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[PB-0071] GBS 분석을 통한 국내 무(Raphanus sativus L.) 품종의 유전적 유연관계 분석
Hui Yeon Hong(Hui Yeon Hong),Jun Ho Lee(Jun Ho Lee),Yoon Ah Jang(Yoon Ah Jang),Jin Hee Kim(Jin Hee Kim),Ji Won Kim(Ji Won Kim),Ji Hyeon Lim(Ji Hyeon Lim),Hye Won Yu(Hye Won Yu),Won Byoung Chae(Won Byo 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
[PB-0073] 무(Raphanus sativus L.) 품종의 표현형적 특성과 heterozygosity 간의 상관관계 분석
Hui Yeon Hong(Hui Yeon Hong),Jun Ho Lee(Jun Ho Lee),Yoon Ah Jang(Yoon Ah Jang),Jin Hee Kim(Jin Hee Kim),Ji Won Kim(Ji Won Kim),Ji Hyeon Lim(Ji Hyeon Lim),Hye Won Yu(Hye Won Yu),Won Byoung Chae(Won Byo 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
( Yu Hui Won ),( Jin Young Chun ),( Sung Hee Park ),( Jeong Hwan Seo ),( Myoung Hwan Ko ),( Yong Chul Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Pulmonary rehabilitation (PR) has been demonstrated to reduce dyspnea, increase exercise capacity, and improve quality of life in individuals with chronic obstructive pulmonary disease (COPD). We report our experiences to operate PR program of COPD in our PR clinic which belongs to Regional Pulmonary Center in Chon-Buk area. Methods: From March to June 2014, hospital records of patients in our PR clinic were reviewed retrospectively. For inpatients program, initial assessment were done by rehabilitation physician and individualized PR programs were prescribed considering patient`s exercise capacity. PR program included aerobic exercise for 30 minutes, resistance training using elastic bandage, breathing retraining (diaphragmatic and pursed lip breathing), device training for secretion management using acapella, fiutter, PEP device, and VEST (high frequency chest wall oscillation), and respiratory muscle training. Outpatient`s PR program was conducted as hospital based PR or home based PR for 8 weeks. Results: In our PR clinic, among total 154 patients who were consulted for PR, 84 (54.5%) was COPD with acute exacerbation (AE) (Table 1). No serious complications were developed during PR program. Eighteen patients (11.7%) refused to practice PR due to personal reasons. For outpatient clinic, eighteen (56.3%) of 32 stable COPD patients were included (Table 1). Characteristics for COPD patients who received PR program were described in Table 2. Among these COPD patients, 34.3% performed hospital based PR, 34.3% home based PR, 20% home-based PR with weekly or every two weeks hospital visit, and 11.4% was missed follow up. Conclusions: For 4 months, patients who underwent PR were gradually increased. Since PR program has been accepted essential, non-medical treatment for COPD, PR should be included to COPD treatment. Also, korean researches about clinical benefits of COPD management would be necessary to settle down PR in Korea.
Early Mobilization and Rehabilitation of Critically-Ill Patients
Yu Hui Won,Hye Min Ji, M.D 대한결핵및호흡기학회 2024 Tuberculosis and Respiratory Diseases Vol.87 No.2
Post-intensive care unit (ICU) syndrome may occur after ICU treatment and includesICU-acquired weakness (ICU-AW), cognitive decline, and mental problems. ICU-AWis muscle weakness in patients treated in the ICU and is affected by the period of mechanicalventilation. Diaphragmatic weakness may also occur because of respiratorymuscle unloading using mechanical ventilators. ICU-AW is an independent predictor ofmortality and is associated with longer duration of mechanical ventilation and hospitalstay. Diaphragm weakness is also associated with poor outcomes. Therefore, pulmonaryrehabilitation with early mobilization and respiratory muscle training is necessaryin the ICU after appropriate patient screening and evaluation and can improve ICU-relatedmuscle weakness and functional deterioration.
Freezing of Gait Following Hypoxic Brain Injury - Two Cases Reports -
Yu Hui Won,김용욱,Mi Hee Park 대한재활의학회 2011 Annals of Rehabilitation Medicine Vol.35 No.1
Freezing of gait (FOG), which is the most common symptoms in Parkinson’s disease, is a unique gait disorder that patients are unable to initiate or continue locomotion. However, the pathophysiology of FOG has been poorly understood. We report two cases, one case is a 26-year old man and the second case is a 65-year old man, who showed FOG following hypoxic brain injuries caused by sudden cardiac arrest and hypovolemic shock, respectively. Brain F-18 FDG-PET images demonstrated the diffuse cortical hypometabolism in case 1 patient, and the decreased metabolism of the subcortical structures in case 2 patient. Two patients showed the typical features of FOG (turning, destination, and tight quarter hesitations combined with kinesia paradoxa) and the abnormal patterns of temporospatial data in kinematic gait analysis. We present two cases of FOG following hypoxic brain injury with reviewing of some literatures.
