Injuries Analysis of Rear Row Occupants Exposed to Vehicle’s Frontal Oblique Collision

Zhou Hua,Liao Jingqian,Zhang Qiaoyu,Zhang Guanghui,Zhang Daowen 한국자동차공학회 2021 International journal of automotive technology Vol.22 No.3

This paper discusses the rear left-hand occupant’s injury during frontal oblique collision with PRESYS software. Based on the simulations among different frontal oblique angles (10 ~ 50 °) and occupant constraint system models, the injury of rear left-hand dummy are analyzed at an initial collision speed of 50 km/h. It is found that the impact on the occupant’s dynamic responses (acceleration and shear forces) by the seat belt is significant and depends upon the oblique angle. With the given vehicle and collision speed, it is observed that the seat belt can effectively reduce the occupant’s head acceleration and the neck longitudinal (Fx) shear force if the collision angle is between 10 ° and 20 °. However, the seat belt increases the occupant’s head resultant acceleration when the collision angle is between 35 ° and 40 °. In addition, when the collision angle is between 10 ° and 50 °, the seat belt can also effectively reduce the occupant\'s chest acceleration. At most collision angles, the seat belt can effectively reduce the overall damage of rear row left occupant in frontal oblique collision, but the WIC (Weighted Injury Criterion) value of the rear row dummy with seat belt is still very large at the collision angle below 30 °. Therefore, the restraint system of the rear row occupants needs to be improved.

Performance Analysis and System Design for Hierarchical Modulated BICM-ID

Qiaoyu Li,Jun Zhang,Lin Bai,Jinho Choi IEEE 2014 IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS Vol.13 No.6

<P>Hierarchical modulation (HM) enables unequal priority transmissions using a signal constellation of non-uniformly spaced constellation points, which is an important property for broadcast systems. Using bit interleaved coded modulation (BICM) and iterative decoding (ID), the performance of HM systems can be further improved. In this paper, we study HM system with BICM-ID or HM-BICM-ID. Since the performance of BICM-ID depends on signal mapping rules, we derive a mapping rule based on distance properties to minimize the bit error rate (BER). Furthermore, we perform the BER performance analysis for HM-BICM-ID based on binary erasure channel (BEC) modeling, which provides BER prediction without time-consuming simulations. Based on the derived BER prediction scheme, we can also perform system design and optimization for applications of HM-BICM-ID. For example, we are able to optimize the constellation priority parameter in a broadcast system to maximize the throughput.</P>

Object Detection Based on Multi-scale Contour Fragments

Xiaofeng Zhang,Qiaoyu Sun,Yue Lu 보안공학연구지원센터 2012 International Journal of Multimedia and Ubiquitous Vol.7 No.2

Silicate Ions Derived from Calcium Silicate Extract Decelerate Ang II-Induced Cardiac Remodeling

Li Xin,Zhang Yanxin,Jin Qishu,Song Qiaoyu,Fan Chen,Jiao Yiren,Yang Chen,Chang Jiang,Dong Zhihong,Que Yumei 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.5

BACKGROUND: Pathological cardiac hypertrophy is one of the main activators of heart failure. Currently, no drug can completely reverse or inhibit the development of pathological cardiac hypertrophy. To this end, we proposed a silicate ion therapy based on extract derived from calcium silicate (CS) bioceramics for the treatment of angiotensin II (Ang II) induced cardiac hypertrophy. METHODS: In this study, the Ang II induced cardiac hypertrophy mouse model was established, and the silicate ion extract was injected to mice intravenously. The cardiac function was evaluated by using a high-resolution Vevo 3100 small animal ultrasound imaging system. Wheat germ Agglutinin, Fluo4-AM staining and immunofluorescent staining was conducted to assess the cardiac hypertrophy, intracellular calcium and angiogenesis of heart tissue, respectively. RESULTS: The in vitro results showed that silicate ions could inhibit the cell size of cardiomyocytes, reduce cardiac hypertrophic gene expression, including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and b-myosin heavy chain (b-MHC), decrease the content of intracellular calcium induced by Ang II. In vivo experiments in mice confirmed that intravenous injection of silicate ions could remarkably inhibit the cardiac hypertrophy and promote the formation of capillaries, further alleviating Ang II-induced cardiac function disorder. CONCLUSION: This study demonstrated that the released silicate ions from CS possessed potential value as a novel therapeutic strategy of pathological cardiac hypertrophy, which provided a new insight for clinical trials.

