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Xiaoping Zhan,Lan Lan,Yuankui Zhang,Jian Chen,Kai Zhao,Shuai Wang,Yuxuan Xin,Zhenmin Mao 대한화학회 2016 Bulletin of the Korean Chemical Society Vol.37 No.2
A new series of 3-substituted 4-(4-methyloxy phenyl)-1H-pyrrole derivatives were synthesized and biologically evaluated for potential anticancer activity. Fifteen targeted compounds showed high selectivity toward normal cells and cancer cells: that is, all targeted compounds had no obvious cytotoxicity toward normal human cells (HUVEC and NIH/3T3), but some compounds exhibited broad-spectrum proliferation inhibitory activity against the screened cancer cell lines. Among these pyrrole derivatives, compounds 3b and 3o showed potent anticancer activity against the MG-63 cell line, with IC50 values of 14.9 and 12.7 μM, respectively. Other pyrrole derivatives also showed promising proliferation inhibitory activity, including compound 3d against A375 (IC50 = 18.6 μM), compound 3f and 3j against MGC80-3 (IC50 = 19.9 μM), and compound 3o against MGC80-3 (IC50 = 11.9 μM). Because the developed pyrrole derivatives showed strong anticancer activity and high selectivity, this new series of pyrrole derivatives could be considered as promising lead compounds for further development of potent and safe anticancer agents.
Zhan-qing Zhang,Yan-bing Wang,,Wei Lu,,Dan-ping Liu,,Bi-sheng Shi,,Xiao-nan Zhang,,Dan Huang,,Xiu-fen Li,,Xin-lan Zhou,,Rong-rong Ding, 대한진단검사의학회 2019 Annals of Laboratory Medicine Vol.39 No.1
Background: We examined changes in hepatitis B core-related antigen (HBcrAg) during the four sequential phases of chronic hepatitis B virus (HBV) infection: hepatitis B e antigen (HBeAg)-positive chronic infection (EPCI) and hepatitis (EPCH), followed by HBeAg-negative chronic infection (ENCI) and hepatitis (ENCH). We compared the performance of serum HBcrAg, hepatitis B surface antigen (HBsAg), and HBV DNA in predicting EPCH and ENCH.
Let-7c Inhibits NSCLC Cell Proliferation by Targeting HOXA1
Zhan, Min,Qu, Qiang,Wang, Guo,Liu, Ying-Zi,Tan, Sheng-Lan,Lou, Xiao-Ya,Yu, Jing,Zhou, Hong-Hao Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Objective: The aim of the present study was to explore mechanisms by which let-7c suppresses NSCLC cell proliferation. Methods: The expression level of let-7c was quantified by qRT-PCR. A549 and H1299 cells were transfected with let-7c mimics to restore the expression of let-7c. The effects of let-7c were then assessed by cell proliferation, colony formation and cell cycle assay. Mouse experiments were used to confirm the effect of let-7c on tumorigenicity in vivo. Luciferase reporter assays and Western blotting were performed to identify target genes for let-7c. Results: HOXA1 was identified as a novel target of let-7c. MTS, colony formation and flow cytometry assays demonstrated that forced expression of let-7c inhibited NSCLC cell proliferation by inducing G1 arrest in vitro, consistent with inhibitory effects induced by knockdown of HOXA1. Mouse experiments demonstrated that let-7c expression suppressed tumorigenesis. Furthermore, we found that let-7c could regulate the expression of HOXA1 downstream effectors CCND1, CDC25A and CDK2. Conclusions: Collectively, these results demonstrate let-7c inhibits NSCLC cell proliferation and tumorigenesis by partial direct targeting of the HOXA1 pathway, which suggests that restoration of let-7c expression may thus offer a potential therapeutic intervention strategy for NSCLC.
Huilan Yang,Lan Shu,Shouming Zhong,Tao Zhan,Xin Wang 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.10
In this paper, we deal with the exponential pinning synchronization (PS) of stochastic T-S fuzzy delayed complex dynamical networks (FDCDNs) with heterogeneous impulsive delays. Unlike the existing works, a fuzzy memory pinning impulsive control (FMPIC) approach is proposed. In order to conquer the difficulties of studying such a general system, sufficient conditions that depend on the discrete-delay and distributed-delay impulsive effects are obtained by employing the Lyapunov function, inequality techniques and stochastic analysis theory. It is shownthat the PS of FDCDNs can be achieved under the designed FMPIC. Numerical simulation on the basis of BA scale-free coupled network is used to illustrate the effectiveness of the theoretical results.
Qingan Yin,Changhe Li,Lan Dong,Xiufang Bai,Yanbin Zhang,Min Yang,Dongzhou Jia,Runze Li,Zhan-qiang Liu 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.8 No.6
Minimum quantity lubrication (MQL) is an emerging green and resource-saving machining technique jetting minute amount lubricants and gas after mixing and atomization. However, MQL development is restricted to mineral oils because of its undegradability and threat to the environment and human health. Vegetable oils can replace mineral oils as base oil for MQL benefitting from its biodegradability and renewable property. Nevertheless, the lubrication mechanism at the tool-workpiece interface of different vegetable oils with various physicochemical properties has not been revealed systematically. In order to verify the interfacial lubrication characteristics of different vegetable oils, MQL milling experiments of AISI 1045 based on fi ve vegetable oils (cottonseed, palm, castor, soybean, and peanut oils) were carried out. The experimental results showed that, palm oil obtained the lowest milling force ( F x = 312 N, F y = 156 N), friction coeffi cient (0.78), and surface roughness values ( Ra = 0.431 μm, RSm = 0.252 mm) and the smoothest surface of workpiece. Furthermore, the physiochemical properties (composition, molecular structure, viscosity, surface tension, and contact angle) of vegetable oil were analyzed. Palm oil with high content of saturated fatty acid, high viscosity and small contact angle can form the lubricating oil fi lm with the highest strength and the largest spreading area at the tool-workpiece interface. Therefore, palm oil can achieve the optimal lubrication effect.
Evaluation of Kinetic Parameters and Mass Transfer of Glucose-fed Granules under Hypoxic Conditions
Yuancai Chen,Shiyu Fu,Huaiyu Zhan,Che-Jen Lin,Huaixia Lan 한국생물공학회 2010 Biotechnology and Bioprocess Engineering Vol.15 No.6
This study demonstrated that the availability of oxygen influenc the kinetic parameters of sludge granules for the utilization and mass transfer of substrates. Batch experiments revealed that substrate utilization of the coupled sludge granules followed Monod’s kinetic model under hypoxic conditions and at initial substrate concentrations ranging from 1,350 to 4,456 mg/L. The corresponding kinetic coefficients of ks (maximum specific substrate glucose utilization rate), Ks (half saturation coefficient),and Y (growth yield) were 5.6 ~ 7.8/day, 58 ~ 64 mg/L, and 0.11 ~ 0.17 mg of MLSS/mg of COD, respectively. Low dissolved oxygen content suppressed the activity of aerobic enzymes, which resulted in a ks value between those of aerobic granules and anaerobic granules. The maximum oxygen consumption rate (ko = 0.89/day) was relatively higher while the half-saturation constant (Ko = 1.71 mg/L)was significantly lower than those of aerobic granules. These results imply that dissolved oxygen was used more efficiently under hypoxic conditions. Thiele modulus (φ)and effectiveness factor (η) analysis revealed that the activity of microorganisms inside the granules was limited by the availability of oxygen. These properties differed from those found in aerobic granules, anaerobic granules,and activated sludge.
Overexpression of the AtSTK Gene Increases Salt, PEG and ABA Tolerance in Arabidopsis
Lei Bing,Cui-Cui Feng,Jing-Lan Li,Xiao-Xu Li,Baocun Zhao,Yin-Zhu Shen,Zhan-Jing Huang,Rong-Chao Ge 한국식물학회 2013 Journal of Plant Biology Vol.56 No.6
AtSTK (At5g02800), which is a serine-threonineprotein kinase gene of Arabidopsis thaliana, was cloned, andits function was studied. The study found that the overexpressionof AtSTK could significantly improve the ability of A. thaliana to tolerate salt, PEG, and ABA stresses. RT-PCRanalysis revealed that the expression of the AtSTK genecould be obviously induced by salt, PEG, and ABA. Theexamination of the physiological characteristics showed thatthe overexpression of AtSTK in Arabidopsis significantlyreduced the plasma membrane permeability, significantlyincreased the proline content, and decreased the MDA content. These changes may reflect the physiological mechanismsthrough which AtSTK overexpression improves stress resistancein Arabidopsis. In addition, the overexpression of the AtSTKgene significantly antagonised the inhibitory effect of highconcentrations of exogenous ABA on Arabidopsis seedgermination. The subcellular localisation results showed thatAtSTK is located in both the cytosol and the nucleus. Theexamination of its tissue-specific expression showed thatAtSTK is expressed in various Arabidopsis tissues and isparticularly strongly expressed in the vessels. The signallingpathway analysis indicated that AtSTK might transfer thesalt stress signal in Arabidopsis through the MAPK pathway.
안봉운 ( Feng Yun An ),현영남 ( Yong Nan Xuan ),안영희 ( Young Hee Ahn ),김미란 ( Mei Lan Jin ),요점춘 ( Zhan Chun Yao ),양금화 ( Jin Hua Liang ),주청선 ( Qing Xian Zhou ),렴성철 ( Cheng Zhe Lian ),황빙군 ( Bing Jun Huang ),소보군 한국녹지환경디자인학회 2008 녹지환경학회지 Vol.4 No.2
Lonicera caerulea L. var. edulis Turcz et Herd. with great nutrient and commercial edible value, is a kind of wild berry resource in regions of Changbai Moutains, China. Systematic cultivation technology for its large-scale production is developed and formation of cultivated land with area of 150 hectares is established. With high-yield technology, the production yield can be increased by twice. Systematic cultivation technology and establishment of technology demonstration garden lay the foundation for construction of production base and large-scale production of Lonicera caerulea L. var. edulis Turcz et Herd.