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Biosafety Risk Control Strategies in Laboratory Animal Research
Weng Shun-tai,Li Qu-wen,Gao Ya-dong,Qiu Yu-feng 한국산업안전보건공단 산업안전보건연구원 2024 Safety and health at work Vol.15 No.1
To understand biosafety's current situation in laboratory animal research and risk factors affecting occupational health. Compliance surveys were conducted by questionnaire via Questionnaire Star (an application app on the Internet) in Chinese. Thirty-nine anonymous questionnaires were collected. The surveyed institution has established 24 types of ABSL (Animal Biosafety Laboratory) and biosafety management organizations and systems equipped with safety equipment. Our study also suggests that the principal of the laboratory establishment fails to perform supervision and inspection responsibilities, the inappropriate design of the animal biosafety laboratory, non-standardized personnel training and health management, non-strict waste management, and insufficient emergency management. The administrative department and work units should address certain safety and occupational health risks in laboratory animal research. The author proposes control strategies based on organizational guarantee, personnel management, emergency management, etc., to help prevent risks and ensure occupational health. Due to regional limitations and small sample size, the results may not be generalisable to all parts of the world. However, some of the key common issues may also be present in other regions, so we believe that this research still has some relevance.
Solubility of N-ethylcarbazole in ethanol+petroleum ether mixtures at various temperatures
Wenge Yang,Keyi Wu,Yong-Hong Hu,Tuan Zhang,Qirun Guo,Shouhai Yang,Ying Shi 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.6
The solubility of N-ethylcarbazole in (ethanol+petroleum ether) binary solvent mixtures was measured with the temperature changing from 280.15 K to 316.15 K. The experimental data matched the solvent/Redlich-Kister (CNIBS/R-K) equation and the Jouyban-Acree equation. Computational results showed the CNIBS/R-K equation was more suitable than the Jouyban-Acree equation. The solution process in the thermodynamic properties, including the Gibbs energy, enthalpy, and entropy, was calculated by the van’t Hoff analysis.
A Service Pipelining Model for Web GIS Based on Distributed Environment
Weng Yu,Cheng WenYi 보안공학연구지원센터 2015 International Journal of Grid and Distributed Comp Vol.8 No.6
Pipeline is one of the classic technologies to enhance efficiency. When the amount of data is becoming more and more big when processing, it becomes a big problem that how to improve the efficiency with existing resources. In the meantime, a large number of older hardware and software feel difficult to deal with new task in new environment with the accumulation of time. In order to ameliorate efficiency of web GIS with low cost, this paper propose a service pipelining model for Web GIS based on distributed environment. The system build a basic service library to reuse plenty of existing resource, and design a segment system to organize pipeline in level of service to improve efficiency. The model can be used in many platforms and occasions, not limited to the application we proposed in this paper. The model we proposed has been proved work well in our experiments and test.
A Multi-Domain Web Text Feature Extraction Model for e-Science Environment
Weng Yu 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.11
The traditional information extraction methods based on specific domain usually depend on the domain dictionaries to discover the text feature. It is inconvenient for reproducing and difficult to transplant in multi-domain environment. The application scope is limited seriously. Oriented to the deficiencies above, a multi-domain web text feature extraction model for e-Science is proposed (named e-FTM). This model adopts the Chinese split words technology without dictionary into the process of multi-domain text feature discovery and avoids the dependency of domain dictionaries effectively. With the help of classification of common and individual features, the model tracks the generation and the development trend of domain events dynamically, and forms a couple of local data centers eventually. Through cooperative scheduling the domain knowledge between different local data centers, the knowledge utilization efficiency of the domain information in the global scope is improved sharply. To validate the performance, the experiments on the multi-domain text feature extraction, topic features dynamical tracking and the domain knowledge cooperative scheduling demonstrate that the model has higher application validity and practicality in e-Science environment.
