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Sung Hee Yoon,Sun Ok Yun,Jung Yong Park,Hee Yeun Won,Eun-Kyung Kim,Hyun-Jung Sohn,Hyun-Il Cho,김태규 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.3
Increasing importance is being given to the stimulation of Th1 response in cancer immunotherapy because its presence can shift the direction of adaptive immune responses toward protective immunity. Based on chemokine receptor expression, CXCR3+CCR4-CD4+ T cells as Th1-type cells were investigated its capacity in monocyte-derived dendritic cell (DC) maturation and polarization, and induction of antigen specific cytotoxic T lymphocytes (CTL) in vitro. The levels of IL-4, IL-5 and IL-10 were decreased to the basal level compared with high production of IFN-γ, TNF-α, and IL-2 in CXCR3+CCR4-CD4+ T cells stimulated with anti-CD3 and anti-CD28 antibodies. Co-incubation of activated CD4+ or CXCR3+CCR4-CD4+ T cells with DC (CD4+/DC or CXCR3+CD4+/DC, respectively) particularly up-regulated IL-12 and CD80 expression compared with DC matured with TNF-α and LPS (mDC). Although there was no significant difference between the effects of the CXCR3+CCR4-CD4+ and CD4+ T cells on DC phenotype expression, CXCR3+CD4+/DC in CTL culture were able to expand number of CD8+ T cells and increased frequencies of IFN-γ secreting cells and overall cytolytic activity against tumor antigen WT-1. These results demonstrated that the selective addition of CXCR3+ CCR4- CD4+ T cells to CTL cultures could enhance the induction of CTLs by DC in vitro, and implicated on a novel strategy for adoptive T cell therapy. Increasing importance is being given to the stimulation of Th1 response in cancer immunotherapy because its presence can shift the direction of adaptive immune responses toward protective immunity. Based on chemokine receptor expression, CXCR3+CCR4-CD4+ T cells as Th1-type cells were investigated its capacity in monocyte-derived dendritic cell (DC) maturation and polarization, and induction of antigen specific cytotoxic T lymphocytes (CTL) in vitro. The levels of IL-4, IL-5 and IL-10 were decreased to the basal level compared with high production of IFN-γ, TNF-α, and IL-2 in CXCR3+CCR4-CD4+ T cells stimulated with anti-CD3 and anti-CD28 antibodies. Co-incubation of activated CD4+ or CXCR3+CCR4-CD4+ T cells with DC (CD4+/DC or CXCR3+CD4+/DC, respectively) particularly up-regulated IL-12 and CD80 expression compared with DC matured with TNF-α and LPS (mDC). Although there was no significant difference between the effects of the CXCR3+CCR4-CD4+ and CD4+ T cells on DC phenotype expression, CXCR3+CD4+/DC in CTL culture were able to expand number of CD8+ T cells and increased frequencies of IFN-γ secreting cells and overall cytolytic activity against tumor antigen WT-1. These results demonstrated that the selective addition of CXCR3+ CCR4- CD4+ T cells to CTL cultures could enhance the induction of CTLs by DC in vitro, and implicated on a novel strategy for adoptive T cell therapy.
A Case of High-degree Atrioventricular Block in a Patient with Ankylosing Spondylitis
( Sang Rok Lee ),( Hyung Wook Park ),( Sang Yub Lim ),( Seo Na Hong ),( Kye Hun Kim ),( Il Suk Sohn ),( Young Joon Hong ),( Ju Han Kim ),( Weon Kim ),( Young Keun Ahn ),( Myung Ho Jeong ),( Jeong Gwan 대한내과학회 2005 대한내과학회 추계학술대회 Vol.69 No.10
Platform Supporting Intelligent Human–Machine Interface (HMI) Applications for Smart Machine Tools
Il-Ha Park,Joo-Sung Yoon,Jin Ho Sohn,Dong Yoon Lee 한국정밀공학회 2024 International Journal of Precision Engineering and Vol.25 No.5
As the Internet of Things, artificial intelligence, and the fourth industrial revolution advance, smart factories and machines increasingly gain intelligent features that enable the integration of more sophisticated functionalities. Approaches to achieving this intelligence involve both internal systems, such as human–machine interface (HMI), and external systems, such as big data platforms and cloud services. Although current research leans toward studying external systems, accomplishing intelligent functions through such means poses more challenges in achieving real-time responses during machining processes than using internal systems. When intellectualizing machine tools through internal HMI systems, three critical issues must be addressed. First, HMI functions are structured to depend on the HMI itself, leading to a ripple effect where a problem occurring in one HMI function impacts the entire system. Second, owing to differences in development tools and programming languages, the interconnectivity between functions developed by multiple stakeholders to be loaded onto the HMI may suffer, leading to potential inefficiencies and increased maintenance costs. Third, although various types of computer numerical control (CNC) machines need to communicate with the HMI function, the diverse communication methods and development tools used by each CNC manufacturer result in identical intelligent functions being developed separately for each CNC type. To address these challenges, this study proposes an innovative HMI platform capable of executing and developing various intelligent functions. The HMI platform and its major components are designed and implemented through component-based development (CBD). Subsequently, the performance and effectiveness of the platform are validated using quality attribute scenarios.
Sung Hoon Chung,Il Sohn 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.6
The effect of NaF and CaO/SiO2 mass pct. ratio (C/S) on the hydrogen solubility in terms of the hydroxyl capacity of theCaO–SiO2–NaF welding flux system was investigated at 1823 K. As a cost-effective alternative to CaF2in welding fluxes,NaF can potentially increase the fluidity, electrical conductivity, and hydroxyl capacity of welding fluxes in advanced highstrengthsteels. Additions of 1.9 to 5.9 mass pct. of NaF was found to depolymerize the structural units in the flux system. Depending on the flux composition, the dominant hydrogen dissolution mechanism varied. At C/S values less than 1.06, theincorporated-hydroxyl dissolution mechanism was dominant in the present flux system, in which SiO2-based complex structuralunits were pronounced. At C/S values above 1.06, the free-hydroxyl dissolution mechanism was pronounced due to thestrong network-modifying CaO content supplemented by NaF. A combination of Fourier transformed infrared, Raman, X-rayphotoelectron spectroscopy and time of flight secondary ion mass spectrometry analysis was used to determine the structuralimplications of NaF additions and C/S, which were correlated to the hydroxyl capacity of the flux. High NaF contents andC/S values were found to depolymerize the complex structural units of the molten flux by supplying greater amounts ofnetwork-modifying free oxygen (O2−) and fluorine (F−) anions to the flux system in the compositional range of this work.
ILLUMINATION ROBUST VEHICLE DETECTION USING KNOWLEDGE BASED MULTI FEATURES EXTRACTION
Sung-il Choi(최성일),Jong-in Son(손종인),Jung-hyun Seo(서정현),Kwang-hoon Sohn(손광훈) 대한전자공학회 2015 대한전자공학회 학술대회 Vol.2015 No.6
Vehicle detection is important in many advanced driver assistance systems. In this paper, we propose a illumination robust forward vehicle detection. The proposed method involves three major components: First, we detect a main lanes and define an adaptive region of interest (ROI) to remove outlier and reduce complexity. Second, we extract vehicle candidates combing multi features of vehicle. Finally, we utilize the distinct property of taillights color to achieve illumination invariant vehicle detection. Experimental results show satisfactory performance with an average detection rate of 96% under various illumination conditions.
( Il Ryoung Sohn ),( Joong Chul Park ),( Jong Sang Kim ) 한국부식방식학회(구 한국부식학회) 2010 Corrosion Science and Technology Vol.9 No.6
In continuous hot dip galvanizing process, oxide formation on steel surface has an influence on Zn wetting. High strength automotive steel contains high amount of Si and Mn, where Si-Mn composite oxides such as Mn2SiO4 or MnSiO3 covers the surface after annealing. Zn wetting depends on how the aluminothermia reaction can reduce the Mn-Si composite oxides and then form inhibition layer such as Fe2Al5 on the steel surface. The outward diffusion of metallic ions such as Mn2+, Si2+ in the steel matrix is very important factor for the formation of the surface oxides on the steel surface. The surface state and grain boundaries provide an important role for the diffusion and the surface oxide reactions. Some elements such as P, Sb, and B have a strong affinity for the interface precipitation, and it influence the diffusivity of metallic ions on grain boundaries. B oxide forms very rapildly on the steel surface during the annealing, and this promote complex oxides with SiO2 or MnO. P has inter-reacted with other elements on the grain boundaries and influence the diffusion through on them. Small addition of Sb could suppress the decarburization from steel surface and retards the formation of internal and external selective oxides on the steel surface. Interface control by the trace elements such as Sb could be available to improve the Zn wettability during the hot dip galvanizing.