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Salvatrione : A Diterpene-monoterpene Conjugate from Salvia bucharica
Viqar Uddin Ahmad,Muhammad Zahid,Muhammad Shaiq Ali,Amir Reza Jassbi,Shakeel Ahmad,Zulfiqar Ali,Muhammad Zafar Iqbal 한국생약학회 2000 Natural Product Sciences Vol.6 No.2
Salvia bucharica belonging to the family Lamiaceae (Labiatae), afforded a novel terpenoid (1) named as salvatrione. The structure of 1 was elucidated through extensive 2-D NMR experiments and the biogenetic pathway of 1 has also been proposed. On biogenetic grounds, 1 may be considered to be a pseudo-triterpenoid as it is derived from the coupling of mono/diterpenic units and not from squalene.
Brahol : A New Derivative of allo-Inositol from Stocksia brahuica
Yiqar Uddin Ahmad,Zulfiqar Ali,Muhammad Shaiq Ali,Muhammad Zahid,Rasool Bakhsh Tareen 한국생약학회 1998 Natural Product Sciences Vol.4 No.3
A new derivative of allo-inosital has been isolated from the aerial parts of Stocksia brahuica and named as brahol (1). The structure of 1 was elucidated with the help of extensive 2D-NMR spectroscopic techniques and identified as 5-O-methyl-allo-inositol. The structure was reconfirmed by acetate derivative (2).
Five-Dimensional Perfect Fluid Collapse with the Cosmological Constant
Muhammad Sharif,Zahid Ahmad 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.4
This paper is devoted to the study of a five-dimensional spherically symmetric perfect fluid collapse with a positive cosmological constant. We take a five-dimensional spherically symmetric metric in the interior region and a five-dimensional Schwarzschild-de Sitter metric in the exterior region. The junction conditions between the interior and the exterior spacetimes are derived. By assuming that the energy density and the pressure satisfy the weak energy condition, we discuss the solution for the interior spacetime with a perfect fluid for both the marginally bound and the non-marginally bound cases. We investigate the apparent horizons and their physical significance and conclude that the cosmological constant slows down the collapse of matter and, hence, limits the size of the black hole. This analysis generalizes four-dimensional perfect fluid collapse. The energy density is found to diverge faster in five dimensions than in four dimensions, indicating faster collapse here. Also, the cosmological horizon and the black hole horizon have larger proper areas than they do in four dimensions. This paper is devoted to the study of a five-dimensional spherically symmetric perfect fluid collapse with a positive cosmological constant. We take a five-dimensional spherically symmetric metric in the interior region and a five-dimensional Schwarzschild-de Sitter metric in the exterior region. The junction conditions between the interior and the exterior spacetimes are derived. By assuming that the energy density and the pressure satisfy the weak energy condition, we discuss the solution for the interior spacetime with a perfect fluid for both the marginally bound and the non-marginally bound cases. We investigate the apparent horizons and their physical significance and conclude that the cosmological constant slows down the collapse of matter and, hence, limits the size of the black hole. This analysis generalizes four-dimensional perfect fluid collapse. The energy density is found to diverge faster in five dimensions than in four dimensions, indicating faster collapse here. Also, the cosmological horizon and the black hole horizon have larger proper areas than they do in four dimensions.
miR-421, miR-155 and miR-650: Emerging Trends of Regulation of Cancer and Apoptosis
Farooqi, Ammad Ahmad,Qureshi, Muhammad Zahid,Coskunpinar, Ender,Naqvi, Syed Kamran-Ul-Hassan,Yaylim, Ilhan,Ismail, Muhammad Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5
It is becoming progressively more understandable that between transcription and translation there lies another versatile regulator that quantitatively controls the expression of mRNAs. Identification of miRNAs as key regulators of wide ranging signaling cascades and modulators of different cell-type and context dependent activities attracted basic and clinical scientists to study modes and mechanisms in details. In line with this approach overwhelmingly increasing in vivo and in vitro studies are deepening our understanding regarding miR-421, mir-155 and miR-650 mediated regulation of cellular activities. We also attempt to provide an overview of long non coding RNAs.
Two New Sesquiterpenes from Pluchea arguta
Viqar Uddin Ahmad,Muhammad Zahid,Rasheeda Khatoon,Zulfiqar Ali,Muhammad Abbas,Muhammad Zafar Iqbal 한국생약학회 1999 Natural Product Sciences Vol.5 No.2
Two new sesquiterpenes, 3`-chloro-2`-hydroxy-3-epi-arguticinin (1) and argutenol (2) belonging to eudesmane and gorgonane classes respectively, have been isolated from Pluchea arguta. Their structures were elucidated with the help of sophisticated spectroscopic techniques including nOe difference and NOESY experiments.
