Application of BASNEF Model in Prediction of Intimate Partner Violence (IPV) Against Women

Zahra Sadat Asadi,Vahideh Moghaddam Hosseini,Masumeh Hashemian,Arash Akaberi 숙명여자대학교 아시아여성연구원 2013 Asian Women Vol.29 No.1

Pd Nanoparticles Immobilized on Boehmite as an Efficient Heterogeneous Catalyst for Lubricant Hydrogenation

Asadi Zahra,Sadjadi Samahe,Bahri-Laleh Naeimeh,Nekoomanesh-Haghighi Mehdi 한국화학공학회 2024 Korean Journal of Chemical Engineering Vol.41 No.3

To furnish high-quality poly-alpha-olefi n oils, hydro-fi nishing under mild reaction conditions by a novel heterogeneous catalyst was accomplished. In this regard, Pd nanoparticles were immobilized on Boehmite. Then, the eff ect of hydrogenation variables, i.e., catalytic loading, reaction pressure, and temperature on the catalytic effi ciency, was investigated with response surface method. According to the results, a hydrogenation effi ciency of 85% was obtained at the optimum reaction conditions of T = 130 °C, P = 8 bar, and catalyst dosage = 5 wt%. Notably, the catalyst was recyclable for four runs with insignifi cant leaching of palladium nanoparticles. The comparison results suggested Pd/Boehmite catalyst as an appropriate alternative to the commercial Pd/Alumina and Pd/Silica. Hot fi ltration test also approved heterogeneous nature of catalysis.

New method in synthesis of nano uranyl(VI) Schiff base complexes: Characterization and electrochemical studies

Zahra Asadi,Mozaffar Asadi,Fahimeh Dehghani Firuzabadi,Mohammad Ranjkesh Shorkaei 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.6

This study presents a new method in synthesis of nano uranyl Schiff base complexes. In thismethod slowaddition of dilute uranyl(VI) acetate solution to dilute Schiff base solution following the reflux for about24 h, yields nano uranyl(VI) Schiff base complexes. Characterization of Schiff base ligands and nanouranyl complexes has been done using 1H NMR, IR, UV–vis spectroscopy, elemental analysis. Schiff baseligands were synthesized by the condensation of one mole 3,4-diaminobenzophenone and two molessalicylaldehyde or substituted salicylaldehyde (3-OMe, 4-OMe, 5-OMe, 5-Br, 5-Cl). The electrochemicalproperties of the uranyl(IV) complexes were investigated by cyclic voltammetry. A good correlation wasobserved between the oxidation potentials and the electron withdrawing character of the substituentson the Schiff base ligands, according to the following trend: 5-MeO < H < 5-Br 5-Cl. Also the effect ofthe position of the substituted groups of Schiff base on the anodic potentials is as follows: 5-OMe < 3-OMe < 4-OMe.

Association of SOD2 rs2758339, rs5746136 and rs2842980 polymorphisms with increased risk of breast cancer: a haplotype-based case–control study

Asadi Sara,Abkar Morteza,Zamanzadeh Zahra,Taghipour Kamalabad Setareh,Sedghi Maryam,Yousefnia Saghar 한국유전학회 2023 Genes & Genomics Vol.45 No.9

Background A growing body of evidence indicates that oxidative stress, high levels of reactive oxygen species (ROS), is implicated in the pathogenesis of breast cancer (BC). Superoxide dismutase (SOD2), a mitochondria-resident antioxidant enzyme, protects cells from ROS by catalytically converting the superoxide radicals into less reactive species. Objective We aimed to investigate whether SOD2 rs2758339, rs5746136 and rs2842980 polymorphisms are associated with increased risk of BC. Methods A total of 100 patients with BC and 100 healthy controls were enrolled in the study. We used polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) assay for genotyping the SOD2 single-nucleotide polymorphisms (SNPs). Under co-dominant, dominant and recessive inheritance models, the genotypic and allelic associations of SOD2 SNPs with susceptibility to BC were evaluated using logistic regression analysis. The haplotype analysis was performed on the SOD2 SNPs to determine their combined effect on the BC risk. Results We found that SOD2 rs5746136 was significantly associated with decreased risk of developing BC in co-dominant and dominant inheritance models (P < 0.05). The SOD2 rs5746136 T allele confers an apparent protective effect against breast carcinogenesis (OR: 1.956; 95% CI 1.312–2.916; P < 0.0001). The SOD2 rs5746136/rs2842980 combined genotypes (CT/AA, CT/AT and TT/AA) were significantly more frequent in healthy subjects compared to BC patients (P < 0.05). The CTA and ACA haplotypes (rs2758339, rs5746136, rs2842980) were found to be a protective and a risk factor for BC, respectively. Conclusion These data strongly suggest that SOD2 rs5746136 was significantly associated with reduced risk of BC, indicating its protective role in BC development.

