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Depletion of adipocyte Becn1 leads to lipodystrophy and metabolic dysregulation
Yaechan Song,Young Jin,Yul Ji,Sung Sik Choe,Yong Geun Jeon,Heeju Na,Tae Wook Nam,Hye Jeong Kim,Hahn Nahmgoong,Sung Min Kim,Jae-woo Kim,Ki Taek Nam,Je Kyung Seong,Daehee Hwang,Chan Bae Park,In Hye Lee 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Macroautophagy is a catabolic process that delivers damaged and unnecessary cytosolic contents to lysosomes for removal of defective subcellular organelles and proteins. Becn1 is a key regulator of autophagy, forming a complex with class III phosphatidylinositol 3-kinase (PI3K-III) to initiate autophagosome formation. Although Becn1 has been implicated in numerous diseases such as cancer, aging, and neurodegenerative disease, its function in mature adipocytes remains elusive. In this study, we implemented Adipoq-Cre to generate adipocyte-specific Becn1 KO (BaKO) mice to identify the function of autophagy in adipose tissue homeostasis. BaKO mice naturally developed severe lipodystrophy and metabolic dysregulation, which were exacerbated upon high dietary fat intake. These mice also acquired adipose tissue inflammation, hepatic steatosis, and insulin resistance which advanced to early mortality. Immortalized stromal vascular cells (imSVCs) were established in-vitro to conditionally knock-out Becn1 upon tamoxifen treatment. Ablation of Becn1 in adipocytes led to programmed cell death in a cell-autonomous manner, accompanied by elevated endoplasmic reticulum (ER) stress gene expression. Furthermore, we observed that Becn1 depletion sensitized mature adipocytes to ER stress through activation of protein kinase R-like ER kinase (PERK) – eukaryotic initiation factor 2α (eiF2α) axis. This led to excessive unfolded protein response (UPR) and accelerated cell death through notable induction of C/EBP homologous protein (CHOP) and Bax expression. Taken together, these data suggest that adipocyte-Becn1 would serve as a crucial player for adipocyte survival and adipose tissue homeostasis.
주예찬(Yaechan Ju),김형국(Hyungguk Kim),권기항(Keehang Kwon) 한국정보과학회 1998 한국정보과학회 학술발표논문집 Vol.25 No.2Ⅰ
인터넷 환경의 대중화와 함께 HTML 문서의 사용 범위가 확대되면서, 많은 소프트웨어 벤더들이 HTML 문서 형식으로 도움말을 제공하고 있다. HTML 문서는 작성하기 쉽고, 문서 관계를 쉽게 나타낼 수 있다는 장점이 있지만 사용자가 원하는 정보를 찾기 어렵고 효과적으로 관리할 수 있는 방법이 부족하다. 본 논문에서는 이 문제를 해결하기 위해 웹이나 지역 머신에 위치한 HTML 문서들에서 정보를 추출하고 데이터 베이스화 시키는 도움말 시스템을 설계하고 구현한다.
Impact factor surge in Korean medical journals during the COVID-19 era: a bibliometric study
Han Mi Ah,Chansu Park,Sejin Park,Hyeonseok Seo,Janghyeog Oh,Dongryeong Kim,Junha Kang,Hanul Kang,Hyunsung Kang,Yaechan Kim 한국과학학술지편집인협의회 2024 Science Editing Vol.11 No.1
Purpose: The multiyear COVID-19 pandemic has affected the volume and speed of publications in scientific journals. This study evaluated trends in the impact measures of international medical journals published in Korea, including the journal impact factor (JIF). Methods: We selected Science Citation Index Expanded journals with the country/region set to Korea and the academic category classified as “clinical medicine” in Journal Citation Reports. Trends in indicators such as the JIF and Journal Citation Indicator (JCI) were assessed for journals with JIF information from 2018 to 2022. Ratios and differences between the measures were calculated to determine the extent of the change. Results: We identified 43 journals, and the average JIF of those journals increased from 2.33 in 2018 and 2.50 in 2019 to 3.45 in 2020 and 3.86 in 2021. Other measures, such as the 5-year JIF and JCI, steadily increased, and the proportion of gold open access journals also increased significantly. However, the JCI and Eigenfactor scores remained steady or showed relatively small increases. Furthermore, impact measures declined in 2022, including a JIF decrease to 3.55. Conclusion: We presented trends in quantitative measurements for international medical journals in Korea, and found an overall increase. Journals need to maintain a rigorous publication process to improve the quality of their research and the research community needs to exercise caution when using quantitative measures to evaluate journals. Further research is required to examine the quantitative indicators of journals, including their publication policies, research topics, and long-term trends.