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- 저자 : Asadi Sara (검색결과 2 건)
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Asadi Sara,Abkar Morteza,Zamanzadeh Zahra,Taghipour Kamalabad Setareh,Sedghi Maryam,Yousefnia Saghar 한국유전학회 2023 Genes & Genomics Vol.45 No.9
Background A growing body of evidence indicates that oxidative stress, high levels of reactive oxygen species (ROS), is implicated in the pathogenesis of breast cancer (BC). Superoxide dismutase (SOD2), a mitochondria-resident antioxidant enzyme, protects cells from ROS by catalytically converting the superoxide radicals into less reactive species. Objective We aimed to investigate whether SOD2 rs2758339, rs5746136 and rs2842980 polymorphisms are associated with increased risk of BC. Methods A total of 100 patients with BC and 100 healthy controls were enrolled in the study. We used polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) assay for genotyping the SOD2 single-nucleotide polymorphisms (SNPs). Under co-dominant, dominant and recessive inheritance models, the genotypic and allelic associations of SOD2 SNPs with susceptibility to BC were evaluated using logistic regression analysis. The haplotype analysis was performed on the SOD2 SNPs to determine their combined effect on the BC risk. Results We found that SOD2 rs5746136 was significantly associated with decreased risk of developing BC in co-dominant and dominant inheritance models (P < 0.05). The SOD2 rs5746136 T allele confers an apparent protective effect against breast carcinogenesis (OR: 1.956; 95% CI 1.312–2.916; P < 0.0001). The SOD2 rs5746136/rs2842980 combined genotypes (CT/AA, CT/AT and TT/AA) were significantly more frequent in healthy subjects compared to BC patients (P < 0.05). The CTA and ACA haplotypes (rs2758339, rs5746136, rs2842980) were found to be a protective and a risk factor for BC, respectively. Conclusion These data strongly suggest that SOD2 rs5746136 was significantly associated with reduced risk of BC, indicating its protective role in BC development.
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Hadi Tohidlou,Seyedeh Sara Shafiei,Shahsanam Abbasi,Mitra Asadi-Eydivand,Mehrnoosh Fathi-Roudsari 한국섬유공학회 2019 Fibers and polymers Vol.20 No.9
Carbon nanotubes (CNT) are beneficent candidates for bone tissue engineering (BTE) applications, mostlybecause of their superior mechanical properties. Although the previous studies confirmed that single-walled carbonnanotubes (SWNTs) have significant effect on biomedical applications but there is no study reported the effect of SWNTs onproperties of the PCL scaffolds for BTE applications. The purpose of this study was to evaluate the effect of aminefunctionalizedsingle-walled carbon nanotubes (aSWNTs) on mechanical properties and in vitro behavior of Polycaprolacton(PCL) scaffolds. PCL as a biocompatible polymeric matrix was composited with different amounts (ranging from 0, 0.1, 0.2,0.5 wt.%) of aSWNTs to enhance structural and functional properties of electrospun scaffolds. Attachment, proliferation,differentiation of rat bone marrow-derived mesenchymal stem cells (rMSCs) seeded onto the scaffolds was analyzed. Themorphology and mechanical properties of the scaffolds were characterized using SEM and tensile test. The results indicatedthat the addition of aSWNTs heightened the tensile strength while bioactivity and degradation rate were increased. Also, theaddition of aSWNTs has significantly amplified the electrical conductivity of PCL solution and resulted in the thinner fiberswith more uniform size distribution. Attachment, proliferation and differentiation of rMSCs were significantly improved. Although the best mechanical property was achieved in the scaffold with 0.2 wt% aSWNT, but the composite scaffold with0.5 wt% aSWNT significantly shows superior proliferation and differentiation of the rMSCs. Alkaline phosphatase activitydemonstrated elevated differentiation of cells on nanocomposite scaffolds.
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