Application of Stem Cells in Targeted Therapy of Breast Cancer: A Systematic Review

Madjd, Zahra,Gheytanchi, Elmira,Erfani, Elham,Asadi-Lari, Mohsen Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

Background: The aim of this systematic review was to investigate whether stem cells could be effectively applied in targeted therapy of breast cancer. Material and Method: A systematic literature search was performed for original articles published from January 2007 until May 2012. Results: Nine studies met the inclusion criteria for phase I or II clinical trials, of which three used stem cells as vehicles, two trials used autologous hematopoetic stem cells and in four trials cancer stem cells were targeted. Mesenchymal stem cells (MSCs) were applied as cellular vehicles to transfer therapeutic agents. Cell therapy with MSC can successfully target resistant cancers. Cancer stem cells were selectively targeted via a proteasome-dependent suicide gene leading to tumor regression. $Wnt/{\beta}$-catenin signaling pathway has been also evidenced to be an attractive CSC-target. Conclusions: This systematic review focused on two different concepts of stem cells and breast cancer marking a turning point in the trials that applied stem cells as cellular vehicles for targeted delivery therapy as well as CSC-targeted therapies. Applying stem cells as targeted therapy could be an effective therapeutic approach for treatment of breast cancer in the clinic and in therapeutic marketing; however this needs to be confirmed with further clinical investigations.

High Expression of Stem Cell Marker ALDH1 is Associated with Reduced BRCA1 in Invasive Breast Carcinomas

Madjd, Zahra,Ramezani, Babak,Molanae, Saadat,Asadi-Lari, Mohsen Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6

Background: Cancer stem cells (CSC) have been described in a variety of malignancies, including breast carcinomas. Among several markers, aldehyde dehydrogenase 1 (ALDH1) has been identified as reliable for breast cancer stem cells. Knockdown of BRCA1 in primary breast epithelial cells leads to an increase in cells expressing ALDH1. Methods: We examined 127 breast carcinomas for expression of ALDH1, using immunohistochemistry and correlated with clinicopathological parameters as well as the BRAC1 status. Results: Comparing the results for both ALDH1 and BRCA1 expression showed a significant inverse association between the two, indicating that reduced BRCA1 was more often seen in breast cancer cells expressing ALDH1 (p-value = 0.044). A total of 24/110 (22%) of tumours displayed the ALDH1 + / BRCA1 -/low phenotype, which showed a trend for a relation with a high grade (p-value= 0.056). Cytoplasmic expression of ALDH1 was not correlated with tumour characteristics. Conclusion: Taken together, our findings suggest that increased ALDH1 is inversely correlated with decreased BRCA1 in a series of unselected breast carcinomas. Therefore, ALDH1 positive (cancer stem) cells with reduced BRCA1 phenotype may indicate a subset of patients for whom specific targeting of the CSC marker ALDH1 and more aggressive adjuvant treatment is appropriate.

The Relationships Among Occupational Safety Climate, Patient Safety Climate, and Safety Performance Based on Structural Equation Modeling

Aghaei Hamed,Sadat Asadi Zahra,Mirzaei Aliabadi Mostafa,Ahmadinia Hassan 대한예방의학회 2020 Journal of Preventive Medicine and Public Health Vol.53 No.6

Objectives: The aim of the present study was to investigate the relationships among hospital safety climate, patient safety climate, and safety outcomes among nurses. Methods: In the current cross-sectional study, the occupational safety climate, patient safety climate, and safety performance of nurses were measured using several questionnaires. Structural equation modeling was applied to test the relationships among occupational safety climate, patient safety climate, and safety performance. Results: A total of 211 nurses participated in this study. Over half of them were female (57.0%). The age of the participants tended to be between 20 years and 30 years old (55.5%), and slightly more than half had less than 5 years of work experience (51.5%). The maximum and minimum scores of occupational safety climate dimensions were found for reporting of errors and cumulative fatigue, respectively. Among the dimensions of patient safety climate, non-punitive response to errors had the highest mean score, and manager expectations and actions promoting patient safety had the lowest mean score. The correlation coefficient for the relationship between occupational safety climate and patient safety climate was 0.63 (p<0.05). Occupational safety climate and patient safety climate also showed significant correlations with safety performance. Conclusions: Close correlations were found among occupational safety climate, patient safety climate, and nurses’ safety performance. Therefore, improving both the occupational and patient safety climate can improve nurses’ safety performance, consequently decreasing occupational and patient-related adverse outcomes in healthcare units.

Developing a wireless sensor network based on a proposed algorithm for healthcare purposes

Reza Abbasi-Kesbi,Zahra Asadi,Alireza Nikfarjam 대한의용생체공학회 2020 Biomedical Engineering Letters (BMEL) Vol.10 No.1

This letter describes a developed wireless sensor network based on a proposed algorithm for monitoring the environmentalparameters in healthcare intentions. This proposed algorithm contains a frame with diff erent packets that are implemented onthe developed wireless sensor network. The developed wireless sensor network consists of one central node as well as foursensor node that has been equipped with various sensors such as temperature, humidity, CO, CO 2 , and passive infrared sensor. In order to test the presented algorithm and the developed wireless sensor network, the sensor nodes are situated in fourdiff erent rooms in a hospital for recording essential parameters of the environment while the central node is put in the nursestation for warning to nurses. The obtained result of the proposed sensor nodes in comparison to gold standards shows rootmean square error 1.1%, 0 .35 ◦C , 0.98% for humidity, temperature and gas, respectively. Also, the obtained results illustratethat the system gives accurate feedback from environmental temperature, humidity, and CO, and CO 2 to the nurse station inorder to increases the possibility of a healthy environment condition for patients.