New DTR Estimation Method Without Measured Solar and Wind Data

Zhan-Feng Ying,Yuan-Sheng Chen,Kai Feng 대한전기학회 2017 Journal of Electrical Engineering & Technology Vol.12 No.2

Dynamic thermal rating (DTR) of overhead transmission lines can provide a significant increase in transmission capacity compared to the static thermal rating. However, the DTR are usually estimated by the traditional thermal model of overhead conductor that is highly dependent on the solar, wind speed and wind direction data. Consequently, the estimated DTR would be unreliable and the safety of transmission lines would be reduced when the solar and wind sensors are out of function. To address this issue, this study proposed a novel thermal model of overhead conductor based on the thermal-electric analogy theory and Markov chain. Using this thermal model, the random variation of conductor temperature can be simulated with any specific current level and ambient temperature, even if the solar and wind sensors are out of function or uninstalled. On this basis, an estimation method was proposed to determine the DTR in the form of probability. The laboratory experiments prove that the proposed method can estimate the DTR reliably without measured solar and wind data.

Expression and Clinical Significance of MicroRNA-376a in Colorectal Cancer

Mo, Zhan-Hao,Wu, Xiao-Dong,Li, Shuo,Fei, Bing-Yuan,Zhang, Bin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21

The incidence of colorectal cancer (CRC) is increasing in many Asian countries and microRNAs have already been proven to be associated with tumorigenesis. Currently, microRNA-376a (miR-376a) expression and association with clinical factors in CRC remains unclear. In this study, real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) was carried out on 53 matched pairs of CRC and adjacent normal mucosa to investigate the expression levels of miR-376a. According to the high or low expression of miR-376a, patients were divided into two groups. The relationship between miR-376a expression and clinicopathological factors of 53 patients was evaluated. Survival analysis of 53 CRC patients was performed with clinical follow-up information and survival curves were assessed by the Kaplan-Meier method. Immunohistochemistry (IHC) staining was performed on sections of paraffin-embedded tissue to investigate the vascular endothelial growth factor (VEGF) expression. MiR-376a showed low expression in cancer tissues compared to the adjacent normal tissues and altered high miR-376a expression tended to be positively correlated with advanced lymph node metastasis and shorter patient survival. VEGF IHC positivity was significantly more common in patients with high expression levels of miR-376a.Those results demonstrated that miR-376a may be a meaningful prognostic biomarker and potential therapeutic target in colorectal cancer.

Differential Change in the Prevalence of the Ascaris, Trichuris and Clonorchis infection Among Past East Asian Populations

Xiaoya Zhan,Hui-Yuan Yeh,Dong Hoon Shin,Jong-Yil Chai,Min Seo,Piers D. Mitchell 대한기생충학열대의학회 2019 The Korean Journal of Parasitology Vol.57 No.6

As we learn more about parasites in ancient civilizations, data becomes available that can be used to see how infection may change over time. The aim of this study is to assess how common certain intestinal parasites were in China and Korea in the past 2000 years, and make comparisons with prevalence data from the 20th century. This allows us to go on to investigate how and why changes in parasite prevalence may have occurred at different times. Here we show that Chinese liver fluke (Clonorchis sinensis) dropped markedly in prevalence in both Korea and China earlier than did roundworm (Ascaris lumbricoides) and whipworm (Trichuris trichiura). We use historical evidence to determine why this was the case, exploring the role of developing sanitation infrastructure, changing use of human feces as crop fertilizer, development of chemical fertilizers, snail control programs, changing dietary preferences, and governmental public health campaigns during the 20th century.

