Prostate cancer and prostatic diseases Best of China, 2018

Ye, Ding-Wei,Zhu, Yao Nature Publishing Group 2019 Prostate cancer and prostatic diseases Vol.22 No.1

A Study on the Influence Factors of Complex User Loyalty of Short Video Platform - Taking Chinese TikTok Users as an Example -

Ye, Ding Yu(엽정우),Cho,Dong Min(조동민) 한국전시산업융합연구원 2021 한국과학예술융합학회 Vol.39 No.3

The purpose of this study is to enrich and deepen the theoretical framework of Continuous Use of Information System,in order to reveal and predict the behavior of users of short video platforms. Moreover, it can also provide some theoretical reference for all kinds of short video platforms to insight into users’ psychological needs and enhance user loyalty. Therefore, Based on the Information System Continuous Use Model, this paper integrates Expectation Confirmation Theory and Flow Experience Theory, taking Chinese TikTok users as the research object, constructs the conceptual model of TikTok users’ loyalty, and analyzes the questionnaire data by using statistical analysis software Amos, which proves the validity of the research hypothesis and model. The research results and contents are as follows:firstly, TikTok has achieved success in terms of sense of belonging,perceived entertainment and user satisfaction, which directly and significantly affect the user’s intention of continuous use, thus obtaining higher user loyalty. Secondly, to further improve user loyalty, TikTok operators should improve the perceived usefulness of short video content and the perceived interaction of TikTok users. Through this research, a new conceptual model of TikTok users’ loyalty was created which can give a benefit to the whole short video platform operators for improving the user retention rate.

A Study on the Influence Factors of Complex Users’ Purchase Intention of Live Commerce - Taking Chinese Douyin Live Commerce Users as an Example -

Ye, Ding Yu(엽정우),Cho,Dong Min(조동민) 한국전시산업융합연구원 2021 한국과학예술융합학회 Vol.39 No.4

This study aims to provide theoretical references for operators and designers of live commerce platforms to improve the quality of service in a more targeted way and increase the conversion rate of goods on live commerce. Therefore, based on the Long Tail Effect Theory, Situational Theory, Perceived Value Theory and Key Opinion Leader Theory. This paper takes Douyin (抖音) live commerce as the research object and constructs a conceptual model to study Chinese users’ purchase intention on Douyin live commerce. The data were collected by questionnaire survey method and analyzed by statistical analysis software SPSS and Amos, proving the validity of the research hypothesis and model. The research results and contents are as follows: the search cost, platform service, purchase context, perceived benefit, key opinion leader have shown a positive impact on the users’ purchase intention, while the perceived risk has harmed the user’s purchase intention. The results demonstrate Douyin should establish a set of training and incentive mechanisms for medium and long-tail hosts to improve their business level and enthusiasm. Second, hosts need to improve their professional ability to help consumers choose the most suitable and cost-effective products. Third, Douyin should improve the basic system of e-commerce to ensure the quality of goods and user experience to enhance the reputation of Douyin live commerce.

Myricetin Protects Against Cytokine-Induced Cell Death in RIN-m5f β Cells

Ye Ding,Zhao-Feng Zhang,Xiao-Qian Dai,Yong Li 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.8

Cytokine-induced cell death is recognized as a major cause of progressive β-cell loss. Tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and interferon γ (IFN-γ) in combination trigger a series of events that lead to β-cell death. In the past few decades, the use of myricetin as an anti-inflammatory and cytoprotective agent has gained much attention. The present study focused on the protective roles of myricetin against cytokine-induced cell death in insulin-secreting RIN-m5f β cells. The results showed that myricetin (especially at concentrations of 10 μM and 20 μM) increased cell viability and decreased cell apoptosis induced by the cytokine mixture of TNF-α (10 ng/mL), IL-1β (5 ng/mL), and IFN-γ (1000 IU/mL) for 3 days. Moreover, the cytokines increased the total and p65 subunit levels of nuclear factor κB, decreased inhibitor κB α levels, stimulated the accumulation of nitric oxide, increased cytochrome c release from mitochondria, and induced reactive oxygen species generation; myricetin (especially at the concentration of 20 μM) abolished all of these parameters. These results suggest that myricetin might have therapeutic value for preventing β-cell death.

