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Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2
Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea
Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor
Williams, Simon J.,Sohn, Kee Hoon,Wan, Li,Bernoux, Maud,Sarris, Panagiotis F.,Segonzac, Cecile,Ve, Thomas,Ma, Yan,Saucet, Simon B.,Ericsson, Daniel J.,Casey, Lachlan W.,Lonhienne, Thierry,Winzor, Dona American Association for the Advancement of Scienc 2014 Science Vol.344 No.6181
<P><B>Universal Immune Function</B></P><P>Certain pathogen effectors are detected in plants by cytoplasmic receptors. First solving the crystal structures of <I>Arabidopsis</I> receptors, <B>Williams <I>et al.</I></B> (p. 299; see the Perspective by <B>Nishimura and Dangl</B>) discovered that in the resting state, the structures form a heterodimer that readies the complex for effector binding and keeps the signaling domains from firing too early. Once the pathogen effector binds, the structure of the complex shifts such that the signaling domains can form a homodimer to initiate downstream signaling. Similarities between these plant-pathogen receptors and Toll-like receptors in animals suggest the molecular mechanisms may translate broadly.</P>
Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression
Williams, Adam,Lee, Gap Ryol,Spilianakis, Charalampos G.,Hwang, Soo Seok,Eisenbarth, Stephanie C.,Flavell, Richard A. National Academy of Sciences 2013 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.110 No.17
<P>The T helper type 2 (Th2) cytokine genes <I>Il4</I>, <I>Il5</I>, and <I>Il13</I> are contained within a 140-kb region of mouse chromosome 11 and their expression is controlled by a locus control region (LCR) embedded within this locus. The LCR is composed of a number of DNase I–hypersensitive sites (HSs), which are believed to encompass the regulatory core of the LCR. To determine the function of these sites, mutant mice were generated in which combinations of these HSs had been deleted from the endogenous LCR, and the effect on Th2 cytokine expression was assessed through the use of in vivo and in vitro models. These experiments revealed that, although all of the hypersensitive sites analyzed are important for appropriate LCR function, some sites are more important than others in regulating cytokine expression. Interestingly, each LCR mutation showed contrasting effects on cytokine expression, in some cases with mutants displaying opposing phenotypes between in vitro cultures and in vivo immunizations. These studies indicated that Rad50 hypersensitive site 6 was the singularly most important HS for Th2 cytokine expression, displaying consistent reductions in cytokine levels in all models tested. Furthermore analysis of chromatin modifications revealed that deletion of Rad50 hypersensitive site 6 impacted epigenetic modifications at the promoters of the <I>Il4</I>, <I>Il5</I>, and <I>Il13</I> genes as well as other regulatory sites within the Th2 locus.</P>
Williams S. Ebhota,Tien-Chien Jen 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.7 No.1
The rise in global urbanization comes with sustainable development challenges, especially in lower-middle-income countries. In response to these urbanization and energy challenges, this study focuses on the roles of energy materials (EMs) advances on community-scale hybrid renewable energy systems (HRES). The study proposes the integration of energy material (EM) R&D into HRES (EMR&D-HRES). The study examines the economic benefits and the environmental and health consequences that trail the deployment of fossil fuels. Special attention was given to SSA, a region that—accommodates the highest population without modern energy; emits the least CO2 to the global CO2 emissions and yet endangered by climate change challenges and air pollution diseases. The study includes global responses to energy challenges, such as increase alternative energies share, with special attention to solar photovoltaic (PV) power generation technologies; policy framework; HRES and effects of PV materials advances on HRES. This study is of the view that a further breakthrough in the production of low-cost flexible thin film PV modules will facilitate energy trilemma accomplishment. The exploitation of the attributes of atomic layer deposition in manufacturing of thin film is seen as a potential future production technique, suitable for efficient flexible thin-film PV module production.
Art as Peace Education at ‘Dark’ Museums and Sites in the United Kingdom, Europe, and Southeast Asia
Williams, Christopher 서울대학교 통일평화연구원 2018 Asian Journal of Peacebuilding Vol.6 No.1
Art increasingly appears at “dark” museums and related formal sites to balance the traditional exhibits of war. This article explores how art might contribute a peace education perceptive in differing countries and a globalizing context. Case studies from the United Kingdom, Europe (West and East), and Southeast Asia (Cambodia and Vietnam) are analyzed. The former deploys new technologies and supports wellknown artists who appeal to art markets. Asian curation relies more on creativity, including children’s and victim’s art. Both deploy artistic devices to symbolize the scale of atrocities and create aesthetic depth-juxtaposition, prominence, perspective, repetition, patterning, and soundscapes. The analysis provides tools and checklists to assist curation and inform artists, and concludes that critical educational processes are as important as the art.
Application and testing of a triple bubbler sensor in molten salts
Williams A.N.,Shigrekar A.,Galbreth G.G.,Sanders J. 한국원자력학회 2020 Nuclear Engineering and Technology Vol.52 No.7
A triple bubbler sensor was tested in LiCleKCl molten salt from 450 to 525 C in a transparent furnace to validate thermal-expansion corrections and provide additional molten salt data sets for calibration and validation of the sensor. In addition to these tests, a model was identified and further developed to accurately determine the density, surface tension, and depth from the measured bubble pressures. A unique feature of the model is that calibration constants can be estimated using independent depth measurements, which allow calibration and validation of the sensor in an electrorefiner where the salt density and surface tension are largely unknown. This model and approach were tested using the current and previous triple bubbler data sets, and results indicate that accuracies are as high as 0.03%, 4.6%, and 0.15% for density, surface tension, and depth, respectively