Effects of Rad51 on Survival of A549 Cells

Yu, Sha-Sha,Tu, Yi,Xu, Lin-Lin,Tao, Xue-Qin,Xu, Shan,Wang, Shan-Shan,Xiong, Yi-Feng,Mei, Jin-Hong Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.1

Rad51, a key factor in the homologous recombination pathway for the DNA double-strand break repair, plays a vital role in genesis of non-small-cell lung cancer (NSCLC). In recent years, more and more studies indicate that high expression of Rad51 is of great relevance to resistance of NSCLC to chemotherapeutic agents and ionizing radiation. However, the underlying molecular mechanisms are poorly understood. In this study, we investigated the role of single Rad51 on cell viability in vitro. Our results show that depletion of endogenous Rad51 is sufficient to inhibit the growth of the A549 lung cancer cell line, by accumulating cells in G1 phase and inducing cell death. We conclude that independent Rad51 expression is critical to the survival of A549 cells and can be an independent prognostic factor in NSCLC patients.

Enhanced Hydrogen Evolution Properties Obtained by Ultrasonic-Cyclic Voltammetry Modification of C-Supported PtCu Thin Film Catalyst

Sha Yi,Bin Yang,Zhan- Sheng Zhang 대한금속·재료학회 2017 METALS AND MATERIALS International Vol.23 No.3

Carbon-supported Pt-Cu (Pt-Cu/C) bimetallic catalyst was synthesized by Ion Beam Sputtering technologyand subsequently annealed in vacuum and electrochemically etched by Ultrasonic-Cyclic Voltammetry (US-CV). Electrochemical measurements indicate that the sample was modified electrochemically by US-CV shows highercatalytic activity towards hydrogen evolution reaction than pure Pt/C. Scanning and transmission electron microscopyand electronic differential system analysis reveal that the surface of post-processed catalyst producedPtCu@Pt core-shell structure which increasing the efficiency of Pt. Transmission electron microscope analysisdisplays that on the surface of PtCu@Pt core-shell particles detects lattice compressive strain, the lattice compressionvariable is around 1.12%. X-ray photoelectron spectroscopy analysis confirms that the Pt4f7/2 binding energyof the post-processed PtCu/C is 71.10 eV, decreased by 0.2 eV compared to pure Pt/C (71.3 eV). It can be inferredthat the enhancement of catalytic property attribute to the Cu atoms modified the geometric structure and electronicstructure of the Pt atoms.

Pepsin and Laryngeal and Hypopharyngeal Carcinomas

Cheng-Yi Yin,Sha-Sha Zhang,Jiang-Tao Zhong,Shui-Hong Zhou 대한이비인후과학회 2021 Clinical and Experimental Otorhinolaryngology Vol.14 No.2

Laryngeal and hypopharyngeal carcinomas are common malignant tumors of the head and neck, and the incidence of both is increasing. Laryngopharyngeal reflux refers to the retrograde flow of gastric contents into the larynx, oropharynx, and/or nasopharynx. It remains controversial whether laryngopharyngeal reflux is a risk factor for laryngeal and hypopharyngeal cancers. The refluxing substances mainly include hydrochloric acid, pepsin, and occasionally bile acids and bile salts, as well as bacteria that colonize the gastrointestinal tract. Loss of epithelium in the mucous membrane of the larynx and hypopharynx is thought to be caused by pepsin. Here, we review the relationships between laryngopharyngeal reflux and both laryngeal and hypopharyngeal carcinomas, as well as the significance of pepsin, methods of clinical detection, and the mechanism of carcinogenesis.

An Access Control Model for Mobile Networks based on the Non-zero-sum Game Theory

Yi-xuan Zhang,Jing-sha He,Ruo-hong Liu 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.4

Access control is the basic of information security. It is always used to protect sensitive information and critical resources from malicious attacks. But the traditional access control models are more adapt to closed network environment. And there are more and more unknown threats and attacks in the open networks, especially the mobile networks. To solve this problem, we propose a new access control model which is applicable to the open mobile networks by using non-zero-sum game theory in this paper. The model is composed by six modules: access evaluation module, access permission determination module, non-zero-sum game theory analysis module, decision-making module, result evaluation module, access feedback module and a prior information database. And in this model, the subjects will choose to be more honest when they make access requests because they all want to get more permission next time. Then we do some experiments to prove this fact.

