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Xingyuan Zhang,Fang Zhang,Changxi Zhang,Jie Li 연세대학교의과대학 2021 Yonsei medical journal Vol.62 No.5
Purpose: Multiple pathways are involved in inducing liver fibrosis, which can damage the integrity of liver. Among them, miR-125b has been found to exert an activating action on hepatic stellate cells. Endoplasmic reticulum stress and autophagy lead toliver disorders. Here, we evaluated the therapeutic influence of miR-125b on the endoplasmic reticulum function in injured liverssubmitted to bile duct ligation. Materials and Methods: For inducing injury, bile duct ligation was done on miR-125b transgenic rats (miR-125b-Tg) in wild typerats. The rat T-6 cells received transfection of miR-125b mimic and Tunicamycin. Protein expressions were observed by westernblot analysis. Results: Compared to wild type rats, liver-injured rats showed significant impairment of liver function as assessed by the total bilirubinlevels. The miR-125b-Tg rats showed decrease in activity of aspartate transaminase and alanine transaminase. Liver tissuesof miR-125b-Tg rats showed weaker fibrotic matrix formation. Upregulation of miR-125b decreased the bile duct ligation-mediatedhepatic disturbances for the expressions of endoplasmic reticulum kinase, inositol-requiring kinase 1alpha, sXBP1, CHOP, LC3,p62, ULK, and caspase-3/-8/-9. T-6 cells transfected with miR-125b mimic and treated with Tunicamycin caused decrease in levelsof cleaved caspase-3, sXBP1, CHOP, and LC3. The miR-125b signaling showed protective effect on the liver tissues subjected to injuryand fibrosis histopathology. Conclusion: This study demonstrates a novel insight into the miR125b-mediated stabilization of endoplasmic reticulum integrity,which slows the progression of injury-induced hepatic deterioration.
Zhang, Qing,Zhang, Xingyuan,Zhang, Wencheng,Pan, Jian,Liu, Ling,Zhang, Haitao,Zhao, Dong,Li, Zhi Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.9
Oleanolic acid (OA) as template molecule, polyamide-6 (PA6) as basement membrane and poly(styrene-comaleic acid) (PSMA) were used to prepare PA6/PSMA-OA molecularly imprinted composite membranes by phase inversion method in supercritical $CO_2$ ($ScCO_2$). The template molecule (OA), [poly(styrene-co-maleic anhydride) (PSMAH), PSMA, molecularly imprinted membranes (MIMs) imprinting OA and MIMs after elution were all characterized by Fourier transform infrared spectroscopy (FTIR). The conditions that were the mass ratio between PSMA and OA from 3:1 to 8:1, temperature of $ScCO_2$ from $35^{\circ}C$ to $50^{\circ}C$ and pressure of $ScCO_2$ 12 MPa to 17 MPa were studied. It was obtained the largest adsorption rate and purity of OA after adsorption of the resultant MIMs, 50.41% and 96.15% respectively. After using PA6 film and non-woven fabrics as basement membrane respectively, it was found that smaller aperture of PA6 was used as basement membrane, a higher adsorption rate and a higher purity of OA after adsorption of the MIMs were obtained, and so were the stability and reproducibility of the resultant MIMs. After template molecules being removed, the MIMs had effective selectivity hydrogen bonding to separately bind in the binary components to the template molecules-oleanolic acid.
Qing Zhang,Wencheng Zhang,Jian Pan,Ling Liu,Haitao Zhang,Dong Zhao,Zhi Li,Xingyuan Zhang 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.9
Oleanolic acid (OA) as template molecule, polyamide-6 (PA6) as basement membrane and poly(styrene-comaleic acid) (PSMA) were used to prepare PA6/PSMA-OA molecularly imprinted composite membranes by phase inversion method in supercritical CO_2 (ScCO_2). The template molecule (OA), [poly(styrene-co-maleic anhydride) (PSMAH), PSMA, molecularly imprinted membranes (MIMs) imprinting OA and MIMs after elution were all characterized by Fourier transform infrared spectroscopy (FTIR). The conditions that were the mass ratio between PSMA and OA from 3:1 to 8:1, temperature of ScCO_2 from 35 ºC to 50 ºC and pressure of ScCO_2 12 MPa to 17 MPa were studied. It was obtained the largest adsorption rate and purity of OA after adsorption of the resultant MIMs, 50.41% and 96.15% respectively. After using PA6 film and non-woven fabrics as basement membrane respectively, it was found that smaller aperture of PA6 was used as basement membrane, a higher adsorption rate and a higher purity of OA after adsorption of the MIMs were obtained, and so were the stability and reproducibility of the resultant MIMs. After template molecules being removed, the MIMs had effective selectivity hydrogen bonding to separately bind in the binary components to the template molecules-oleanolic acid.
Preparation and Properties of Graphene Oxide-Modified Anti-UV Waterborne Polyurethane Nanocomposites
Xingyuan Ma,Mingrui Zhang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2020 NANO Vol.15 No.02
In this present study, graphene oxide (GO) was used as a secondary chain extender and a functional modification assistant to fabricate a three-dimensional nanocomposite (GO-WPU) with waterborne polyurethane (WPU) through the prepolymer dispersion. The tensile strength and elastic modulus of GO-WPU with 0.2 wt.% GO content, compared with those of pure WPU, increase by 170.38% and 50.9%, respectively. Even with a small amount of GO content added, the ultraviolet absorption rate significantly increased, whereas the ultraviolet transmittance decreased significantly. Other properties such as thermal stability and so on were also much enhanced. These results suggested that the functional nanocomposite GO-WPU prepared through the prepolymer dispersion will be an effective fabrication approach and have a wider scope of applications in functional coating materials and film materials.
International Knowledge Flows and Productivity: Intra- vs. Inter-Industry Spillovers
Naoto Jinji,Xingyuan Zhang 한국국제경제학회 2015 International Economic Journal Vol.29 No.3
The effects of international knowledge spillovers on total factor productivity (TFP) at the industry level are examined by using a panel of 13 manufacturing industries across 15 OECD countries over 23 years. We distinguish between intra- and inter-industry spillovers from the information on patent applications and citations. Patent data are taken from the Japan Patent Office and the United States Patent and Trademark Office. Using four alternative spatial panel estimation techniques, we find that international knowledge spillovers within the same industry significantly contribute to sectoral TFP. In contrast, there is little evidence of a positive effect of international knowledge spillovers on TFP across industries.