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Jeon, Yong Geun,Lee, Jae Ho,Ji, Yul,Sohn, Jee Hyung,Lee, Dabin,Kim, Dong Wook,Yoon, Seul Gi,Shin, Kyung Cheul,Park, Jeu,Seong, Je Kyung,Cho, Je-Yoel,Choe, Sung Sik,Kim, Jae Bum American Diabetes Association 2020 Diabetes Vol.69 No.1
<P>Adipose tissue is the key organ coordinating whole-body energy homeostasis. Although it has been reported that ring finger protein 20 (RNF20) regulates lipid metabolism in the liver and kidney, the roles of RNF20 in adipose tissue have not been explored. Here, we demonstrate that RNF20 promotes adipogenesis by potentiating the transcriptional activity of peroxisome proliferator–activated receptor-γ (PPARγ). Under normal chow diet feeding, <I>Rnf20</I> defective (<I>Rnf20</I><SUP><I>+/−</I></SUP>) mice exhibited reduced fat mass with smaller adipocytes compared with wild-type littermates. In addition, high-fat diet–fed <I>Rnf20</I><SUP><I>+/−</I></SUP> mice alleviated systemic insulin resistance accompanied by a reduced expansion of fat tissue. Quantitative proteomic analyses revealed significantly decreased levels of PPARγ target proteins in adipose tissue of <I>Rnf20</I><SUP><I>+/−</I></SUP> mice. Mechanistically, RNF20 promoted proteasomal degradation of nuclear corepressor 1 (NCoR1), which led to stimulation of the transcriptional activity of PPARγ. Collectively, these data suggest that RNF20-NCoR1 is a novel axis in adipocyte biology through fine-tuning the transcriptional activity of PPARγ.</P>
Photoacoustic imaging probe for detecting lymph nodes and spreading of cancer at various depths
Lee, Yong-Jae,Jeong, Eun-Ju,Song, Hyun-Woo,Ahn, Chang-Geun,Noh, Hyung Wook,Sim, Joo Yong,Song, Dong Hoon,Jeon, Min Yong,Lee, Susung,Kim, Heewon,Zhang, Meihua,Kim, Bong Kyu SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS 2017 JOURNAL OF BIOMEDICAL OPTICS Vol.22 No.9
Jeon, Sangho,Park, Seung-Nam,Yoo, Yong Shim,Hwang, Jisoo,Park, Chul-Woung,Lee, Geun Woo Optical Society of America 2010 Optics letters Vol.35 No.23
<P>A two-substrate method is developed to simultaneously determine emissivity, transmittance, and reflectance of semitransparent materials with a single measurement under the same environment at elevated temperature. The three quantities can be obtained through the emissivities of substrates and the apparent emissivities resulting from the radiance of the sample heated by substrates. The two-substrate method is compared with the conventional method by measuring sapphire samples with various thicknesses, resulting in good agreements for all the samples. The present method will be useful to measure the temperature dependence of optical properties of porous ceramic materials.</P>
A TGA study on the chlorination reaction kinetics of Zircaloy-4 cladding hulls
Jeon, Min Ku,Choi, Yong Taek,Kang, Kweon Ho,Park, Geun Il Elsevier 2015 JOURNAL OF NUCLEAR MATERIALS Vol.459 No.-
<P><B>Abstract</B></P> <P>The chlorination reaction kinetics of Zircaloy-4 cladding hulls were investigated using a home-made thermogravimetric analysis for a hull chlorination (TGA-HC) system. The reproducibility of the TGA-HC system was verified by repeated measurements at an identical condition, which showed only 6.6% of maximum difference. The effect of total flow rate (<I>Q</I>) was investigated for <I>Q</I> of 120 and 240mL/min, and it was revealed that the reaction rate is not influenced in this condition. Using the Sharp–Hancock plot, the volumetric contraction model was identified as the most suitable model for the Zircaloy-4 chlorination reaction. The influence of chlorine partial pressure was studied at 9.21, 16.9, and 23.4kPa of Cl<SUB>2</SUB> partial pressure conditions, and it was identified that the reaction rate is proportional to the chlorine partial pressure on the order of (0.669). The effect of reaction temperature was investigated for 300–450°C, and it was revealed that the chlorination reaction exhibits an activation energy of 26.2kJ/mol. Using the experimental and fitting results, the reaction rate equation for the Zircaloy-4 chlorination reaction was achieved, but the equation was valid only until the conversion fraction (<I>α</I>) reaches up to (0.60). When <I>α</I> is higher than 0.60, the volumetric contraction model was not applicable. A second-order reaction rate equation was suggested for the 0.6< <I>α</I> region, although it needs further investigation.</P>