8.3% Carbamide Peroxide 함유 펜 형 자가미백제인 BIancTis Forte의 색조개선 및 안전성에 관한 임상연구

이진경,민선홍,홍성태,오소람,정신혜,황영혜,유성엽,배광식,백승호,이우철,손원준,금기연 대한치과보존학회 2009 Restorative Dentistry & Endodontics Vol.34 No.2

This clinical study evaluated the whitening effect and safety of polymer based-pen type BlancTis Forte(NIBEC) containing 8.3% carbamide peroxide. Twenty volunteers used the BlancTis Forte whitening agent for 2 hours twice a day for 4 weeks As a control. Whitening Effect Pen (LG) containing 3% hydrogen peroxide was used by 20 volunteers using the same protocol. The change in shade (ΔE^(*) color difference) was measured using Shadepilot™ (DeguDent) before, during and after bleaching (2 weeks, 4 weeks and postbleaching 4 weeks). A clinical examination for any side effects (tooth hypersensitivity or soft tissue complications) was also performed at each check-up. The following results were obtained. 1 Both the experimental and control groups displayed a noticeable change in shade (ΔE) of over 2 No significant differences were found between the two group (p>0.05) implying that the two agents have a similar whitening effect. 2 The whitening effect was mainly due to changes in a and b values rather than in L value (brightness). The experimental group showed a significantly higher change in b value thus yellow shade than the control(p < 0.05) 3 None of the participants complained of tooth hypersensitivity or soft tissue complications confirming the safety of both whitening agents 8.3%의 carbamide peroxide를 함유한 펜형 코팅용 미백제인 BlancTis Forte (NIBEC, Seosul & JinCheon)를 실험군으로, 3% hydrogen peroxide를 함유한글 Whitening Effect Pen (LG. Seoul) 제재를 대조군으로 각각 피험자 20명에게 2시간씩 1일 2회 제조사의 지시대로 치아표면에 4주간 적용하도록 지시하고 색조개선 효능과 안전성을 평가하였다. 미백 효과는 미백 전 및 미백 2주, 4주 및 미백 종료 4주 후에 Shadopilot™을 이용하여 색 변화를 측정하였고, 매 내원시기마다 모든 환자는 치수생활력 검사와 치주 및 치태 검사를 통해 부작용 여부 (치아과민증 및 구감 내 연조직의 부작용)를 기록한 후 다음과 같은 결과를 얻었다. 1.실험군 및 대조군의 색 변화량 (ΔE)은 2이상으로 인지할 수 있는 색 변화를 보였으며, 두 제품 간에는 통계적으로 유의한 차이를 보이지 않아 (p > 0.05) 유사한 미백효능을 나타냄을 알 수 있었다. 2,미백효과는 명도의 개선보다는 주로 a. b값의 변화에 의한 것으로 특히 실험군에서 b값의 변화, 즉 황색조의 개선효과가 대조군에 비해 유의성 있게 높은 것으로 나타났다 (p <0.05). 3.치아나 치은의 과민증이나 이상증상을 호소하는 피험자는 없어 두 제품 모두 안전성을 확인할 수 있었다.

심장박동 측정 센서회로 IC 설계에 관한 연구

이우람,이완직,원창수,손상희 청주대학교 산업과학연구소 2008 産業科學硏究 Vol.26 No.1

Interface IC design for heart beat measurement sensor is proposed and executed by using current control schmitt trigger. The function of interface IC is to measure the heart beat using PPG from sensor. This circuit is composed of analog circuit that converts current signal of sensor to voltage and digital circuit that converts it to digital value. Applying OTA to schmitt trigger and oscillator, operation speed is faster and linear error is smaller than the conventional one. Besides, follow features such as low power consumption, simple configuration and high resolution, are realized by IC design.

