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Formation mechanism of BAMLET by 2D Raman correlation analysis
Park, Yeonju,Park, Yujeong,Jin, Sila,Kim, Jung Won,Jung, Young Mee Elsevier 2018 Journal of molecular structure Vol.1171 No.-
<P><B>Abstract</B></P> <P>A partially unfolded bovine α-lactalbumin (ALA) and oleic acid (OA) complex called bovine α-lactalbumin made lethal to tumor cells (BAMLET) is a tumoricidal complex. For the first time, this study investigated the pH-induced formation mechanism of the ALA/OA complex using Raman spectroscopy. For a deeper understanding of the formation mechanism of the ALA/OA complex with decreasing pH, principal component analysis (PCA) and two-dimensional correlation spectroscopy (2D-COS) were applied to pH-dependent Raman spectra of the ALA/OA complex. Based on the results of the PCA and 2D-COS analyses, we successfully elucidated the formation mechanism of the ALA/OA complex at the molecular level. We also confirm that the ALA/OA complex formed below pH 3.0.</P> <P><B>Highlights</B></P> <P> <UL> <LI> For the first time, we investigated the pH-induced formation mechanism of the α-lactalbumin/oleic acid (ALA/OA) complex using Raman spectroscopy. </LI> <LI> We successfully elucidated the formation mechanism of the ALA/OA complex at the molecular level. </LI> <LI> Results of the PCA and 2D-COS analyses showed the ALA/OA complex formed below pH 3.0. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Park, Yeonju,Seo, Yongil,Chae, Boknam,Pyo, Dongjin,Chung, Hoeil,Hwang, Hyonseok,Jung, Young Mee WILEY‐VCH Verlag 2015 ChemPhysChem Vol.16 No.2
<P><B>Abstract</B></P><P>In this study, the thermal denaturation mechanism and secondary structures of two types of human insulin nanoparticles produced by a process of solution‐enhanced dispersion by supercritical fluids using dimethyl sulfoxide (DMSO) and ethanol (EtOH) solutions of insulin are investigated using spectroscopic approaches and molecular dynamics calculations. First, the temperature‐dependent IR spectra of spherical and rod‐shaped insulin nanoparticles prepared from DMSO and EtOH solution, respectively, are analyzed using principal component analysis (PCA) and 2D correlation spectroscopy to obtain a deeper understanding of the molecular structures and thermal behavior of the two insulin particle shapes. All‐atom molecular dynamics (AAMD) calculations are performed to investigate the influence of the solvent molecules on the production of the insulin nanoparticles and to elucidate the geometric differences between the two types of nanoparticles. The results of the PCA, the 2D correlation spectroscopic analysis, and the AAMD calculations clearly reveal that the thermal denaturation mechanisms and the degrees of hydrogen bonding in the spherical and rod‐shaped insulin nanoparticles are different. The polarity of the solvent might not alter the structure or function of the insulin produced, but the solvent polarity does influence the synthesis of different shapes of insulin nanoparticles.</P>
Frost avoidance: sodium alginate + CaCl2 can postpone flowering of ‘Kawanakajima Hakuto’ peach trees
Park Yeonju,신현석 한국원예학회 2022 Horticulture, Environment, and Biotechnology Vol.63 No.5
