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- 저자 : Changxi Zhang (검색결과 5 건)
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Ruoyu Zhang,Changxi Feng,Ruoyu Zhang,Guangchao You,Rui Liu 한국강구조학회 2017 International Journal of Steel Structures Vol.17 No.1
In order to investigate mechanical properties of L-shaped column composed of concrete-filled square steel tubes (LCFT column) under eccentric compression, LCFT columns were designed and tested. Through two eccentric compression experiments, the failure mode, the curves of loading-displacement for the whole member and the curves of deflection for mono column (single limb of LCFT column) were obtained. Nonlinear finite element analysis was also employed in this investigation, in which thickness of tube flange, connecting plate thickness and diameter of the hole on connecting plate were discussed. According to results of eccentric compression test and finite element analysis, analytical method of bearing capacity of LCFT columns is proposed based on the yielding criterion of the cross-sectional edge stresses. Results of analytical method, finite element analysis and eccentric compression experiment are resistant with each other, and the accuracy of the analytical method in this paper is verified.
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Xingyuan Zhang,Fang Zhang,Changxi Zhang,Jie Li 연세대학교의과대학 2021 Yonsei medical journal Vol.62 No.5
Purpose: Multiple pathways are involved in inducing liver fibrosis, which can damage the integrity of liver. Among them, miR-125b has been found to exert an activating action on hepatic stellate cells. Endoplasmic reticulum stress and autophagy lead toliver disorders. Here, we evaluated the therapeutic influence of miR-125b on the endoplasmic reticulum function in injured liverssubmitted to bile duct ligation. Materials and Methods: For inducing injury, bile duct ligation was done on miR-125b transgenic rats (miR-125b-Tg) in wild typerats. The rat T-6 cells received transfection of miR-125b mimic and Tunicamycin. Protein expressions were observed by westernblot analysis. Results: Compared to wild type rats, liver-injured rats showed significant impairment of liver function as assessed by the total bilirubinlevels. The miR-125b-Tg rats showed decrease in activity of aspartate transaminase and alanine transaminase. Liver tissuesof miR-125b-Tg rats showed weaker fibrotic matrix formation. Upregulation of miR-125b decreased the bile duct ligation-mediatedhepatic disturbances for the expressions of endoplasmic reticulum kinase, inositol-requiring kinase 1alpha, sXBP1, CHOP, LC3,p62, ULK, and caspase-3/-8/-9. T-6 cells transfected with miR-125b mimic and treated with Tunicamycin caused decrease in levelsof cleaved caspase-3, sXBP1, CHOP, and LC3. The miR-125b signaling showed protective effect on the liver tissues subjected to injuryand fibrosis histopathology. Conclusion: This study demonstrates a novel insight into the miR125b-mediated stabilization of endoplasmic reticulum integrity,which slows the progression of injury-induced hepatic deterioration.
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Ruoyu Zhang,Bin Rong,Guangchao You,Changxi Feng,Rui Liu 국제구조공학회 2016 Steel and Composite Structures, An International J Vol.22 No.2
In order to investigate mechanical properties and load-bearing capacity of T-shaped Concrete-Filled Square Steel Tubular (TCFST) composite columns under eccentric axial load, three T-shaped composite columns were tested under eccentric compression. Experimental results show that failure mode of the columns under eccentric compression was bending buckling of the whole specimen, and mono column performs flexural buckling. Specimens behaved good ductility and load-bearing capacity. Nonlinear finite element analysis was also employed in this investigation. The failure mode, the load-displacement curve and the ultimate bearing capacity of the finite element analysis are in good agreement with the experimental ones. Based on eccentric compression test and parametric finite element analysis, the calculation formula for the equivalent slenderness ratio was proposed and the bearing capacity of TCFST composite columns under eccentric compression was calculated. Results of theoretical calculation, parametric finite element analysis and eccentric compression experiment accord well with each other, which indicates that the theoretical calculation method of the bearing capacity is advisable.
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Yinghao Song,Changxi Li,Jingjing Guan,Cheng Li,Haisheng Wu,Xinzhi Cheng,Bingyu Ling,Jinglang Zhang 대한통증학회 2022 The Korean Journal of Pain Vol.35 No.1
Background: Percutaneous transforaminal endoscopic discectomy (PTED) has been widely used in the treatment of lumbar degenerative diseases. Epidural injection of steroids can reduce the incidence and duration of postoperative pain in a short period of time. Although steroids are widely believed to reduce the effect of surgical trauma, the observation indicators are not uniform, especially the long-term effects, so the problem remains controversial. Therefore, the purpose of this paper was to evaluate the efficacy of epidural steroids following PTED. Methods: We searched PubMed, Embase, and the Cochrane Database from 1980 to June 2021 to identify randomized and non-randomized controlled trials comparing epidural steroids and saline alone following PTED. The primary outcomes included postoperative pain at least 6 months as assessed using a visual analogue scale (VAS) and the Oswestry Disability Index (ODI). The secondary outcomes included length of hospital stay and the time of return to work. Results: A total of 451 patients were included in three randomized and two nonrandomized controlled trials. The primary outcomes, including VAS and ODI scores, did not differ significantly between epidural steroids following PTED and saline alone. There were no significant intergroup differences in length of hospital stay. Epidural steroids were shown to be superior in terms of the time to return to work (P < 0.001). Conclusions: Intraoperative epidural steroids did not provide significant benefits, leg pain control, improvement in ODI scores, and length of stay in the hospital, but it can enable the patient to return to work faster.
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Computational Model of the Elastic Stiff ness of Panel Zone in Diaphragm-Through Connections
Bin Rong,Ziheng Yang,Ruoyu Zhang,Changxi Feng 한국강구조학회 2019 International Journal of Steel Structures Vol.19 No.5
The elastic stiff ness of the panel zone in diaphragm-through connection between square steel tubular column and H-shaped steel beam subjected to lateral loads is studied in this paper. Through analyzing the deformation mechanism of diaphragmthrough connection, the rotation of the panel zone is found to be the superposition of bending deformation of the column and shear deformation of the panel zone. Based on the mechanical model, the computational method of the elastic stiff ness of the panel zone in the diaphragm-though connection is developed. To verify the computational method, three cruciform specimens were tested subjected to a set of anti-symmetrical cyclic load at the beam tips. Based on the test results, the developed fi nite element model is verifi ed and used in the follow-up parametric analysis to check the applicability of the proposed computational method. Key variables involved are the width of column, thickness of column and the height-towidth ratio of the core tube.
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