to analyze endophytic fungal diversity. A double-layer agar technique was used to challenge the phytopathogens of P. notoginseng. Results: A total of 89 fungi were obtained from the roots, stems, leaves, and seeds of P. notoginseng, and 41 isolates representing different morphotypes were selected for taxonomic characterization. The fungal isolates belonged to Ascomycota (96.6%) and Zygomycota (3.4%). All isolates were classified to 23 genera and an unknown taxon belonging to Sordariomycetes. The number of isolates obtained from different tissues ranged from 12 to 42 for leaves and roots, respectively. The selected endophytic fungal isolates were challenged by the root-rot pathogens Alternaria panax, Fusarium oxysporum, Fusarium solani, Phoma herbarum, and Mycocentrospora acerina. Twenty-six of the 41 isolates (63.4%) exhibited activity against at least one of the pathogens tested. Conclusion: Our results suggested that P. notoginseng harbors diversified endophytic fungi that would provide a basis for the identification of new bioactive compounds, and for effective biocontrol of notoginseng root rot.

Endophytic fungi harbored in Panax notoginseng: diversity and potential as biological control agents against host plant pathogens of root-rot disease

You-Kun Zheng,Cui-Ping Miao,Hua-Hong Chen,Fang-Fang Huang,Yu-Mei Xia,You-Wei Chen,Li-Xing Zhao 고려인삼학회 2017 Journal of Ginseng Research Vol.41 No.3

Background: Endophytic fungi play an important role in balancing the ecosystem and boosting host growth. In the present study, we investigated the endophytic fungal diversity of healthy Panax notoginseng and evaluated its potential antimicrobial activity against five major phytopathogens causing rootrot of P. notoginseng. Methods: A culture-dependent technique, combining morphological and molecular methods, was used to analyze endophytic fungal diversity. A double-layer agar technique was used to challenge the phytopathogens of P. notoginseng. Results: A total of 89 fungi were obtained from the roots, stems, leaves, and seeds of P. notoginseng, and 41 isolates representing different morphotypes were selected for taxonomic characterization. The fungal isolates belonged to Ascomycota (96.6%) and Zygomycota (3.4%). All isolates were classified to 23 genera and an unknown taxon belonging to Sordariomycetes. The number of isolates obtained from different tissues ranged from 12 to 42 for leaves and roots, respectively. The selected endophytic fungal isolates were challenged by the root-rot pathogens Alternaria panax, Fusarium oxysporum, Fusarium solani, Phoma herbarum, and Mycocentrospora acerina. Twenty-six of the 41 isolates (63.4%) exhibited activity against at least one of the pathogens tested. Conclusion: Our results suggested that P. notoginseng harbors diversified endophytic fungi that would provide a basis for the identification of new bioactive compounds, and for effective biocontrol of notoginseng root rot.

Facile Fabrication of WO₃ Nanoplates Thin Films with Dominant Crystal Facet of (002) for Water Splitting

Zheng, Jin You,Song, Guang,Hong, Jisang,Van, Thanh Khue,Pawar, Amol Uttam,Kim, Do Yoon,Kim, Chang Woo,Haider, Zeeshan,Kang, Young Soo American Chemical Society 2014 Crystal Growth & Design Vol.14 No.11

<P>Single crystalline orthorhombic phase tungsten trioxide monohydrate (<I>O</I>-WO<SUB>3</SUB>·H<SUB>2</SUB>O, space group: <I>Pmnb</I>) nanoplates with a clear morphology and uniform size distribution have been synthesized by the hydrothermal method and fabricated on the surface of fluorine doped tin oxide (FTO) coated glass substrates with selective exposure of the crystal facet by the finger rubbing method. The rubbing method can easily arrange the <I>O</I>-WO<SUB>3</SUB>·H<SUB>2</SUB>O nanoplates along the (020) facet on the FTO substrate. The <I>O</I>-WO<SUB>3</SUB>·H<SUB>2</SUB>O nanoplate can be converted to monoclinic phase WO<SUB>3</SUB> (γ-WO<SUB>3</SUB>, space group: <I>P</I>21/<I>n</I>) with dominant crystal facet of (002) without destroying the plate structure. Crystal morphologies, structures, and components of the powders and films have been determined by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, Raman, X-ray photoelectron spectroscopy, etc. The band gap energies of the <I>O</I>-WO<SUB>3</SUB>·H<SUB>2</SUB>O and γ-WO<SUB>3</SUB> nanoplates were determined as ca. 2.26 and 2.49 eV, respectively. Photoelectrochemical properties of the films with (002) dominant crystal facet have also been checked for discussion of further application in water oxidation. The advantage of (002) facet dominant film was investigated by comparing to one spin-coated γ-WO<SUB>3</SUB> thin film with the same thickness via photoelectrochemical characterizations such as photocurrent, incident photon to current efficiency, and electrochemical impedance spectroscopy.</P><P>Single crystalline orthorhombic phase <I>O</I>-WO<SUB>3</SUB>·H<SUB>2</SUB>O nanoplates with clear morphology and uniform size distribution have been synthesized by the hydrothermal method and fabricated as (020)-oriented film by the finger rubbing method. The (020)-oriented <I>O</I>-WO<SUB>3</SUB>·H<SUB>2</SUB>O film can be converted to monoclinic phase (002)-oriented γ-WO<SUB>3</SUB> film by calcination. Photoelectrochemical properties have been examined for further application in solar water oxidation.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/cgdefu/2014/cgdefu.2014.14.issue-11/cg5012154/production/images/medium/cg-2014-012154_0016.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cg5012154'>ACS Electronic Supporting Info</A></P>

Localization of QTLs for Husk Proportion and Lignin Content Using a High-Density Genetic Linkage Map of Brassica napus

Fu You Fu,Lie Zhao Liu,You Rong Chai,Li Chen,Tao Yang,Ai Fen Ma,Cun Ming Qu,Lin Jiang,Zheng Sheng Zhang,Jia Na Li 한국유전학회 2007 Genes & Genomics Vol.29 No.3

Husk proportion (HP) and lignin content (LC) are two important traits of seed quality of B. napus. Efficient selection of these two traits is an important way to improve the seed quality in meal improvement. A set of recombinant inbred lines (RILs) of B. napus (GH06 × Zhongyou 821) was used for mapping QTLs of HP and LC in a two-year study in different environments. 509 markers (78 SSR markers, 66 RAPD markers and 365 SRAP markers) were mapped on 26 linkage groups with an average length of 73.96 cM. The map covered a total of 1923 cM, and the average distance between two adjacent markers was 3.78 cM. Analysis of variance of LC and HP indicated that. LC might not be significantly affected by environment (F = 2.96 < 3.02) and HP might be affected by genotype × environment interactions. A total of 15 significant QTLs were detected in eight linkage groups with a LOD threshold value of 2.5 (LR ≥ 11.5) by CIM, explaining 4.99-16.14% of phenotype variation. Some QTLs of LC and HP were detected in near regions of the same linkage groups, such as qLCBB05-6-1 and qLCWZ06-6-1, qLCBB05-10-2 and qLCBB06-10-1 and qLCWZ06-10-2, qHPBB05-9-3 and qHPBB06-9-1, qHPBB05-10-4 and qHPBB06-10-2 and qHPBB06-10-3 and qHPWZ06-10-1. This study indicates that the repeatedly detected QTLs of LC and HP might be major-effect QTLs of LC and HP.