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Tung Nguyen-Thach,Nguyen Canh-Hung,Nguyen Van-Duong,Nguyen Thi-Hong-Thuy,Nguyen Van-Lam,Tran Cao-Son,Pham Thi-Minh-Hue 한국약제학회 2020 Journal of Pharmaceutical Investigation Vol.50 No.4
Purpose The study aimed firstly to determine the release behavior of the model drug (berberine chloride) from the dry coated tablets. The second objective of this study was to evaluate the exact location of the dry coated tablets in in vivo. Methods The colon targeting tablets were developed by dry powder coating technique on pan coater. The drug release behavior was determined in the three continuous mediums: pH 1.2; 7.4 and 6.8 plus pectinase. The location of the dry coated tablets in the gastrointestinal tract of human volunteers was observed through the X-ray imaging of the dry coated tablets containing the optimized radiocontrast agents. Results The release kinetics of berberine chloride from the dry coated tablets was mainly controlled by erosion and enzyme sensitive mechanism. The optimum dry coated tablets having the coating powders of pectin 102:HPMC K4 M (2:1) with the coating level of 200%, and the tablet core with BaSO4 10% and iobitridol 30% as radiocontrast agents were observed in the caecum and ascending colon of human volunteers after 5–6 h of oral administration. Conclusion The successful development of these dosage forms is believed to have a high potential in precisely monitoring the release of highly potent drugs such as anti-inflammatory drugs in bowel diseases.
Nguyen Huu Tung,Chau Van Minh,Phan Van Kiem,Hoang Thanh Huong,Tran Thu Ha,Nguyen Tien Dat,Nguyen Xuan Nhiem,Nguyen Xuan Cuong,Jae-Hee Hyun,Hee-Kyoung Kang,김영호 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.12
One new C29 sterol with a cyclopropane ring at C-25 and C-26, aragusteroketal B (1), and aragusterol B (2) were isolated from the Vietnamese marine sponge Ianthella sp. Their structures were elucidated by extensive spectroscopic analyses. Both 1 and 2 showed moderate cytotoxic activity against MCF-7, SK-Hep-1, and HeLa cell lines with IC50 in the range of 12.8-27.8 μM.
Chemical Components from the Vietnamese Soft Coral Lobophytum sp.
Tung, Nguyen Huu,Minh, Chau Van,Kiem, Phan Van,Huong, Hoang Thanh,Nam, Nguyen Hoai,Cuong, Nguyen Xuan,Quang, Tran Hong,Nhiem, Nguyen Xuan,Hyun, Jae-Hee,Kang, Hee-Kyoung,Kim, Young-Ho 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.4
Chromatographic separation resulted in the identification of one new squalene derivative, named lobophytene (1), three cembranoid diterpenes (2-4), and two sterols (5 and 6) from the Vietnamese marine soft coral Lobophytum sp. Their structures were identified on the basis of extensive spectroscopic data and comparison of those with reported data. Compounds 1 and 2 showed significant cytotoxic activities against lung (A549) and colon (HT-29) cell lines with $IC_{50}$ values of 8.2 and $5.6\;{\mu}M$ for 1; 5.1 and $1.8\;{\mu}M$ for 2, respectively.
A New Sterol from the Soft Coral Lobophytum crassum
Nguyen, Phuong Thao,Nguyen, Hoai Nam,Nguyen, Xuan Cuong,Nguyen, Xuan Nhiem,Pham, The Tung,Tran, Hong Quang,Nguyen, Thi Thanh Ngan,Phan, Van Kiem,Chau, Van Minh,Kim, Young Ho Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.1
Nguyen Thu Hang,Nguyen Mai Chi,Nguyen Hoang Trung,Thi Y Van Tran,Vu Ngoc Trung,Thu Hang Bui,Duc Trinh Chu,Bui Tung Thanh,Jen Chun-Ping,Quang Loc Do 한국농업기계학회 2024 바이오시스템공학 Vol.49 No.1
Purpose Circulating tumor cell separation and analysis have played a critical role in cancer diagnosis, prognosis, and treatment. In this work, we aim to design and investigate a novel biochip that integrates dielectrophoresis, microfl uidic technology to separate circulating tumor cells from blood cells. To create a dielectrophoresis-induced non-uniform electric fi eld, a facing-electrode design was proposed and utilized, in which a slanted electrode array and a simple rectangular ground electrode are placed parallel on the top and bottom parts of the microfl uidic channel, respectively. This design can reduce the particle position dependence in the microchannel and the complexity of the microfabrication process. Methods The separation process, effi ciency, and optimization of the proposed device were numerically investigated using the fi nite element method. Parametric research was conducted to comprehensively examine the impact of various operating and design factors on the cell movement and trajectories in the microfl uidic device. Results The results indicated the potential of the proposed biochip to ensure cancer cell separation from blood cells with high effi ciency, high purity in a label-free, non-invasive, easy integration, and low-cost manner. Under the optimal conditions, the separation effi ciency reached 92%, 88%, and 96% for human colon cancer cells (HT-29), red blood cells, and white blood cells, respectively. Conclusions In this study, a novel DEP-based microfl uidic chip was proposed to separate HT-29 tumor cells from blood cells and numerically investigated to verify the performance of the biochip design. Our fi ndings could provide a foundation for further theoretical and practical investigations. The proposed system can separate cancer cells from red blood cells and white blood cells as well as off ers numerous advantages, such as compact size, low voltage, high effi ciency, non-invasiveness, and label-free nature. The tumor cell enrichment platform has the potential for application in cancer detection, analysis, and assessment.
