Inhibition of Dll4/Notch1 pathway promotes angiogenesis of Masquelet’s induced membrane in rats

Qian Tang,Haimin Jin,Minji Tong,Gang Zheng,Zhongjie Xie,Shangkun Tang,Jialei Jin,Ping Shang,Huazi Xu,Liyan Shen,Yu Zhang,Haixiao Liu 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

The Masquelet’s induced membrane technique for repairing bone defects has been demonstrated to be a promising treatment strategy. Previous studies have shown that the vessel density of induced membrane is decreased in the late stage of membrane formation, which consequently disrupts the bone healing process. However, relatively little is known about certain mechanisms of vessel degeneration in the induced membrane tissue and whether promotion of angiogenesis in induced membranes can improve bone regeneration. Here, we showed that the Delta-like ligand 4/ Notch homolog 1 (Dll4/Notch1) pathway was relatively activated in the late stage of induced membrane, especially at the subcutaneous site. Then, DAPT, a classical γ-secretase inhibitor, was applied to specifically inhibit Notch1 activation, followed by up-regulation of vascular endothelial growth factor receptor 2 (VEGFR2) and CD31 expression. DAPTmodified induced membranes were further confirmed to contribute to bone regeneration after autogenous bone grafting. Finally, in vitro experiments revealed that knocking down Notch1 contributed to the functional improvement of endothelial progenitor cells (EPCs) and that DAPT-treated induced membrane tissue was more favorable for angiogenesis of EPCs compared with the vehicle group. In conclusion, the present findings demonstrate that Dll4/ Notch1 signaling is negatively associated with the vessel density of induced membrane. Pharmacological inhibition of Notch1 attenuated the vessel degeneration of induced membrane both in vitro and in vivo, which consequently improved bone formation at the bone defect site and graft resorption at the subcutaneous site.

Spatial Distribution Pattern and Association of Crowns and Saplings for Major Tree Species in the Mixed Broadleaved-Korean Pine Forest of Xiaoxing'an Mountains, China

Jin, Guangze,Li, Zhihong,Tang, Yan,Kim, Ji-Hong Korean Society of Forest Science 2009 한국산림과학회지 Vol.98 No.2

This study was conducted to evaluate spatial distribution pattern and spatial association of crowns (${\geq}10m$ of height) and saplings (<10 m of height and ${\geq}2cm$ of DBH) for four major tree species (Pinus koraiensis, Abies nephrolepis, Acer mono, and Tilia amurensis) in the mixed broadleaved-Korean pine forest of Xiaoxing'an Mts. Vegetation data were collected in the 9 ha permanent sample plot, and the analysis adopted the point pattern analysis method. Main results are as follows; 1) crowns and saplings of major species showed clumped distribution pattern in small scale, became random distribution as the scale was increased. 2) Saplings of Pinus koraiensis performed poor regeneration under the crowns of Pinus koraiensis and Abies nephrolepis; Saplings of Abies nephrolepis did good regeneration under the crowns of Pinus koraiensis and Abies nephrolepis; and crowns of Acer mono and Tilia amurensis had little effect on the distribution of saplings of Pinus koraiensis and Abies nephrolepis. Saplings of Acer mono and Tilia amurensis made good regeneration under the crowns of Pinus koraiensis and Tilia amurensis; and the crowns of Acer mono and Abies nephrolepis had little effect on the distribution of saplings of Acer mono.

FEM Model-Based Investigation of Ultrasonic TOFD for Notch Inspection

Tang, Ziqiao,Yuan, Maodan,Wu, Hu,Zhang, Jianhai,Kim, Hak-Joon,Song, Sung-Jin,Kang, Sung-Sik The Korean Society for Nondestructive Testing 2014 한국비파괴검사학회지 Vol.34 No.1

A two-dimensional numerical model based on the finite element method was built to simulate the wave propagation phenomena that occur during the ultrasonic time of flight diffraction (TOFD) process. First, longitudinal-wave TOFD was simulated, and the numerical results agreed well with the theoretical results. Shear-wave TOFD was also investigated because shear waves have higher intensity and resolution. The shear wave propagation was studied using three models with different boundary conditions, and the tip-diffracted shear-to-longitudinal wave was extracted from the A-scan signal difference between the cracked and non-cracked specimens. This signal showed very good agreement between the geometrical and numerical arrival times. The results of this study not only provide better understanding of the diffraction phenomena in TOFD, but also prove the potential of shear-wave TOFD for practical application.

