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Transmission ability of Zika virus with artificially infected Aedes albopictus in Korea
Yang Sung‐Chan,Lee Hee-Il,Kim Hyunwoo,Lee Wook‐Gyo 한국곤충학회 2021 Entomological Research Vol.51 No.8
Zika virus (ZIKV), a virus mainly occurring in South America, is now globally distributed. Understanding the pathogen transmission cycle in a vector is exceptionally important in developing disease control strategies. In this study, we performed ZIKV microinjection in Aedes albopictus (Skuese), to estimate its vertical and horizontal transmission ability. The virus infection rate was confirmed by real-time qPCR in the F1 generation derived from the ZIKV-injected Ae. albopictus. The minimum infection rate (MIR) of the F1 generation was highest when they were injected with the virus at 6–12 h (MIR: 16.1) and lowest at 12–24 h (MIR: 4.7) after feeding. In the developmental stage of the F1 progeny, MIR values were 1.0, 1.3, and 6.7 in each egg, larval, and adult stage, respectively, but ZIKV was not detected in the pupa stage. Virus transmission ability was not significantly different between the collection areas (Tongyeong and Jeju). Ae. albopictus demonstrated a high venereal transmission rate of ZIKV and was detected in males (6 pool/7 pool) and females (6 pool/7 pool), confirming that ZIKV can be transmitted from infected mosquitoes to uninfected mosquitoes via mating. This is the first study of the administration of a ZIKV microinjection to Ae. albopictus in Korea and suggests a possibility of a potential mechanism for the virus to survive during adverse conditions via vertical transmission.
Photolysis Properties of Merocyanine Dye LB Films by Various Time of UV Irradiation
Yang, Chang-Heon,Lee, Ji-Yoon,Sung, Gi-Chan,Kim, Gyong-Chol,Shin, Hoon-Kyu,Kwon, Young-Soo American Scientific Publishers 2011 Journal of Nanoscience and Nanotechnology Vol.11 No.2
<P>We fabricated the merocyanine dye LB films with arachidic acid (MD LB films). We compared absorption peak of before and after added Cd2+. The optical absorption peak of the MD LB films was shifted to 610 nm at 535 nm, when Cd2+ ions were added. We also investigated the optical absorption peak of the LB films by various time at 365 nm UV. We confirmed J-aggregation and photolysis properties. This is that studied the application possibility of the switching device and the nonvolatile memory.</P>
Yang, Hee-Man,Park, Chan Woo,Lim, Sujin,Park, Sung-Il,Chung, Bong Hyun,Kim, Jong-Duk Royal Society of Chemistry 2011 Chemical communications Vol.47 No.46
<P>Cross-linked magnetic nanoparticles were developed to improve the structural stability of amphiphilic polymer coated magnetic nanoparticles. These nanoparticles show strong potential for biomedical applications such as magnetic resonance imaging (MRI).</P> <P>Graphic Abstract</P><P>Biocompatible cross-linked magnetic nanoparticles loaded with fluorescence dye were prepared, and their biomedical applicability was evaluated. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1cc16191a'> </P>
Experience with Ledipasvir/Sofosbuvir-Based Treatment for the Treatment of HCV Genotype 1a in Korea
( Chan Ran You ),( Sang Wook Choi ),( Sun Hong Yoo ),( Jung Hyun Kwon ),( Soon Woo Nam ),( Se Hyun Cho ),( Joon-Yeol Han ),( Do Seon Song ),( U Im Chang ),( Jin Mo Yang ),( Sung Won Lee ),( Hae Lim Le 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: In this multicenter retrospective cohort study, we aimed to evaluate the effectiveness of IFN-free direct acting anti-viral agents (DAA) for patients with HCV genotype 1a in a real life setting in Korea. Methods: We analyzed clinical data of all consecutive DAA-treated patients for chronic HCV genotype 1a infection from eight clinical centers in Korea. Between May 2016 to April 2017, 35 patients were included in this study. The primary efficacy endpoint was end of treatment response (ETOR) and sustained virological response 12 weeks (SVR12). Adverse events (AEs) and laboratory data were also collected for analysis. Results: A total of 35 patients with genotype 1a HCV infection, 8 patients (22.9%) had compensated liver cirrhosis and 14 patients (40%) were treatment-experienced. Ledipasvir/sofosbuvir (LDV/SOF) with ribavirin were administered to six of seven treatment-experienced patients with cirrhosis. Thirteen patients were over 65 years old (37.1%) and female patients were dominant (65.7%, 23/35 patients). The Child-Pugh scores of all patients were 5 or 6. The rate of SVR12 was 94.7% (18/19 patients) and the rate of ETOR was 96.6% (28/29 patients). SVR12 and ETOR were obtained in all patients completed treatment for 12 weeks. Five of 33 patients (15.2%) had detectable HCV RNA at week 4 of therapy, but all of them achieved SVR12. LDV/SOF without ribavirin was tolerated well. The dose of ribavirin was reduced in two patients because they complained fatigue and general weakness after the treatment of LDV/SOF with ribavirin. Conclusions: In patients with HCV genotype 1a infection, LDV/SOF based regimen was very effective and well tolerated.
