盛明巴蜀文人楊慎對孔明的批評

楊釗(Yang Zhao) 동아인문학회 2017 동아인문학 Vol.39 No.-

Yang Shen had made many comments on Kong Ming, which can be seen in his works, poems, poetic criticisms and “the Whole Shu Yiwenzhi”. Yang Shen mainly focused on the analysis of hot issues such as the moral and utilitarian achievements, the academic and governance abilities of Kong Ming. Yang Shen’s purpose in comments on Kong Ming aimed was to admire for former worthies and educate the future generation, not pedantically to look for quotes in order to embellish his writings.

MLL4 Regulates the Progression of Non-Small-Cell Lung Cancer by Regulating the PI3K/AKT/SOX2 Axis

Yang Yang,Rongfang Qiu,Qiaoyou Weng,Ziwei Xu,Jingjing Song,Siyu Zhao,Miaomiao Meng,Dengke Zhang,Chunli Kong,Hailin Wang,Min Xu,Zhongwei Zhao,Jiansong Ji 대한암학회 2023 Cancer Research and Treatment Vol.55 No.3

Purpose Mixed-lineage leukemia protein 4 (MLL4/KMT2D) is a histone methyltransferase, and its mutation has been reported to be associated with a poor prognosis in many cancers, including lung cancer. We investigated the function of MLL4 in lung carcinogenesis. Materials and Methods RNA sequencing (RNA-seq) in A549 cells transfected with control siRNA or MLL4 siRNA was performed. Also, we used EdU incorporation assay, colony formation assays, growth curve analysis, transwell invasion assays, immunohistochemical staining, and in vivo bioluminescence assay to investigate the function of MLL4 in lung carcinogenesis. Results We found that MLL4 expression was downregulated in non–small cell lung cancer (NSCLC) tissues compared to adjacent normal tissues and tended to decrease with disease stage progression. We analyzed the transcriptomes in control and MLL4- deficient cells using high-throughput RNA deep sequencing (RNA-seq) and identified a cohort of target genes, such as SOX2, ATF1, FOXP4, PIK3IP1, SIRT4, TENT5B, and LFNG, some of which are related to proliferation and metastasis. Our results showed that low expression of MLL4 promotes NSCLC cell proliferation and metastasis and is required for the maintenance of NSCLC stem cell properties. Conclusion Our findings identify an important role of MLL4 in lung carcinogenesis through transcriptional regulation of PIK3IP1, affecting the PI3K/AKT/SOX2 axis, and suggest that MLL4 could be a potential prognostic indicator and target for NSCLC therapy.

楊愼 《全蜀藝文志》 編輯的文化背景考論

楊釗(Yang Zhao) 중국어문학연구회 2016 중국어문학논집 Vol.0 No.98

Yang Shen, in the introduction to “Arts and Literatures History of the Whole Shu nation”, provided that the cultural background of editting this book was to “carry forward the fragrance of the Si Zi, and write the Su nation’s history”. Thus the selected works in this book were not only the literatural ones but also those that reflected the Bashu’s history and academic thoughts. Meanwhile, he had self-consciously assumed the responsibilities of the inheritance of the rural culture and encouraging the backwards through editting the book. Yang Shen and his son had carried forward the local culture through the following three aspects, that is, to devote much attention to the nation’ history, to praise the local loyal bachelors and to place emphasize on the moral education.Besides, Yang Shen and his son had taken great pains to discuss these issues and carry out the social pracitice.

