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Sunmin Park,Won Park,Shin-Hyung Park,Joo Young Kim,Jin Hee Kim,Haeyoung Kim,Yeon-Sil Kim,Won Kyung Cho,Won Sup Yoon,Dae Sik Yang 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.3
Objective: This study aimed to evaluate the oncologic outcomes according to disease burden in uterine cervical cancer patients with metachronous distant metastases. Methods: Between 2005 and 2015, 163 patients with metachronous distant metastases from uterine cervical cancer after receiving a definitive therapy were evaluated at seven institutions in Korea. Low metastatic burden was defined as less than 5 metastatic sites, whereas high metastatic burden was others. Each metastasis site was divided based on the lymph node (LN) and organs affected. The overall survival (OS) and progression-free survival (PFS) were assessed. Cox proportional hazards models, including other clinical variables, were used to evaluate the survival outcomes. Results: The median follow-up duration was 22.2 months (range: 0.3–174.8 months). Para- aortic LNs (56.4%), lungs (26.4%), supraclavicular LNs (18.4%), and peritoneum (13.5%) were found to be the common metastasis sites. Among 37 patients with a single metastasis, 17 (45.9%) had LN metastases and 20 (54.1%) had organ metastases. The 1- and 2-year OS rates were 73.9% and 55.0%, respectively, whereas the PFS rates were 67.2% and 42.9%, respectively. SCC Ag after recurrence and high metastatic burden were significant factors affecting the OS (p=0.004 and p<0.001, respectively). Distant organ recurrence, short disease-free interval (≤2 years), and high metastatic burden were unfavorable factors for PFS (p=0.003, p=0.011, and p=0.002, respectively). Conclusion: A favorable oncologic outcome can be expected by performing salvage treatments in selected patients with a long disease-free interval, low metastatic burden, and/ or lymphatic-only metastasis.
( Sunmin Yim ),( Jung Yup Kim ),( Jae Yun Lim ),( Ju-yeon Choi ),( Han-saem Kim ),( Jung-in Kim ),( Jung Min ),( Joon Hong Min ),( Young Jun Choi ),( Jae Hui Nam ),( Ga-young Lee ),( Won-serk Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Background: A low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet (QSND) laser has been used for treatment of pigmented disorders. However, the photobiological mechanism of the low-fluence 1064-nm QSND laser is not yet fully understood. Objectives: To evaluate inhibitory effects of the low-fluence 1064-nm QSND laser on the melanogenesis and assess whether increasing the number of passes of low-fluence the 1064-nm QSND laser has positive correlation with improvements of the pigmentation. Methods: The skins of six Hair Moprpholoy-2 melanin-possessing hairless mice were treated with ultraviolet B radiation followed by 0, 2, 4, 6 passes the low-fluence 1064-nm QSND laser. Pigmentation changes of skins were evaluated with spectrophotometry and pigmentation-related protein expressions. Additionally, biopsy specimens were obtained to figure out the difference of melanin particles. Results: The low-fluence 1064-nm QSND laser improved the lightness of the skin in comparison to the control skin. Biopsy specimens showed decreased amounts of melanin particles. In the western blot of the specimen, expressions of MITF and tyrosinase were reduced. Conclusion: The low-fluence 1064-nm QSND laser has effects on the melanogenesis which change expressions of the pigmentation-related proteins. Moreover, the more passes of the laser toning can bring the more progress on the skin pigmentation.
김화영(Hwayoung Kim),김형민(Hyungmin Kim),송민수(Minsu Song),안지훈(Jihun An),김강현(Ganghyun Kim),김선민(Sunmin Kim),김찬현(Chanhyun Kim),박성우(Seoungwoo Park),이준우(Junu Lee),이준기(Joonki Rhee),임재혁(Jaehyuk Im),정승수(Seungsu Jeo 한국추진공학회 2022 한국추진공학회 학술대회논문집 Vol.2022 No.5
본 논문은 경기대학교 KURBC 팀이 설계한 모듈형 신기전K22에 대한 설계과정과 그 근거를 서술하였다. 로켓의 임무는 ‘로켓 발사 후 낙하 시 낙하산 사출 및 안전한 회수’이다. 목표 고도는 400m, 연료는 질산칼륨-소르비톨(KNSB)이다. 낙하산 사출 방법은 동체와 낙하산이 안전하게 보호되는 용수철 사출을 선택했다. 본 팀은 이번 대회에서 CFRP 카본으로 로켓의 동체를 만들고, 내부를 모듈로 구성함으로써 차별점을 두었다. 또한 RF 장거리 통신 기술을 이용하여 발사 전후의 데이터를 체계적으로 기록하여 후속 연구에 참고할 예정이다. This paper describes the design process and basis for the modular Shinkijeon-K22 designed by the KURBC team of Kyonggi University. The rockets mission is devising a method for parachute injection and safe recovery when falling after launching the rocket. The target altitude is 400 m and the fuel is potassium nitrate-solvitol (KNSB). The spring injection method was used for the parachute injection, in which the fuselage and parachute are safely protected. We made a difference by making the rockets fuselage with CFRP carbon and configuring the interior as a module. In addition, RF long-distance communication technology will be used to systematically record data before and after launch and refer it to subsequent studies.
( Jung Yup Kim ),( Sunmin Yim ),( Jae Yun Lim ),( Ju-yeon Choi ),( Han-saem Kim ),( Jung-in Kim ),( Jung Min ),( Joon Hong Min ),( Young Jun Choi ),( Jae Hui Nam ),( Ga-young Lee ),( Won-serk Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Background: Scars can affect patients, leading to emotional complications. Various laser technologies including fractional laser, Q-Switched Nd:YAG laser, and pulsed dye laser have been tried to revise the scar. Up to now, there has been no reliable study to evaluate an effect of picosecond Nd:YAG laser for reducing scars. Objectives: This retrospective clinical study was performed to investigate the beneficial effect of picosecond Nd:YAG laser in treatment for hypertrophic scars. Methods: A retrospective review was conducted on patients treated with picosecond Nd:YAG laser for the purpose of scar improvement. Twenty-seven patients with hypertrophic scars were included in this study. The vancouver scar scale (VSS), global assessment score (GAS), and participant’s subjective satisfaction were used to determine the effect of scar improvement. All side effects were recorded to assess the safety of the modality. Results: Mean age of patients was 33.4±15.2 years old and male-to-female ratio was 2:3. Mean total treatment session was 3.4±1.3 and mean total duration of treatment was 13±7.3 weeks. Average VSS score was remarkably decreased after treatment. Average GAS and participant’s satisfaction indicated fair cosmetic improvement. No significant side effects were observed during follow-up. Conclusion: Picosecond Nd:YAG laser may be considered as an effective and safe optional modality for the treatment of scar.
Kim, Yangho,Park, Sunmin,Kim, Nam-Soo,Lee, Byung-Kook The Korean Society for Preventive Medicine 2013 예방의학회지 Vol.46 No.2
Objectives: The inherent nature of the Korean National Health and Nutrition Examination Survey (KNHANES) design requires special analysis by incorporating sample weights, stratification, and clustering not used in ordinary statistical procedures. Methods: This study investigated the proportion of research papers that have used an appropriate statistical methodology out of the research papers analyzing the KNHANES cited in the PubMed online system from 2007 to 2012. We also compared differences in mean and regression estimates between the ordinary statistical data analyses without sampling weight and design-based data analyses using the KNHANES 2008 to 2010. Results: Of the 247 research articles cited in PubMed, only 19.8% of all articles used survey design analysis, compared with 80.2% of articles that used ordinary statistical analysis, treating KNHANES data as if it were collected using a simple random sampling method. Means and standard errors differed between the ordinary statistical data analyses and design-based analyses, and the standard errors in the design-based analyses tended to be larger than those in the ordinary statistical data analyses. Conclusions: Ignoring complex survey design can result in biased estimates and overstated significance levels. Sample weights, stratification, and clustering of the design must be incorporated into analyses to ensure the development of appropriate estimates and standard errors of these estimates.
Kim, Min Jung,Yang, Hye Jeong,Moon, Bo Reum,Kim, Ji Eun,Kim, Kang Sung,Park, Sunmin Hindawi 2017 Evidence-based Complementary and Alternative Medic Vol.2017 No.-
<P>Testosterone deficiency deteriorates glucose and lipid metabolism with reducing muscle mass. We investigated whether the consumption of water extracts of<I> Gastrodia elata </I>Blume rhizome (GEB) rich in gastrodin would reduce the symptoms of testosterone deficiency and improve blood flow in orchidectomized (ORX) rats. ORX rats were given high-fat diets supplemented with either 1% cellulose (ORX-control), 0.3% GEB (GEB-L), or 1% GEB (GEB-H) for 8 weeks. Sham-operated rats were fed the same diet as OVX-control rats (normal-control). ORX-control rats had reduced serum testosterone levels by one-fifth, compared to normal-control rats. ORX-control rats exhibited decreased lean body mass, attenuated blood flow, and impaired cholesterol metabolism and glucose control due to decreased insulin secretory response. GEB increased serum insulin levels dose-dependently and GEB-H mostly enhanced dyslipidemia in ORX rats. GEB completely normalized arterial thrombosis time and blood flow in ORX rats. Interestingly, ORX-control rats showed attenuated hepatic insulin signaling but greater AMPK and CREB activities, which reduced triglyceride accumulation, compared to normal-control. GEB-H improved hepatic insulin signaling but maintained the AMPK and CREB activities in ORX rats. In conclusions, GEB ameliorated the impairment of cholesterol and glucose metabolism and blood flow in ORX rats. GEB may be a potential preventive measure for reducing the risk of cardiovascular diseases associated with testosterone deficiency.</P>
Kim, Backki,Woo, Sunmin,Kim, Mi-Jung,Kwon, Soon-Wook,Lee, Joohyun,Sung, Sang Hyun,Koh, Hee-Jong Elsevier 2018 Food chemistry Vol.241 No.-
<P><B>Abstract</B></P> <P>Flavonoids are naturally occurring phenolic compounds with potential health-promoting activities. Although anthocyanins and phenolic acids in coloured rice have been investigated, few studies have focused on flavonoids. Herein, we analysed flavonoids in a yellow grain rice mutant using UHPLC-DAD-ESI-Q-TOF-MS, and identified 19 flavonoids by comparing retention times and accurate mass measurements. Among them, six flavonoids, isoorientin, isoorientin 2″-<I>O</I>-glucoside, vitexin 2″-<I>O</I>-glucoside, isovitexin, isoscoparin 2″-<I>O</I>-glucoside and isoscoparin, were isolated and fully identified from the yellow grain rice mutant, and the levels were significantly higher than wild-type, with isoorientin particularly abundant in mutant embryo. Significant differences in total phenolic compounds and antioxidant activity were observed in mutant rice by DPPH, FRAP and TEAC assays. The results suggest that the representative six flavonoids may play an important role in colouration and antioxidant activity of embryo and endosperm tissue. The findings provide insight into flavonoid biosynthesis and the possibility of improving functionality in rice.</P> <P><B>Highlights</B></P> <P> <UL> <LI> High level of flavonoids containing rice mutant is reported for the first time. </LI> <LI> 19 flavonoids were identified or tentatively identified in a yellow grain mutant by UHPLC-DAD-ESI-Q-TOF-MS. </LI> <LI> Isoorientin was particularly abundant in embryo tissue. </LI> <LI> Yellow grain mutant showed the high phenolic content and antioxidant activity. </LI> </UL> </P>