짧은 동영상 플랫폼 이용자 충성도 영향 요인에 대한 연구 -중국 틱톡 사용자를 중심으로-

엽정우 ( Ye Ding Yu ),조동민 ( Cho Dong Min ) 한국기초조형학회 2021 한국기초조형학회 학술발표논문집 Vol.2021 No.1

Joint Fingerprinting/Encryption for Medical Image Security

Conghuan Ye,Zenggang Xiong,Yaoming Ding,Xueming Zhang,Guangwei Wang,Fang Xu 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.1

Electronic health records (EHRs) facilitates the healthcare process. However, it can also cause serious security and privacy problems. While various conventional encryption mechanisms can solve some aspects of these problems, they cannot address the illegal distribution of decrypted medical images. To protect decrypted medical images from being illegally distributed by an authorized staff member, the scheme proposed in this paper provides a joint fingerprinting and encryption (JFE) scheme based on GoL (Game of Life) and DNA computing with the purpose of protecting medical media distribution. In this study, GoL and DNA are used to confuse in DWT domain and diffusion in spatial domain respectively, and fingerprints are embedded into the HL and LH subbands of DWT domain. The use of fingerprinting along with encryption can provide a double-layer of protection to medical image. Experimental results show the effectiveness of the proposed scheme.

<i>Salmonella enterica</i> Serovar Typhimurium Interacts with CD209 Receptors To Promote Host Dissemination and Infection

Ye, Chenglin,Li, Qiao,Li, Xinyi,Park, Chae Gyu,He, Yingxia,Zhang, Yingmiao,Wu, Bicong,Xue, Ying,Yang, Kun,Lv, Yin,Ying, Xiao-Ling,Ding, Hong-Hui,Cai, Huahua,Alkraiem, Ayman Ahmad,Njiri, Olivia,Tembo, American Society for Microbiology 2019 Infection and immunity Vol.87 No.8

<P><I>Salmonella enterica</I> serovar Typhimurium, a Gram-negative bacterium, can cause infectious diseases ranging from gastroenteritis to systemic dissemination and infection. However, the molecular mechanisms underlying this bacterial dissemination have yet to be elucidated. A study indicated that using the lipopolysaccharide (LPS) core as a ligand, <I>S</I>.</P><P><I>Salmonella enterica</I> serovar Typhimurium, a Gram-negative bacterium, can cause infectious diseases ranging from gastroenteritis to systemic dissemination and infection. However, the molecular mechanisms underlying this bacterial dissemination have yet to be elucidated. A study indicated that using the lipopolysaccharide (LPS) core as a ligand, <I>S</I>. Typhimurium was able to bind human dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (hCD209a), an HIV receptor that promotes viral dissemination by hijacking antigen-presenting cells (APCs). In this study, we showed that <I>S</I>. Typhimurium interacted with CD209s, leading to the invasion of APCs and potentially the dissemination to regional lymph nodes, spleen, and liver in mice. Shielding of the exposed LPS core through the expression of O-antigen reduces dissemination and infection. Thus, we propose that similar to HIV, <I>S</I>. Typhimurium may also utilize APCs via interactions with CD209s as a way to disseminate to the lymph nodes, spleen, and liver to initiate host infection.</P>

Expression Characteristics of Proteins of the Insulin-like Growth Factor Axis in Non-small Cell Lung Cancer Patients with Preexisting Type 2 Diabetes Mellitus

Ding, Jing,Tang, Jie,Chen, Xin,Men, Hai-Tao,Luo, Wu-Xia,Du, Yang,Ge, Jun,Li, Cong,Chen, Ye,Cheng, Ke,Qiu, Meng,Liu, Ji-Yan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