論錢穆對漢代『春秋』學的硏究

楊兆貴 ( Yang¸ Zhao Gui ),趙殷尙 ( Cho¸ Eun Sang ) 한국중국학회 2021 중국학보 Vol.97 No.-

錢穆對秦漢史、漢代經學研究飮譽學林, 影響很大。他這兩方面的論著大多已逾半世紀, 在出土文獻日益增多、研究方法多元化等學風下, 他的論著有哪些價值?對當代相關研究有什麼影響?筆者結合他這兩方面的研究, 聚焦他的漢代『春秋』學, 以見他治學、見解之一斑。 要探討他對漢代『春秋』學的看法, 則先簡介他對『春秋』及三傳的看法。他與傳統主張孔子作『春秋』的看法相同, 並從史學肯定『春秋』、『左傳』的史學價值。他認為漢代經學今古文之別是王官學與百家言之殊, 而非文字古今之異。這是他論漢代經今古文最具特色的部分。他撰『孔子與春秋』一文, 著重闡釋『公羊』學的精神, 強調孔子『春秋』以百家言而成為新的王官學。他在不同時期對『公羊』學與董仲舒的評價不同。他認為漢儒多通古今, 因此治『春秋』者多能兼採三傳或兩傳之義、說。他又指出, 『春秋』學與漢代思想尤其是災異說、禪讓說、禮制說有密切的關係。 Prof. Qian Mu has a great influence on the honorary scholars of Qin and Han history and Han dynasty studies. Most of his works in these two areas have been over half a century. With the increasing number of unearthed documents and diversified research methods, what is the value of his works? And what is the impact on contemporary related research? This essay combines his research in these two areas and focuses on his study of Chun Qiu in the Han Dynasty, so as to see his academic research methods and insights. To explore his views on the study of Chun Qiu in the Han Dynasty, the first part of the essay introduces his views on Chun Qiu and the three ‘Zhuan’. He is the same as the traditional view that Confucius wrote Chun Qiu, and affirmed the historical value of Chun Qiu and Zuo Zhuan from his historiography. He believes that the difference between modern and ancient literatures in Han dynasty is the difference between Ancient Official Document and Philosophers, rather than the difference between ancient and modern writing. He wrote the article Confucius and Chun Qiu, focusing on explaining the spirit of school of Gong Yang, emphasizing that Confucius' Chun Qiu became a new official ideology with the philosophical thought in Han China. He had different evaluations of Gong Yang and Dong Zhongshu in different periods. He believes that the Han scholars are mostly integrated with the ancient and modern literatures, so most of them who studied Chun Qiu can adopt the meaning and theories of the three or two ‘Zhuan’ at the same time. He also pointed out that the study of Chun Qiu has a close relationship with the thoughts of the Han Dynasty, especially the theory of catastrophe, concession, and etiquette.

Investigation on large turbo-generator stator end winding dynamic characteristics based on response surface method

Zhao, Yang,Xiao, Yang,Lu, Sheng,Sun, Hao,Huo, Wenhao,Liao, Yong The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.10

The natural frequencies corresponding to the particular mode shapes of a large turbo-generator must not be in the resonance region before delivery. Different parameters may clearly affect these dynamic characteristics. Different from other studies, this paper introduces a method for obtaining the inherent characteristics of end winding in a short period of time under multiple simultaneously changing parameters. The proposed process is based on the response surface method (RSM). In this method, the main concerned natural frequencies were taken as the critical index to describe the dynamic behaviors of the end winding, with which the mathematical relationship between the dynamic characteristics and design variables was analyzed. First, the stiffness of the rings, stiffness of the radial braces and number of pins bonded to the radial braces were used as samples for orthogonal experimental design. Then, the natural modes and frequencies of 25 different samples were acquired by conducting modal analysis with ABAQUS software. Utilizing these dynamic results, a second-order polynomial response surface model was established to describe the relationships between natural frequencies and these three different parameters. Then, the quality of this model was verified by calculating the valuating indexes for comparison with support vector regression (SVR). With the response surface model, the variation regularities of the natural frequencies and modes due to the above parameters were discussed. The method proposed in this paper can enable natural frequencies in the whole design space to be quickly determined without finite-element analysis, greatly improving the development efficiency and laying a foundation for dynamic response prediction during normal operation with different parameters and additional large turbo-generator stator end winding optimization.

TORQUE CONTROL ALLOCATION BASED ON CONSTRAINED OPTIMIZATION WITH REGENERATIVE BRAKING FOR ELECTRIC VEHICLES

Yang Zhao,Weiwen Deng,Jian Wu,Rui He 한국자동차공학회 2017 International journal of automotive technology Vol.18 No.4

This paper proposes a constrained optimization-based torque control allocation method aimed to improve energy efficiency, and thus, driving range for electric vehicles. In the proposed method, the cost function is defined not only to achieve desired yaw moment for vehicle handling and stability, but also to minimize power losses for energy efficiency. The particular attention is paid to the power losses due to tire slips both longitudinally and laterally. The constraints are also set based on thorough investigation on various causes of power disppation such that the torque is allocated with restraint to use regenerative braking in its maximum capacity. The proposed control allocation method has been tested and verified to be effective on energy efficiency improvement through both simulation and experiment under various driving maneuvers.