내용기반 이미지 검색을 위한 문자-에지 맵의 특징을 이용한 자연이미지에서의 텍스트 영역 추출

박종천,황동국,이우람,권교현,전병민 충북대학교 컴퓨터정보통신 연구소 2006 컴퓨터정보통신연구 Vol.14 No.2

자연이미지에 포함된 텍스트는 많은 중요한 정보를 포함하고 있다. 그러므로 자연이미지에서 텍스트를 추출할 수 있다면 다양한 분야에서 활용될 수 있다. 본 논문에서는 문자-에지 맵 패턴 히스토그램을 분석함으로서 텍스트 영역을 추출하는 방법을 제안한다. 첫 번째 단계로, Canny 에지 검출기로 에지를 추출하여 16가지 에지 맵을 생성하고, 두 번째 단계로 16가지 에지 맵을 조합하여 문자 특징을 갖는 8가지 문자-에지 맵을 생성한다. 세 번째 단계로 8가지 문자-에지 맵과 16가지 에지 맵을 이용하여 텍스트 후보 영역을 추출 하고, 마지막으로 텍스트 후보 영역에 대한 검증은 문자-에지 맵의 패턴 히스토그램 및 텍스트 영역의 구조적 특징을 이용하여 수행하였다. 실험결과 제안한 방법은 복잡한 배경, 다양한 글꼴, 다양한 텍스트 컬러로 구성된 자연이미지에서 텍스트 영역을 효과적으로 추출하였다. The text to be included in the natural images has many important information. Therefore, if we can extract the text in natural images, it can be applied to many important applications. In this paper, we propose a text region extraction method using pattern histogram of character-edge maps. In the first step, we extract edges with the Canny edge detector and create 16 kinds of edge maps from the extracted edges. In the second step, we make 8 kinds of character-edge maps that has a character features with combination of edge maps. In the third step, we extract a text regions using 8 kinds of character-edge maps and 16 kinds of edge maps. Finally, verification about candidate of the text regions uses pattern histogram of character-edge maps and structural features of text regions. The proposed method is experimented with various kinds of natural images. Experimental results show that the proposed method extracts a text regions composed of complex background, various letters, various text colors effectively.

Low-Level Microsatellite Instability as a Potential Prognostic Factor in Sporadic Colorectal Cancer

Lee, Soo Young,Kim, Duck-Woo,Lee, Hye Seung,Ihn, Myong Hoon,Oh, Heung-Kwon,Min, Byung Soh,Kim, Woo Ram,Huh, Jung Wook,Yun, Jung-A.,Lee, Kang Young,Kim, Nam Kyu,Lee, Woo Yong,Kim, Hee Cheol,Kang, Sung- Wolters Kluwer Health 2015 Medicine Vol.94 No.50

<P><B>Abstract</B></P><P>Although microsatellite instability-high (MSI-H) colorectal cancers (CRCs) have been shown to exhibit a distinct phenotype, the clinical value of MSI-low (MSI-L) in CRC remains unclear. We designed this study to examine the clinicopathologic characteristics and oncologic implications associated with MSI-L CRCs.</P><P>We retrospectively reviewed data of CRC patients from 3 tertiary referral hospitals in Korea, who underwent surgical resection between January 2003 and December 2009 and had available MSI testing results. MSI testing was performed using the pentaplex Bethesda panel. Clinicopathologic features and oncologic outcomes were compared between MSI-L and microsatellite stable (MSS) CRCs; prognostic factors for survival were also examined.</P><P>Of the 3019 patients reviewed, 2621 (86.8%) were MSS, and 200 (6.6%) were MSI-L; the remaining 198 (6.6%) were MSI-H. MSI-L and MSS CRCs were comparable in terms of their clinicopathologic features, with the exception of proximal tumor location (MSI-L 30.0% vs MSS 22.1%, <I>P</I> = 0.024) and tumor size (MSI-L 5.2 ± 2.6 cm vs MSS 4.6 ± 2.1 cm, <I>P</I> = 0.001). No differences were detected in either 3-year disease-free survival (MSI-L 87.2% vs MSS 82.6%, <I>P</I> = 0.121) or 5-year overall survival (OS) (MSI-L 74.2% vs MSS 78.3%, <I>P</I> = 0.131) by univariable analysis. However, MSI-L was an independent prognostic factor for poor OS by Cox regression analysis (hazard ratio 1.358, 95% confidence interval 1.014–1.819, <I>P</I> = 0.040).</P><P>MSI-L may be an independent prognostic factor for OS in sporadic CRCs despite their clinicopathologic similarity to MSS. Further studies investigating the significance of MSI-L in the genesis and prognosis of CRCs are needed.</P>

Controlling the interfacial dipole via functionalization of quinoxaline-based small molecules for electron transport layer in organic light emitting diodes

Lee Seok Woo,Fan Xiangyang,Whang Dong Ryeol,Jang Ji Won,Choi Hyosung,Chang Dong Wook,Lee Bo Ram 한국정보디스플레이학회 2023 Journal of information display Vol.24 No.3

Optoelectronic devices with organic semiconductors, such as organic light-emitting diodes (OLEDs), have received much attention because they offer ease of processing and device flexibility. However, practical application of these devices is still hindered by relatively poor device performance and lack of cost-effective fabrication process, which represent properties largely determined by the molecular dipole moments of the organic molecules. In this study, we designed and prepared novel quinoxaline-phosphine oxide small molecules (QPSMs) as the electron transport layer (ETL) for the solution-processable OLEDs by tuning the end functional group of the aromatic QPSMs. A key design criterion was controlling the dipole moments of QPSMs, which confers (1) convenient deposition on the emission layer without further annealing through solubility in isopropanol and (2) improved electron injection/transport behavior through effective band level matching of the devices. In particular, the optimized OLEDs with (4-(2,3-bis(4-methoxyphenyl)quinoxalin-5-yl)phenyl)diphenylphosphine oxide (MQxTPPO1) exhibit external quantum efficiency (EQE) of 6.12%. Our results demonstrate the potential application of QPSMs as next-generation ETLs in organic semiconductors.