The rise in early spring temperatures due to climate change has been advancing the flowering period of peach trees. This phenomenon increases the possibility of frost damage in early spring and consequently reduces the productivity of peach trees, causing economic losses. Under aberrant spring temperatures, delaying peach flowering could be used to avoid frost damage. Thus, the objective of this study was to investigate whether treatment with sodium alginate and CaCl2 in the 2nd (swollen bud) blooming stage could delay peach flowering as a strategy to avoid frost. Regarding the expression rate at the 3rd (calyx green) stage, the control treatment (CT, distilled water) showed a sharp increase from 8 days after treatment (DAT), peaking at 14 DAT. However, the 5AG group (5% sodium alginate + 100 mM CaCl2) and the 7AG group (7% sodium alginate + 100 mM CaCl2) had the maximum expression rate at 17 DAT. After maximum expression, expression in the CT sharply diminished, whereas the 5AG and 7AG treatments showed gentle decreases. At the 4th (calyx red) stage, the CT, 5AG, and 7AG treatments reached peak expression at 20 DAT (43.5%, 31.9%, and 40.2%, respectively). How- ever, maximum expression levels of all treatments were below ~ 50%. The 5th (first pink) stage was first expressed in all treatments when the expression rate at the 4th stage peaked in all groups at 20 DAT. Maximum expression was 50.7% in the CT, 33.7% in the 5AG treatment, and 49.2% in the 7AG treatment. This tendency was similar to that at the 4th stage. Particularly, expression in the 5AG treatment diminished more slowly than that in the CT and 7AG treatment at the 3rd, 4th, and 5th stages. The CT group bloomed first at 20 DAT, reaching full bloom at 81.4%, ahead of the AG treatments at 28 DAT, while the 7AG and 5AG groups bloomed fully at 34 and 37 DAT, respectively. Our results suggest the 5AG treatment is suitable to delay peach flowering when phenological development of the flower buds reaches the 2nd stage.
QCA 퍼지 셋 이념분석을 통해 본 훈육목적의 학대 행위 판결에 대한 고찰
박연주 ( Yeonju Park ),정수정 ( Sujeong Jeong ) 사단법인 아시아문화학술원 2021 인문사회 21 Vol.12 No.5
본 연구는 아동교육 및 돌봄과 관련이 있는 보육교사ㆍ돌보미들의 아동학대에 대한 판결문을 살펴 각 양형 요소가 판결에 미치는 영향을 분석하였다. 또한 훈육행위가 형량에 어떠한 영향을 주고 있으며, 현 아동학대 행위에 대한 양형기준의 문제점이 무엇인지를 조사하여 정책적 제언을 제시함을 목적으로 하였다. 본 연구는 판결문의 내용에 대한 분석을 위해 QCA(qualitative comparative analysis) 퍼지 셋 이념분석(fuzzy-set ideal analysis)을 활용하여 질적 개념을 양적으로 측정함으로써 좀 더 명확한 해석을 하고자 하였다. 그 결과 가해자 요인이나 공통적 훈육기준에 따라 형량이 결정되고 있지 않음을 살펴볼 수 있었다. 이러한 연구 결과는 아동학대 행위의 처벌기준이 일관되게 적용되지 않음을 나타내는 것으로 특히 훈육행위가 가해자인 행위자의 정당행위의 항변사유가 될 수 있는 근거로 작용 될 수 있으며, 재판에서는 여전히 판사의 재량적 요소가 판결에 지대한 영향을 미치고 있음을 알 수 있게 한다. 이러한 연구 결과를 토대로 본 연구에서는 처벌의 기준이 되는 훈육행위의 지표를 마련하고 훈육과 관련한 사회복지 교육프로그램의 지속적 실시의 필요성을 제언하였다. This study analyzed the impact of each factor in punishment on the ruling by looking at the rulings of child abuse of child care teachers and caregivers related to child education and care. The aim of this study is to provide policy suggestions by investigating how discipline practices affect the sentence and what are the problem of the punishment criteria for current child abuse. This study tried to make a clearer interpretation for analysis about the content of the ruling by using QCA fuzzy-set ideal analysis; as a result, the sentence was not determined according to the perpetrator factor or common criteria of disciplinary practices. These findings indicate that the criteria for punishment of child abuse are not consistently applied; particularly, disciplinary practices can be used as a basis for reasons for the protest of the actor’s legitimate act; and it still show that the discretionary elements of the judge have a significant impact on the ruling. Based on the results of these studies, this study set up an indicator of disciplinary practices as the basis for punishment and proposed the need for continuous implementation of social welfare education programs related to discipline.