Modeling of the Temperature Dependence of the Dielectric Function of Biaxial α-SnS
Nguyen Hoang Tung,Le Van Long,Kim Tae Jung,Nguyen Xuan Au,Kim Young Dong 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.77 No.11
The dielectric functions of biaxial α-SnS at temperatures from 27 to 350 K are modeled with an analytic expression for Tauc-Lorentz oscillators. The temperature dependence of all the obtained parameters are fitted to third-order polynomial equations. The results provide a comprehensive database of the coefficients, which allows the construction of the dielectric function of biaxial α-SnS at arbitrary temperatures from 27 to 350 K and in the spectra range from 0.73 to 6.0 eV, which can be converted to optical constant values such as refractive indices and the absorption coefficients along the armchair-, zigzag-, and c-axes directions for designing optoelectronic devices based on the SnS material.
Van Hoa Nguyen,Thi Mai Phung Bui,Thanh Phong Le,Hoang Tung Nguyen,Minh Tuyen Truong,Minh Nhut Do,Van Nha Duong 인간식물환경학회 2022 인간식물환경학회지 Vol.25 No.6
Background and objective: For countries vulnerable to climate change as Vietnam, indigenous knowledge (IK) might assist in revealing the values of local people's adaptations to environmental stresses and potentially support decision-making. Despite IK can provide the adaptive capacity of local people's activities within environmental contexts, but it is rapidly vanishing. This study aimed to describe the documentation of IK associated with climate change adaptation of farmers in the Vietnam Mekong Delta (VMD). Methods: We focused on collecting and establishing online access to IK documents through collaboration between IK holders, public sector, collecting institutions, and researchers in the five agro-ecological zones of the VMD. An online IK database for storing IK documents has been designed and implemented based on the web application schema. Results: Through interviews, we gathered IK from farming practices that are well-adapted to climate risks such as floods, droughts, and saltwater intrusions as well as traditional knowledge being used to forecast weather, flood, and saltwater intrusion. The database for storing IK documents has been successfully deployed using free and open-source software. The database currently contains more than 260 IK documents, with their location on agro-ecological zones displayed on a web-based map. Conclusion: We have captured and provided an online access to IK on climate change adaptation of the farmers in the VMD. This research is expected as an initial strategy for long-term sustainable development of the agriculture system in this region.
Steamed Ginseng-Leaf Components Enhance Cytotoxic Effects on Human Leukemia HL-60 Cells
Tung, Nguyen Huu,Song, Gyu Yong,Minh, Chau Van,Kiem, Phan Van,Jin, Long Guo,Boo, Hye-Jin,Kang, Hee-Kyoung,Kim, Young Ho The Pharmaceutical Society of Japan 2010 Chemical & pharmaceutical bulletin Vol.58 No.8
<P>Three new dammarane-type glycosides, named ginsenosides SL<SUB>1</SUB>—SL<SUB>3</SUB> (<B>1</B>—<B>3</B>), and eleven known compounds (<B>4</B>—<B>14</B>) were isolated from the heat-processed leaves of <I>Panax ginseng</I>. Their structures were elucidated on the basis of extensive chemical and spectroscopic methods. Cytotoxic-activity testing of compounds <B>1</B>—<B>14</B> against human leukemia HL-60 cells showed that ginsenosides Rh<SUB>3</SUB> (<B>11</B>) and Rk<SUB>2</SUB> (<B>12</B>) exhibited potent effects with IC<SUB>50</SUB> values of 0.8 and 0.9 μ<SMALL>M</SMALL>. In addition, ginsenosides SL<SUB>3</SUB> (<B>3</B>), 20<I>S</I>-Rg<SUB>2</SUB> (<B>7</B>), F<SUB>4</SUB> (<B>10</B>), 20<I>S</I>-Rh<SUB>2</SUB> (<B>13</B>) displayed strong activity with IC<SUB>50</SUB> values of 9.0, 9.0, 7.5, and 8.2 μ<SMALL>M</SMALL>, respectively. This is the first report on chemical components of the steamed ginseng leaves.</P>