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Feng, Xiao-Shan,Yang, Yan-Tong,Gao, She-Gan,Ru, Yi,Wang, Gong-Ping,Zhou, Bo,Wang, Yu-Feng,Zhang, Peng-Fei,Li, Pu-Yu,Liu, Yong-Xuan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5
Objective: To establish the prevalence and distribution profile of esophageal squamous cell carcinomas (ESCCs) over a 22-yr period in North China. Methods: Using endoscopy for primary diagnosis and histological analysis for the further confirmation, a total of 74,854 ESCC patients aged 20-89 between January 1985 and December 2006 were investigated to analyze the epidemiological profile including prevalence rates, distribution of age-of-onset, gender and geographical area of ESCC in Luoyang, the highest incidence area of North China. Results: A total of 4092 cases of ESCC were finally diagnosed among 74,854 patients who had their first endoscopies. The prevalence among males was higher than that among females (p<0.01), resulting in an overall male:female OR of 1.2 (95%CI, 1.2-1.3). The prevalence in rural areas was higher than in urban areas (p<0.01), resulting in an overall rural:urban OR of 2.6 (95%CI, 2.4-2.9). The rural:urban ORs and the 95% CI increased continuously from 2.6, 2.3-3.0 to 2.7, 2.2-3.3, respectively, for 4 consecutive periods during the 22-yr study period. Moreover, the median age of onset among females was higher than that among males (p<0.01). For both sexes and in both areas, the prevalence rates declined and the median age of onset rose for 4 consecutive periods in the 22-yrs time frame (p<0.01). Conculsions: These data reveal the epidemiological profile of ESCC in the area of North China, and suggest that urban areas and rural people account for a growing proportion of the ESCC patients although the prevalence of ESCC significantly declined and the median age-of-onset postponed over the 22-yrs period. Moreover, the prevalence status of ESCC in rural areas also underlines the need for public health initiatives aimed at reducing risk factors of this fatal disease.
Stathmin is a Marker of Progression and Poor Prognosis in Esophageal Carcinoma
Wang, Feng,Xuan, Xiao-Yan,Yang, Xuan,Cao, Lei,Pang, Li-Na,Zhou, Ran,Fan, Qin-Xia,Wang, Liu-Xing Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8
Stathmin, also called oncoprotein 18, is a founding member of the family of microtubule-destabilizing proteins that play a critical role in the regulation of mitosis. At the same time stathmin has been recognized as one of responsible factors in cancer cells. The aim of this study was to assess stathmin status, its correlations with clinicopathological parameters and its role as a progosnostic marker in EC patients. The protein and mRNA levels of stathmin were examined byimmunohistochemistry (IHC) and in situ hybridization in 100EC tissues and adjacent noncancerous tissues. mRNA and protein expression of stathmin in three EC cell lines(EC9706, ECa109, EC1 commonly used in research) were also analyzed using immunocytochemistry, western blot and in situ hybridization. The prognostic value of Stathmin expression within the tumor tissues were assessed by Cox regression and Kaplan-Meier analysis. We showed that stathmin expression was significantly higher in EC tissues than in adjacent noncancerous tissues. High stathmin immunostaining score in the EC was positively correlated with tumor differentiation, Tumor invasion, Lymph node metastases, and TNM stage. In addition, we demonstrated that three EC cell lines examined, were constitutively expressing a high level of stathmin. Of those, EC-1 showed the strongest mRNA and protein expression for the stathmin analyzed. Kaplan-Meier analysis showed that significantly longer 5-year survival rate was seen in EC patients with high Stathmin expression, compared to those with low expression of Stathmin expression. Furthermore, multivariate Cox proportional hazard analyses revealed that Stathmin was an independent factors affecting the overall survival probability. In conclusion, our data provide a basis for the concept that stathmin might be associated with EC development and progression. High levels of Stathmin expression in the tumor tissues may be a good prognostic marker for patients with EC.
Self-Updating One-Time Password Mutual Authentication Protocol for Ad Hoc Network
( Feng Xu ),( Xin Lv ),( Qi Zhou ),( Xuan Liu ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.5
As a new type of wireless network, Ad hoc network does not depend on any pre-founded infrastructure, and it has no centralized control unit. The computation and transmission capability of each node are limited. In this paper, a self-updating one-time password mutual authentication protocol for Ad hoc network is proposed. The most significant feature is that a hash chain can update by itself smoothly and securely through capturing the secure bit of the tip. The updating process does not need any additional protocol or re-initialization process and can be continued indefinitely to give rise to an infinite length hash chain, that is, the times of authentication is unlimited without reconstructing a new hash chain. Besides, two random variable are added into the messages interacted during the mutual authentication, enabling the protocol to resist man-in-the-middle attack. Also, the user`s identity information is introduced into the seed of hash chain, so the scheme achieves anonymity and traceability at the same time.
Feng-Jun Zhang,Zhuo Zhang,Han Xuan,Hong-Chen Xia,Lei Zhu,오원춘,Fazhi Xie 한국세라믹학회 2014 한국세라믹학회지 Vol.51 No.6
Magnetic-graphene nanosheets have been synthesized via a simple effective chemical precipitation method followed by heattreatment. The composite nanosheets are super paramagnetic at room temperature and can be separated by an external magneticfield. The prepared magnetic-graphene nanosheets were characterized by X-ray diffraction (XRD), scanning electron microscopy(SEM), transmission electron microscopy (TEM), Raman spectroscopy, and BET surface area analysis. The resultsdemonstrated the successful attachment of iron oxide nanoparticles to graphene nanosheets. It was found that the attachednanoparticles were mainly Fe3O4. The magnetic-graphene nanosheets showed near complete methyl orange removal within 10mintues and would be practically usable for methyl orange separation from water.
Fabrication and Analyses of Bionic Polymer Lens System
Xuan Yin Wang,Dan Liang,Feng Tang,Jia Wei Du 한국고분자학회 2016 폴리머 Vol.40 No.2
In this paper, we design and fabricate a bionic solid tunable lens which is mainly made of polymer materials. The lens focal length can be changed flexibly by pressing the lens surface to alter the curvature radius. A detailed description of the lens structure, materials and fabrication process is presented. The lens mechanical properties and deformation process are simulated and analyzed using Ansys software. A precise experimental device based on a stepping motor is fabricated to measure and analyze the relationship between the displacement load and focal length. The lens focal length can be reversibly changed from 31.8 to 14.1 mm under 1 mm variation of displacement load. This paper offers a feasible way for the design, fabrication, and actuation of the solid tunable lens, which can be used in various machine vision apparatus.
Zhang, Feng-Jun,Zhang, Zhuo,Xie, Fa-Zhi,Xuan, Han,Xia, Hong-Chen,Zhu, Lei,Oh, Won-Chun The Korean Ceramic Society 2014 한국세라믹학회지 Vol.51 No.6
Magnetic-graphene nanosheets have been synthesized via a simple effective chemical precipitation method followed by heat treatment. The composite nanosheets are super paramagnetic at room temperature and can be separated by an external magnetic field. The prepared magnetic-graphene nanosheets were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy, and BET surface area analysis. The results demonstrated the successful attachment of iron oxide nanoparticles to graphene nanosheets. It was found that the attached nanoparticles were mainly $Fe_3O_4$. The magnetic-graphene nanosheets showed near complete methyl orange removal within 10 mintues and would be practically usable for methyl orange separation from water.