Tool Wear Performance in Face Milling Inconel 182 using Minimum Quantity Lubrication with Different Nozzle Positions

Cheng-Dong Wang,Ming Chen,Qin-Long An,Min Wang,Yi-Hong Zhu 한국정밀공학회 2014 International Journal of Precision Engineering and Vol. No.

Minimum quantity lubrication (MQL) is one of the promising Green Manufacturing Technology to meet the challenge of machining difficult-to-cut material Inconel 182 which is deposited by Shield Metal Arc Welding (SMAW). Unlike the flood lubrication, in MQL, only a small amount of non-toxic biodegradable oil are directly sprayed to the cutting zone by compressed air, which can reduce friction coefficient and temperature. Wear performance of uncoated tool inserts and Physical Vapor Deposition (PVD) coated tool inserts are evaluated by comparison during up and down face milling Inconel 182 with different MQL nozzle positions. Results indicate that uncoated tool inserts are not suitable for face milling Inconel 182 in all lubrication conditions due to the severe flank wear and the catastrophic breakage. On the contrary, PVD coated tool inserts have longer tool life compared to uncoated ones in all lubrication conditions. MQL nozzle positioned at tool cut into workpiece and positioned at tool cut out of workpiece in down milling as well as MQL nozzle positioned at tool cut out of workpiece in up milling can effectively prolong tool life of PVD coated tool inserts, which can be selected as the optimal lubrication solution for face milling Inconel 182.

GPH1 is involved in glycerol accumulation in the three-dimensional networks of the nematode-trapping fungus Arthrobotrys oligospora

Qin-Yi Wu,Yue-Yan Zhu,Cheng-Gang Zou,Ying-Qian Kang,Lian-Ming Liang 한국미생물학회 2016 The journal of microbiology Vol.54 No.11

Turgor is very important for the invasive growth of fungal pathogens. Glycerol, a highly osmotic solvent, is considered to play an important role in turgor generation. The nematophagous fungus Arthrobotrys oligospora mainly lives as a saprophyte. In the presence of nematodes, A. oligospora enters the parasitic stage by forming three-dimensional networks (traps) to capture nematodes. In A. oligospora, we found that glycerol accumulated during nematode-induced trap formation. We demonstrated that deleting gph1, which encodes glycogen phosphorylase, decreased the glycerol content, compared with that of a wild-type strain. Although the number of traps induced by nematodes was not affected in the Δgph1 mutant, the capture rate was lower. Meanwhile, deleting gph1 also affected the growth rate and conidiation capacity of the fungus. These results indicate that glycerol derived from GPH1 is essential for the full virulence of A. oligospora against nematodes.

The 765G>C Polymorphism in the Cyclooxygenase-2 Gene and Gastric Cancer Risk: an Update by Meta-analysis

Zhao, Fen,Zhu, Hong,Huang, Min,Yi, Cheng,Huang, Ying Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6

Background: The 765G>C polymorphism in cyclooxygenase-2 (COX-2) gene has been extensively investigated for association with gastric cancer (GC). However, the results of different studies have been inconsistent. The aim of this study is to comprehensively evaluate the genetic risk of -765G>C polymorphism in the COX-2 gene for GC. Materials and Methods: We searched Pubmed, Embase, Medline, CNKI database, Wanfang database, Weipu database, and Chinese Biomedical database, covering all publications (last search been performed on Jan 10, 2014). Statistical analyses were performed using Revman 5.2 and STATA 10.0 software. Results: A total of 1,874 cases and 3,005 controls in 10 case-control studies were included in this meta-analysis. The results indicated that the variant C allele carriers (GC+CC) had a 69% increased risk of GC when compared with the homozygote GG (odds ratio (OR)=1.69, 95% confidence interval (CI), 1.10-2.61 for GC+CC vs GG). In the subgroup analysis by ethnicity, significant elevated risks were associated with C allele carriers in Asians (OR=1.75, 95%CI=1.40-2.18, and p<0.00001) and in Indians (OR=8.38, 95%CI=4.34-16.16, and p<0.00001) but not in Caucasians (OR=1.07, 95%CI=0.81-1.42, and p=0.62) or in Dutch (OR=0.53, 95%CI= 0.33-0.87, and p= 0.01).In the subgroup analysis by Helicobacter pylori (H. pylori) status, a significantly increased risk was identified among H. pylori (+) (OR=3.58, 95%CI=2.33-3.50, and p<0.00001) and H. pylori (-) (OR=2.32, 95%CI=1.46-3.69, and p=0.0004). Conclusions: This meta-analysis suggested that the -765G>C polymorphism in the COX-2 gene could be a risk factor for GC in Asians and Indians.

