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김영숙,김애정,김선여,김순경 순천향대학교 기초과학연구소 1999 순천향자연과학연구 논문집 Vol.5 No.1
This study was conducted to investigate the effect of mulberry leaves on lipid metabolism in adult females. The subjects(n=13) intake 1.8g mulberry leaves powdered per day with the common diet. To conduct this study, anthropometric measurements, daily nutrients intake, and serum lipids(total-cholesterol, HDL-cholesterol, triglycerides, LDL-cholesterol) were measured 3 times(before, after 2week and 4week during the experimental periods). The results are as follows: Serum LDL-cholesterol contents were significantly(P<0.05) decreased with treatment of mulberry leaves powder. And serum total-cholesterol and triglycerides were decreased, but did not show significant differences.
한방 다이어트 식품 HBM(Healthy Body Maker)의 체중감소 및 혈청 콜레스테롤 저하 효과
박재상,김애정,김선여 동아시아식생활학회 2001 동아시아식생활학회지 Vol.11 No.4
This study was performed to investigate the effects of HBM(Healthy Body Maker) on the weight loss and serum cholesterol level of rats. Twenty male Sprague-Dawley rats weighing 200±5g were grouped into 2. Rats were raised for 6 weeks with diet containing 0% and 5% of HBM. 1. There were no clinical signs for all the experimental period(6 weeks) in 0% and 5% groups. 2. At 3 and 6 weeks, body weight of 5% HBM group was significantly lower than that of control group. respectively (p<0.05, p<0.01). 3. At 4 weeks, the level of MCHC of 5% HBM group was significantly higher than that of control group(p<0.01). And at 6 weeks the level of RBC and Hct of 5% HBM group were significantly higher than those of control group(p<0.05). 4. At 6 weeks, the level of serum cholesterol of 5% HBM group was significantly lower than that of control group. 5. Absolute liver weight of 5% HBM group was significantly lower than that of control group(p<0.05). 6. Minor subaceous sickness of liver cell in the control group appeared but no symptom of liver cell in 5% HBM group, It is concluded that HBM was a safe and effective diet food which aided in inducing weight loss in rat without any observed harmful clinical side effects.
황금(黃芩)의 4-VO로 유발한 흰쥐뇌허혈에 대한 신경방어효과
李秉哲,林康鉉,金榮玉,金善礪,安德均,朴虎君,金護哲 대한본초학회 1999 大韓本草學會誌 Vol.14 No.2
Scutellariae Radix(SR), the root of Scutellaria baicalensis G_EORGI, whose property, flavour and channel tropism is bitter in flavour, cold in property(寒), acting on the lung, gallbladder, stomach and large intestine channels(歸?,?,?,大??), has the effects of clearing away heat and dampness(淸熱??), purging fire, detoxicating(?火解?), stopping bleeding(止血) and preventing miscarriage(安?). This drug is one of the popular drugs in traditional Korean medicine, which has been used to antipyretic, antibacterial, antitoxic and antihypersensitive effects. So this study was planned to check the neuroprotective effect of SR on the global ischemia induced by 4-vessel occlusion in Wister rats. and SR extract was lyophilized after extraction with 70% methanol. We induced 4-vessel occlusion for 10 minutes and reperfused again. The number of CA1 pyramidal neurons were counted after 7 days of reperfusion under the cresyl violet staining. The result obtained that in 4-VO ischemia, SR showed significantly neuroprotective effects(1,000 and 500 ㎎/㎏ of SR extracts, p<0.05) compared with control group. Each neuroprotective ratio was about 27.4 %, 23.2 % respectively. Consequently, Scutellariae Radix has neuroprotective effects on the global ischemia induced by 4-vessel occlusion in Wistar rats.
( Sun Yeou Kim ),( Ji Ho Park ),( Ye Ji Hong ),( Seul A Kim ) 한국응용약물학회 2011 Biomolecules & Therapeutics(구 응용약물학회지) Vol.19 No.4
In this study, we found that Forsythiae fructus (FF) and one of its main compounds, arctigenin, signifi cantly inhibited nitric oxide production in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. Arctigenin also suppressed the expression of inducible nitric oxide synthase and cyclooxygenase-2, and inhibited the activation of extracellular signal-regulated kinase, c-Jun N-terminal kinase and p38. Moreover, it also reduced levels of proinfl ammatory cytokines, interleukin 1β, tumor necrosis factor α and prostaglandin E2, and inhibited neuronal death in LPS-treated organotypic hippocampal cultures. Therefore, we suggest that arctigenin may confer a neuroprotective effect via the inhibition of neuroinfl ammation.
Nocatriones A and B, Photoprotective Tetracenediones from a Marine-Derived <i>Nocardiopsis</i> sp.
Kim, Min Cheol,Hwang, Eunson,Kim, Taejung,Ham, Jungyeob,Kim, Sun Yeou,Kwon, Hak Cheol American Chemical Society and American Society of 2014 Journal of natural products Vol.77 No.10
<P>Two new tetracenedione derivatives, nocatriones A (<B>1</B>) and B (<B>2</B>), were discovered from the culture broth of a marine actinomycete, <I>Nocardiopsis</I> sp. KMF-002, which was isolated from the tissue of an unidentified dark purple marine sponge. The structures of <B>1</B> and <B>2</B>, which are tetracenediones containing α-pyrone substituents, were determined to be 3,8,10,11-tetrahydroxy-2-(4-hydroxy-2-oxo-2<I>H</I>-pyran-6-yl)-1-methyltetracene-5,12-dione (<B>1</B>) and 3,8,10,12-tetrahydroxy-2-(4-hydroxy-2-oxo-2<I>H</I>-pyran-6-yl)-1-methyltetracene-6,11-dione (<B>2</B>). Ultraviolet B (UVB)-irradiated cells treated with 10 μM nocatrione A (<B>1</B>) significantly decreased the level of MMP-1, a protein that degrades collagen and other extracelluar matrix components that comprise dermal tissue, when compared to untreated cells. These results support that nocatriones A (<B>1</B>) and B (<B>2</B>) may show antiphotoaging activity in UVB-irradiated models.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2014/jnprdf.2014.77.issue-10/np5006086/production/images/medium/np-2014-006086_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np5006086'>ACS Electronic Supporting Info</A></P>
Antihepatotoxic zeaxanthins from the Fruits of Lycium chinense
Kim, Sun-Yeou,Kim, Hong-Pyo,Huh, Hoon,Kim, Young-Choong The Pharmaceutical Society of Korea 1997 Archives of Pharmacal Research Vol.20 No.6
A $CHCl_3$:MeOH extract of the fruit of Lycium chinense Mill. (Solanaceae) was found to afford significant protection against carbon tetrachloride-induced toxicity in primary cultures of rat hepatocytes. Subsequent activity-guided fractionation resulted in the isolation of zeaxanthin and zeaxanthin dipalmitate as antihepatotoxic components. Incubation of injured hepatocytes with zeaxanthin dipalmitate reduced the levels of glutamic pyruvic transaminase (GPT) and sorbitol dehydrogenase (SDH) released from damaged cells to 60.5% and 76.3% of those released from untreated controls, respectively. Zeaxanthin also reduced the levels of GPT and SDH to 68.5% and 61.3% of the levels of those released from the untreated contro. The results confirm the hepatoprotective activities of zeaxanthins. Antihepatotoxic activities of zeaxanthins are comparable to that of silybin.
Phenolic Glycosides from the Twigs of <i>Salix glandulosa</i>
Kim, Chung Sub,Kwon, Oh Wook,Kim, Sun Yeou,Choi, Sang Un,Kim, Jae Yoon,Han, Ji Young,Choi, Soo Im,Choi, Jong Gil,Kim, Ki Hyun,Lee, Kang Ro American Chemical Society and American Society of 2014 Journal of natural products Vol.77 No.8
<P>As a part of an ongoing search for bioactive constituents from Korean medicinal plants, the phytochemical investigations of the twigs of <I>Salix glandulosa</I> afforded 12 new phenolic glycosides (<B>1</B>–<B>12</B>) and a known analogue (<B>13</B>). The structures of <B>1</B>–<B>13</B> were characterized by a combination of NMR methods (<SUP>1</SUP>H and <SUP>13</SUP>C NMR, <SUP>1</SUP>H–<SUP>1</SUP>H COSY, HMQC, and HMBC), chemical hydrolysis, and GC/MS. The absolute configuration of <B>13</B> [(1<I>R</I>,2<I>S</I>)-2-hydroxycyclohexyl-2′-<I>O</I>-<I>trans</I>-<I>p</I>-coumaroyl-β-<SMALL>d</SMALL>-glucopyranoside] was determined for the first time. Compounds <B>1</B>–<B>3</B>, <B>6</B>, and <B>7</B> exhibited inhibitory effects on nitric oxide production in lipopolysaccharide-activated murine microglial cells (IC<SUB>50</SUB> values in the range 6.6–20.5 μM).</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2014/jnprdf.2014.77.issue-8/np500488v/production/images/medium/np-2014-00488v_0003.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np500488v'>ACS Electronic Supporting Info</A></P>