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Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma
Yang, Y.,Kelly, P.,Shaffer, A.L.,Schmitz, R.,Yoo, H.M.,Liu, X.,Huang, D.W.,Webster, D.,Young, R.M.,Nakagawa, M.,Ceribelli, M.,Wright, G.W.,Yang, Y.,Zhao, H.,Yu, X.,Xu, W.,Chan, W.C.,Jaffe, E.S.,Gascoy Cell Press 2016 CANCER CELL Vol.29 No.4
Chronic active B cell receptor (BCR) signaling, a hallmark of the activated B cell-like (ABC) subtype of diffuse large B cell lymphoma (DLBCL), engages the CARD11-MALT1-BCL10 (CBM) adapter complex to activate IκB kinase (IKK) and the classical NF-κB pathway. Here we show that the CBM complex includes the E3 ubiquitin ligases cIAP1 and cIAP2, which are essential mediators of BCR-dependent NF-κB activity in ABC DLBCL. cIAP½ attach K63-linked polyubiquitin chains on themselves and on BCL10, resulting in the recruitment of IKK and the linear ubiquitin chain ligase LUBAC, which is essential for IKK activation. SMAC mimetics target cIAP½ for destruction, and consequently suppress NF-κB and selectively kill BCR-dependent ABC DLBCL lines, supporting their clinical evaluation in patients with ABC DLBCL.
Liu, Hong Feng,Zhao, ZhengLin,Zhang, Jie,Wu, Yi Yan,Jiao, Yu,Wu, Tong,Kim, Sang Chan,Lee, Bong Hyo,Fan, Yu,Lee, Chul Won,Kim, Young Woo,Yang, Chae Ha,Zhu, Xiao Dong,Zhao, Rong Jie Elsevier 2019 Neuroscience Letters Vol.705 No.-
<P><B>Abstract</B></P> <P>Noradrenergic projections from the nucleus tractus solitarius (NTS) to the hypothalamic paraventricular nucleus (PVN) are involved in nicotine (Nic) dependence. Nic induces hypothalamic norepinephrine (NE) release through <I>N</I>-methyl-<SMALL>D</SMALL>-aspartate receptors (NMDARs) and nitric oxide in the NTS. However, acupuncture attenuates Nic withdrawal-induced anxiety. Therefore, this study investigated the effects of acupuncture on Nic-induced hypothalamic NE release. Rats received an intravenous infusion of Nic (90 μg/kg, over 60 s) and extracellular NE levels in the PVN were determined by in vivo microdialysis. Immediately after Nic administration, the rats were bilaterally treated with acupuncture at acupoint HT7 (Shen-Men) or PC6 (Nei-Guan), or a non-acupoint (tail) for 60 s. Acupuncture at HT7, but not at PC6 or the tail, significantly reduced Nic-induced NE release. However, this was abolished by a post-acupuncture infusion of either NMDA or sodium nitroprusside into the NTS. Additionally, acupuncture at HT7, but not the control points, prevented Nic-induced plasma corticosterone secretion and inhibited Nic-induced increases in the phosphorylation of neuronal nitric oxide synthase (nNOS) and endothelial NOS in the NTS. These findings suggest that acupuncture at HT7 reduces Nic-induced NE release in the PVN via inhibition of the solitary NMDAR/NOS pathway.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Acupuncture inhibited nicotine-induced hypothalamic norepinephrine release. </LI> <LI> Acupuncture diminished nicotine-induced plasma corticosterone secretion. </LI> <LI> Acupuncture reversed nicotine-induced phosphorylation of solitary nNOS and eNOS. </LI> <LI> NMDA abolished acupunctural effects on nicotine-induced norepinephrine release. </LI> <LI> NO abolished acupunctural effects on nicotine-induced norepinephrine release. </LI> </UL> </P>
A decade of liver organoids: Advances in disease modeling
Yue Liu,Jian-Ying Sheng,Chun-Fang Yang,Junjun Ding,Yun-Shen Chan 대한간학회 2023 Clinical and Molecular Hepatology(대한간학회지) Vol.29 No.3
Liver organoids are three-dimensional cellular tissue models in which cells interact to form unique structures in culture. During the past 10 years, liver organoids with various cellular compositions, structural features, and functional properties have been described. Methods to create these advanced human cell models range from simple tissue culture techniques to complex bioengineering approaches. Liver organoid culture platforms have been used in various research fields, from modeling liver diseases to regenerative therapy. This review discusses how liver organoids are used to model disease, including hereditary liver diseases, primary liver cancer, viral hepatitis, and nonalcoholic fatty liver disease. Specifically, we focus on studies that used either of two widely adopted approaches: differentiation from pluripotent stem cells or epithelial organoids cultured from patient tissues. These approaches have enabled the generation of advanced human liver models and, more importantly, the establishment of patient-tailored models for evaluating disease phenotypes and therapeutic responses at the individual level.
Jo, Yang Hee,Shin, Bora,Liu, Qing,Lee, Ki Yong,Oh, Dong-Chan,Hwang, Bang Yeon,Lee, Mi Kyeong American Chemical Society and American Society of 2014 Journal of natural products Vol.77 No.11
<P>Four new prenylated xanthones, cudracuspixanthones A–D (<B>1</B>–<B>4</B>), two new prenylated benzophenones, cudracuspiphenones A (<B>5</B>) and B (<B>6</B>), and 11 known xanthones (<B>7</B>–<B>17</B>) were isolated from the roots of <I>Cudrania tricuspidata</I>. The absolute configurations of compounds <B>2</B>–<B>4</B> were deduced by the comparison of the calculated optical rotation values with the measured data. Compounds <B>1</B>, <B>5</B>, and <B>6</B> showed moderate antiproliferative activity on HSC-T6 cells with IC<SUB>50</SUB> values of 9.7, 3.3, and 7.1 μM, respectively. Compounds <B>2</B>–<B>4</B>, <B>10</B>, and <B>14</B>–<B>16</B> had weaker activity. Flow cytometric analysis suggested that compounds <B>1</B> and <B>5</B> inhibited HSC-T6 cell proliferation in part by inducing apoptosis.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2014/jnprdf.2014.77.issue-11/np5002797/production/images/medium/np-2014-002797_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np5002797'>ACS Electronic Supporting Info</A></P>
PANM DB ver 5.0 : An update of PANM, Database for invertebrate NGS data analysis
Jun Yang Jeong,Jie Eun Park,Dae Kwon Song,Chan-Eui Hong,Yong Tae Kim,Hyeonjun Shin,Ziwei Liu,Hyeyoon Jo,Min Kyu Sang,Hongray Howrelia Patnaik,Bharat Bhusan Patmaik,Se Won Kang,So Young Park,Jun Sang L 한국수산과학회 양식분과 2022 한국수산과학회 양식분과 학술대회 Vol.2022 No.10