Influence of Water Molecules on Polarization Behavior and Time–Frequency Dielectric Properties of Cellulose Insulation

Wen Hao,Cheng Lin,Jiang Yi,Zhu Taiyun,Chen Zhong,Dai Xize,Gao Chenyu 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.3

Oil-immersed power transformer plays an important role in power transmission and transformation engineering. Moisture is one of the important factors to determine its insulation performance. Molecular simulation technique is used to study the mechanism of water molecules on the micro polarization behavior of cellulose insulation materials. The number of hydrogen bonds, solubility parameters, total dipole moment and polarizability are analyzed. These characteristics explain the action mechanism of water molecules on cellulose insulation. At the same time, the time domain and frequency dielectric response of cellulose insulation materials with diff erent moisture content are explored. The dielectric modulus spectrum is introduced to replace the traditional frequency dielectric spectroscopy to characterize the micro relaxation process of cellulose insulation under diff erent moisture content. Finally, the characteristic parameters are extracted from the polarization, depolarization current and dielectric modulus spectrum curves to evaluate the moisture content of cellulose insulation materials. The results show that the number of hydrogen bonds, binding energy density, solubility parameter, total dipole moment and polarizability increase with the increase of water content. It should be noted that dielectric modulus spectroscopy can eff ectively characterize the relaxation behavior of cellulose insulation materials. The moisture content of cellulose insulation can be quantitatively evaluated by DC conductivity, insulation resistance, imaginary part relaxation peak of dielectric modulus and integral value of real part and imaginary part of dielectric modulus.

Chinese herbal injections for coronavirus disease 2019 (COVID-19): A narrative review

Xiao-Bin Zhu,Meng Guo,Zhi-Hui Zhang,Li-Hua Sun,Lei Liu,Li-Juan Zhou,Chun-Lei Shan,Yi Yang,Lian-Di Kan,Liu-Cheng Li 한국한의학연구원 2021 Integrative Medicine Research Vol.10 No.4

Background The outbreak of Coronavirus disease 2019 (COVID-19) has caused more than 180 million infections and 3.9 million deaths. To date, emerging clinical evidence has shown the synergetic benefits of Chinese herbal injections in treating this contagious respiratory disease. This review aims to summarize and analyze the efficacy and safety of Chinese herbal injections in the therapy of COVID-19. Methods The literature from 3 electronic databases, PubMed, CNKI, and Web of Science, were searched using the search terms “COVID-19”, “SARS-CoV-2”, “traditional Chinese medicine”, “herb”, “herbal”, and “injection”. Then the identified articles were comprehensively evaluated. Results Limited data demonstrated that Chinese herbal injections could significantly improve the clinical outcomes of COVID-19 patients, especially in combination with conventional treatment strategies. The benefits of which were mainly associated with the relief of symptoms, prevention of secondary infection, regulation of inflammation and immune function. There was also evidence showing the inhibitory effects on SARS-CoV-2 replication in vitro. Nevertheless, available real-world data suggested the increased risk of adverse event. Furthermore, the defects of existing researches and the insights for discovering novel antiviral drugs were prospectively discussed. Conclusion Evidence-based advances revealed that Chinese herbal injections such as XueBiJing injection and ShenMai injection, exerted potent effects against COVID-19. Further laboratory researches and clinical evaluation are needed to gather scientific evidence on the efficacy and safety.

Loss of Primary Cilia Results in the Development of Cancer in the Murine Thyroid Gland

Lee, Junguee,Yi, Shinae,Chang, Joon Young,Kim, Jung Tae,Sul, Hae Joung,Park, Ki Cheol,Zhu, Xuguang,Cheng, Sheue-yann,Kero, Jukka,Kim, Joon,Shong, Minho Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.2

Communications at the interface between the apical membrane of follicular cells and the follicular lumen are critical for the homeostasis of thyroid gland. Primary cilia at the apical membrane of thyroid follicular cells may sense follicular luminal environment and regulate follicular homeostasis, although their role in vivo remains to be determined. Here, mice devoid of primary cilia were generated by thyroid follicular epithelial cell-specific deletion of the gene encoding intraflagellar transport protein 88 (Ift88). Thyroid follicular cellspecific Ift88-deficient mice showed normal folliculogenesis and hormonogenesis; however, those older than 7 weeks showed irregularly dilated and destroyed follicles in the thyroid gland. With increasing age, follicular cells with malignant properties showing the characteristic nuclear features of human thyroid carcinomas formed papillary and solid proliferative nodules from degenerated thyroid follicles. Furthermore, malignant tumor cells manifested as tumor emboli in thyroid vessels. These findings suggest that loss-of-function of Ift88/primary cilia results in malignant transformation from degenerated thyroid follicles.

A monophosphonic group-functionalized ion-imprinted polymer for a removal of Fe3+ from highly concentrated basic chromium sulfate solution

Guang-jin Zhu,Hai-yan Tang,Peng-hui Qing,Hong-ling Zhang,Xi-chuan Cheng,Zai-hua Cai,Hong-bin Xu,Yi Zhang 한국화학공학회 2020 Korean Journal of Chemical Engineering Vol.37 No.5

An ion-imprinted polymer (IIP) with monophosphonic groups was prepared by thermal copolymerization. Bis(2-methacryloxyethyl) phosphate (BMAOP) was used as functional monomer to react with Fe3+ in dimethyl sulfoxide (DMSO). Ethylene glycol dimethacrylate (EGDMA) was used as cross-linker during polymerization process. A suitable molar ratio of BMAOP to Fe3+ was investigated by UV/Vis/NIR Spectrometer and ICP-OES. The obtained results showed that the monophosphonic groups could be selectively combined with Fe3+ in solutions containing other coexisting ions, and the selectivity could be further enhanced by ion-imprinted process. The prepared IIP was used for removing trace Fe3+ from high concentration basic chromium sulfate solutions. After adsorption process, the concentration of Fe3+ could be reduced from 4.486mg L1 to 0.171mg L1, which was much lower than the concentration in the solution treated by non-imprinted polymer (NIP). Moreover, the IIP exhibited excellent recyclability after six adsorption-desorption cycles.