Diamine-Functionalization of a Metal-Organic Framework Adsorbent for Superb Carbon Dioxide Adsorption and Desorption Properties

Lee, Woo Ram,Kim, Jeong Eun,Lee, Sung Jin,Kang, Minjung,Kang, Dong Won,Lee, Hwa Young,Hiremath, Vishwanath,Seo, Jeong Gil,Jin, Hailian,Moon, Dohyun,Cho, Moses,Jung, Yousung,Hong, Chang Seop WILEY-VCH 2018 CHEM SUS CHEM Vol.11 No.10

A nucleic acid hydrolyzing recombinant antibody confers resistance to curtovirus infection in tobacco

Lee, Gunsup,Shim, Hye-Kyung,Kwon, Myung-Hee,Son, Su-Hwan,Kim, Ki-Yoon,Park, Eul-Yong,Lee, Taek-Kyun,Lee, Woo-Ram,Auh, Chung-Kyoon,Kim, Donggiun,Kim, Yong-Sung,Lee, Sukchan Springer-Verlag 2013 Plant cell, tissue and organ culture Vol.115 No.2

Bee Venom Reduces Atherosclerotic Lesion Formation via Anti-Inflammatory Mechanism.

Lee, Woo-Ram,Kim, Soo-Jung,Park, Ji-Hyun,Kim, Kyung-Hyun,Chang, Young-Chae,Park, Yoon-Yup,Lee, Kwang-Gill,Han, Sang-Mi,Yeo, Joo-Hong,Pak, Sok Cheon,Park, Kwan-Kyu Institute for Advanced Research in Asian Science a 2010 The American journal of Chinese medicine Vol.38 No.6

<P>The components of bee venom (BV) utilized in the current study were carefully scrutinized with chromatography. Despite its well documented anti-inflammatory property, there are no reports regarding the influence of BV on the expression of cellular adhesion molecules in the vascular endothelium. A great amount of information exists concerning the effects of an atherogenic diet on atherosclerotic changes in the aorta, but little is known about the molecular mechanisms and the levels of gene regulation involved in the anti-inflammatory process induced by BV. The experimental atherosclerosis was induced in mice by a lipopolysaccharide (LPS) injection and an atherogenic diet. The animals were divided into three groups, the NC groups of animals that were fed with a normal diet, the LPS/fat group was fed with the atherogenic diet and received intraperitoneal injections of LPS, and the LPS/fat + BV group was given LPS, an atherogenic diet and intraperitoneal BV injections. At the end of each treatment period, the LPS/fat + BV group had decreased levels of total cholesterol (TC) and triglyceride (TG) in their serum, compared to the LPS/fat group. The LPS/fat group had significant expression of tumor necrosis factor (TNF)-관 and interleukin (IL)-1관 in the serum, compared with the NC group (p < 0.05). The amount of cytokines reduced consistently in the BV treatment groups compared with those in LPS/fat group. BV significantly reduced the amount of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), transforming growth factor-관1 (TGF-관1) and fibronectin in the aorta, compared with the LPS/fat group (p < 0.05). A similar pattern was also observed in the heart. In conclusion, BV has anti-atherogenic properties via its lipid-lowering and anti-inflammatory mechanisms.</P>

Recovering Color of Dark Images Using Tone Mapping and MSRCR

Woo-Ram Lee,Dong-Guk Hwang,Byoung-Min Jun 보안공학연구지원센터 2014 International Journal of Software Engineering and Vol.8 No.1

Gene silencing by cell-penetrating, sequence-selective and nucleic-acid hydrolyzing antibodies

Lee, Woo-Ram,Jang, Ji-Young,Kim, Jeong-Sun,Kwon, Myung-Hee,Kim, Yong-Sung Oxford University Press 2010 Nucleic acids research Vol.38 No.5

<P>Targeting particular mRNAs for degradation is a fascinating approach to achieve gene silencing. Here we describe a new gene silencing tool exploiting a cell-penetrating, nucleic-acid hydrolyzing, single-domain antibody of the light-chain variable domain, 3D8 VL. We generated a synthetic library of 3D8 VL on the yeast surface by randomizing residues located in one of two β-sheets. Using 18-bp single-stranded nucleic acids as target substrates, including the human Her2/neu-targeting sequence, we selected 3D8 VL variants that had ∼100–1000-fold higher affinity and ∼2–5-fold greater selective hydrolyzing activity for target substrates than for off targets. 3D8 VL variants efficiently penetrated into living cells to be accumulated in the cytosol and selectively decreased the amount of target sequence-carrying mRNAs as well as the proteins encoded by these mRNAs with minimal effects on off-target genes. In particular, one 3D8 VL variant targeting the Her2 sequence showed more efficient downregulation of Her2 expression than a small-interfering RNA targeting the same Her2 sequence, resulting in apoptotic cell death of Her2-overexpressing breast cancer cells. Our results demonstrate that cell-penetrating 3D8 VL variants with sequence-selective, nucleic-acid-hydrolyzing activity can selectively degrade target mRNAs in the cytosol, providing a new gene silencing tool mediated by antibody.</P>