( Yu Hui Won ),( Jin Young Chun ),( Sung Hee Park ),( Jeong Hwan Seo ),( Myoung Hwan Ko ),( Yong Chul Lee ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: Pulmonary rehabilitation (PR) has been demonstrated to reduce dyspnea, increase exercise capacity, and improve quality of life in individuals with chronic obstructive pulmonary disease (COPD). We report our experiences to operate PR program of COPD in our PR clinic which belongs to Regional Pulmonary Center in Chon-Buk area. Methods: From March to June 2014, hospital records of patients in our PR clinic were reviewed retrospectively. For inpatients program, initial assessment were done by rehabilitation physician and individualized PR programs were prescribed considering patient’s exercise capacity. PR program included aerobic exercise for 30 minutes, resistance training using elastic bandage, breathing retraining (diaphragmatic and pursed lip breathing), device training for secretion management using acapella, flutter, PEP device, and VEST (high frequency chest wall oscillation), and respiratory muscle training. Outpatient’s PR program was conducted as hospital based PR or home based PR for 8 weeks. Results: In our PR clinic, among total 154 patients who were consulted for PR, 84 (54.5%) was COPD with acute exacerbation (AE) (Table 1). No serious complications were developed during PR program. Eighteen patients (11.7%) refused to practice PR due to personal reasons. For outpatient clinic, eighteen (56.3%) of 32 stable COPD patients were included (Table 1). Characteristics for COPD patients who received PR program were described in Table 2. Among these COPD patients, 34.3% performed hospital based PR, 34.3% home based PR, 20% home-based PR with weekly or every two weeks hospital visit, and 11.4% was missed follow up. Conclusions: For 4 months, patients who underwent PR were gradually increased. Since PR program has been accepted essential, non-medical treatment for COPD, PR should be included to COPD treatment. Also, korean researches about clinical benefits of COPD management would be necessary to settle down PR in Korea.
Hyung, Seok-Won,Lee, Min Young,Yu, Jong-Han,Shin, Byunghee,Jung, Hee-Jung,Park, Jong-Moon,Han, Wonshik,Lee, Kyung-Min,Moon, Hyeong-Gon,Zhang, Hui,Aebersold, Ruedi,Hwang, Daehee,Lee, Sang-Won,Yu, Myeon American Society for Biochemistry and Molecular Bi 2011 Molecular & cellular proteomics Vol.10 No.10
장류 및 젓갈 분리 균주 추출물의 비만세포 매개 항염증효과
Yu-Jin Ko(고유진),Hui-Hun Kim(김희훈),Eun-Jung Kim(김은정),Jin-Yong Kim(김진용),Sang-Dong Kang(강상동),Yong-Hwi Son(손용휘),Sin-Yang Choi(최신양),Seong-Kwan Cha(차성관),Jong-Won Kim(김종원),Jeong-Ok Lee(이정옥),Chung-Ho Ryu(류충호) 한국생명과학회 2011 생명과학회지 Vol.21 No.3
본 연구에서 장류 및 젓갈 유래 균체를 각각 sonication, 100℃에서 30 min, 125℃에서 15 min의 조건으로 추출하여 HMC-1에 처리하였을 때, 이 추출방법에 따른 HMC-1매개 염증반응 억제효과를 조사하였다. 추출방법을 달리하여 추출한 장류 및 젓갈 유래 균체 J80, G147이 HMC-1생존율에 미치는 영향은 대조구 B (Not treated)와 비교하였을 때 86~96%로 유의적 차이를 보이지 않아 장류 및 젓갈 유래 균체에 의한 세포 독성은 나타나지 않았다. 장류 및 젓갈 유래 균체의 모든 전처리구에서 histamine 유리 억제효과를 나타내었으며 특히, 100℃에서 30min 동안 가열하였을 때 histamine 억제율이 J80에서 28.86%, G147에서 41.14%으로 가장 높게 나타냈다. IL-8분비량은 J80, G147의 모든 전처리구에서 IL-8 분비억제효과가 나타났으며, J80의 경우 100℃, 30 min에서 처리한구에서 분비량이 0.78 ng/㎖로 대조구 B (Not treated)에 비하여 약 28.45%의 분비억제효과로 가장 높게 나타내었다. G147의 경우 125℃, 15 min에서 처리한 구에서 분비량이 0.73 ng/㎖로 약 36.52%의 분비억제효과로 가장 높게 나타내었다. IL-6 분비량을 측정한 결과 J80, G147의 모든 실험구에서 IL-6 분비억제효과가 나타났으며, J80에서는 100℃, 30 min한 D구의 분비량이 0.40 ng/㎖으로 대조구 B (Not treated)에 비하여 약 38.46%의 분비억제효과로 가장 높았으며, G147 역시 100℃, 30 min 동안 처리한 D구의 분비량이 0.27 ng/㎖으로 대조구 B (Not treated)에 비하여 56.45%의 분비억제효과로 가장 높게 나타냈다. TNF-α 분비량 역시 IL-6와 마찬가지로 J80, G147에서 대조구 B보다 낮은 분비량으로 TNF-α 분비 억제효과가 나타났으며 J80의 경우 100℃, 30 min 처리한 D의 TNF-α 분비량이 0.052 ng/㎖으로 66.67%의 분비억제효과로 가장 높았으며, G147의 경우 sonication을 처리한 C구의 TNF-α 분비량이 0.086 ng/㎖으로 41.1%의 분비억제효과로 다른 구에 비해 높은 억제효과를 나타내었다. 