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MLL4 Regulates the Progression of Non-Small-Cell Lung Cancer by Regulating the PI3K/AKT/SOX2 Axis
Yang Yang,Rongfang Qiu,Qiaoyou Weng,Ziwei Xu,Jingjing Song,Siyu Zhao,Miaomiao Meng,Dengke Zhang,Chunli Kong,Hailin Wang,Min Xu,Zhongwei Zhao,Jiansong Ji 대한암학회 2023 Cancer Research and Treatment Vol.55 No.3
Purpose Mixed-lineage leukemia protein 4 (MLL4/KMT2D) is a histone methyltransferase, and its mutation has been reported to be associated with a poor prognosis in many cancers, including lung cancer. We investigated the function of MLL4 in lung carcinogenesis. Materials and Methods RNA sequencing (RNA-seq) in A549 cells transfected with control siRNA or MLL4 siRNA was performed. Also, we used EdU incorporation assay, colony formation assays, growth curve analysis, transwell invasion assays, immunohistochemical staining, and in vivo bioluminescence assay to investigate the function of MLL4 in lung carcinogenesis. Results We found that MLL4 expression was downregulated in non–small cell lung cancer (NSCLC) tissues compared to adjacent normal tissues and tended to decrease with disease stage progression. We analyzed the transcriptomes in control and MLL4- deficient cells using high-throughput RNA deep sequencing (RNA-seq) and identified a cohort of target genes, such as SOX2, ATF1, FOXP4, PIK3IP1, SIRT4, TENT5B, and LFNG, some of which are related to proliferation and metastasis. Our results showed that low expression of MLL4 promotes NSCLC cell proliferation and metastasis and is required for the maintenance of NSCLC stem cell properties. Conclusion Our findings identify an important role of MLL4 in lung carcinogenesis through transcriptional regulation of PIK3IP1, affecting the PI3K/AKT/SOX2 axis, and suggest that MLL4 could be a potential prognostic indicator and target for NSCLC therapy.
Solubility of N-ethylcarbazole in ethanol+petroleum ether mixtures at various temperatures
Wenge Yang,Keyi Wu,Yong-Hong Hu,Tuan Zhang,Qirun Guo,Shouhai Yang,Ying Shi 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.6
The solubility of N-ethylcarbazole in (ethanol+petroleum ether) binary solvent mixtures was measured with the temperature changing from 280.15 K to 316.15 K. The experimental data matched the solvent/Redlich-Kister (CNIBS/R-K) equation and the Jouyban-Acree equation. Computational results showed the CNIBS/R-K equation was more suitable than the Jouyban-Acree equation. The solution process in the thermodynamic properties, including the Gibbs energy, enthalpy, and entropy, was calculated by the van’t Hoff analysis.
Huijuan Yang,Zhi-Hua Yang,Wenge Dong 대한기생충학ㆍ열대의학회 2022 The Korean Journal of Parasitology Vol.60 No.4
Laelapinae mites are involved in transmission of microbial diseases between wildlife and humans, with an impact on public health. In this study, 5 mite members in the subfamily Laelapinae (laelapin mites; LM) were morphologically identified by light microscopy, and the phylogenetic relationship of LM was analyzed in combination with the sequence information of part of the LM cytochrome oxidase subunit I (cox1) gene. The morphological identification revealed that 5 mites belonged to the genera Laelaps and Haemolaelaps, respectively. Sequence analysis showed that the ratio of non-synonymous mutation rate to synonymous mutation rate of LM was less than 1, indicating that the LM cox1 gene had undergone purifying selection. Phylogenetic analysis showed that the Laelapinae is a monophyletic group. The genera Haemolaelaps and Hyperlaelaps did not separated into distinct clades but clustered together with species of the genus Laelaps. Our morphological and molecular analyses to describe the phylogenetic relationships among different genera and species of Laelapinae provide a reference for the improvement and revision of the LM taxonomy system.
Yang Hua,Xu Xi,Chengyi Qu,Jinglong Du,Maofeng Weng,Bao Ye 한국인터넷정보학회 2024 KSII Transactions on Internet and Information Syst Vol.18 No.1
Most frequency-domain remote sensing image watermarking algorithms embed watermarks at random locations, which have negative impact on the watermark invisibility. In this study, we propose an adaptive watermarking scheme for remote sensing images that considers the information complexity to select where to embed watermarks to improve watermark invisibility without affecting algorithm robustness. The scheme converts remote sensing images from RGB to YCbCr color space, performs two-level DWT on luminance Y, and selects the high frequency coefficient of the low frequency component (〖HH〗_2^Y) as the watermark embedding domain. To achieve adaptive embedding, 〖HH〗_2^Y is divided into several 8*8 blocks, the entropy of each sub-block is calculated, and the block with the maximum entropy is chosen as the watermark embedding location. During embedding phase, the watermark image is also decomposed by two-level DWT, and the resulting high frequency coefficient (〖HH〗_2^W) is then embedded into the block with maximum entropy using α- blending. The experimental results show that the watermarked remote sensing images have high fidelity, indicating good invisibility. Under varying degrees of geometric, cropping, filtering, and noise attacks, the proposed watermarking can always extract high identifiable watermark images. Moreover, it is extremely stable and impervious to attack intensity interference.