Shake-table testing of a 1:5 reduced-scale five-story masonry-infilled reinforced concrete frame structure

Shao-Ge Cheng,Yi-Xiu Zhu,Kui Sun,Wei-Ping Zhang 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.79 No.3

This paper presents a shaking table test carried out on a 1:5 reduced-scale five-story masonry-infilled reinforced concrete (RC) frame model. Multi-level simulated earthquake motions with increasing shaking severity were used as input to deform the model structure from an elastic to a near-collapse state. The dynamic characteristics, acceleration response, displacement response, damage state, energy dissipation behavior and stiffness degradation of each story were summarized for each stage. The tests indicate that cracks developed at the masonry-frame interface during minor shaking that caused infill to separate from the frame; however, its in-plane load bearing capacity was maintained. Moreover, the infill was able to resist infrequent earthquakes without causing instability or collapse of the structure. Thus, it is rational to consider masonry infill as a structural element in the seismic design of structures. Moreover, the story drift ratio of 1/400 can be regarded as the performance criterion for controlling frame structure cracking, and the story drift ratio of 1/100 can be regarded as the performance criterion for the peak bearing capacity of a frame structure. The test results could provide a reference not only for the seismic appraisal of existing buildings, but also for the seismic design of new buildings.

The -765G>C Polymorphism in the Cyclooxygenase-2 Gene and Digestive System Cancer: a Meta-analysis

Zhao, Fen,Cao, Yue,Zhu, Hong,Huang, Min,Yi, Cheng,Huang, Ying Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

Background: Published data regarding associations between the -765G>C polymorphism in cyclooxygenase-2 (COX-2) gene and digestive system cancer risk have been inconclusive. The aim of this study was to comprehensively evaluate the genetic risk of the -765G>C polymorphism in the COX-2 gene for digestive system cancer. Materials and Methods: A search was performed in Pubmed, Medline (Ovid), Embase, CNKI, Weipu, Wanfang and CBM databases, covering all studies until Feb 10, 2014. Statistical analysis was performed using Revman5.2. Results: A total of 10,814 cases and 16,174 controls in 38 case-control studies were included in this meta-analysis. The results indicated that C allele carriers (GC+CC) had a 20% increased risk of digestive system cancer when compared with the homozygote GG (odds ratio (OR)=1.20, 95% confidence interval (CI), 1.00-1.44 for GC+CC vs GG). In the subgroup analysis by ethnicity, significant elevated risks were associated with C allele carriers (GC+CC) in Asians (OR = 1.46, 95% CI=1.07-2.01, and p=0.02) and Africans (OR=2.12, 95% CI=1.57-2.87, and p< 0.00001), but not among Caucasians, Americans and mixed groups. For subgroup analysis by cancer type (GC+CC vs GG), significant associations were found between the -765G>C polymorphism and higher risk for gastric cancer (OR=1.64, 95% CI=1.03-2.61, and p=0.04), but not for colorectal cancer, oral cancer, esophageal cancer, and others. Regarding study design (GC+CC vs GG), no significant associations were found in then population-based case-control (PCC), hospital-based case-control (HCC) and family-based case-control (FCC) studies. Conclusions: This meta-analysis suggested that the -765G>C polymorphism of the COX-2 gene is a potential risk factor for digestive system cancer in Asians and Africans and gastric cancer overall.

Full-scale testing and modeling of the mechanical behavior of shield TBM tunnel joints

Wen-qi Ding,Yi-cheng Peng,Zhi-guo Yan,Bi-wei Shen,He-hua Zhu,Xin-xin Wei 국제구조공학회 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.45 No.3

For shield TBM (Tunnel Boring Machine) tunnel lining, the segment joint is the most critical component for determining the mechanical response of the complete lining ring. To investigate the mechanical behavior of the segment joint in a water conveyance tunnel, which is different from the vehicle tunnel because of the external loads and the high internal water pressure during the tunnel’s service life, full-scale joint tests were conducted. The main advantage of the joint tests over previous ones was the definiteness of the loads applied to the joints using a unique testing facility and the acquisition of the mechanical behavior of actual joints. Furthermore, based on the test results and the theoretical analysis, a mechanical model of segment joints has been proposed, which consists of all important influencing factors,including the elastic-plastic behavior of concrete, the pre-tightening force of the bolts and the deformations of all joint components, i.e., concrete blocks, bolts and cast iron panels. Finally, the proposed mechanical model of segment joints has been verified by the aforementioned full-scale joint tests.