포항산 천연 제올라이트와 합성 제올라이트에 의한 금속 이온의 제거

박상윤,장세복,김덕수,김양 濟州大學校 基礎科學硏究所 1996 基礎科學硏究 Vol.9 No.2

국내 경상북도 포항시 남구에서 채취한 4종의 천연 제올라이트를 화학성분 분석, X-선 회절, 열시차분석 실험, 열중량분석 실험으로 분석하였다. 이들 제올라이트의 주성분은 석영, mordenite, heulandite가 함유된 clinoptilolite이었다. NaOH, Ca(OH)₂, HCI 용액으로 처리한 천연 제올라이트의 성질은 X-선 회절법과 열시차분석 실험법으로 연구하였다. 천연 제올라이트와 화학적으로 처리한 제올라이트, 합성 제올라이트를 이용하여 Cu²+, Cd²+, Hg²+, Pb²+, Cr6+등의 중금속 이온과 알칼리 금속 K- 이온의 제거능력을 비교하였고, 중금속 이온 용액의 pH값과 초기농도, 중금속 이온을 제거하는데 소요되는 반응 시간의 효과 등을 비교하였다. 천연 제올라이트에 Ca²+, Pb²+, and Cu²+ 이온용액을 각각 5ppm첨가한 결과 제거율이 94%, 95%, 97%까지 증가되었다. 또한 0.5N NaOH와 0.5 N HCI 용액으로 처리한 매석산 천연 제올라이트를 이용하여 Hg²+ 이온용액을 5ppm 첨가한 결과 제거율이 약 80% 정도였다. 매석산 천연 제올라이트와 합성 제올라이트 A,X 및 Y가 Hg²+ 이온의 최대 제거율을 나타내었다. The four natural zeolites collected in Pohang, Kyungsang buk-do, Korea, were analyzed by means of wet chemical methods, X-ray diffraction, DTA, and TGA. The results indicate that the primary species of those zeolites are clinoptilolite mixed with quartz, mordenite, and heulandite. These zeolites were treated with NaOH, Ca(OH)₂, and HCI solution and their differences were also studied by X-ray diffraction method and differential thermal analysis method. The capabilities of removing heavy metal ions, such as Cu²+, Cd²+, Hg²+, Pb²+ and Cr6+, and alkaline ion, K+ ions with original zeolites, chemically treated zeolites, and synthetic zeolites were compared. The effect of pH value of solution and initial concentration of heavy metal ions, and the effect of reaction time in removing heavy metal ions were ions were studied. The experimental results showed that up to 94%, 95%, and 97% of Ca²+, Pb²+, and Cu²+ ions could be removed, respectively, out of 5 ppm of untreated natural zeolites. About 80% of the Hg²+ ions could be also removed out of 5 ppm Hg²+ ions solution with Maesuk mt. natural zeolite which was treated with 0.5N NaOH and 0.5 N HCI solution. It was found that Maesuk mt. natrual zeolite was most efficient in removing Hg²+ ions compared with the other natural zeolites studied in this work and synthetic zeolite A, X and Y.

제주도 주요하천의 기저유출량 산정

문덕철,양성기,고기원,박원배 한국환경과학회 2005 한국환경과학회지 Vol.14 No.4

Groundwater in Jeju Island, flowing through main stream, is spring water from underground. To set a fixed quantity of groundwater flowing from surface in a hydrological view, 4 downstream (Woedo stream, Gangjung stream, Yeonwoe stream and Ongpo stream) were selected to calculate the characteristic of baseflow and the base-flow discharge through the data on tachometry. There were 11 to 14 level peak caused by runoff, mostly occurred during monsoon season. Also, duration of runoff was 15 to 25 hours, well reflecting the characteristic of inclined, short stream length in Jeju Island and pervious hydrogeographical feature. In case of Gangjung stream, Yeonwoe stream and Ongpo stream, variation of stream water level by baseflow rose above during summer, which was closely linked to the distribution of seasonal precipitation. From autumn to spring, water level fell below while that of Woedo stream remained the same all year round. Data on the water level observed in Woedo stream and Gangjung stream in every single minutes was applied to weir formula(equation of Oki and Govinda Rao) to calculate baseflow discharge. Also, using the data on current and water level calculated in Ongpo stream and Yeonwoe stream, water level-water flow rating was applied to assess baseflow discharge.

