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흰쥐 척수 손상후 Parvalbumin과 Calbindin D-28K 함유신경세포에 관한 면역세포화학적 연구
김종중,정윤영,임유택,박상수,박영란,김현곤,문정석 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.2
Background and Objectives: This study was done to compared the distribution of the two calcium-binding proteins immunoreactive neurons, parvalbumin immunoreactiv (PV-IR) and calbindin D-28K immunoreactive (CB-IR) neurons in the spinal cord after transection. Materials and Methods: Twenty rats were divided into 3 groups (control, complete spinal cord injury (SCI), and right and left spinal cord hemisection). SCI was produced by cutting the spinal cord use blades 11 with scalpel handles. Results: In this experiment, CB-IR neurons were mainly found in many pyramidal cells distributed in the brain stem and spinal cord of rats. PV-IR Neurons were demonstrated in all lamina of the gray matter of the spinal cord. These immunoreactive cells had the highest density in the layer I and II of dorsal horn and several nuclei of the ventral horn of the all the segments of the spinal cord. CB-IR neuropil labeling was strongly noted in all the segments of the spinal cord. In contrast PV-IR neurons were different in distribution, size and morphology in the spinal cord. The number of PV-IR neurons were greater than in the spinal cord compared with the CB-IR neurons. CB-IR and PV-IR somata were round, oval, spindle and polygonal in shape, and were unipolar, bipolar, multipolar and horizontal in types. The diameters of the somata of the PV-IR and CB-IR neurons were 40-50 ㎛, respectively. Also dendrites of PV-IR and CB-IR neurons were densely arrayed in network.
Seo, You‐,Kyong,Yoon, Ji Woong,Lee, Ji Sun,Hwang, Young Kyu,Jun, Chul‐,Ho,Chang, Jong‐,San,Wuttke, Stefan,Bazin, Philippe,Vimont, Alexandre,Daturi, Marco,Bourrelly, Sandrine,Llewelly WILEY‐VCH Verlag 2012 Advanced Materials Vol.24 No.6
<P>The energy‐efficient dehumidification over hier‐archically porous metal‐organic frameworks (MOFs) with hydrothermal stability is reported on page 806 by Jong‐San Chang and co‐workers. Their promising water sorption properties lead to a new type of advanced water adsorbents for the effective utilization of low‐grade thermal energy as well as solar energy. These MOFs would be potential alternatives to commercial water adsorbents, which are used for industrial or indoor desiccant applications such as desiccant dehumidifiers/humidifiers, gas dryers, adsorptive air‐conditioning systems, fresh water production, and adsorption heat transformation. </P>
( Hyeok Jun Yoon1 ),( Young Hyun You ),( Ye Eun Kim ),( Young Ja Kim ),( Won Sik Kong ),( Jong Guk Kim ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.8
The ectomycorrhizal fungus Tricholoma matsutake grows symbiotically with Pinus densiflora. Phenylalanine ammonia-lyase (E.C. 4.3.1.24) catalyzes the conversion of L-phenylalanine to trans-cinnamic acid. The role of fungal phenylalanine ammonia-lyase, however, has not been clear until now. In this study, the gene encoding phenylalanine ammonia-lyase (PAL), which was isolated from T. matsutake, was cloned and characterized. The PAL gene (tmpal) consists of 2,160 nucleotides, coding for a polypeptide containing 719 amino acid residues. The deduced amino acid sequence of tmpal from T. matsutake shows high identity (70%) with that from Laccaria bicolor. Comparative analysis of the PAL genes among T. matsutake and other species of the class Agaricomycetes showed that both active sites and binding sites were significantly conserved among these genes. The transcriptional analysis of the PAL gene revealed a differential gene expression pattern depending on the developmental stages (mycelium, primordium, stipe, pileus, and gills) of T. matsutake. These results suggest that the PAL gene in T. matsutake plays an important role in multiple physiological functions.
염철민,최유식,변석종,조순행,윤제용 대한상하수도학회 2002 상하수도학회지 Vol.16 No.2
This study was conducted to investigate the haloacetic acid (HAAs) formation characteristics in raw and treated water in Korea. The raw and treated water from the five major rivers were examined to measure the HAAs concentrations and compared those with literature values. Major findings are as follows. First, average HAAs concentration of treated water (collected from three water treatment plants) in Korea appeared to be 62.5±66.7㎍/L (n=7) and this level is higher than the average trihalomethanes (THMs) concentration (13.2±12.9㎍/L, n=6933) reported recently. Second, the average formation potential of TCAA and DCAA after three days was found as 103±74㎍/L (n=14) and 76±36㎍/L (n=14), respectively. As this result was applied to US-EPA developed model equation for TCAA and DCAA formation, dissolved organic matter (DOM) in Korea has a tendency to produce more TCAA and DCAA as compared to US. This phenomenon was especially notable in DCAA. The sum of weight percentage of TCAA and DCAA which are individual component of HAAS was composed of 80% of HAAs.