Design of Piezoelectric Energy Harvesting System by Magnetic Force?Controlled Resonance Frequency
YANG, CHAN HO,SONG, DANIEL,WOO, MIN SIK,HONG, SEONG KWANG,BAEK, KI HWAN,SUNG, TAE HYUN Gordon and Breach 2013 Ferroelectrics Vol.449 No.-
<P> We designed a piezoelectric energy harvesting system that can be controlled the resonance frequency to the frequency of external energy. A permanent magnet (10 mm × 10 mm × 5 mm) was affixed to the free end of cantilever, and a permanent magnet was affixed to each of the four faces of a rotor at 90° angles. The effect of the dimension of the permanent magnets (20 mm × 20 mm × 10 mm, 30 mm × 20 mm × 10 mm, and 40 mm × 20 mm × 10 mm) and the effect of the pole array (NNNN, SSSS, NSNS, and NNSS) were experimentally tested. The optimum conditions were selected by testing varied distances between the magnets at varied rpm. The experiments demonstrated that the maximum output voltage was generated for the largest magnet and the minimum distance. The most effective way to control the resonance frequency was to modify the pole arrays of magnets affixed to the rotor. Furthermore, the optimum conditions were determined at each distance by changing the pole array and rpm. Simulation software supports the experimental results. </P>
( Sung Won Lee ),( Hae Lim Lee ),( Nam Ik Han ),( Hee Yeon Kim ),( Chang Wook Kim ),( Chan Ran You ),( Sang Wook Choi ),( Se Hyun Cho ),( Joon-Yeol Han ),( Do Seon Song ),( U Im Chang ),( Jin Mo Yang 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: The aim of this study was to determine the factors associated with the development of major clinical adverse events in genotype 1 hepatitis C virus (HCV) infected Korean patients who received direct-acting antiviral (DAA) therapy in real clinical settings. Methods: A total of 648 genotype 1 HCV infected patients who received DAA therapy between May 2016 and January 2018 at the liver units of the Catholic University of Korea were analyzed. Primary endpoints were hepatic decompensation and/or treatment discontinuation due to adverse events and the development of de novo hepatocellular carcinoma (HCC). Results: The median follow-up period was 12.8 months (range, 1.3~34.8). 70.7% of the patients had chronic hepatitis and 29.3% compensated cirrhosis. Treatment discontinuation due to adverse events occurred in 2.8% (18/648), hepatic decompensation in 1.4% (9/648) and de novo HCC developed in 3.1% (19/620) of the patients. In multivariate analysis, baseline platelet count less than 150,000/㎣ (P=0.022), estimated glomerular filtration rate (eGFR) less than 50 mL/min/1.73㎡ (P=0.037) and baseline serum albumin less than 3.5g/dL (P=0.035) were independently associated with hepatic decompensation and/or treatment discontinuation due to adverse events. Also, platelet count less than 150,000/㎣ was independently associated with the development of de novo HCC (P=0.048). Conclusions: Patients with low platelet count and serum albumin level, which are indicators of portal hypertension, and patients with renal impairment were more likely to experience hepatic decompensation and/or treatment discontinuation due to adverse events. Low platelet count was associated with de novo HCC development. These patients should be meticulously followed up during and after the DAA therapy.
Baseband Noise Reduction Method Using Captured TX Signal for UHF RFID Reader Applications
Sung-Chan Jung,Min-Su Kim,Youngoo Yang IEEE 2012 IEEE transactions on industrial electronics Vol.59 No.1
<P>This paper presents a baseband noise reduction method in the receiver for UHF RFID readers. The signal captured from the transmitter after passing through the main delay components is fed as an LO signal into the down-converter in the receiver. At the down-converter, the LO signal and the leakage signal from the transmitter to the receiver are mixed with each other. The matching of the delay between the two correlated signals virtually eleminates the additional baseband noise included in the phase noises after their mixing. Lowering the baseband noise improves the sensitivity of the receiver, thus allowing the RFID tags to be read further away from the reader. The proposed method was applied to a portable UHF RFID reader for its validation. Compared to the conventional configuration, the simulated baseband noise level of more than 26 dB was reduced by the proposed method. The measured sensitivity of about 19 dB was also improved. As a result, the reading distance was extended by 1.9 m from 2.02 to 3.92 m.</P>