역전사 중합효소 연쇄반응을 이용한 사람의 활성 T세포 항원 CTLA-4 유전자 클로닝 및 마우스 L세포에서의 발현

조양자,장경덕,정용훈,박장환,김경희 한양대학교 의과대학 1993 한양의대 학술지 Vol.13 No.2

Occupancy of the T-cell receptor (TCR) by antigen in association with class Ⅱ MHC molecule is required for the initiation of T cell activation. However TCR stimulation is not a sufficient signal to account for all the observed events that occur during T cell activation. And in the absence of a second costimulatory signal provided by abtigen presenting cell antigen specific signal may lead to clonal inactivation or energy. CD28, a T cell surface molecule first defined by monoclonal antibody 9.3 on human cells, appears to function as an alternative, TCR/CD3-independent, activation pathway for T cell. This molecule provides costimulatory signal for T cell proliferation by increasing a number of lymphokines and cytokines production. A T cell activation antigen CTLA-4 is homologous to CD28 with 28% amino acid and 67% of nucleic acid homology in the protein coding region. CTLA-4 was ofiginally identified by the differential screening follosing subtractive hybridization of murine cytotoxic T cell cDNA library and mapped to the same lacation on chromosome 2 in human and chromosome 1 in mouse as CD28. These findings and activation associated expression pattern of CTLA-4 raise question about functional role of this molecule in T cell activation. In this study human CTLA-4 cDNA was amplified from phytohemagglutinin (PHA)-stimulated human peropheral blood lymphocytes mRNA by using reverse transcription-ploymerase chain reaction (RT-PCR) method. And amplified human CTLA-4 cDNA was subsequently cloned into pRC/CMV vector. In double stranded DNA sequencing the 331st base of protein coding region was changed from guanylic acid of human CTLA-4 from alanine to threonine. Murind L cell transfected with this clone expressed 36kD protein. It appears that this dirrerence of molecular weight between native (34kD) and recombinant (36kD) human CTLA-4 molecule may due to glycosylation differences. The cDNA and murine CTLA-4 molecule may due to glycosylation differences. The cDNA and murine L cell lines expressing human CTLA-4 developed by this study would contribute in future work unveiling the biological rile of CTLA-4 in T cell activation.

한약에 의해 유발된 급성 간질성 신염 2례

김덕윤,박동건,김응석,강영모,양창헌,이정호,이동철,이영현,김정란 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

간질성 신염은 신장의 간질을 선택적으로 침범하는 염증성 질환으로 여러가지 원인에 의해 유발되며, 이 중 약물에 의한 경우는 각종 항생제, 비스테로이드성 진통제, 항경련제, 이뇨제, 면역억제제등에 의한 증례들이 보고되고 있다. 현재 각종 질환-특히 만성질환-의 치료에서 한약이 차지하는 비중이 적지 않으나, 그 각각의 성분들이 유발할 수 있는 부작용들에 대한 연구는 거의 없는 실정이다. 저자들은 관절염 치료를 위해 중국산 한약을 복용한 후 복통, 피로감 및 육안적 혈뇨를 주소로 내원한 두 환자에서, 단백뇨와 신기능 장애를 보여 시행한 신조직 생검상 급성 간질성 신염에 합당한 병리학적 소견을 보이고, 한약 복용 중지 후 급속한 회복을 보여, 한약에 의해 유발된 것으로 사료되는 급성 간질성 신염 2예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Acute interstitial nephritis is a disease characterized by renal interstitial inflammatory cell infiltration and acute renal functional deterioration. This is caused mainly by antibiotics, NSAID and diuretics such as thiazide, but cases induced by herb medication are rare. We experienced two cases of acute interstitial nephritis after treatment with herb medication. One 71-year-old female patient and the other 60-year-old female were admitted to the hospital because of general weakness and gross hematuria. Microscopic hematuria, pyuria, and proteinuria were presented. After definitive diagnosis with a renal biopsy, we noted rapid recovery of renal function by drug withdrawal and steroid therapy. We report these cases with a review of the referenced literatures. Key Words : Herb medication, Acute Interstitial nephritis.

A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia

Yang, Suk-Kyun,Hong, Myunghee,Baek, Jiwon,Choi, Hyunchul,Zhao, Wanting,Jung, Yusun,Haritunians, Talin,Ye, Byong Duk,Kim, Kyung-Jo,Park, Sang Hyoung,Park, Soo-Kyung,Yang, Dong-Hoon,Dubinsky, Marla,Lee, Nature Pub. Co 2014 Nature genetics Vol.46 No.9

Thiopurine therapy, commonly used in autoimmune conditions, can be complicated by life-threatening leukopenia. This leukopenia is associated with genetic variation in TPMT (encoding thiopurine S-methyltransferase). Despite a lower frequency of TPMT mutations in Asians, the incidence of thiopurine-induced leukopenia is higher in Asians than in individuals of European descent. Here we performed an Immunochip-based 2-stage association study in 978 Korean subjects with Crohn's disease treated with thiopurines. We identified a nonsynonymous SNP in NUDT15 (encoding p.Arg139Cys) that was strongly associated with thiopurine-induced early leukopenia (odds ratio (OR) = 35.6; P<SUB>combined</SUB> = 4.88 × 10<SUP>−94</SUP>). In Koreans, this variant demonstrated sensitivity and specificity of 89.4% and 93.2%, respectively, for thiopurine-induced early leukopenia (in comparison to 12.1% and 97.6% for TPMT variants). Although rare, this SNP was also strongly associated with thiopurine-induced leukopenia in subjects with inflammatory bowel disease of European descent (OR = 9.50; P = 4.64 × 10<SUP>−4</SUP>). Thus, NUDT15 is a pharmacogenetic determinant for thiopurine-induced leukopenia in diverse populations.