Background: Preexisting type 2 diabetes mellitus (T2DM) affects the prognosis and mortality of patients with some cancers. Insulin like growth factor (IGF) and insulin receptor (IR) signaling axes play important roles in both cancer and diabetes development. We aimed to explore the expression characteristics of proteins in IGF/IR axis in non-small cell lung cancer (NSCLC) cases with preexisting T2DM. Methods: Fifty-five NSCLC patients with preexisting T2DM were retrospectively included and matched by 55 NSCLC without diabetes at a 1:1 ratio. The expression of proteins in IGF/IR axis was detected by immunohistochemical staining. Clinicopathological data were collected to analyze their relationship with the protein expression. Results: Both IGF 1 receptor (IGF-1R) and insulin receptor substrate 2 (IRS-2) showed higher expression in the NSCLC with T2DM group, compared with those without T2DM. The high expression of IGF-1R and IRS-2 were found to be negatively associated with lymph node metastases and T staging in the T2DM group, respectively, and IRS-2 expression was also found more in the subgroup whose T2DM duration was more than 4 years. No difference was detected in the expression of IRS-1, IGF-1, IGF-2, IGFBP3, IR and mTOR between groups with or without T2DM. Conclusion: Our study found higher expression of IGF-1R and IRS-2 proteins in NSCLC patients with preexisting T2DM, and that there was an association with early stage NSCLC, which suggested that IGF signaling may play an important early event in development of NSCLC associated with diabetes.

Preparation and Biocompatibility Study of Contrast-Enhanced Hernia Mesh Material

Ding Xuzhong,Zhu Jiachen,Liu Anning,Guo Qiyang,Cao Qing,Xu Yu,Hua Ye,Yang Yumin,Li Peng 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.4

BACKGROUND: Meshes play a crucial role in hernia repair. However, the displacement of mesh inevitably leads to various associated complications. This process is difficult to be traced by conventional imaging means. The purpose of this study is to create a contrast-enhanced material with high-density property that can be detected by computed tomography (CT). METHODS: The contrast-enhanced monofilament was manufactured from barium sulfate nanoparticles and medical polypropylene (PP/Ba). To characterize the composite, stress tensile tests and scanning electron microscopy (SEM) was performed. Toxicity and biocompatibility of PP/Ba materials was verified by in vitro cellular assays. Meanwhile, the inflammatory response was tested by protein adsorption assay. In addition, an animal model was established to demonstrate the long-term radiographic effect of the composite material in vivo. Subsequent pathological tests confirmed its in vivo compatibility. RESULTS: The SEM revealed that the main component of the monofilament is carbon. In vitro cell experiments demonstrated that novel material does not affect cell activity and proliferation. Protein adsorption assays indicated that the contrast-enhanced material does not cause additional inflammatory responses. In addition, in vivo experiments illustrated that PP/Ba mesh can be detected by CT and has good in vivo compatibility. CONCLUSION: These results highlight the excellent biocompatibility of the contrast-enhanced material, which is suitable for human abdominal wall tissue engineering.

Influence of Ribosomal Protein L39-L in the Drug Resistance Mechanisms of Lacrimal Gland Adenoid Cystic Carcinoma Cells

Ye, Qing,Ding, Shao-Feng,Wang, Zhi-An,Feng, Jie,Tan, Wen-Bin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.12

Background: Cancer constitutes a key pressure on public health regardless of the economy state in different countries. As a kind of highly malignant epithelial tumor, lacrimal gland adenoid cystic carcinoma can occur in any part of the body, such as salivary gland, submandibular gland, trachea, lung, breast, skin and lacrimal gland. Chemotherapy is one of the key treatment techniques, but drug resistance, especially MDR, seriously blunts its effects. As an element of the 60S large ribosomal subunit, the ribosomal protein L39-L gene appears to be documented specifically in the human testis and many human cancer samples of different origins. Materials and Methods: Total RNA of cultured drug-resistant and susceptible lacrimal gland adenoid cystic carcinoma cells was seperated, and real time quantitative RT-PCR were used to reveal transcription differences between amycin resistant and susceptible strains of lacrimal gland adenoid cystic carcinoma cells. Viability assays were used to present the amycin resistance difference in a RPL39-L transfected lacrimal gland adenoid cystic carcinoma cell line as compared to control vector and null-transfected lacrimal gland adenoid cystic carcinoma cell lines. Results: The ribosomal protein L39-L transcription level was 6.5-fold higher in the drug-resistant human lacrimal gland adenoid cystic carcinoma cell line than in the susceptible cell line by quantitative RT-PCR analysis. The ribosomal protein L39-L transfected cells revealed enhanced drug resistance compared to plasmid vector-transfected or null-transfected cells as determined by methyl tritiated thymidine (3H-TdR) incorporation. Conclusions: The ribosomal protein L39-L gene could possibly have influence on the drug resistance mechanism of lacrimal gland adenoid cystic carcinoma cells.