Weng, Ling-Ling,Xiang, Jian-Feng,Lin, Jin-Bo,Yi, Shang-Hui,Yang, Li-Tao,Li, Yi-Sheng,Zeng, Hao-Tao,Lin, Sheng-Ming,Xin, Dong-Wei,Zhao, Hai-Liang,Qiu, Shu-Qi,Chen, Tao,Zhang, Min-Guang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24
Liver cancer is one of leading digestive malignancies with high morbidity and mortality. There is an urgent need for the development of novel therapies for this deadly disease. It has been proven that asparagus polysaccharide, one of the most active derivates from the traditional medicine asparagus, possesses notable antitumor properties. However, little is known about the efficacy of asparagus polysaccharide as an adjuvant for liver cancer chemotherapy. Herein, we reported that asparagus polysaccharide and its embolic agent form, asparagus gum, significantly inhibited liver tumor growth with transcatheter arterial chemoembolization (TACE) therapy in an orthotopic hepatocellular carcinoma (HCC) tumor model, while significantly inhibiting angiogenesis and promoting tumor cell apoptosis. Moreover, asparagine gelatinous possessed immunomodulatory functions and showed little toxicity to the host. These results highlight the chemotherapeutic potential of asparagus polysaccharide and warrant a future focus on development as novel chemotherapeutic agent for liver cancer TACE therapy.
Solvent extraction of Fe3+ from the hydrochloric acid route phosphoric acid by D2EHPA in kerosene
Yang Jin,Yujing Ma,Yanling Weng,Xuhong Jia,Jun Li 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.5
It is necessary to remove Fe3+ from the hydrochloric acid route phosphoric acid before it is purified by trin-butyl phosphate (TBP), otherwise the final product will fail because of the excessive iron content. Di-(2-ethylhexyl) phosphoric acid (D2EHPA, HA) is effective for Fe3+ extraction. Therefore, the solvent extraction of Fe3+ from the HCl-route phosphoric acid by D2EHPA in kerosene is investigated. The effects of the extraction time, temperature and concentrations of phosphoric acid, D2EHPA, calcium chloride and Fe3+ on the extraction process are studied. The mechanism of the extraction is explained and the extracted species is demonstrated to be FeClA2 4HA. D2EHPA has a high efficiency for Fe3+ extraction from the synthesis and actual HCl-route phosphoric acid with extraction percent of 98.61% and 96.50%, respectively via a cross-current 3-stage extraction. The loaded organic phase is effectively stripped (99.9%) using 6 mol/L hydrochloric acid. The extractant also has a high stability under a closed operation condition. D2EHPA can serve as an adequate extractant for the extraction of Fe3+ from the HCl-route phosphoric acid.
Weng, Wan-Wen,Dong, Meng-Jie,Zhang, Jun,Yang, Jun,Xu, Qin,Zhu, Yang-Jun,Liu, Ning-Hu Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22
Aim: The purpose of the current study was to conduct a systematic review of the published literature to evaluate the diagnostic accuracy of FDG-PET, PTE/CT, MRI and scintigraphy for multiple myeloma related bone disease. Methods: Through a search of PubMed, EMBASE, and the Cochrane Library, two reviewers independently assessed the methodological quality of each study. We estimated pooled sensitivity, specificity, positive and negative likelihood ratios (PLR and NLR), and two sample Z-tests were conducted to evaluate for differences in sensitivity, specificity, area under the curve (AUC), and the $Q^*$ index between any two diagnostic modalities. Results: A total of 17 studies were reviewed. The MRI had a pooled sensitivity of 0.88, specificity of 0.68, AUC of 0.897, and $Q^*$ index of 0.828, whereas for MIBI, the corresponding values were 0.98, 0.90, 0.991, and 0.962, respectively, and for bone scan, they were 066, 0.83, 0.805, and 0.740, respectively. The corresponding values of MIBI were 0.98, 0.90, 0.991, and 0.962, respectively. For PET and PET/CT, the values were 0.91, 0.69, 0.927 and 0.861, respectively. Statistically significant differences were not found in the sensitivity, specificity, AUC, and $Q^*$ index between MRI, scintigraphy, FDG-PET and PET/CT. Conclusions: On the condition that X ray is taken as a reference in our study, we suggested that FDG-PET, PTE/CT, MRI and scintigraphy are all associated with high detection rate of bone disease in patients with MM. Thus, in clinical practice, it is recommended that we could choose these tests according to the condition of the patient.
Yang, C.C.,Weng, S.H. Techno-Press 2013 Advances in concrete construction Vol.1 No.3
Mortar microstructure is considered as a three-phase composite material, which is cement paste, fine aggregate and interfacial transition zone. Interfacial transition zone is the weakest link between the cement paste and fine aggregate, so it has a significant role to determine the properties of cementitious composites. In this study, specimens (w/c = 0.35, 0.45, 0.55) with various volume fractions of fine aggregate ($V_f$ = 0, 0.1, 0.2, 0.3 and 0.4) were cast and tested. To predict the equivalent migration coefficient ($M_e$) and migration coefficient of interfacial transition zone ($M_{itz}$), double-inclusion method and Mori-Tanaka theory were used to estimate. There are two stages to estimate and calculate the thickness of interfacial transition zone (h) and migration coefficient of interfacial transition zone ($M_{itz}$). The first stage, the data of experimental chloride ion migration coefficient ($M_s$) was used to calculate the equivalent migration coefficient of fine aggregate with interfacial transition zone ($M_e$) by Mori-Tanaka theory. The second stage, the thickness of interfacial transition zone (h) and migration coefficient of interfacial transition zone ($M_{itz}$) was calculated by Hori and Nemat-Nasser's double inclusion model. Between the theoretical and experimental data a comparison was conducted to investigate the behavior of interfacial transition zone in mortar and the effect of interfacial transition zone on the chloride migration coefficient, the results indicated that the numerical simulations is derived to the $M_{itz}/M_m$ ratio is 2.11~8.28. Additionally, thickness of interfacial transition zone is predicted from $10{\mu}m$, 60 to $80{\mu}m$, 70 to $100{\mu}m$ and 90 to $130{\mu}m$ for SM30, M35, M45 and M55, respectively.