Gaseous signal molecule SO2 regulates autophagy through PI3K/ AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes

Zhao Junxiong,Wu Qian,Yang Ting,Nie Liangui,Liu Shengquan,Zhou Jia,Chen Jian,Jiang Zhentao,Xiao Ting,Yang Jun,Chu Chun 대한약리학회 2022 The Korean Journal of Physiology & Pharmacology Vol.26 No.6

Myocardial fibrosis is a key link in the occurrence and development of diabetic cardiomyopathy. Its etiology is complex, and the effect of drugs is not good. Cardiomyocyte apoptosis is an important cause of myocardial fibrosis. The purpose of this study was to investigate the effect of gaseous signal molecule sulfur dioxide (SO2) on diabetic myocardial fibrosis and its internal regulatory mechanism. Masson and TUNEL staining, Western-blot, transmission electron microscopy, RT-qPCR, immunofluorescence staining, and flow cytometry were used in the study, and the interstitial collagen deposition, autophagy, apoptosis, and changes in phosphatidylinositol 3-kinase (PI3K)/AKT pathways were evaluated from in vivo and in vitro experiments. The results showed that diabetic myocardial fibrosis was accompanied by cardiomyocyte apoptosis and down-regulation of endogenous SO2-producing enzyme aspartate aminotransferase (AAT)1/2. However, exogenous SO2 donors could up-regulate AAT1/2, reduce apoptosis of cardiomyocytes induced by diabetic rats or high glucose, inhibit phosphorylation of PI3K/AKT protein, up-regulate autophagy, and reduce interstitial collagen deposition. In conclusion, the results of this study suggest that the gaseous signal molecule SO2 can inhibit the PI3K/AKT pathway to promote cytoprotective autophagy and inhibit cardiomyocyte apoptosis to improve myocardial fibrosis in diabetic rats. The results of this study are expected to provide new targets and intervention strategies for the prevention and treatment of diabetic cardiomyopathy.

Central role of autophagic UVRAG in melanogenesis and the suntan response

Yang, Yongfei,Jang, Gyu-beom,Yang, Xuanjun,Wang, Qiaoxiu,He, Shanshan,Li, Shun,Quach, Christine,Zhao, Shihui,Li, Fan,Yuan, Zengqiang,Lee, Hye-Ra,Zhong, Hanbing,Liang, Chengyu National Academy of Sciences 2018 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.115 No.33

<P>UV-induced cell pigmentation represents an important mechanism against skin cancers. Sun-exposed skin secretes alpha-MSH, which induces the lineage-specific transcriptional factor MITF and activates melanogenesis in melanocytes. Here, we show that the autophagic tumor suppressor UVRAG plays an integral role in melanogenesis by interaction with the biogenesis of lysosome-related organelles complex 1 (BLOC-1). This interaction is required for BLOC-1 stability and for BLOC-1-mediated cargo sorting and delivery to melanosomes. Absence of UVRAG dispersed BLOC-1 distribution and activity, resulting in impaired melanogenesis in vitro and defective melanocyte development in zebrafish in vivo. Furthermore, our results establish UVRAG as an important effector for melanocytes' response to alpha-MSH signaling as a direct target of MITF and reveal the molecular basis underlying the association between oncogenic BRAF and compromised UV protection in melanoma.</P>

CNN 기반 익수자 탐지 모델 설계 방안에 관한 연구

ZHAO YANG,강정호,이경창 제어로봇시스템학회 2023 제어로봇시스템학회 국내학술대회 논문집 Vol.2023 No.6

Constructing foldable cylindrical surfaces via unfolded waterbomb origami units

Zhao Yan,Wei Yinglei,Jia Yiyang,Li Shiling,Zhang Mingyue,Zeng Lanling,Yang Yang,Mitani Jun 한국CDE학회 2022 Journal of computational design and engineering Vol.9 No.4

Origami tessellations have shown the potential to be utilized for approximating curved target surfaces by folding a set of elemental units. As those units are in partially folded states, the origami approximation captures the outline of the target while demonstrating a corrugated surface. In this paper, we focus on the cylindrical surface and propose a method for constructing its discrete version via square or rectangular units with crease patterns inspired by the waterbomb tessellation. We unify the unit size through optimization to realize cost-efficient constructions. Three-dimensional curved structures are deployed by folding collinear creases between adjacent rows of units and the other creases in each row are remained unfolded. The deployed structure can still be folded to a compact state by folding all creases. To flexibly approximate the outline of the target surface, we analyse relationships between the width and height of the rectangular unit and utilize variations of the waterbomb tessellation to control the region of the origami structure when fully folded. The proposed method provides a novel solution to the so-called inverse-origami-design problem for generating foldable cylindrical surfaces using unfolded waterbomb origami units.