http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Lim, Wonchung,Park, Yeomyung,Cho, Jungyoon,Park, Choa,Park, Joonwoo,Park, Young-Kwon,Park, Hyunsung,Lee, YoungJoo BioMed Central 2011 Breast cancer research Vol.13 No.2
<P><B>Introduction</B></P><P>Estrogen receptor (ER) β is predicted to play an important role in prevention of breast cancer development and metastasis. We have shown previously that ERβ inhibits hypoxia inducible factor (HIF)-1α mediated transcription, but the mechanism by which ERβ works to exert this effect is not understood.</P><P><B>Methods</B></P><P>Vascular endothelial growth factor (VEGF) was measured in conditioned medium by enzyme-linked immunosorbent assays. Reverse transcription polymerase chain reaction (RT-PCR), Western blotting, immunoprecipitation, luciferase assays and chromatin immunoprecipitation (ChIP) assays were used to ascertain the implication of ERβ on HIF-1 function.</P><P><B>Results</B></P><P>In this study, we found that the inhibition of HIF-1 activity by ERβ expression was correlated with ERβ's ability to degrade aryl hydrocarbon receptor nuclear translocator (ARNT) via ubiquitination processes leading to the reduction of active HIF-1α/ARNT complexes. HIF-1 repression by ERβ was rescued by overexpression of ARNT as examined by hypoxia-responsive element (HRE)-driven luciferase assays. We show further that ERβ attenuated the hypoxic induction of VEGF mRNA by directly decreasing HIF-1α binding to the VEGF gene promoter.</P><P><B>Conclusions</B></P><P>These results show that ERβ suppresses HIF-1α-mediated transcription via ARNT down-regulation, which may account for the tumour suppressive function of ERβ.</P>
Park, Yeomyung,Park, Joonwoo,Lee, Yonghee,Lim, Wonchung,Oh, Byung-Chul,Shin, ChanYoung,Kim, Wansup,Lee, YoungJoo Springer 2011 Journal of molecular medicine Vol.89 No.2
<P>Mammalian MST2 kinase plays an important role in cell proliferation, survival, and apoptosis. In search of interacting proteins of MST2, we found that estrogen receptor alpha (ER alpha) co-immunoprecipitates with MST2 and its adaptor protein human Salvador (hSAV). Using reporter assays, we observed that overexpression of MST2 and hSAV leads to ligand-independent activation of ER alpha in human breast cancer MCF-7 cells, which was attenuated by the knockdown of hSAV. Furthermore, using truncated mutants of hSAV, we observed that the C terminus of hSAV is necessary and sufficient for the induction of ER alpha transactivation. The expression of hSAV and MST2 results in the phosphorylation of ER alpha at serine residues 118 and 167 and represses ER alpha expression. We then investigated the incidence of MST2 and ER alpha expression with other tumor biomarkers using commercially available tissue microarrays. Among 40 breast cancer samples analyzed, 60% (24 out of 40) expressed MST2. Nineteen among the 40 cases were MST2-positive and ER alpha-negative, implying a correlation between expressions of MST2 with loss of ER alpha in breast tumor samples. This study suggests that MST and hSAV act as novel co-regulators of ER alpha and may play an important role in breast cancer pathogenesis.</P>
Diagonally-reinforced Lane Detection Scheme for High-performance Advanced Driver Assistance Systems
Park, Mingu,Yoo, Kyoungho,Park, Yunho,Lee, Youngjoo The Institute of Electronics and Information Engin 2017 Journal of semiconductor technology and science Vol.17 No.1
In this paper, several optimizations are proposed to enhance the quality of lane detection algorithms in automotive applications. Considering the diagonal directions of lanes, the proposed limited Hough transform newly introduces image-splitting and angle-limiting schemes that relax the number of possible angles at the line voting process. In addition, unnecessary edges along the horizontal and vertical directions are pre-defined and removed during the edge detection procedures, increasing the detecting accuracy remarkably. Simulation results shows that the proposed lane recognition algorithm achieves an accuracy of more than 90% and a computing speed of 92 frame/sec, which are superior to the results from the previous algorithms.