A Novel Sub-optimum Data Transmission Algorithm for Wireless Sensor Networks

Jin Wang,Bo Tang,Tinghuai Ma,Yuhui Zheng,Jeong-Uk Kim 보안공학연구지원센터 2012 International Journal of Hybrid Information Techno Vol.5 No.4

Two new tirucallane triterpenoids from the leaves of Aquilaria sinensis

Jin Tang Cheng,Ya Qiong Han,Juan He,Xing De Wu,Liao Bin Dong,Li Yan Peng,Yan Li,Qin Shi Zhao 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.9

Two new tirucallane triterpenoids, aquilacallanesA–B (1–2), together with 15 known compounds(3–17) were isolated from the leaves of Aquilaria sinensis. The structures of these new compounds were elucidated onthe basis of extensive spectroscopic analyses. All compoundswere evaluated for their cytotoxic activity againstfive human cancer cell lines. The known compounds,ursolic acid (7) and 5,7,40-trimethoxyflavone (14), exhibitedweak cytotoxic activity against some cells.

Preliminary Results for the Treatment of a Pain-Causing Osteoporotic Vertebral Compression Fracture with a Sky Bone Expander

Jin-bo Liu,Xue-ming Tang,Nan-wei Xu,Hong-tao Bao 대한영상의학회 2008 Korean Journal of Radiology Vol.9 No.5

Objective: Vertebral compression fractures (VCFs) are common complications of osteoporosis. The expansion of VCFs with a Sky Bone Expander is a new procedure which improves kyphotic deformities and decreases pain associated with VCFs. The purpose of this study was to investigate the preliminary results for the treatment of painful osteoporotic VCFs with a Sky Bone Expander. Materials and Methods: Twenty-six patients with pain-causing VCFs were treated with a Sky Bone Expander. This operation involved the percutaneous insertion of the Sky Bone Expander into a fractured vertebral body transpedicularly. Following the expansion, the Sky Bone Expander was contracted and removed, resulting in a cavity to be filled with bone cement. All fractures were analyzed for improvement in sagittal alignment. Clinical complications, pain relief and ambulation status were evaluated 1 day, 1 week, 1 month, and 3 months after the operation. Results: Twenty-four hours after the operation, all the patients treated experienced some degree of pain relief. In addition, no postoperative neurologic complications were noted. The average operative time was 42.4 ± 15.5 min per vertebra. Moreover, an average cement volume of 3.5 mL (range, 2.5 ± 5.0 mL) was injected per vertebra. The average anterior height was 18.4 ± 5.1 mm preoperatively and 20.5 ± 5.3 mm postoperatively (p < 0.01). Furthermore, the average midline height was 15.5 ± 5.2 mm preoperatively and 18.9 ± 4.0 mm postoperatively (p < 0.01). The Cobb angle improved from 18.5 ± 8.2 degrees preoperatively to 9.2 ± 4.0 degrees postoperatively (p < 0.01). The Visual Anabog Scale scores decreased from 7.7 ± 1.8 points preoperatively to 3.1 ± 2.0, 2.9 ± 1.7, 2.6 ± 1.5 and 2.9 ± 11.3 after 1 day, 1 week, 1 month and 3 months after the operation, respectively. Cement extrusion was observed in four patients without any neurologic symptoms. Conclusion: As a result of this study, we can postulate that the expansion of compressed vetrebra with a Sky Bone Expander is a safe and minimally invasive procedure resulting in the restoration of vertebral body height and the relief of pain associated with VCFs. Objective: Vertebral compression fractures (VCFs) are common complications of osteoporosis. The expansion of VCFs with a Sky Bone Expander is a new procedure which improves kyphotic deformities and decreases pain associated with VCFs. The purpose of this study was to investigate the preliminary results for the treatment of painful osteoporotic VCFs with a Sky Bone Expander. Materials and Methods: Twenty-six patients with pain-causing VCFs were treated with a Sky Bone Expander. This operation involved the percutaneous insertion of the Sky Bone Expander into a fractured vertebral body transpedicularly. Following the expansion, the Sky Bone Expander was contracted and removed, resulting in a cavity to be filled with bone cement. All fractures were analyzed for improvement in sagittal alignment. Clinical complications, pain relief and ambulation status were evaluated 1 day, 1 week, 1 month, and 3 months after the operation. Results: Twenty-four hours after the operation, all the patients treated experienced some degree of pain relief. In addition, no postoperative neurologic complications were noted. The average operative time was 42.4 ± 15.5 min per vertebra. Moreover, an average cement volume of 3.5 mL (range, 2.5 ± 5.0 mL) was injected per vertebra. The average anterior height was 18.4 ± 5.1 mm preoperatively and 20.5 ± 5.3 mm postoperatively (p < 0.01). Furthermore, the average midline height was 15.5 ± 5.2 mm preoperatively and 18.9 ± 4.0 mm postoperatively (p < 0.01). The Cobb angle improved from 18.5 ± 8.2 degrees preoperatively to 9.2 ± 4.0 degrees postoperatively (p < 0.01). The Visual Anabog Scale scores decreased from 7.7 ± 1.8 points preoperatively to 3.1 ± 2.0, 2.9 ± 1.7, 2.6 ± 1.5 and 2.9 ± 11.3 after 1 day, 1 week, 1 month and 3 months after the operation, respectively. Cement extrusion was observed in four patients without any neurologic symptoms. Conclusion: As a result of this study, we can postulate that the expansion of compressed vetrebra with a Sky Bone Expander is a safe and minimally invasive procedure resulting in the restoration of vertebral body height and the relief of pain associated with VCFs.

