풍선 확장술로 치료한 담관결석과 동반된 총담관 막양구조

백성민 ( Sung Min Baek ),김동욱 ( Dong Uk Kim ),장선미 ( Sun Mi Jang ),송병구 ( Byeong Gu Song ),박종만 ( Jong Man Park ),이대성 ( Dae Sung Lee ),김중근 ( Joong Keun Kim ),황경림 ( Kyung Lim Hwang ) 대한췌장담도학회 2014 대한췌담도학회지 Vol.19 No.3

Bile duct web is very rare disease and it`s etiology is controversial. Some webs are occurred in the presence of chronic inflammation, frequently associated with bile duct stone, but others are thought to be congenital. Many patients with bile duct web are asymptomatic, but they sometimes present symptom of biliary obstruction and cholangitis. It can be diagnosed by endoscopic retrograde cholangiopancreatogram, typically appearing as thin and shelf like radiolucent ring. We report a case of the common bile duct web with bile duct stones diagnosed by Endoscopic retrograde cholangiopancreatography (ERCP) in a 65-year-old man. The patient was treated by balloon dilatation successfully.

대구지역의 대기오염도 특성평가(I) : 지역별 및 계절별 농도변동을 중심으로 Locational and Seasonal variations

백성옥,최진수,황승만,김광은 嶺南大學校 環境問題硏究所 1996 環境硏究 Vol.15 No.2

본 연구는 대구지방환경관리청과 유관기관 등에서 과거 7년간(1988~1994년) 측정한 대기질 관련자료중 아황산가스, 분진, 일산화탄소, 질소산화물 및 오존을 대상으로 통계분석하여 각기 배출강도가 다른 지역별 농도분포 특성을 평가하였고 대구지역의 전반적인 대기질 변화추이를 파악하였다. 그 결과 각 지점별 아황산가스의 농도는 전형적인 동고하저형을 나타내었으며, 도시가스공급과 황함량규제등 연료변환 정책의 효과로 인해 점차적으로 감소하고 있는 추세를 보이고 있다. 부유분진은 결측치가 많아 장기적인 농도변화추이를 판단하기는 어려웠으나 아황산가스와 같이 큰 계절적인 변동은 보이지 않았다. 질소산화물의 전반적인 농도분포는 장기 환경기준치 50ppb를 초과하지 않는 수준이었으나 최근엔 이동배출원의 영향이 가중되어 그 농도가 꾸준히 증가하는 추세인 반면 동고하저형의 계절적인 변동을 나타내는 일산화탄소는 가정용 무연탄 사용량의 감소로 대기중 일산화탄소의 농도는 점점 감소하고 있는 추세이다. 오존은 전반적으로 일사량이 많은 하절기에 농도가 높았고 동절기에는 농도가 낮은 경향을 보였다. 한편 주요 대기오염물질의 장·단기 기준달성도를 비교분석한 결과 대구지역의 대기오염물질중 아황산가스의 고농도 발생빈도는 공업지역에 집중되어 있었으며 질소산화물과 일산화탄소는 아직은 장·단기 환경기준을 초과하지 않는 수준으로 나타났고, 분진과 오존의 경우는 공업지역 뿐만 아니라 전지역에서 그 발생빈도가 유사하게 나타났다. In this study, characteristics and distributional patterns of the concentrations of air pollutants in Taegu area were evaluated using a data-base established from the ambient air quality monitoring stations for the period of 1989 to 1994. The result of this study demonstrated that in each sampling site, the SO_2 concentrations were much higher in winter than those in summer. However, a decreasing tendency was clearly shown in the annual variation of SO_2 concentrations, largely due to the use of LPG instead of anthracite coal for local heating systems and to the fuel policy of using lower sulfur content fuel in industrial sectors. Unlike SO_2, there was no distinct seasonal variation in the concentrations of suspended particulate matter. Concentrations of NO_x were found to be generally lower than the long term ambient air quality standard (50 ppb). The NO_x concentration has been gradually increased, reflecting the rapidly increased number of vehicles In this area, while the CO levels In ambient air were declind because of the reduced use of coal for domestic purposes. The Ozone concentrations in Taegu area exhibited that there has been already photochemical smog phenomena during the summer season when the insolation is strong.

대구지역의 대기오염도 특성평가(Ⅱ) : 대기질 변수의 시간별 변동을 중심으로 Hourly variations of air quality parameters

백성옥,최진수,황승만 嶺南大學校 環境問題硏究所 1996 環境硏究 Vol.16 No.1

요약문본 연구에서는 과거 7년간의 실측자료를 이용하여 대구지역 주요 대기오염물질에 대 한 대기오염도 분석 및 광화학스모그 기간중의 대기질 평가는 물론 대기오염도 해석에 지배 적인 영향을 미치는 기상자료를 이용하여 대구지역의 시정감쇄 요인분석 및 풍향, 풍속과 대기안정도를 분석하였다. 주요 대기오염물질의 일주 시간대별 농도변화는 아황산가스와 분 진의 경우 오전 8~10시경과 오후 4시경에 각각 최고, 최저농도를 나타내였고 이산화질소는 오전·오후의 교통량증가와 기상인자의 복합적인 영향으로 두차례의 최고농도를 나타냈다. 일산화탄소는 시간 환경기준치에 크게 못미치는 수준으로 동절기와 하절기의 시간별 농도변 화 양상이 서로 상이하게 나타났으며 오존은 일사량이 증가하기 시작하는 오전 10시경으로 나타났다. 또한 대구지역 오존농도의 발생빈도는 최근(1993~1994)으로 올수록 증가하는 경향 을 보였으며 오존농도와 그 영향인자와의 상관성 역시 일사량과 이산화질소가 가장 중요변 수임이 증명되었다. 최근 6년간의 기상자료를 분석한 결과 시정거리는 가을철이 월편균 17~20km 정도로 가장 좋았으며 풍향, 풍속 및 대기안정도는 서북서풍이 연중 14.0%, 2m/sec 이하의 저풍속이 전체의 36.5%, 중립조건인 D등급이 전체의 48.1%로 각각 나타나 대구지역이 대기오염의 확산에 불리한 조건임을 시사하고 있다.AbstractWith empirical data obtained for last 7 years, this study was conducted to analyze major pollutants and to evaluate the air quality of Taegu during the period of photochemical smog. In addition to this, causes of visibility reduction in Taegu, wind speed, wind direction and atmospheric stability were also analyzed. In terms of the variation of concentration for each pollutant by time during daytime, the highest concentration of SOz and partic ulates was measured at around 8~10 o'clock, and the lowest concentration of those pollutants was found at approximately 15~16 o'clock.In the case of NO;, due to the traffic and complex atmospheric conditions, the highest concentration was measured twice a day. The concentration of CO was much less than the atmospheric standard. The difference in the variation of CO concentration with respect to time was found between summer and winter. Ozone concentration increased with surging amount of insolation and the highest level of ozone was presented at between 15 and 16 o'clock with no respect to season. High concentration of ozone was observed much more requently in last 2 years (1993~1994) and it is verified that the insolation and NOz were main sources to be highly related to ozone concentration. As the result of investigation of meteorological data obtained for last 7 years, the highest visibility (17~20 km) was found in autumn as the monthly average value. As conclusion, the analyzed data-base indicated that it is difficult to spread air pollutants out of metropolitan Taegu city because of low wind speed (lower than 2 m/s), wind direction (Northwest), and atmospheric stability (D).

Preview 알고리즘을 이용한 용접로봇의 경로제어

조만호,양상민,백고길 大田産業大學校 2001 한밭대학교 논문집 Vol.18 No.-

The robustness of a seam tracking for the automatic welding system is studied. Ac servo motor is used to control the position and velocity of the weld torch. The CCD camera locates ahead of weld torch to preview the weld line, and brings about the inaccuracy on the weld speed. The advanced optimal preview control was used to enhance the tracking performance. The experiment results showed that the tracking performance was improved significantly.

조선업 도장작업자의 유사노출군과 노출변이; 크실렌 노출을 중심으로

고상백,노영만,임현우,신용철,김수근,최홍열,김재용,장성훈 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.4

목적 : 조선업 도장 작업자의 크실렌 노출을 평가하기 위하여, 수행직무 및 밀폐특성에 따라 유사노출군으로 구분하여 노출 변이 및 동질성을 파악하고자 하였다. 방법 : 3회 이상 반복측정이 이루어진 근로자 중동일공정에서 직무상 변동이 없는 근로자 총 28명을 대상으로 하였다. 노출농도 값을 대수전환(lOgtransformation)하여 근로자간, 근로자내 노출 분산요소을 추정하기 위하여, nested randomeffects ANOVA model을 활용하였다. 선정된 유사노출군 내 구성원의 측정 평균이 동일하다고 할수 있는지를 검정하기 위하여 분산요인(9f)을 산출하였고, 쿨즈0.031일 경우 동일하다고 생각하였다.또한 노출 값을 대수전환하여 95 %의 근로자(b-R9s)가 2배수 범위 내에 측정값을 가질 경우 동일하다고 생각하였다. bwRSS의 값을 유사노출군내의 근로자들간(between worker)의 기하표준편차(bwsy)를 구한 후 exp(3.92 bwsy)로 계산하여 산출하였고, 그 값이 2이하이면 동일하다고 생각하였다. 결과 : 일반적으로 유사노출군은 노출농도가 비슷한 것이라는 생각과는 달리, 직무에 근거한 유사노출군은 동질성 검정상 이질적이었다. 분무도장과 붓도장 모두 bwRss은 2를 초과하였고, 룰 또한 0.031를 초과하여 변이 폭이 컸다. 그러나 밀폐특성에 따른 노출 분포의 변이성은 직무만으로 구분했을 때의 변이지표 보다 그 수치가 낮아 밀폐특성으로 직무의 변이성을 설명 할 수 있었다. 결론 : 직무에 근거한 유사노출군이 동질적이지알다는 결과는 유사노출군으로 구분된 근로자의 업무특성이 하나의 유사노출군으로 설정할 수 없다는 점을 시사한다. 따라서 향후 작업환경 측정 시 직무뿐만 아니라 특정 업무(specific task) 또는 세부작업현황까지 파악할 필요성을 제시하고 있다. Objectives : This study was conducted to assess the concentration of xylene exposure and exposure variability of a similar exposure group (SEG) in accordance with job title and confined space. Method : The study subjects included 28 workers working in the painting process in the ship-building industry. Measurement of subjects were repeated three times. Within and between-worker exposure valiance components were estimated from log-transformed exposure concentrations employing a one-way nested random effects analysis of variance model. A uniformly exposed group was defined as one where the between-worker variance(σB2) was less than or equal to 0.031 or bwR95 ≤2, where bwR95 =exp(3.92 bwSy) , representing the radio of the mean exposures of the 97.5th and 2.5th percentile groups of the workers sampled. Result : The results indicated that, contrary to popular belief, similar exposed groups based on job title were heterogeneous. The between-worker variance(σB2) is large(≥0.031) and the ratios of the 97.5th and 2.5th percentile workers of the log normally distributed exposures of each group of worriers was more than 2. However dividing job title into confined space (in-block, out-block, in/out-block) decreased the between-worker exposure variability. Conclusion : This study focused on the quantitative aspects of exposure in painters in the ship-building industry. We cannot accept the assumption that SEG are uniformly exposed, as a major component of variation in exposure relates to differences in tacks or other factors. Therefore, the observational schemes can be improved by investigating Job-specific task and practice.

간 세포암에서 VEGF, TGF-β1, b-FGF 발현의 의의

김성용,남충현,주종우,채만규,백무준,이문수,김형철,안현철,김홍수,김창진,김창호 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Purpose: Angiogenesis is important for the proliferation and the metastasis of solid tumors. The growth of a solid tumor is widely recognized to depend on the process of neovascularrozation. Without angiogenesis, tumors cease to grow beyond even a few milimeters in diameter. It has been shown that tumor vascular density is an independent prognostic marker in several types of human tumors and is known to correlate with poor prognosis. To date, many angiogenic factors have been identified, such as transforming growth factor-α(TGF-α), transforming growth factor-β(TGF-β), fibroblast growth factor family(FGF), vascular endothelial growth factor(VEGF), platelet derived endothelial cell growth factor(PD-ECGF), tumor necrosis factor-α(TNF-α), and angiogenin. Hepatocellular carcinoma(HCC) is the second most common tumor in Korean males and is known as a typical hypervascular tumor with frequent portal vein invastion. The authors identified the expreesion of VEGF, TGF-β1, and b-FGF in HCC specimens and evaluated the relationship between these growth factors and the clinicopathologic characteristics of HCC. Method: We reviewed the medical records of 30 patients who were diagnosed as hepatocellular carinoma treated with hepatic resection between January 1994 and December 1998 in Soonchunhyang University Chunan Hospital. The selection of the cases was decided according to the condition of paraffin block fixation. The prognostic factors such as age, sex, tumor size, concentration of serum α-fetoprotein, presence of liver cirrhosis, presence of tumor emboli in portal vein, TMN stage, amount of transfusion during the operation, hepatitis B virus(HBV) infection, and Edmonson-Steiner(E-S) grade were investigated. Relationship between the prognostic factors and the immunopathologic expression of the TGF-β1, b-FGF, and VEGF was examined. Result: Thirty patients (24 males, 6 females) were included in the current study. The patient's mean age was 50.6 years and the age ranged from 36 to 65 years. The mean size of the tumor was found to be 5.2cm. All the patients were follewed up for 7 to 63 months. Child's classification A patients were 23(76.7%)cases, B patients were 7(23.3%)cases, and C was none. Immunohistochemical staining of HCC tumor mass in VEGF expression patients were 17(56.7%), b-FGF expression patients were 10(33.3%), and TGF-β1 expression patients were 10(33.3%). VEGF expression or more than one positive expression among the three factors correlated with tumor size and the stage of HCC but did not correlated with other clinicopathological characteristics. TGF-β1 and b-FGF did not correlate with any clinicopathological characteristics. Conclusion: The results suggest that the expression of VEGF or more than one positive expression among the three factors in HCC cells may be a significant prognostic factor of HCC.

급성 충수염으로 진단된 예측 불가 염증성 맹장 종물에 대한 외과적 고찰

민경진,백무준,채만규,김성용,이문수,김창호,김재준,송옥평 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Purpose: An unexpected inflammatory cecal mass of uncertain etiology was encountered during surgery for presumed appendicitis. In this case, the surgeon couldn't exclude differential diagnosis which were severe appendicitis involving the cecal region, diverticular disease, other inflammatory bowel diseases, and neoplasm. Therefore, this finding leads to a therapeutic dilemma for the surgeon, when making surgical decisions during the operation. The aim of this study was to resolve this dilemma, a retrospective review was undertaken in this study. Methods: A retrospective study was performed to review the management of this problem at Soonchunhyang University Chunan Hospital for eight and half years from July 1991 to December 1999. A review of the emergency operation records identified 50 patients who had undergone ileocecal resection or right hemicolectomy for an inflammatory ileocecal mass of uncertain etiology when operated on for probable appendicitis. Results: Altogether, 39 patients underwent ileocecal resection, and 11 patients underwent right hemicolectomy. The final pathologic diagnosis was appendiceal abscess in 32 patients (63%), cecal diverticulitis in 7 patients (14%), neoplasm in 6 patients (12%), appendiceal phlegmon in 3 patients (6%), ileal tuberculosis in 1 patient (2%) and Anisakiasis in another patient (2%). The neoplasm of the 6 neoplasm patients was ascending colon cancer for 4 patients and cecal cancer for 2 patients. There was no mortality in this group. Conclusion: Although most inflammatory cecal masses are caused by benign disease, all cases in which the intraoperative diagnosis is unclear, any pathologic diagnosis including neoplasm cannot be ruled out. So this suggest ileocecal resection or right hemicolectomy to remove a possible underlying malignancy, and to decrease morbidity and mortality.

감초 추출물이 면역응답에 미치는 영향

심호기,백반석,황성원,배만종 경산대학교 생명자원개발연구소 1996 생명자원과 산업 Vol.1 No.-

감초에서 분리한 각각의 추출물(HWE, ME, AE)을 BALB/c mouse에 투여하여 탐식작용, 용혈반형성, 용혈소 역가특정 및 Rosette형성 실험을 통해 감초가 면역응답에 미치는 영향을 조사하였다. 1. 탐식능 측정에서 복강침출세포(PEC)와 비장세포(spleen cell)는 CON군에 비하여 가각의 약물투여군이 Candida parapsilosis에 대한 효과가 약간 높은 경향을 나타냈지만 유의성은 없었다. 2. 용혈반 형성 및 용혈소 역가측정에서는 CON군에 비하여 HWE, ME, AE투여 군이 유의성을 나타냈다. 3. Rosette형성에 대한 측정에서는 CON군에 비하여 ME, AE투여 군이 높은 유의성을 나타냈다. 본 실험 결과에서 감초 추출물들은 Candida paraprapsilosis에 대하여 약간의 탐식증진효과를 나타냈으며, 항체생성세포의 용혈반 시험 및 용혈소 역가측정과 Rosette형성측정에서의 유의성을 나타낸 것은 감초가 세포성 면역을 주도하는 T세포를 활성화시킬 뿐만 아니라, 체액성 면역을 주도하는 B세포를 활성화시킨다는 것을 확인 할 수 있다. The inverstigation of effecting immune response on BALB/c mouse was experimented with hot water extract(HWE), 50% methanol extract(ME) and aaceton extract(AE) 〔which was extracted from Glycyrrhiza glabra〕. The experiment was carried out by phagocytosis, hemolytic plaque assay, hemolysin titration and rosette assay. Peritoneal exudative cells and spleen cells in phagocytosis ability; the experimental group has shown a slight increase in Candida parapsilosis(HWE, ME & AE). The experiment shows no relevant correlation. The experiment of hemolytic plaque assay and hemolysin titration was treated by HWE, ME and AE. The experimental group was treated by ME and AE through the measurement of rosette assay. The experimental group has given significant increase compared with the control. As the result, the extracts of Glycyrrhiza glabra (HWE, ME and AE) has effedted slightly to Cnadida parapsilosis in phagocytosis. The reason of effecting the immunocyte in hemolysin titration, rosette assay and hemolytic plaque assay ; Glycyrrhiza glabra has activated the T-cell which controlled cell mediated immunity. Same with B-cell which could also control humoral immunity.

대구지역 실내 외 공기중 주요 대기오염물질의 농도조사에 관한 연구

최진수,백성옥,김영민,박상곤,정점희,황승만 嶺南大學校 環境問題硏究所 1995 環境硏究 Vol.15 No.1

최근 현대인의 실내거주시간이 일상생활시간의 80% 이상을 차지할 정도로 크게 증가하면서 보건·위생학적 측면에서 실내공기질은 매우 중요한 관심사로 등장하게 되었다. 본 연구는 1994년 8월의 여름철과 1994년 12월 ∼1995년 1월의 겨울철에 대구를 중심으로 가정집, 사무실, 식당과 같은 3가지 유형의 일반주거환경 중 실내·외 공기를 대상으로 실행되었다. 측정항목으로는 RSP, CO, CO₂, NO₂등의 주요 기준성 오염물질과 Bioaerosol을 선정하였다. 본 연구의 결과, 각 성분대상물질의 실내·외 농도는 실내거주환경 및 여름과 겨울, 두 계절에 따라 영향을 받는 것으로 나타났으며 실내·외 농도비교에서 RSP, CO, CO₂의 실내농도는 대부분의 지역에서 실외에 비하여 높은 농도를 나타냈다. 각 실내거주환경에 따른 실내·외의 농도는 가정, 사무실에 비하여 식당에서 상대적으로 높은 농도를 나타냈으며 실내·외 농도비 또한 식당에서 상대적으로 큰 값을 나타냈다. 여름과 겨울의 두 계절에 따른 RSP, CO, CO₂의 실내·외 농도는 여름철에 비하여 겨울철에 더욱 높은 농도를 나타냈으나 Bioaerosol의 실내·외 colony/plate는 여름철에 더욱 높은 수치를 나타냈다. The study was carried out to investigate the concentrations of indoor air pollutants such as respirable suspended particulate (RSP), carbon monoxide (CO), carbon dioxide (CO₂), nitrogen dioxide (NO₂) and bioaerosol at homes, offices and restaurants in Taegu city. Indoor and outdoor concentrations of these pollutants were observed simultaneously from August 1994 for summer to January 1995 for winter. The results were summarized as follows : 1. Both in summer and in winter, the indoor concentrations of RSP, CO, and CO₂; were higher than the outdoor concentrations, the indoor concentrations of major air pollutants (RSP, CO, CO₂, NO₂) in restaurants were higher than those in homes and offices. 2. The indoor and outdoor concentrations of RSP, CO, and CO₂; in winter were significantly higher than those in summer, on the other hand. The CFU/plate of bioaerosol in winter was lower than that in summer. These results suggested that indoor levels of air pollutants were affected by various indoor characteristics such as smoking, cooking, ventilation rate, winter heating systems, and behavioral activity of occupants.

HPLC 시스템을 이용한 大氣中 多核芳香族 炭化水素의 定量에 關한 硏究

정재필,황승만,박철용,백성옥 嶺南大學校 工業技術硏究所 1991 연구보고 Vol.19 No.1

In this study, an analytical procedure was evaluated for the determination of atmospheric PAH, both in gaseous and particulate phases. The method involves Soxhlet extraction of the filters and Tenax adsorbent, followed by a clean-up stage using a silica mini column prior to analysis by reversephase HPLC with wavelength programmable fluorescence and UV detection. A total of 18 PAH were identified and quantified, all of which have been of environmental concern. In order to validate the methodology and to ensure compatibility of the results, the analytical method used for the determination of PAH was evaluatd with respect to the efficiencies of extraction and clean-up procedure, HPLC separation, and lower limits of detection. In addition, substrate dependency of PAH recovery was also investigated for the two type of filter(glass fiber and PTEF filters) and Tenax adsorbent.