Weng, Ling-Ling,Xiang, Jian-Feng,Lin, Jin-Bo,Yi, Shang-Hui,Yang, Li-Tao,Li, Yi-Sheng,Zeng, Hao-Tao,Lin, Sheng-Ming,Xin, Dong-Wei,Zhao, Hai-Liang,Qiu, Shu-Qi,Chen, Tao,Zhang, Min-Guang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24
Liver cancer is one of leading digestive malignancies with high morbidity and mortality. There is an urgent need for the development of novel therapies for this deadly disease. It has been proven that asparagus polysaccharide, one of the most active derivates from the traditional medicine asparagus, possesses notable antitumor properties. However, little is known about the efficacy of asparagus polysaccharide as an adjuvant for liver cancer chemotherapy. Herein, we reported that asparagus polysaccharide and its embolic agent form, asparagus gum, significantly inhibited liver tumor growth with transcatheter arterial chemoembolization (TACE) therapy in an orthotopic hepatocellular carcinoma (HCC) tumor model, while significantly inhibiting angiogenesis and promoting tumor cell apoptosis. Moreover, asparagine gelatinous possessed immunomodulatory functions and showed little toxicity to the host. These results highlight the chemotherapeutic potential of asparagus polysaccharide and warrant a future focus on development as novel chemotherapeutic agent for liver cancer TACE therapy.
Characterization of the B cell receptor repertoire of patients with acute coronary syndrome
Weng Ruiqiang,Liu Sudong,Gu Xiaodong,Zhong Zhixiong 한국유전학회 2022 Genes & Genomics Vol.44 No.1
Background: Acute coronary syndrome (ACS) is a complex cardiovascular disease whose development involves the dysregulation of adaptive immune responses. Though it has been proven that T cells associate with inflammation in the development of ACS, the function of B cells in disease remains unclear. Objective: The aim of this study was to reveal the diversity of the B cell receptor (BCR) repertoire of patients with ACS. Methods: We conducted a pilot study to sequence the immune repertoire of peripheral blood mononuclear cells (PBMCs) from patients with ACS, including acute myocardial infarction (AMI) and unstable angina (UA), and quantitatively characterized BCR repertoires by bioinformatics analysis. Results: We found that patients with AMI and UA had lower BCR repertoire diversity compared with controls with normal coronary arteries (NCA). Lower percentages of productive unique BCR nt sequences and higher percentages of top 200 unique BCR sequences were identified in AMI and UA patients than NCA controls. Patients had various preferential usage of V and J genes from B cell clones in accordance with the disease severity of coronary arteries. AMI patients had distinct CDR3 amino acids, and their frequency differed among patients with ACS. Conclusions: Our results indicate that differential BCR signatures represent an imprint of distinct repertoires among ACS patients. This study thereby opens up the prospect of studying disease-relevant B cells to better understand and treat ACS.
Mobile taxi booking application service’s continuance usage intention by users
Weng, Gooi Sai,Zailani, Suhaiza,Iranmanesh, Mohammad,Hyun, Sunghyup Sean Pergamon 2017 Transportation Research Part D. Transport & Enviro Vol.57 No.-
<P><B>Abstract</B></P> <P>The long-term development of a mobile booking taxi application service depends on the continued use of its passengers. The aim of this study is to investigate the determinants of the mobile taxi booking application service’s continuance intention, using the technology continuance theory by including the perceived risk and subjective norms. The data were collected by surveying 387 users of the mobile taxi application service. The data were analysed by applying the partial least squares technique. The analysis showed that the technology continuance theory has extensive power to explain the continuance intention to use the mobile booking taxi application. Subjective norms also have a significant effect on the attitude of mobile booking taxi application users which represents an important contribution to technology continuance theory extension. The theoretical and practical significances of the study have been discussed.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The early acceptance of an MTB Apps does not guarantee continuation. </LI> <LI> Studies on continuance intention of users toward MTB App use are still lacking. </LI> <LI> Results will help App developers to grasp the factors that result in continued MTB App use. </LI> </UL> </P>