Development of Biological Water Quality Monitoring Equipment Based on Machine Vision

Tang Yiping,You Sisi,Yang Zhongyuan,Jin Shunjing 제어로봇시스템학회 2006 제어로봇시스템학회 국제학술대회 논문집 Vol.2006 No.10

Face Sketch Synthesis Based on Local and Nonlocal Similarity Regularization

Tang, Songze,Zhou, Xuhuan,Zhou, Nan,Sun, Le,Wang, Jin Korea Information Processing Society 2019 Journal of information processing systems Vol.15 No.6

Face sketch synthesis plays an important role in public security and digital entertainment. In this paper, we present a novel face sketch synthesis method via local similarity and nonlocal similarity regularization terms. The local similarity can overcome the technological bottlenecks of the patch representation scheme in traditional learning-based methods. It improves the quality of synthesized sketches by penalizing the dissimilar training patches (thus have very small weights or are discarded). In addition, taking the redundancy of image patches into account, a global nonlocal similarity regularization is employed to restrain the generation of the noise and maintain primitive facial features during the synthesized process. More robust synthesized results can be obtained. Extensive experiments on the public databases validate the generality, effectiveness, and robustness of the proposed algorithm.

IOMMU Para-Virtualization for Efficient and Secure DMA in Virtual Machines

Tang, Hongwei,Li, Qiang,Feng, Shengzhong,Zhao, Xiaofang,Jin, Yan Korean Society for Internet Information 2016 KSII Transactions on Internet and Information Syst Vol.10 No.12

IOMMU is a hardware unit that is indispensable for DMA. Besides address translation and remapping, it also provides I/O virtual address space isolation among devices and memory access control on DMA transactions. However, currently commodity virtualization platforms lack of IOMMU virtualization, so that the virtual machines are vulnerable to DMA security threats. Previous works focus only on DMA security problem of directly assigned devices. Moreover, these solutions either introduce significant overhead or require modifications on the guest OS to optimize performance, and none can achieve high I/O efficiency and good compatibility with the guest OS simultaneously, which are both necessary for production environments. However, for simulated virtual devices the DMA security problem also exists, and previous works cannot solve this problem. The reason behind that is IOMMU circuits on the host do not work for this kind of devices as DMA operations of which are simulated by memory copy of CPU. Motivated by the above observations, we propose an IOMMU para-virtualization solution called PVIOMMU, which provides general functionalities especially DMA security guarantees for both directly assigned devices and simulated devices. The prototype of PVIOMMU is implemented in Qemu/KVM based on the virtio framework and can be dynamically loaded into guest kernel as a module, As a result, modifying and rebuilding guest kernel are not required. In addition, the device model of Qemu is revised to implement DMA access control by separating the device simulator from the address space of the guest virtual machine. Experimental evaluations on three kinds of network devices including Intel I210 (1Gbps), simulated E1000 (1Gbps) and IB ConnectX-3 (40Gbps) show that, PVIOMMU introduces little overhead on DMA transactions, and in general the network I/O performance is close to that in the native KVM implementation without IOMMU virtualization.

Sensorless Estimation of Single-Phase Hybrid SRM using Back-EMF

Tang, Ying,He, Yingjie,Lee, Dong-Hee,Ahn, Jin-Woo The Korean Institute of Electrical Engineers 2017 Journal of Electrical Engineering & Technology Vol.12 No.1

This paper presents a novel scheme to estimate the rotor position of a single-phase hybrid switched reluctance motor (HSRM). The back-EMF generated by the permanent magnet (PM) field whose performance is motor parameter independent is adopted as an index to achieve the sensorless control. The differential value of back-EMF is calculated by hardware and processed by DSP to capture a fixed rotor position four times for every mechanical cycle. In addition, to accomplish the normal starting of HSRM, the determination method of the turn-off time position at the first electrical cycle is also proposed. In this way, a sensorless operation scheme with adjustable turn on/off angle can be achieved without substantial computation. The experimental verification using a prototype drive system is provided to demonstrate the viability of the proposed position estimation scheme.