위의 결과를 통해서 장류 및 젓갈 유래 균체의 3가지 전처리 방법 중 100℃, 30 min 처리 시 염증 반응 억제 효과가 가장 높을 것으로 예상된다. 결과를 미루어보아 장류를 섭취하는 대표적인 방법인 가열하여 찌개로 조리과정 중장류 및 젓갈 속의 균체가 열에 가열되면서 염증억제효과 높일 수 있는 가장 좋은 조리 방법으로 사료되며, 이는 대중들이 가장 가깝게 염증반응 억제효과를 볼 수 있는 식품일 것이다. 또한 염장처리과정만을 거친 젓갈을 섭취하는 것보다 열처리과정을 거친 젓갈을 섭취할 경우 염증억제효과를 더 높일 수 있을 것으로 예상된다. The mast cell is one of the major effector cells in inflammatory reactions and can be found in most tissues throughout the body. Activated mast cells can produce histamine, as well as a wide variety of other inflammatory mediators such as eicosanoids, proteoglycans, proteases, and several pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α, and interleukins (IL-6), IL-8, IL-4, IL-13. In the present study, we isolated two bacterial strains (J80 and G147) from fermented soybean and Jeotgal,and investigated the inhibitory effects of their extracts which were prepared by several pretreatment methods (sonication for 20 min, heating at 100℃ for 30 min, autoclaving at 121℃ for 15 min) on the mast cell-mediated inflammatory response. The pretreated bacterial extracts had no cytotoxicity against Human Mast Cell (HMC-1). Among various pretreatments, the extracts treated at 100℃ showed highest inhibition of histamine release (J80, 28.46%; G147, 41.14%). The J80 and G147 extracts treated at 100℃ resulted in the inhibition of IL-6 secretion by 38.46% and 56.45%, respectively. The J80 extract treated at 100℃ resulted in the inhibition of TNF-α secretion by 66.67%, but G147 extract showed the highest inhibition effect by 41.1% when treated with sonication. These results suggest that bacterial extracts treated at 100℃ have a higher level of anti-inflammatory effects than other treatments such as sonication or autoclaving.
Yu, Sang-Hui,Oh, Seunghan,Cho, Hye-Won,Bae, Ji-Myung Elsevier 2017 The Journal of prosthetic dentistry Vol.118 No.5
<P><B>Abstract</B></P> <P><B>Statement of problem</B></P> <P>Studies that evaluated the strength of complete dentures reinforced with glass-fiber mesh or metal mesh on a cast with a simulated oral mucosa are lacking.</P> <P><B>Purpose</B></P> <P>The purpose of this in vitro study was to compare the mechanical properties of maxillary complete dentures reinforced with glass-fiber mesh with those of metal mesh in a new test model, using a simulated oral mucosa.</P> <P><B>Material and methods</B></P> <P>Complete dentures reinforced with 2 types of glass-fiber mesh, SES mesh (SES) and glass cloth (GC) and metal mesh (metal) were fabricated. Complete dentures without any reinforcement were prepared as a control (n=10). The complete dentures were located on a cast with a simulated oral mucosa, and a load was applied on the posterior artificial teeth bilaterally. The fracture load, elastic modulus, and toughness of a complete denture were measured using a universal testing machine at a crosshead speed of 5 mm/min. The fracture load and elastic modulus were analyzed using 1-way analysis of variance, and the toughness was analyzed with the Kruskal-Wallis test (α=.05). The Tukey multiple range test was used as a post hoc test.</P> <P><B>Results</B></P> <P>The fracture load and toughness of the SES group was significantly higher than that of the metal and control groups (<I>P<</I>.05) but not significantly different from that of the GC group. The elastic modulus of the metal group was significantly higher than that of the control group (<I>P<</I>.05), and no significant differences were observed in the SES and GC groups.</P> <P><B>Conclusions</B></P> <P>Compared with the control group, the fracture load and toughness of the SES and GC groups were higher, while those of the metal group were not significantly different.</P>