개 시상하부의 Neuropeptides에 대한 면역조직화학적 연구
장인엽,정윤영,김종중,문정석,김준수,모근석,임용,유호진 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.1
The distribution and localization of somatostatin(SOM), neuropeptide Y(NPY), vasopressin(VP), and oxytocin(OT) were studied with a immunohistochemical technique in the canine hypothalamus. The SOM-immunoreactive perikarya were concentrated in the anterior periventricular and the arcuate nuclei. Immunoreactive terminals were observed in the arcuate, the ventromedial hypothalamic, the suprachismatic nuclei and the external layer of the median emmence. A great number of NPY-immunoreactive cell bodies were found in the arcuate nucleus and NPY fibers were located throughout the hypothalamus with the highest concentration especially in the paraventricular (PVN) and the acuate nuclei. Moderately or densely stained fibers were also observed in the median eminence, the suprachiasmatic. the periventricular, the ventromedial hypothalamic, the dorsomedial hypothalamic and the medial preoptic nuclei, and the stria terminalis. Both VP-and OT-containing perikarya were found mainly in the PVN and supraoptic nucleus(SON). but a few were seen in the perifornical area, the lateral hypothalamus, the dorsal hypothalamic and the periventricular nucleus. The fibers originated from the PVN were projected to the SON via ventral or dorsal area of the fornix.
( Jong Yoon Chung ),( You Jin Lee ),( Jae Hyung Lee ),( Mi Young Jung ),( Ji Ho Park ),( Jong Hee Lee ),( Dong Youn Lee ),( Joo Heung Lee ),( Jun Mo Yang ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Infantile hemangioma (IH) is benign vascular tumor found in approximately 5-10 % of all newborns and infants. Most do not need treatment due to their spontaneous regression, some may need intervention due to disfigurement and serious complication. Recently oral propranolol has been proposed as a novel treatment option for IH, but there were few controlled studies and studies that compared with "wait and see". Objectives: We conducted a retrospective observational study to compare the efficacy of oral propranolol with “wait and see” in the treatment of IH. Methods: A retrospective chart review was performed on 22 children who visited Samsung medical center from 2008 to 2013. 11 children with IH who were only treated with oral propranolol (2mg/kg/day) was evaluated and 11 children with IH who came to the clinic for regular check-up more than 6 months without any treatment were evaluated. Changes in the size, texture, and color of the tumor were evaluated on 4 weeks, 12 weeks and 24 weeks after initial visit. The treatment response was evaluated using a 3-point scale system: good, partial, and no response. Results: Of the 11 children who received oral propranolol, 10 (91%) demonstrated good response, 1 (9%) showed a partial response. And of the 11 children left untreated, 2 (18%) showed good response, 6 (55%) showed partial response, and 3 (25%) showed no response. Conclusion: Propranolol showed significantly better clinical outcome than “wait and see” in short term follow up.
P225 : Clinicohistopathological study of pigmented contact dermatitis
( You Jin Lee ),( Jong Yoon Jung ),( Jae Hyoung Lee ),( Mi Young Jung ),( Ji Ho Park ),( Jong Hee Lee ),( Dong Yoon Lee ),( Joo Heung Lee ),( Jun Mo Yang ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Pigmented contact dermatitis (PCD) is a non-eczematous variant of contact dermatitis, characterized clinically by reticular hyperpigmentation over face and neck, especially on lateral surfaces. If it occurs only on face, confusion with melasma or other aging pigmentary issues might happen and patients sometimes get through laser treatments for this pigmentation with a result of unsatisfaction. At a glance, clinical manifestation of PCD looks like all about cosmetic issues. However, the exact diagnosis and clearing out possible causative agents should be made before laser treatment in order to achieve successful treatment outcome Objectives: To evaluate clinical and histopathological characteristics of PCD patients Methods: Case series study with retrospective chart review was done. Each biopsy specimen(Lesion) was evaluated comparing to non-lesional specimen(normal control) Results: Mean age was 52.3yr, average onset was 19.7months. Patients reported possible causative agents as hair dyes (55%,11/20) and cosmetics (25%,5/20). 15 patients tested patch test (TRUE test)-75%(11/15) positive for fragrance mix, nickel sulphate etc. Under histopathologic review, prominent hydrophic change observed 30%(4/12) of patient Conclusion: To the best of our knowledge, this is the largest study on the clinicohistopathological features of PCD in Korea. We hope this result will be the clue for diagnosis and treatment of PCD in Korea.
Effects of Herbal Extracts on Hair Growth Promotion in Experimental Animal Model
Jong-Soo Kim, Bong Su Kang, Ja Seon Yoon, Dang-Young Kim, Jae-Hwang Jeong, Eun-young Kim, Sang Yoon Nam, Young Won Yun, Beom Jun Lee 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.2
The current study was conducted in order to investigate promotional effects of herbal extracts on hair growth in an animal model of mice. There were four experimental groups, including distilled water (DW) as a negative control (NC), 3% minoxidil (MXD) as a positive control (PC), 50% ethanol (EtOH) as a vehicle control (VC), and herbal extract (HE) as the experimental treatment (E). The HE was extracted with ethanol from plants, including Gardenia, Mentha arvensis, Rosemary, and Lavender. Six-week-old C57BL/6 male mice were shaved with an electric clipper and the test materials were topically treated with 0.2 ml per mouse daily for three weeks. Photographic evaluation of hair re-growth was performed weekly during a period of three weeks. The number of mast cells was counted on the dorsal skin section of mice. The enzymes, alkaline phosphatase (ALP) and γ-glutamyl transpeptidase (γ-GT), were determined using a biochemical autoanalyzer. No clinical signs were observed in any of the experimental groups. As a result of photometric analysis, topical application of HE to dorsal skin for two weeks resulted in significantly faster acceleration of hair regrowth, compared with that of the NC or VC group (P<0.05). The PC and E groups showed a significant decrease in mast cell population, compared to the NC group. Activities of ALP and γ-GT were significantly increased in the PC and E groups, compared to the NC or VC group (P<0.05). Taken together, these results suggest that the herbal extract may have hair-growth promoting activity equal to that of MXD.