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자색고구마로부터 분리한 안토시아닌 분획물의 고지방식이로 유도된 인슐린 저항성과 간 지질 축적 개선 효과
남송이(Song Yee Nam),장환희(Hwan Hee Jang),김정봉(Jung Bong Kim),이성현(Sung Hyun Lee),이영민(Young Min Lee) 동아시아식생활학회 2016 동아시아식생활학회지 Vol.26 No.3
Anthocyanins, a class of flavonoids, are natural water-soluble pigments, mainly found in vegetables and fruits. Anthocyanins have attractive pharmacological activities, such as anti-oxidant, anti-inflammatory, anti-cancer, and anti-diabetic effects. The purpose of this study was to investigate the inhibitory effects of the anthocyanin-rich fraction (ANF) from purple sweet potato on high fat diet-induced insulin resistance and hepatic steatosis. C57BL/6J mice were assigned to the following groups (n=8 per group): normal fat diet (NF); high fat diet (HF); high fat diet with ANF 50mg/kg (ANF50). Normal fat or high fat diets were fed for a total of 17 weeks, and ANF was orally administrated for 8 weeks (from 10 to 17 weeks, five times/week). In our results, there were no significant differences in body weight, food intake, and tissue weight upon ANF supplementation. The levels of serum triacylglycerol, total-cholesterol, and glucose were also not affected by ANF supplementation. However, ANF supplementation significantly decreased serum insulin and HOMA-IR levels as well as prevented hepatic fat accumulation in high fat-fed mice. These results show that ANF may be beneficial for improving high fat-induced insulin resistance and protecting against development of hepatic steatosis.
Yee, Su-Bog,Lee, Jung-Hwa,Chung, Hae-Young,Im, Kwang-Sik,Bae, Song-Ja,Choi, Jae-Soo,Kim, Nam-Deuk The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.2
We investigated the anti-proliferative effects of luteolin and apigenin, isolated from Ixeris sonchifolia Hance, on HepG2 human hepatocellular carcinoma cells. In MTT assay luteolin showed more efficient anti-proliferative effects on cells than apigenin did. According to propidium iodide staining and flow cytometry studies, we postulated that these effects might be a result of cell cycle arrest. Hence we examined the changes of protein expressions related to cell cycle arrest. Western blotting data demonstrated that the down-regulated expression of CDK4 was correlated to the increase of p53 and CDK inhibitor $p21^{WAF1/CIP1}$ protein. These data suggest that luteolin may have potential as an anti-cancer agent.
Awake extracorporeal membrane oxygenation as bridging for lung transplantation
( Nam Eun Kim ),( Su Hwan Lee ),( Song Yee Kim ),( Moo Suk Park ),( Young Sam Kim ),( Jin Gu Lee ),( Hyo Chae Park ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: As lung transplantation (LTx) become a standard treatment for end-stage disease of lung, bridging to LTx with extracorporeal membrane oxygenation (ECMO) is increasing for either terminal respiratory failure or pre-transplant pulmonary rehabilitation. This study investigated outcome in patients with bridging to lung transplantation with ECMO, especially in Awake ECMO. Method: In this single-center study, we retrospectively reviewed 229 consecutive LTx patients from October 2012 to March 2019. Among them, 56 patients received ECMO support while waiting for the LTx, these enrolled patients were analyzed according to their sedation and airway access status. Result: The proportion of patients with bridged ECMO and awake ECMO gradually increased recently, during the study period. Acute exacerbation of idiopathic pulmonary fibrosis (51.8%) was major cause of bridged ECMO, followed by CTD-ILD (17.9%). Mean age of ECMO patients was 54.8 ± 10.0, and mean ECMO support days was 12.9 ± 9.7 days. Twenty-five patients were awake during receiving ECMO. Among them, 13 patients were performed extubation, 4 patients were performed tracheostomy, and 8 patients maintained endotracheal tube for airway access. Between non-awake ECMO patients and awake ECMO patients, there were no significant difference with respect to age, sex, body mass index, ECMO support days and 3 month mortality. However, awake ECMO patients had a significant shorter median ICU stays compared with non-awake ECMO [awake vs. non-awake, 7 (4.5-16) vs. 17 (11-35), P = 0.004]. Furthermore, in Kaplan-Meier survival analysis, patient who were performed extubation or tracheostomy among awake EMCO patients showed statistically significant survival rate compared to EMCO patients who maintained endotracheal tube or non-awake status (log rank P = 0.019). Conclusion: Bridged ECMO could be useful strategy for waiting of LTx. And awakening and removal of the endotracheal tube during ECMO supply can be helpful in ICU stays and survival after LTx.
Effect of Basiliximab in Acute Kidney Injury Developed within 6 Months after Lung Transplantation
( Nam Eun Kim ),( Moo Suk Park ),( Ha Eun Kim ),( Song Yee Kim ),( Su Jin Jeoung ),( Beom Seok Kim ),( