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Zhongyuan Tian,Lu Yang,Penghui Li,Yuncai Xiao,Jian Peng,Xiliang Wang,Zili Li,Mei Liu,Dingren Bi,Deshi Shi 한국통합생물학회 2016 Animal cells and systems Vol.20 No.2
Enterococcus faecium HDRsEf1 strain used as a probiotic to inhibit intestine inflammation and improve animal growth performance has been proved by our research team; however, it remains unclear how HDRsEf1 was recognized by intestine cells and how it activates the downstream pathway which benefit intestine health. In this study, HDRsEf1 was used to stimulate HT-29 cell line to partially uncover the intestine benefit mechanism of HDRsEf1. The results of cell viability assays showed that HDRsEf1 had no toxicity on HT-29 at concentrations up to 1 × 108 CFU/mL, HDRsEf1 could upregulate the TLR1, TLR2, and TLR6 mRNA level, especially TLR2, and significantly downregulate the mRNA level of TLR4, TLR5, TLR7, TLR8, but did not significantly affect the mRNA or protein level of MyD88, which suggests that HDRsEf1 activates the TLR2 pathway in an MyD88-independent pattern. HDRsEf1 could significantly downregulate the mRNA level of pro-inflammatory factors IL-1β, IL-6, IL-8, IL-12p35, IL-17, and TNF-α and did not affect the anti-inflammatory factors IL-10, PPAR-γ, and TSLP; besides HDRsEf1 did not upregulate the degradation of IκB in HT-29 cells. By contrast, enterohemorrhagic E. coli (EHEC) O157:H7 strongly up-regulated the mRNA level of pro-inflammatory factors IL-1β, IL-6, IL-8, IL-23, and TNF-α, downregulated obviously anti-inflammatory factor PPAR-ɣ, and obviously upregulated the degradation of IκB, which suggested that HDRsEf1 may act as an antagonist to regulate intestine inflammation response to intestine pathogen. These findings shed a light on the intestine benefit mechanism of HDRsEf1.
A Hyperlink-Extended Language Model for Microblog Retrieval
Zhongyuan Han,Muyun Yang,Leilei Kong,Haoliang Qi,Sheng Li 보안공학연구지원센터 2015 International Journal of Database Theory and Appli Vol.8 No.6
Microblog retrieval has received much attention in recent years. In microblog retrieval, the content linked by URLs is one of the most important information of a microblog. We present a Hyperlink-extended model for microblog retrieval that combines content of microblogs and the content of embedded hyperlinks webpages using a probabilistic ranking function based on language model. Hyperlink-extended language model incorporates the users' information retrieval requirements and the microblog author’s expression needs. Using standard TREC 2011 and TREC 2012 microblog retrieval collection, various aspects of our microblog retrieval model are evaluated. Results show our model significantly outperform the art-of-the-state URL-based approaches and the best performance of TREC 2012 microblog retrieval.
A Temporal Microblog Filtering Model
Zhongyuan Han,Muyun Yang,Leilei Kong,Haoliang Qi,Sheng Li 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.1
The rapid growth in the popularity of social networking and microblogging has led to a new way of finding and broadcasting information in the recent years. The real-time microblog filtering emerges as the times require. The task of real-time microblog filtering is to decide if subsequently posted tweets are relevant to a given query which represents the special information needs. One-side feedback is one of the most difficult problems in microblog filtering. This paper focuses on exploiting the time profile of relevant microblogs to address this problem. A temporal microblog filtering based on retrieval model is proposed. Specifically, similarity threshold achieved by the language model is adjusted according to temporal burst. Evaluated on the TREC 2012 microblog real-time filtering track dataset, the experimental results show that the proposed model is significantly better than several baselines.
Sangheon Yi,Yoshiki Saito,Zhongyuan Chen,Dong Yoon Yang 한국지질과학협의회 2006 Geosciences Journal Vol.10 No.1
The wel-defined pollen record in massive marineclay deposits from the subaqueous Changjiang (Yangtze River)delta reveals changes in vegetation and inferred climate during thelast about 1600 years. Climatic periods inferred from the pollentively warm/wet conditions comparable to Medieval Warm Period(AD 9101085) with a strengthen summer monsoon, (3) a relativelycool and wet conditions possibly corresponding to Little Ice Age(LIA; AD 10851815) with a weaken summer monsoon, and finally(4) the present warm period, since AD 1815. The pollen aridityindex based on variations in humidity suggests that thre subpe-riods within the LIA can be identified: wet LIA-1 (AD 10851170),dry LIA-2 (AD 11701330), and wet LIA-3 (AD 13301815).
Jehanzeb Khan,Guy Kateta Malangisha,Abid Ali,Ahmed Mahmoud,Jinghua Yang,Mingfang Zhang,Zhongyuan Hu 한국원예학회 2021 Horticulture, Environment, and Biotechnology Vol.62 No.5
Lead (Pb) is one of the most abundant toxic heavy metals, which have a serious impact on the growth and yield of crop plants. Nitric oxide (NO) is a natural signaling molecule that regulates the growth and productivity of plants. Here, exogenous NOwas found to enhance Pb tolerance in watermelon, which resulted in more Pb restriction in roots and less up-translocatedPb to aerial parts. Pb stress, however, led to an increase in shoot dry weight, root biomass, root relative water content, leafmalondialdehyde (MDA) content, and the total soluble protein content in leaves and roots. By contrast, shoot height andfresh weight, leaf biomass, and root MDA content were decreased under Pb stress. NO treatments alleviated Pb toxicity bydecreasing Pb translocation, enhancing root growth (elongation and biomass), inducing antioxidant enzymes activities, andreducing root MDA contents in watermelon seedlings. In conclusion, our results provide useful insights into the mechanismof Pb tolerance in cucurbit crops and information for the cultivation management of watermelon in the presence of thisheavy metal (Pb).