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( Bong Su Kang ),( Hyun Ji Park ),( Ja Seon Yoon ),( Dang Young Kim ),( Jae Hwang Jeong ),( Eun Young Kim ),( Sang Yoon Nam ),( Young Won Yun ),( Jong Soo Kim ),( Beom Jun Lee ) 한국수의공중보건학회 2012 예방수의학회지 Vol.36 No.1
Both iron-deficient and zinc-sufficient diets have been known to be associated with a decreased risk of colon cancer. We investigated that effect of dietary zinc on the formation of colonic aberrant crypt foci (ACF) induced by azoxymethane (AOM) followed by dextran sodium sulfate in iron-deficient mice. Five-week old ICR mice were acclimated for 1 week and fed on iron-deficient diet (4.50 ppm iron) with three different zinc levels (0.01, 0.1, and 1.0 ppm) for 12 weeks. The total number of aberrant crypt (AC) and ACF was measured in the colonic mucosa after methylene blue staining. The total ACF numbers of low Zn (LZn), medium Zn (MZn) and high Zn (HZn) diet groups were 10.00 ± 2.67, 8.78 ± 3.12, and 7.96 ± 2.44, respectively and there were no significant differences among the groups. However, the total AC numbers of HZn (27.07 ± 3.88) and MZn (26.39 ± 5.59) diet groups were significantly low compared to LZn (22.57 ± 5.09) diet group (p<0.01). Cytosolic SOD activity was the highest in LZn diet group. But thiobarbituric acid-reactive substances level in liver was also the highest in LZn diet group compared to other groups. There is no difference in cell proliferation in mucous membrane among the groups, while apoptotic positive cells were increased in the HZn diet group. The high zinc diet exhibited decreased β-catenin-stained areas on the mucous membrane of colon compared to the LZn or MZn diet group. These findings indicate that dietary zinc might exert a modulating effect on development of ACF/AC in the mice with iron-deficient status.
( Sang Bong Ahn ),( Dae Won Jun ),( Bo-kyeong Kang ),( Jae Yoon Jeong ),( Joo Hyun Sohn ),( Byoung Kwan Son ),( Ki Young Lee ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Intestinal microbiota is known to be closely associated with the incidence of obesity and nonalcoholic fatty liver disease (NAFLD). This study aimed to investigate effects of probiotics treatment on visceral fat area (VFA) and intrahepatic fat (IHF) fraction in NAFLD. Methods: Sixty-eight obese NAFLD patients (>5% fat fraction using MRI-derived proton density fat fraction (PDFF)) divided into the probiotics and the placebo group for twelve weeks. The probiotics mixture consists of six kinds of probiotics. VFA and IHF measured by MRI-PDFF. Body fat and muscle composition was evaluated by multi-frequency bioimpedence analysis. Liver stiffness was measured by transient elastography. Results: Body weight and total body fat amount were more reduced in probiotics group compare to placebo group. IHF fraction (16.3±15.0à14.1±7.7, P=0.032) reduced after 12 weeks probiotics treatment compare to baseline, but not in placebo group. Reduction rate of IHF (mean difference: -2.61%, P=0.012) was also more in probiotics group compare to placebo. Triglyceride level reduced after 12 weeks probiotics treatment compare to baseline. Probiotics group showed also more decrease triglyceride concentration (mean difference; -34.0 mg/dl, P=0.0033). Deep sequencing of the fecal microbiome revealed that the amount of Agathobaculum, Dorea (OTU 527923), Blautia, Ruminoccous, and Dorea (OTU 195044, OUT 470168) were increased in patients who were improved fatty liver. Conclusions: The 12-week treatment of probiotics resulted in a significant reduction of IHF and BMI in obese NAFLD patients.
[P322] A case of intralymphatic histiocytosis associated with breast cancer
( Yoon Soo Kim ),( Min Sung Kim ),( Bong Seok Shin ),( Chan Ho Na ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Intralymphatic histiocytosis (IH) is a rare disease with variable and nonspecific clinical features, but with characteristic histopathological findings. Histopathologically, dilated lymphatic vessels containing aggregates of mononuclear cells are observed in the reticular dermis. IH is often associated with other diseases; such as rheumatoid arthritis, osteoarthritis, joint metal implantation, and breast cancer occurred over mastectomy scar. Although the pathogenesis of IH is not defined, some authors suggest that lymphatic vessel engorgement by histiocytes migrating from neighboring inflammatory reactions may play a key pathogenic role. A 50-year-old female presented with multiple tender erythematous plaques on both breast and right shoulder. On past history, she underwent both breast conservation operation 3 years ago. Laboratory findinds were WBC 12,340/mm3, neutrophil 88.1%, ESR 10mm/hr, CRP 9.73mg/dL and procalcitonin 0.089ng/mL. Histopathologic findings showed irregularly dilated vessels with intraluminal cells in dermis. Endothelial cells lining the vessels were positive for D2-40 staining, which is a marker for lymphatic endothelial cells, and intraluminal cells were positive for CD68 staining, which is a marker for histiocytes. She improved with conservative therapy. To our knowledge, this is the first case of IH in association with breast cancer in the Korean dermatologic literature.
