Underutilisation of Physical Rehabilitation Therapy by Cancer Patients in Korea: a Population-based Study of 958,928 Korean Cancer Patients

Cho Songhee,Chung Seung Hyun,Kang Minjoo,Jo Aejeong,Sim Sung Hoon,Kim Yu Jung,Yang Eun Joo 대한의학회 2021 Journal of Korean medical science Vol.36 No.46

Background: Advanced cancers are associated with more severe symptoms and greater impairment. Although most patients with metastatic cancer would benefit from rehabilitation, few patients receive appropriate rehabilitation therapy. We explored the use of rehabilitation therapy by cancer patients. Our data represented the entire population of Korea. The analyses were performed according to cancer type and stage. Methods: We extracted rehabilitation utilization data of patients newly diagnosed with cancer in the period of 2011–2015 from the Korea Central Cancer Registry, which is linked to the claims database of the National Health Insurance Service (n = 958,928). Results: The utilisation rate increased during the study period, from 6.0% (11,504) of 192,835 newly diagnosed patients in 2011 to 6.8% (12,455) of 183,084 newly diagnosed patients in 2015. Patients with central nervous system (28.4%) and bone (27.8%) cancer were most likely to undergo physical rehabilitation. The rehabilitation rate was higher in patients with metastatic than localised or regional cancer (8.7% vs. 5.3% vs. 5.5%). Conclusion: This claims-based study revealed that rehabilitation therapy for cancer patients is underutilised in Korea. Although patients with metastasis underwent more intensive rehabilitation than patients with early stage cancer, those without brain and bone tumours (the treatment of which is covered by insurance) were less likely to use rehabilitation services. Further efforts to improve the use of rehabilitation would improve the outcomes of cancer patients.

Effect of Plant Growth Regulators in In Vitro Culture of Hippophae rhamnoides

Songhee Lee,Wonwoo Cho,Hyeonsoo Jang,Romika Chandra,Sora Lee,Hoduck Kang 강원대학교 산림과학연구소 2021 Journal of Forest Science Vol.37 No.2

This study was carried out to establish in vitro propagation system influenced by plant growth regulators through organogenesis with three different seed sources (China, Mongolia and Russia) for conservation of genetic resources in Northeast Asia. The experiment compared two different carbon sources (commercial sugar, sucrose), which showed no significant differences in germination rate. Induced adventitious buds from leaf segments were found to be highly effective when supplemented with 1.0 mg/L BA, 1.0 mg/L Kinetin, and 5.0 mg/L IAA, in the case of Chinese origin 96.8%, Russian origin R-1: 95.6%, R-2: 85.6%, and Mongolian origin M-2: 77.8%. It was effective in BA and Kinetin with supplemented with IAA, respectively. Shooting development was also efficient in Woody Plant Media (WPM) supplemented with 1.0 mg/L BA, 1.0 mg/L Kinetin and 5.0 mg/L IAA.

Physiological Characteristics of Zelkova serrata Street Trees in Goyang and Paju, South Korea

Songhee Lee,Sora Lee,Seonghun Lee,Wonwoo Cho,Su Young Woo,Hoduck Kang,Tae Kyung Yoon 강원대학교 산림과학연구소 2023 Journal of Forest Science Vol.39 No.1

Street trees have been incorporated into urban forests to regulate the microclimate and provide shade as well as provide aesthetic and environmental functions and to evaluate their physiological characteristics. Zelkova serrata is a major tree species that has been planted on various South Korean streets. We determined the physiological characteristics of Z. serrata in street trees of Goyang and Paju in Gyeonggi Province. According to survey sites, net CO2 assimilation rates was 13.9-16.4 μmol CO2 m-2s-1, chlorophyll fluorescence (Fv/Fm) was 0.80-0.82, and proline contents was showed 3.4-3.7 mg g-1 FW. The studied trees were assumed to be physiologically stressed, but it was found that Z. serrata was planted as street trees were not significantly stressed when compared to chlorophyll fluorescence responses and proline contents. In the future, the continuous monitoring system is needed to evaluate the physiological characteristics of urban trees.

Effects of Plug Cell Trays, Soil and Shading Rates on Seed Germination and Seedling Growth Characteristics of Hippophae rhamnoides L.

Songhee Lee,Wonwoo Cho,Romika Chandra,Jiwon Han,Hoduck Kang 강원대학교 산림과학연구소 2020 Journal of Forest Science Vol. No.

In this study, basic data with respect to the introduction of Hipphophae rhamnoides L. and its cultivation in Korea could be obtained. According to the size of the plug cell tray, Chinese origin’s rate of seed germination was relatively high in 128 plug cell tray, and growth was vibrant in 50 plug cell tray. The germination and growth of Russian origin seeds showed that they were relatively effective in 50 plug cell tray and with respect to soil environment, TKS-2 soil with untreated shading relatively promoted both germination and growth for Chinese origin, the rate of germination was high in bed soil for horticulture and growth result was good in TKS-2 in the case of Russian origin. It was confirmed that the germination rate of Chinese origin H. rahmnoides L. was highest in untreated shading and the shoot growth was vibrant in 70% shading while the growth in roots was vibrant in the untreated shading. In the Russian origin, H. rhamnoides L. the germination rate in 30% and 70% shading was about 50% which was higher than that in the untreated shading and general growth was vibrant in 30% shading.

외부환경 변화를 고려한 A형 접지극의 매설깊이 기준 연구

차송희(Songhee Cha),류기환(Kihwan Ryu),김용성(Yong-Seong Kim),이금환(Geum-Hwan Lee),조구현(KuHyun Cho),신성수(Seong-su Shin) 한국조명·전기설비학회 2021 조명·전기설비학회논문지 Vol.35 No.12

The purpose of this paper is to study on depth of A-Class earth electrode for maintaining the earthing resistance of electrical installation. IEC, BS, NEC, NESC were investigated and compared with KEC regulation, for soil temperature (freezing or frostline), earth potential, and moisture effect (drying). Furthermore, we demonstrate the effect of water and temperature on the depth of the earth electrode was tested. In addition, the effect on moisture and temperature according to the depth of the earth electrode was tested. Based on the result of this study, it is intended to derive the depth of the earth electrode that is safe and reliable in electrical installations.

Nutrient analysis and in vitro rumen fermentation of commercial formulated concentrates for finishing Hanwoo steers

Hanbin Kim,Songhee Lee,Soohyun Jeong,Joongkook Park,Taeksoon Shin,Byungwook Cho,Seongkeun Cho,Byeongwoo Kim,Jakyeom Seo 충남대학교 농업과학연구소 2016 Korean Journal of Agricultural Science Vol.43 No.5

지역별 아파트 매매가격지수와 심리지수 간의 실증 분석: 설문 심리지수와 검색어 심리지수를 중심으로

백송희 ( Baek Songhee ),조미경 ( Cho Mikyoung ),강명구 ( Kang Myounggu ) 한국부동산분석학회 2022 不動産學硏究 Vol.28 No.4

최근 아파트 매매가격의 급격한 상승과 더불어 지역별 아파트 매매가격이 차이가 나는 비동조화 현상이 관찰되었다. 최근 기대 이익 및 주거 편의성 등 소비자들의 심리는 지역간 아파트 매매가격의 편차를 설명하는 주요 요인으로 설명되어지고 있다. 하지만 설문조사, 검색어, 뉴스 및 소셜 미디어 등 사람들의 심리를 측정하는 방법이 다양함에도 불구하고 다양한 심리변수와 아파트 매매가격 간의 관계를 비교분석하는 연구는 미비한 실정이다. 따라서 이 연구에서는 주택 가격에 유의한 영향을 미치는 기존 거시경제변수와 함께 부동산 시장 참여자의 심리를 대표하는 설문 심리지수와 네이버 검색어 심리지수를 이용하여 아파트 매매가격 간의 관계를 분석한다. 분석의 공간적 범위는 서울, 수도권, 비수도권으로 설정하고 분석방법은 VECM을 사용한다. 분석 결과, 설문 심리지수는 검색어 심리지수에 비하여 단기적으로 안정적이며, 아파트 매매가격과 장기적으로 정(+)의 관계를 보였다. 반 면에 검색어 심리지수는 단기적으로 불안정하며 아파트 매매가격과 장기적으로 부(-)의 관계를 보이는 것으로 나타났다. 이는 검색어를 통해 나타난 사람들의 심리가 설문을 통해 나타난 사람들의 심리에 비해 불안정하고 아파트 매매가격에 따라 유사하게 움직이지 않는 특징을 보여주고 있다. Apartment sale price indexes by region in the Seoul metropolitan area and non-metropolitan areas have been observed to vary considerably and lack coordination. Recently, consumer psychology, such as expected profit and housing convenience, has been explained as a major factor in explaining the difference in apartment sales prices between regions. Studies that compare and analyze the relationship between various sentiment variables and apartment sale prices remain limited although there are various methods to measure people’s sentiment, such as by using surveys, search terms, the news, and social media. Therefore, in this study, we analyze the relationship between apartment sale prices and sentiment variables by using the survey sentiment index and the sentiment index of Naver search terms. The Vector Error Correction Model(VECM) is used for the analysis. Results show that the survey sentiment index is stable in the short term compared to the search-based sentiment index. It also shows a positive relationship with the apartment sale price index in the long term. This shows that the sentiment of people shown through search terms is unstable compared to the people’s sentiment shown through the survey and does not move similarly according to the sale price of apartments.