Cyclo[<i>m</i>]pyridine[<i>n</i>]pyrroles: Hybrid Macrocycles That DisplayExpanded π-Conjugationupon Protonation

Zhang, Zhan,Lim, Jong Min,Ishida, Masatoshi,Roznyatovskiy, VladimirV.,Lynch, Vincent M.,Gong, Han-Yuan,Yang, Xiaoping,Kim, Dongho,Sessler, Jonathan L. American Chemical Society 2012 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.134 No.9

<P>Novel hybrid cyclo[<I>m</I>]pyridine[<I>n</I>]pyrroles have been synthesized using Suzuki coupling.Their NMRand optical spectroscopic features and solid state structural parametersprovide support for the proposal that these species are best describedas locally aromatic compounds devoid of long-range intersubunit conjugation.However, an extension of the π-conjugation in the macrocyclescan be realized through protonation, as inferred from optical spectroscopicand X-ray diffraction-based structural studies.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2012/jacsat.2012.134.issue-9/ja211985k/production/images/medium/ja-2011-11985k_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja211985k'>ACS Electronic Supporting Info</A></P>

Determination of equivalent blasting load considering millisecond delay effect

Song, Zhan-Ping,Li, Shi-Hao,Wang, Jun-Bao,Sun, Zhi-Yuan,Liu, Jing,Chang, Yu-Zhen Techno-Press 2018 Geomechanics & engineering Vol.15 No.2

In the analysis of the effects of rock tunnel blasting vibration on adjacent existing buildings, the model of simplified equivalent load produces higher calculation result of vibration, due to the lack of consideration of the millisecond delay effect. This paper, based on the static force equivalence principle of blasting load, proposes a new determination method of equivalent load of blasting vibration. The proposed method, based on the elastic-static force equivalence principle of stress wave, equals the blasting loads of several single blastholes in the same section of millisecond blasting to the triangle blasting load curve of the exploded equivalent elastic boundary surface. According to the attenuation law of stress wave, the attenuated equivalent triangle blasting load curve of the equivalent elastic boundary is applied on the tunnel excavation contour surface, obtaining the final applied equivalent load. Taking the millisecond delay time of different sections into account, the time-history curve of equivalent load of the whole section applied on the tunnel excavation contour surface can be obtained. Based on Sailing Tunnel with small spacing on Sanmenxia-Xichuan Expressway, an analysis on the blasting vibration response of the later and early stages of the tunnel construction is carried out through numerical simulation using the proposed equivalent load model considering millisecond delay effect and the simplified equivalent triangle load curve model respectively. The analysis of the numerical results comparing with the field monitoring ones shows that the calculation results obtained from the proposed equivalent load model are closer to the measured ones and more feasible.

Case Study of the Effect of Rainfall Infiltration on a Tunnel Underlying the Roadbed Slope with Weak Inter-Layer

Sheng-yuan Fan,Zhan-ping Song,Yu-wei Zhang,Nai-fei Liu 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.5

It is a common type of tunnel under-cross the roadbed slope with weak inter-layer. Rainfall infiltration will cause soil softening, matric suction and strength reduction, which seriously threaten the safety of slope and tunnel. This paper presents a case where a tunnel underlying the roadbed slope with weak inter-layer in Guiyang 1# line, China. The seepage calculation model in MIDAS GTS/NX software, considering hydraulic permeability coefficient characteristiccurve and soil-water characteristic curve, was used to analyze the stress and deformation of the roadbed slope and tunnel. The results reveal that rainfall infiltration has great influence on the deformation of roadbed slope with weak inter-layer and the force of internal tunnel. Slope displacement increases rapidly in the early stage and decreases in the late stage, but the absolute value of displacement increases continuously and the slope safety factor decreases gradually, which makes the slope in a dangerous state. The force of tunnel lining increases in the early stage and decreases with the recovery of soil strength after rainfall. The control effects of anchor cable and anti-slide pile reinforcement on slope sliding and tunnel stress were studied. And the anchor cable reinforcement measure is more effective on reducing slope slip and tunnel lining structure internal force.

Discovery of Eurytrema Eggs in Sediment from a Colonial Period Latrine in Taiwan

Hui-Yuan Yeh,Chieh-fu Jeff Cheng,ChingJung Huang,Xiaoya Zhan,Weng Kin Wong,Piers D. Mitchell 대한기생충학열대의학회 2019 The Korean Journal of Parasitology Vol.57 No.6

In this study we take a closer look at the diseases that afflicted Japanese police officers who were stationed in a remote mountainous region of Taiwan from 1921 to 1944. Samples were taken from the latrine at the Huabanuo police outpost, and analyzed for the eggs of intestinal parasites, using microscopy and ELISA. The eggs of Eurytrema sp., (possibly E. pancreaticum), whipworm and roundworm were shown to be present. True infection with Eurytrema would indicate that the policemen ate uncooked grasshoppers and crickets infected with the parasite. However, false parasitism might also occur if the policemen ate the uncooked intestines of infected cattle, and the Eurytrema eggs passed through the human intestines. These findings provide an insight into the diet and health of the Japanese colonists in Taiwan nearly a century ago.