Alcohol Drinking Increased the Risk of Advanced Colorectal Adenomas
( Yoon Kyung Song ),( Young Sook Park ),( Choon Sik Seon ),( Hye Jin Lim ),( Byung Kwan Son ),( Sang Bong Ahn ),( Young Kwan Jo ),( Seong Hwan Kim ),( Yun Ju Jo ),( Ji Hyun Lee ),( Seung Chan Kim ) 대한장연구학회 2015 Intestinal Research Vol.13 No.1
Background/Aims: Age, sex, gene and life style are modulating risks for colon cancer. Although alcohol intake may impact on colorectal adenoma, clear association has not been established yet. We aimed to investigate effects of alcohol consumption on the characteristics of colorectal adenoma. Methods: Patients who underwent colonoscopic polypectomy of colorectal ad-enoma in the department of gastroenterology of Eulji hospital through 2005 to 2012, having both blood tests and ultrasound or abdominal CT examination were enrolled. The alcohol drinking patients were subdivided into normal or abnormal laboratory group, and alcoholic liver diseases group. Results: 212 patients with colorectal adenoma were analyzed; advanced adenoma and multiple adenoma were found in 68 (32.0%) and 79 (37.2%) patients. When compared to the nondrinker group (120/212 patients), the alcohol drinker group (92/212 patients) represented significantly high odds ratios (ORs) for advanced adenoma (OR, 2.697; P=0.002), and multiple adenoma (OR, 1.929; P=0.039). Among alcohol drinker (92 patients), the ORs of advanced adenoma were 6.407 (P=0.003) in alcoholic liver diseases group (17 patients), 3.711 (P=0.002) in the alcohol drinker with ab-normal lab (24 patients), and 2.184 (P=0.034), in the alcohol drinker with normal lab (51 patients) compared to nondrinker group. Conclusions: This study showed that alcohol drinking may influence on the development of advanced colorectal adenoma and multiplicity. Especially in the group with alcoholic liver diseases and with abnormal lab presented significantly higher ORs of advanced adenoma. (Intest Res 2015;13:74-79)
Dexmedetomidine attenuates H<sub>2</sub>O<sub>2</sub>-induced cell death in human osteoblasts
Yoon, Ji-Young,Park, Jeong-Hoon,Kim, Eun-Jung,Park, Bong-Soo,Yoon, Ji-Uk,Shin, Sang-Wook,Kim, Do-Wan The Korean Dental Society of Anesthsiology 2016 Journal of Dental Anesthesia and Pain Medicine Vol.16 No.4
Background: Reactive oxygen species play critical roles in homeostasis and cell signaling. Dexmedetomidine, a specific agonist of the ${\alpha}2$-adrenoceptor, has been commonly used for sedation, and it has been reported to have a protective effect against oxidative stress. In this study, we investigated whether dexmedetomidine has a protective effect against $H_2O_2$-induced oxidative stress and the mechanism of $H_2O_2$-induced cell death in normal human fetal osteoblast (hFOB) cells. Methods: Cells were divided into three groups: control group-cells were incubated in normoxia without dexmedetomidine, hydrogen peroxide ($H_2O_2$) group-cells were exposed to $H_2O_2$ ($200{\mu}M$) for 2 h, and Dex/$H_2O_2$ group-cells were pretreated with dexmedetomidine ($5{\mu}M$) for 2 h then exposed to $H_2O_2$ ($200{\mu}M$) for 2 h. Cell viability and apoptosis were evaluated. Osteoblast maturation was determined by assaying bone nodular mineralization. Expression levels of bone-related proteins were determined by western blot. Results: Cell viability was significantly decreased in the $H_2O_2$ group compared with the control group, and this effect was improved by dexmedetomidine. The Hoechst 33342 and Annexin-V FITC/PI staining revealed that dexmedetomidine effectively decreased $H_2O_2$-induced hFOB cell apoptosis. Dexmedetomidine enhanced the mineralization of hFOB cells when compared to the $H_2O_2$ group. In western blot analysis, bone-related protein was increased in the Dex/$H_2O_2$ group. Conclusions: We demonstrated the potential therapeutic value of dexmedetomidine in $H_2O_2$-induced oxidative stress by inhibiting apoptosis and enhancing osteoblast activity. Additionally, the current investigation could be evidence to support the antioxidant potential of dexmedetomidine in vitro.