Efficacy of Hepatitis A Vaccination and Factors Impacting on Seroconversion in Patients with Inflammatory Bowel Disease :

Park, Sang Hyoung,Yang, Suk-Kyun,Park, Soo-Kyung,Kim, Jong Wook,Yang, Dong-Hoon,Jung, Kee Wook,Kim, Kyung-Jo,Ye, Byong Duk,Byeon, Jeong-Sik,Myung, Seung-Jae,Kim, Jin-Ho Oxford University Press 2014 Inflammatory bowel diseases Vol.20 No.1

The long-term efficacy of azathioprine in steroid-dependent ulcerative colitis

Park, Soo-Kyung,Yang, Suk-Kyun,Ye, Byong Duk,Kim, Kyung-Jo,Yang, Dong-Hoon,Jung, Kee Wook,Park, Sang Hyoung,Kim, Jong Wook,Byeon, Jeong-Sik,Myung, Seung-Jae,Kim, Jin-Ho Informa Healthcare 2013 Scandinavian journal of gastroenterology Vol.48 No.12

<P><B><I>Objective.</I></B> The long-term efficacy of azathioprine (AZA) in steroid-dependent ulcerative colitis (UC) is still unclear. We aimed to evaluate the efficacy of AZA in patients with steroid-dependent UC. <B><I>Material and methods.</I></B> We retrospectively reviewed the medical records of 106 patients with steroid-dependent UC who were administered AZA. Three-year outcomes of AZA therapy were evaluated. The outcome of the treatment was defined as (1) success, indicating induction and maintenance of remission throughout the study period (complete success) or remission followed by infrequent and short relapses (partial success); or (2) failure, indicating the absence of remission, frequent or prolonged relapses, infliximab administration, or colectomy. <B><I>Results.</I></B> Of the 106 patients, 73 (68.9%) continued on AZA for >6 months (AZA therapy group) and 33 (31.1%) discontinued AZA within 6 months due to intolerance (AZA intolerance group, <I>n</I> = 20), colectomy (<I>n</I> = 6), or follow-up loss (<I>n</I> = 7). Three-year outcomes for 106 patients were success in 54.7% (complete success, 35.8%; partial success, 18.9%), failure in 32.1% (frequent or prolonged relapses, 12.3%; infliximab administration, 5.6%; colectomy, 14.2%), and follow-up loss or death in 13.2%. The success rate increased to 71.2% (complete success, 46.6%; partial success, 24.7%) when the analysis was confined to the 73 patients who continued AZA for > 6 months. The 3-year success rate was higher in the AZA therapy group (71.2%) than the AZA intolerance group (25.0%) (<I>p</I> < 0.001). <B><I>Conclusions.</I></B> AZA is an effective treatment for steroid-dependent UC. The efficacy of AZA is well sustained over 3 years.</P>

Recanalization of Organized Thrombi Demonstrated by Coronary CT Angiography Compared With OCT

Yang, Dong Hyun,Kang, Soo-Jin,Kim, Young-Hak,Kang, Joon-Won,Ahn, Jung-Min,Park, Duk-Woo,Lee, Seung-Whan,Lee, Cheol Whan,Park, Seong-Wook,Park, Seung-Jung,Lim, Tae-Hwan Elsevier Science B.V. Amsterdam 2016 JACC CARDIOVASCULAR IMAGING Vol.9 No.7

Long-term Prognosis of Crohnʼs Disease and Its Temporal Change Between 1981 and 2012 : A Hospital-based Cohort Study from Korea

Park, Sang Hyoung,Yang, Suk-Kyun,Park, Soo-Kyung,Kim, Jong Wook,Yang, Dong-Hoon,Jung, Kee Wook,Kim, Kyung-Jo,Ye, Byong Duk,Byeon, Jeong-Sik,Myung, Seung-Jae,Yoon, Yong Sik,Yu, Chang Sik,Kim, Jin-Ho Oxford University Press 2014 Inflammatory bowel diseases Vol.20 No.3

기술해설 : 제철소 에너지 수급동향

박양덕 ( Yang Duk Park ) 대한금속재료학회 ( 구 대한금속학회 ) 1995 금속제련 학술회의 Vol.- No.-