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S-226 Impact of High sensitivity troponin I on management of acute chest pain
( Sang Ho Min ),( Byeong Joo Bae ),( Bum Sung Kim ),( Chang Hee Kwon ),( Sung Hea Kim ),( Hyun-joong Kim ),( Sang Man Chung ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Background/Introduction: It is challenging for physicians to manage patients presenting with acute chest pain, especially those with non-diagnostic ECG and normal initial set of cardiac enzymes. Compared with conventional Troponin, high sensitivity troponin (hs-TnI) have greater sensitivity and negative predictive value, conversely reduced specificity and positive predictive value.?Purpose: We aimed to investigate the impact of hs-TnI on clinical decision, including influence on admission rate and diagnostic tools.?Methods: Among total 3170 patients presenting acute chest pain, those with elevated cardiac markers and diagnostic changes in ECG were excluded. Total 128 patients with acute chest pain were assessed with either conventional troponin (cTnI) (N=59, From March to May of 2014, cTnI group), or high sensitive troponin (hs-cTnI) (N=69, From March to May of 2015, hs-cTnI group). First, we compared the admission rate between cTnI and hs-cTnI groups (Outpatient follow-up, admission to General ward or admission to ICU). Second, we sought the difference of diagnostic tools between two groups after ER discharge (Conventional angiogram, Coronary CT or Functional testing).?Results: There were no differences in baseline characteristics between two groups including demographic and cardiovascular risk factors. The hs-TnI group show low admission rate to general ward (28.8% vs 13%, p<0.05) and more outpatient follow-up visit after discharge (32.2% vs 52.2%. p<0.05). But ICU admission rate show no difference between two groups (39.0% vs 34.8%). In view of diagnostic procedures which specialist choose after ER discharge, there are differences between two groups, showing fewer conventional angiogram (59.3% vs 42%, p<0.05) in hs-TnI group, more functional tests with TMT or stress Echo in cTnI group (1.70% vs 17.4%, p<0.05). Conclusions: With emphasis on negative predictive value of hs-TnI in patients with non-diagnostic ECG and negative cardiac enzymes, the introduction of hs-TnI replacing conventional troponin modified the management of chest pain toward less aggressive approach, in means of reduced admission rate and invasive testing in real world setting.
Bae, Ji-Young,Moon, Sun-Hwa,Choi, Jung-Ah,Park, Jong-Sug,Hahn, Bum-Soo,Kim, Ki-Yong,Kim, Byung-Han,Song, Jae-Young,Kwon, Dae-Hyuck,Lee, Suk-Chan,Kim, Jong-Bum,Yang, Joo-Sung The Korean Association of Immunobiologists 2009 Immune Network Vol.9 No.6
Foot-and-mouth disease virus (FMDV) is a small single-stranded RNA virus which belongs to the family Picornaviridae, genus Apthovirus. It is a principal cause of FMD which is highly contagious in livestock. In a wild type virus infection, infected animals usually elicit antibodies against structural and non-structural protein of FMDV. A structural protein, VP1, is involved in neutralization of virus particle, and has both B and T cell epitopes. A RNA-dependent RNA polymerase, 3D, is highly conserved among other serotypes and strongly immunogenic, therefore, we selected VP1 and 3D as vaccine targets. VP1 and 3D genes were codon-optimized to enhance protein expression level and cloned into mammalian expression vector. To produce recombinant protein, VP1 and 3D genes were also cloned into pET vector. The VP1 and 3D DNA or proteins were co-immunized into 5 weeks old BALB/C mice. Antigen-specific serum antibody (Ab) responses were detected by Ab ELISA. Cellular immune response against VP1 and 3D was confirmed by ELISpot assay. The results showed that all DNA- and protein-immunized groups induced cellular immune responses, suggesting that both DNA and recombinant protein vaccine administration efficiently induced Ag-specific humoral and cellular immune responses.