The compression-shear properties of small-size seismic isolation rubber bearings for bridges

Wu, Yi-feng,Wang, Hao,Sha, Ben,Zhang, Rui-jun,Li, Ai-qun Techno-Press 2018 Structural monitoring and maintenance Vol.5 No.1

Taking three types of bridge bearings with diameter being 100 mm as examples, the theoretical analysis, the experimental research as well as the numerical simulation of these bearings is conducted. Since the normal compression and shear machines cannot be applied to the small-size bearings, an improved equipment to test the properties of these bearings is proposed and fabricated. Besides, the simulation of the bearings is conducted based on the explicit finite element software ANSYS/LS-DYNA, and some parameters of the bearings are modified in the finite element model to reduce the computation cost effectively. Results show that all the research methods are capable of revealing the fundamental properties of the small-size bearings, and a combined use of these methods can better catch both the integral properties and the inner detailed mechanical behaviors of the bearings.

Mucin2 is Required for Probiotic Agents-Mediated Blocking Effects on Meningitic E. coli-Induced Pathogenicities

Jing Yi Yu,Xiao Long He,Santhosh Puthiyakunnon,Liang Peng,Yan Li,Li Sha Wu,Wen Ling Peng,Ya Zhang,Jie Gao,Yao Yuan Zhang,Swapna Boddu,Min Long,Hong Cao,Sheng He Huang 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.10

Study on the response surface optimization of online upgrading of bio-oil with MCM-41 and catalyst durability analysis

Liu Sha,Cai Yi-xi,Fan Yong-sheng,Li Xiao-hua,Wang Jia-jun 대한환경공학회 2017 Environmental Engineering Research Vol.22 No.1

Direct catalysis of vapors from vacuum pyrolysis of biomass was performed on MCM-41 to investigate the effects of operating parameters including catalyzing temperature, catalyzing bed height and system pressure on the organic yields. Optimization of organic phase yield was further conducted by employing response surface methodology. The statistical analysis showed that operating parameters have significant effects on the organic phase yield. The organic phase yield first increases and then decreases as catalyzing temperature and catalyzing bed height increase, and decreases as system pressure increases. The optimal conditions for the maximum organic phase yield were obtained at catalyzing temperature of 502.7℃, catalyzing bed height of 2.74 cm and system pressure of 6.83 kPa, the organic phase yield amounts to 15.84% which is quite close to the predicted value 16.19%. The H/C, O/C molar ratios (dry basis), density, pH value, kinematic viscosity and high heat value of the organic phase obtained at optimal conditions were 1.287, 0.174, 0.98 g/cm3, 5.12, 5.87 mm2/s and 33.08 MJ/kg, respectively. Organic product compositions were examined using gas chromatography/mass spectrometry and the analysis showed that the content of oxygenated aromatics in organic phase had decreased and hydrocarbons had increased, and the hydrocarbons in organic phase were mainly aliphatic hydrocarbons. Besides, thermo-gravimetric analysis of the MCM-41 zeolite was conducted within air atmosphere and the results showed that when the catalyst continuously works over 100 min, the index of physicochemical properties of bio-oil decreases gradually from 1.15 to 0.45, suggesting that the refined bio-oil significantly deteriorates. Meanwhile, the coke deposition of catalyst increases from 4.97% to 14.81%, which suggests that the catalytic activity significantly decreases till the catalyst completely looses its activity.