Genome-wide analysis of maize MBD gene family and expression profiling under abiotic stress treatment at the seedling stage

Qian Yexiong,Ren Qiaoyu,Jiang Lingyu,Zhang Jing,Chen Changle,Chen Liang 한국식물생명공학회 2020 Plant biotechnology reports Vol.14 No.3

Methyl-CpG-binding domain (MBD) proteins in plants are important trans-acting factors specifically recognizing methylated DNA. The MBD proteins can compact chromatins to repress transcription by recruiting chromatin-modifying complexes that contain histone deacetylase activities and chromatin remodeling factors, and play a crucial biological role in the growth and development in plants. Currently, very little is known regarding the structure and function of MBD genes in plants. In this study, we performed a genome-wide identification and expression profile analysis of maize MBD genes (ZmMBDs) from the latest version of the maize (B73) genome. By analyzing phylogenetic relationship of MBD gene families from Arabidopsis, rice, wheat, and maize, all 14 MBD proteins in maize were categorized into four subclasses. Furthermore, chromosome location and schematic structure revealed an unevenly distribution on chromosomes and structure features of MBD genes in maize, respectively. Eventually, EST expression data mining, microarray data clustering analysis, and semi-quantitative and quantitative expression profile analyses detected in seedling leaves and stems by heat, drought, and salt-stress treatments have demonstrated that these genes had temporal and spatial expression pattern and exhibited different expression levels under heat, drought, and salt-stress conditions, suggesting that functional diversification of the MBD gene family in maize. In addition, through electrophoretic mobility shift assay (EMSA) a representative MBD protein, ZmMBD11, exhibited in vitro DNA-binding activity, indicating that that the MBD proteins in maize might play a role in reading cytosine methylation. Taken together, these results would provide an important theoretical basis for future functional verification of ZmMBD genes and also facilitate future experimental research to further unravel the mechanisms of epigenetic regulation in plants.

Surgical management of inflammatory bowel disease in China: a systematic review of two decades

( Qiao Yu ),( Ren Mao ),( Lei Lian ),( Siew Chien Ng ),( Shenghong Zhang ),( Zhihui Chen ),( Yanyan Zhang ),( Yun Qiu ),( Baili Chen ),( Yao He ),( Zhirong Zeng ),( Shomron Ben-horin ),( Xinming Song 대한장연구학회 2016 Intestinal Research Vol.14 No.4

Background/Aims: The past decades have seen increasing incidence and prevalence of inflammatory bowel disease (IBD) in China. This article aimed to summarize the current status and characteristics of surgical management for IBD in China. Methods: We searched PubMed, Embase, and Chinese databases from January 1, 1990 to July 1, 2014 for all relevant studies on the surgical treatment IBD in China. Eligible studies with sufficient defined variables were further reviewed for primary and secondary outcome measures. Results: A total of 74 studies comprising 2,007 subjects with Crohn`s disease (CD) and 1,085 subjects with ulcerative colitis (UC) were included. The percentage of CD patients misdiagnosed before surgery, including misdiagnosis as appendicitis or UC, was 50.8%±30.9% (578/1,268). The overall postoperative complication rate was 22.3%±13.0% (267/1,501). For studies of UC, the overall postoperative complication rate was 22.2%±27.9% (176/725). In large research centers (n>50 surgical cases), the rates of emergency operations for CD (P =0.032) and in-hospital mortalities resulting from both CD and UC were much lower than those in smaller research centers (n≤50 surgical cases) (P =0.026 and P <0.001, respectively). Regarding the changes in CD and UC surgery over time, postoperative complications (P =0.045 for CD; P =0.020 for UC) and postoperative in-hospital mortality (P =0.0002 for CD; P =0.0160 for UC) both significantly improved after the year 2010. Conclusions: The surgical management of IBD in China has improved over time. However, the rates of misdiagnosis and postoperative complications over the past two decades have remained high. Large research centers were found to have relatively better capacity for surgical management than the smaller ones. Higher quality prospective studies are needed in China. (Intest Res 2016;14:322-332)