Novel Folded-KES Architecture for High-Speed and Area-Efficient BCH Decoders
Byeonggil Park,Seungyong An,Jongsun Park,Youngjoo Lee IEEE 2017 IEEE transactions on circuits and systems. a publi Vol.64 No.5
<P>In this brief, we present a novel folding technique for high-speed and low-cost Bose-Chaudhuri-Hocquenghem (BCH) decoders. In the conventional BCH decoder, the critical path lies on the Galois-field (GF) multiplier of the key equation solver, where the speedup of the critical path is very difficult due to a significant area increase. In the proposed work, the regularly structured GF multiplier is introduced to be efficiently folded to reduce the complexity and the critical delay. Moreover, the conventional global folding scheme can be applied to further reduce the hardware costs. The implementation results show that the proposed folding scheme enhances the area efficiency by 1.73 and 1.9 times in the Digital Video Broadcasting-Satellite-Second Generation system and the storage controller, respectively.</P>
Minsuh Park,Geumhee Gwak,Jungbin Kim,조현진,Keunho Yang,Yujin Lee,Kyeongmee Park,Jiyoung Kim,Youngjoo Shin,Yeyoung Seo 한국유방암학회 2022 Journal of Breast Disease Vol.10 No.1
Purpose: The biggest concern related to ductal carcinoma in situ (DCIS) is local recurrence and recurrence patterns. The purpose of this study was to investigate the relationship between clinicopathological factors and relapse in patients treated with DCIS. Methods: We reviewed medical records of 104 patients who were diagnosed as DCIS between January 1999 and December 2015 at a single institute. We compared and analyzed clinicopathological factors such as age at diagnosis, preoperative lesions on ultrasonography, preoperative tumor markers, operation methods in the breast, histological grade, nuclear grade, resection margin, comedonecrosis, estrogen receptor/progesterone receptor expression, human epidermal factor receptor 2/neu expression, Ki-67, postoperative implementation of adjuvant hormonal therapy, and radiotherapy by dividing them into recurrent and non-recurrent groups. Results: Seventeen patients (16.3%) of 104 patients relapsed in the ipsilateral or contralateral breast. The median follow-up period of non-relapsed group was 4.9 years (range, 0.5–19.15) and the median follow-up period of relapsed group was 3.5 years (range, 1.4–14.13). Clinicopathological factors that were significantly related to relapse were nuclear grade (p=0.022) and Ki-67 (p=0.025) based on the results of chi-square or Fisher’s exact analysis. In multivariate analysis using logistic regression, Ki-67 (p=0.021) was significantly associated with DCIS relapse. Conclusion: This study suggested that the higher Ki-67 over 14% was strongly associated with DCIS relapse.
Diagonally-reinforced Lane Detection Scheme for High-performance Advanced Driver Assistance Systems
Mingu Park,Kyoungho Yoo,Yunho Park,Youngjoo Lee 대한전자공학회 2017 Journal of semiconductor technology and science Vol.17 No.1
In this paper, several optimizations are proposed to enhance the quality of lane detection algorithms in automotive applications. Considering the diagonal directions of lanes, the proposed limited Hough transform newly introduces image-splitting and angle-limiting schemes that relax the number of possible angles at the line voting process. In addition, unnecessary edges along the horizontal and vertical directions are pre-defined and removed during the edge detection procedures, increasing the detecting accuracy remarkably. Simulation results shows that the proposed lane recognition algorithm achieves an accuracy of more than 90% and a computing speed of 92 frame/sec, which are superior to the results from the previous algorithms.
박영주(Youngjoo Park) 한국기독교교육정보학회 2013 기독교교육정보 Vol.37 No.-
현재 우리나라에서의 교육과정은 기존 국가나 사회로부터 주어진 문서로서의 의미보다는 학교나 교사 수준에서 합의되고 구성된 경험이라는 의미로 관점의 변화가 이루어지고 있다. 이러한 변화 추세에 부응하여 주어진 교육과정을 학교와 자신의 교실 상황에 맞추어 재해석하고 수업 행위 속에서 구체적으로 실현하는 교육과정 전문가로 성장하기 위한 교사들의 노력과 그들의 역량강화가 그 어느 때보다 요구되고 있다. 기독 교사들에게는 공식 교육과정인 국가 수준 교육과정의 효율적 실행 및 기독교 교육의 목표 달성이라는 개인적 소명으로 인한 이중의 선한 부담이 주어져 있다. 따라서 기독 교사들은 공교육 현장이 요구하는 기준과 조건 만족에 안주하는 것이 아니라, 자신의 기독교 신앙적 가치를 반영하는 자기 주도적 교육과정 재구성 작업을 통해 교사로서의 전문성 신장을 도모해야 하며, 이를 통해 학생들에게 질적인 학습 및 삶을 전수해주어야 한다. 본 연구는 기독 교사들의 신앙과 세계관을 바탕으로 한 수준 높은 교육과정 재구성 작업을 촉진하기 위하여 1990년대 말 미국에서 Wiggins 와 McTighe에 의해 개발된 이해 중심 교육과정 설계 모형(UBD)을 몇 가지 실천 사례 분석과 함께 기독교 교육적 관점에서 검토하고, 그 활용 방안을 모색하였다. UBD는 개별 교사들이 자신의 기독교 신앙과 철학을 바탕으로 교과의 핵심 가치들을 분석하고 이를 단원 수준의 재구성 작업에 일관성 있게 반영할 수 있는 대안으로 기대된다. Currently, curriculum perspective is changing from a given document from a government or society, to a meaningful agreement at the level of schools and teachers regarding educational experiences. In response to these trends, professional competencies of school teachers are strongly required in order to interpret official curriculum and reorganize teaching practices according to their classroom or school situation. This study investigates the possibility of using Understanding By Design (UBD) model in order to facilitate reconstruction work of the unit level curriculum in the way to reflect a teacher"s Christian belief and philosophy. Case studies and deep review from Christian perspective on UBD are presented in the hope of supporting Christian teachers" professional development.