An Approach for HVCB Mechanical Fault Diagnosis Based on a Deep Belief Network and a Transfer Learning Strategy

Jianyong Zheng,Yi Pan,Fei Mei,Huiyu Miao,Kedong Zhu,Haoyuan Sha 대한전기학회 2019 Journal of Electrical Engineering & Technology Vol.14 No.1

Traditional fault diagnosis for a high-voltage circuit breaker (HVCB) encounters the following problems: the fault features extracted by traditional shallow models is of weak expression ability, and the accuracy of fault identification can be affected by the lack of labeled training samples. To overcome these problems, we present a new approach for HVCB mechanical fault diagnosis based on a deep belief network (DBN) and a transfer learning strategy. This approach uses a DBN to achieve the deep mining and adaptive extraction of the inherent features of sample data, and combines the transfer learning method to improve the accuracy of the fault diagnosis model, which uses a large amount of selective auxiliary data to augment the tiny amount of target data learning by adjusting the weight of training samples. The target sample data are obtained by collecting the coil current signal of the HVCB from fault simulation experiments, and the auxiliary sample data are obtained through simulation based on the electromagnetic system mathematical model of the HVCB spring mechanism. The experimental results show that compared with the traditional feature extraction and fault diagnosis method, the DBN approach combined with transfer learning can achieve stronger feature learning and generalization ability

Pollen record of the mid- to late-Holocene centennial climate change on the East coast of South Korea and its influential factors

Song, Bing,Yi, Sangheon,Jia, Hongjuan,Nahm, Wook-Hyun,Kim, Jin-Cheul,Lim, Jaesoo,Lee, Jin-Young,Sha, Longbin,Mao, Limi,Yang, Zhongyong,Nakanishi, Toshimichi,Hong, Wan,Li, Zhen Elsevier 2018 Journal of Asian earth sciences Vol.151 No.-

<P><B>Abstract</B></P> <P>To understand historical climate change in western Pacific coastal areas, a sediment core (SOJ-2) from the stable sedimentary environment of the Songjiho Lagoon on the east coast of South Korea was obtained for centennial-resolution palynological analysis. The ages of the SOJ-2 core is well controlled by carbon 14 dating with high-resolution accelerator mass spectrometry (AMS), and the results indicated a general warm to cold climate trend from the mid-Holocene to the present, which can be divided into two different stages: a warmer stage between 6842 and 1297 cal yr BP and a colder stage from 1297 cal yr BP to the present, with fluctuations during these stages. The climate was wetter from 6842 to 6227 cal yr BP and 4520 to 1297 cal yr BP and was drier from 6227 to 4520 cal yr BP. The climate changed to cold and dry during the period from 1297–425 cal yr BP. The impact of human activity on the climate began at approximately 1297 cal yr BP and became pronounced starting in 425 cal yr BP. The general cooling trend may represent a response to decreasing solar insolation; however, the relative dryness or wetness of the climate may have been co-determined by westerlies and the East Asian summer monsoon (EASM). The climate had a teleconnection with the North Atlantic region, resulting from changes in solar activity. Nevertheless, EI Niño–Southern Oscillation (ENSO) activity played an important role in impacting the EASM changes in western Pacific coastal areas.</P> <P><B>Highlights</B></P> <P> <UL> <LI> There is a centennial resolution climate record from 6842 cal yr BP to present. </LI> <LI> The general cooling trend was probably triggered by decreasing solar insolation. </LI> <LI> The precipitation was co-determined by westerlies and the East Asian Summer Monsoon. </LI> <LI> The ENSO activity may be an important factor for East Asian Summer Monsoon change. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Online Hop Timing Detection and Frequency Estimation of Multiple FH Signals

Zhi-Chao Sha,Zhang-Meng Liu,Zhi-Tao Huang,Yi-Yu Zhou 한국전자통신연구원 2013 ETRI Journal Vol.35 No.5

This paper addresses the problem of online hop timing detection and frequency estimation of multiple frequencyhopping (FH) signals with antenna arrays. The problem is deemed as a dynamic one, as no information about the hop timing, pattern, or rate is known in advance, and the hop rate may change during the observation time. The technique of particle filtering is introduced to solve this dynamic problem, and real-time frequency and direction of arrival estimates of the FH signals can be obtained directly, while the hop timing is detected online according to the temporal autoregressive moving average process. The problem of network sorting is also addressed in this paper. Numerical examples are carried out to show the performance of the proposed method.