New DTR Estimation Method Without Measured Solar and Wind Data

Ying, Zhan-Feng,Chen, Yuan-Sheng,Feng, Kai The Korean Institute of Electrical Engineers 2017 Journal of Electrical Engineering & Technology Vol.12 No.2

Dynamic thermal rating (DTR) of overhead transmission lines can provide a significant increase in transmission capacity compared to the static thermal rating. However, the DTR are usually estimated by the traditional thermal model of overhead conductor that is highly dependent on the solar, wind speed and wind direction data. Consequently, the estimated DTR would be unreliable and the safety of transmission lines would be reduced when the solar and wind sensors are out of function. To address this issue, this study proposed a novel thermal model of overhead conductor based on the thermal-electric analogy theory and Markov chain. Using this thermal model, the random variation of conductor temperature can be simulated with any specific current level and ambient temperature, even if the solar and wind sensors are out of function or uninstalled. On this basis, an estimation method was proposed to determine the DTR in the form of probability. The laboratory experiments prove that the proposed method can estimate the DTR reliably without measured solar and wind data.

MiR-124 regulates apoptosis in hypoxia-induced human brain microvessel endothelial cells through targeting Bim

Jie Pu,Yuan Long,Jian Zhou,Yanqiang Zhan,Xiaoyong Qin 한국응용생명화학회 2018 Applied Biological Chemistry (Appl Biol Chem) Vol.61 No.6

Human brain microvessel endothelial cells (HBMECs) are crucial for brain vascular repair and maintenance. The high-expressed expressions of micro- RNA-124 (miR-124) in brain have been investigated and revealed in many researches. In this work, we aimed to investigate the role of miR-124 in apoptosis of HBMECs and the underlying mechanism. Here, we found the lowexpressed miR-124 in hypoxia-induced HBMECs using qRT-PCR analysis. MiR-124 targeting 30-untranslated region (30-UTR) of Bim mRNA was predicted by Targetscan database. Importantly, the decreased miR-124 expression and increased Bim expression, an opposite trend, were obtained in hypoxia-induced HBMECs. The further confirmation of the correlation between miR-124 and Bim was conducted by miR-124 overexpression and dual luciferase reporter assays. The inhibitory role of miR- 124 in Bim expression was evidenced by results obtained from miR-124 overexpression analysis. Luciferase reporter assay further proved that miR-124 directly targeted the two conserved seed sites in the Bim 30-UTR. The inhibited apoptosis of HBMECs was observed under both miR-124 overexpression and Bim knockdown condition in flow cytometry analysis. Collectively, these findings outline that miR-124 regulates apoptosis in hypoxia-induced HBMECs through targeting Bim, providing a better understanding of the role of miR-124 in apoptosis of HBMECs.

A novel active disturbance rejection-based control strategy for a gun control system

Qiang Gao,Zhan Sun,Guolai Yang,Runmin Hou,Li Wang,Yuan-Long Hou 대한기계학회 2012 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.26 No.12

To compensate for the nonlinearity and to achieve finely-tuned tracking accuracy of a gun control system driven by an AC machine,an improved active disturbance rejection control (IADRC) strategy with neural network embedding (NN-IADRC) is developed in this paper. The proposed IADRC, which has amnestic memory effects, can be regarded as an extension of the conventional ADRC (CADRC),making it a special case of the IADRC. To further attenuate the dependence on system models and enhance the disturbance rejection capacities of the IADRC strategy, an on-line NN-based optimum updating approach is also developed in this paper. Finally, a series of experiments are conducted on the semi-physical simulation platform to estimate the performance of the control system and the effects of the memory factor on the system. The experimental results confirm that the proposed NN-IADRC is highly robust. The results also confirm that it performs more excellently than the CADRC and that its fine tuning has attained tracking accuracy.