Sepsis in Patients Receiving Immunosuppressive Drugs in Korea: Analysis of the National Insurance Database from 2009 to 2013

Seung-Young Oh,Songhee Cho,Hannah Lee,장은진,Se Hee Min,Ho-Geol Ryu 대한중환자의학회 2015 Acute and Critical Care Vol.30 No.4

Background: The aim of this study is to evaluate the influence of immunosuppressants on in-hospital mortality from sepsis. Methods: Using data of the Health Insurance Review & Assessment Service, we collected data from patients who were admitted to the hospital due to sepsis from 2009 to 2013. Based on drugs commonly used for immunosuppression caused by various diseases, patients were divided into three groups; immunosuppressant group, steroid-only group, and control group. Patients with no history of immunosuppressants or steroids were assigned to the control group. To identify risk factors of in-hospital mortality in sepsis, we compared differences in patient characteristics, comorbidities, intensive care unit (ICU) care requirements, and immunodeficiency profiles. Subgroup analysis according to age was also performed. Results: Of the 185,671 included patients, 13,935 (7.5%) were in the steroid-only group and 2,771 patients (1.5%) were in the immunosuppressant group. The overall in-hospital mortality was 38.9% and showed an increasing trend with age. The steroid-only group showed the lowest in-hospital mortality among the three groups except the patients younger than 30 years. The steroid-only group and immunosuppressant group received ICU treatment more frequently (p < 0.001), stayed longer in the hospital (p < 0.001), and showed higher medical expenditure (p < 0.001) compared to the normal group. Univariate and multivariate analyses revealed that age, male gender, comorbidities (especially malignancy), and ICU treatment had a significant effect on in-hospital mortality. Conclusions: Despite longer hospital length of stay and more frequent need for ICU care, the in-hospital mortality was lower in patients taking immunosuppressive drugs than in patients not taking immunosuppressive drugs.

Bioactivation of Aromatic Amines by Human CYP2W1, An Orphan Cytochrome P450 Enzyme

Chang-Yong Eun,Songhee Han,Young-Ran Lim,Hyoung-Goo Park,Jung-Soo Han,Kyoung Sang Cho,Young-Jin Chun,Donghak Kim 한국독성학회 2010 Toxicological Research Vol.26 No.3

The human genome contains approximately 13 orphan cytochrome P450 (P450, CYP) genes, of which the apparent function or substrate has not been identified. However, they seem to possess their own biological relevance in some tissues or developmental stages. Here, we characterized the heterologously expressed CYP2W1, an orphan P450 enzyme. The recombinant CYP2W1 protein containing a 6 × (His)-tag at Nterminus has been expressed in Escherichia coli and purified. Expression level of CYP2W1 holoenzyme was around 500 nmol P450 holoenzyme per liter culture medium. The reduced CO difference spectrum of CYP2W1 showed a maximum absorption at 449 ㎚. CYP2W1 indicated the significant induction to bioactivate Trp-P-1, MeIQ, and IQ in E. coli DJ701 tester strain. However, the bioactivation of B[α]P, and NNK by CYP2W1 was relatively low. The model structure of CYP2W1 suggested the characteristic P450 folds with the lengths and orientations of the individual secondary elements. The F-G loop is situated on the distal side of heme to accommodate the flexibility of active site of CYP2W1. These studies can provide useful information for the finding of its biological roles and structure-function relationships of an orphan CYP2W1 enzyme.

Do Cardiac Rehabilitation Affect Clinical Prognoses Such as Recurrence, Readmission, Revascularization, and Mortality After AMI?: Systematic Review and Meta-Analysis

Chul Kim,Insun Choi,Songhee Cho,Ae Ryoung Kim,Wonseok Kim,Sungju Jee 대한재활의학회 2021 Annals of Rehabilitation Medicine Vol.45 No.1

Objective We conducted a systematic review and meta-analysis to analyze the effects of cardiac rehabilitation (CR) on post-discharge prognoses of patients with acute myocardial infarction (AMI). Methods A literature search was conducted through four international medical and two Korean databases. Primary outcomes for the effectiveness of CR included all-cause mortality, cardiovascular mortality, recurrence, revascularization, major adverse cardiovascular event, major adverse cardiocerebrovascular event, and readmission. We summarized and analyzed results of studies about CR for AMI, including not only randomized controlled trials (RCTs) but also non-RCTs. We calculated the effect size separately by the study type. Results Fourteen articles were finally selected. Of these, two articles were RCTs, while 12 were non-RCTs. In RCTs, the overall mortality rate was lower in the group that participated in CR than that in the conventional care group by 28% (relative risk=0.72; 95% confidence interval, 0.34–1.57). Among non-RCTs, CR participation significantly decreased the overall risk of mortality. Moreover, the rates of recurrence and major adverse cardiovascular events were lower in the group that participated in CR compared to those in the non-CR group. Conclusion The meta-analysis shows that CR reduces the risk of re-hospitalization and all-cause mortality after AMI, compared to no participation in CR. This outcome was seen in RCTs as well as in non-RCTs. More studies are necessary for concrete conclusions about the beneficial effects of CR after AMI in various settings.