A Phase 1 Study Using Autologous Natural Killer Cells in Patients with HAIC-Hepatocellular Carcinoma
( Sung Bum Cho ),( Chung Hwan Jun ),( Sung Kyu Choi ),( Woo Kyun Bae ),( Je Jung Lee ),( Yang Jun Kang ),( Cheol Kyun Cho ),( Yang Seok Ko ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Natural killer (NK) cell-based immunotherapy has recently been tried with advances of understanding the role of immune defense against hepatocellular carcinoma (HCC). To improve NK cells therapy, we focused to increasing delivery of NK cells and synergic effect combined with hepatic arterial infusion chemotherapy (HAIC). Methods: We did a prospective, open label, phase 1 trial of the safety and efficacy of autologous NK cells through hepatic arterial infusion as sequential therapy after HAIC in advanced HCC patients. Between March 2016 and July 2017, 11 patients were included who showed favorable response more than stable disease (SD) after 2 sessions of HAIC in advanced HCC patients with child A. A total 4 sessions of HAIC were performed the protocols of infusion of cisplatin (25/m2) and 5-fluorouracil (750/m<sup>2</sup>) for 4 days every 3-4 weeks interval. The peripheral blood mononuclear cells of patients by leukapheresis were ob-tained after 3<sup>rd</sup> HAIC and NK cells were expanded for 2 weeks under Current Good Manufacturing Practices (cGMP). Patients received planned dosage of NK cells through chemoport into hepatic artery for 5 days after 4<sup>th</sup> HAIC (3 patients; 2.5x108, 3 patients; 5x10<sup>8</sup>, 5 patients; injection of 10x10<sup>8</sup> NK cells). The primary end point was safety of NK cell injection; secondary endpoint included objective response rate (modified Response Evaluation Criteria In Solid Tumors), time to progression, dura-tion of response and immunologic efficacy. Results: Any adverse events of NK cells injection were none according to dosage. An objective response was observed in 7 patients (63.6%) included three complete responses and four partial responses. Stable disease was observed in 2 patients and progressive disease was in 2 patients and thus disease control rate was 81.8%. The mean duration of time to progression was 9.7±5.3 month and duration of response without chemotherapy was 6.1±5.2 month. The newly metastatic lesion was occurred in 3 patents (27.2%; lymph node 1 patients, Lung 2 patients). Two patients were died by tumor progression and others were still alive. The increasing immunologic response was observed in 5 patients (55 %) to evaluate cytotoxicity and NK cell proportion of peripheral mononuclear cells after NK cell injection. Conclusions: The HAIC and NK cells immunotherapy is safe and effective treatment in the advance HCC patient with favorable liver function. The additional studies are urgently required to establish the new novel treatment.
Bae, Jean-Hee,Hur, Sung-Bum The Korean Society of Fisheries and Aquatic Scienc 2011 Fisheries and Aquatic Sciences Vol.14 No.4
To find seasonally optimal microalgae for mass culture of the rotifer Brachionus plicatilis, the growth rates of 12 microalgal species (two marine Chlorella spp., five marine Nannochloris spp., two marine Nannochloropsis spp., one estuarine Nannochloropsis sp., and two estuarine Chlorella spp.) were compared at $25^{\circ}C$ at 15 psu and 30 psu. Among these, six species showing high growth rates were chosen and examined again at high ($30^{\circ}C$ and $32^{\circ}C$) and low ($10^{\circ}C$) temperatures. Their amino and fatty acids and the dietary value of the rotifers that fed on each microalgal species were examined. Nannochloris sp. (KMMCC-119) and Chlorella vulgaris (KMMCC-120) showed the highest growth rates at temperatures over $30^{\circ}C$ and at $10^{\circ}C$, respectively. The growth rate of Nannochloris was higher than those of Chlorella and Nannochloropsis at high temperatures, but lower than those of the latter at low temperatures. The growth rate of rotifers fed on Nannochloropsis was highest and that of those fed on Chlorella was lowest. Levels of eicosapentaenoic acid and docosahexaenoic acid were highest in Nannochloropsis and lowest in Nannochloris. However, total amino acid content was highest in Nannochloris and lowest in Chlorella. In conclusion, Nannochloropsis sp. (KMMCC-33) was the best microalgal species for the mass culture of the rotifer. However, during high- or low-temperature seasons in which Nannochloropsis does not grow well, Nannochloris spp. (KMMCC-119, 395) and C. vulgaris (KMMCC-120) would adequately replace Nannochloropsis sp. (KMMCC-33).
Bae Seongman,Lee Yun Woo,Lim So Yun,Lee Ji-Hyang,Lim Joon Seo,Lee Sojeong,Park Soyeon,Kim Sun-Kyung,Lim Young-Ju,Kim Eun Ok,Jung Jiwon,Kwon Hyouk-Soo,Kim Tae-Bum,Kim Sung-Han 대한의학회 2021 Journal of Korean medical science Vol.36 No.17
Background: We performed a prospective survey on the adverse reactions following the first dose of two types of vaccines against coronavirus disease 2019 (COVID-19) in healthcare workers (HCWs) in South Korea. Methods: HCWs at a tertiary referral hospital in Seoul, South Korea, received a chimpanzee adenovirus-vectored vaccine (ChAdOx1 nCoV-19) or an mRNA-based vaccine (BNT162b2) between March 5 and March 26, 2021. The HCWs were asked to report adverse reactions through a mobile self-report questionnaire for three days after vaccination. Results: A total of 7,625 HCWs received the first dose of ChAdOx1 or BNT162b2 vaccine during the study period. Of them, 5,866 (76.9%) HCWs (ChAdOx1, n = 5,589 [95.3%]; BNT162b2, n = 277 [4.7%]) participated at least once in the survey, of whom 77% were female and 86% were younger than 50 years. The overall adverse reaction rate was 93% in the ChAdOx1 group and 80% in the BNT162b2 group (P < 0.001). Both local and systemic reactions were more commonly reported in the ChAdOx1 group, and the difference was larger in systemic reactions such as fever and fatigue. In the ChAdOx1 group, the incidence of adverse reactions was significantly higher in females and those in the younger age groups, while the BNT162b2 group showed such difference according to age. Conclusion: In our prospective survey, vaccine-associated adverse reactions were more commonly reported in the ChAdOx1 group than in the BNT162b2 group. Females and younger age groups experienced vaccine-associated adverse reactions more frequently.