TRAIL and Bortezomib: Killing Cancer with Two Stones
Qureshi, Muhammad Zahid,Romero, Mirna Azalea,Attar, Rukset,Javed, Zeeshan,Farooqi, Ammad Ahmad Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.4
Cancer genomics and proteomics have undergone considerable broadening in the past decades and increasingly it is being realized that solid/liquid phase microarrays and high-throughput resequencing have provided platforms to improve our existing knowledge of determinants of cancer development, progression and survival. Loss of apoptosis is a widely and deeply studied process and different approaches are being used to restore apoptosis in resistant cancer phenotype. Modulating the balance between pro-apoptotic and anti-apoptotic proteins is essential to induce apoptosis. It is becoming more understood that pharmacological inhibition of the proteasome might prove to be an effective option in improving TRAIL induced apoptosis in cancer cells. Keeping in view rapidly accumulating evidence of carcinogenesis, metastasis, resistance against wide ranging therapeutics and loss of apoptosis, better knowledge regarding tumor suppressors, oncogenes, pro-apoptotic and anti-apotptic proteins will be helpful in translating the findings from benchtop to bedside.
Muhammad Umer Zahid,Anjum Khalique,Shafqat Nawaz Qaisrani,Muhammad Ashraf,Ali Ahmad Sheikh,Muhammad Umar Yaqoob Asian Australasian Association of Animal Productio 2023 Animal Bioscience Vol.36 No.7
Objective: Present study was designed to evaluate the efficacy of Acacia nilotica bark extract as an alternative to antibiotic growth promoters in broilers. Methods: Six hundred, day-old broiler chicks were randomly divided into six groups (NC, without any supplementation; AB, NC+Zinc Bacitracin; PB, NC+Safmannan; ANBE1, NC+A. nilotica bark extract 0.1%; ANBE3, NC+A. nilotica bark extract 0.3%; ANBE5, NC+A. nilotica bark extract 0.5%), with ten replicates per group (10 chicks/replicate) and feeding trial was lasted for 35 days. Results: Results showed that weight gain (1,296.63 g) and feed conversion ratio (FCR, 1.59) of AB was better than NC, during the finisher phase. Overall FCR of AB (1.53), PB (1.54), and ANBE5 (1.54) was significantly (p<0.05) better than NC. From carcass parameters relative weight of wing and heart were highest in ANBE3 (2.5% and 1.51%, respectively). Significantly (p<0.05) highest blood glucose level was observed in NC (264.5 mg/dL) and highest albumin concentration was found in AB (1.46 mg/dL). In addition, antibody titer levels against ND and IBD were higher in ANBE5 than NC, while higher relative weight of bursa was observed in ANBE3 than NC. The villus height to crypt depth ratio in all experimental groups was better than NC. Conclusion: Acacia nilotica bark extract could be a suitable alternative to antibiotic growth promoters to support the growth in broilers.
Effect of Varying Top Beam Reinforcement Anchorage Details on Ductility of HSC Beam-Column Joints
Ali Ahmed,Muhammad Mazhar Saleem,Zahid Ahmad Siddiqui 대한토목학회 2019 KSCE Journal of Civil Engineering Vol.23 No.5
The ductility of external beam-column joints effects seismic behavior of a structure and can be a reason for structural collapse. High strength concrete and large amount of steel present in the joint region reduces the ductility even further. This study presents a radical way of increasing high strength concrete external beam-column joint’s ductility by varying the beam top reinforcement detailing. Two types of joints (three specimens each) were tested, type-1 specimens were prepared as per regular standards while type-2 specimens were prepared by reducing the beam’s top reinforcement anchoring in the column. Load-deflection behavior was studied to observe the stiffness degradation and energy dissipation by joints. Experimental results demonstrated that type-2 specimens were considerably more ductile as compared to type-1 specimens. The energy dissipated by type-2 joints (with 40% less reinforcing bar area in the beam) was 41.5% more than type-1 joints without substantial stiffness degradation. Furthermore, it was observed that by reducing the steel reinforcement in beam, the cracks location changed from inside the joint to beam-column joint’s face which may be attributed for increased ductility in type-2 joints. This study shows that by changing the steel reinforcement detailing near external beam-column joints, fatigue behavior and energy absorption capacity can be enhanced hence providing better performance against seismic activities.
Anthocyanins: Targeting of Signaling Networks in Cancer Cells
Sehitoglu, Muserref Hilal,Farooqi, Ammad Ahmad,Qureshi, Muhammad Zahid,Butt, Ghazala,Aras, Aliye Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5
It is becoming progressively more understandable that phytochemicals derived from edible plants have shown potential in modelling their interactions with their target proteins. Rapidly accumulating in-vitro and in- vivo evidence indicates that anthocyanins have anticancer activity in rodent models of cancer. More intriguingly, evaluation of bilberry anthocyanins as chemopreventive agents in twenty-five colorectal cancer patients has opened new window of opportunity in translating the findings from laboratory to clinic. Confluence of information suggests that anthocyanins treated cancer cells reveal up-regulation of tumor suppressor genes. There is a successive increase in the research-work in nutrigenomics and evidence has started to shed light on intracellular-signaling cascades as common molecular targets for anthocyanins. In this review we bring to l imelight how anthocyanins induced apoptosis in cancer cells via activation of extrinsic and intrinsic pathways.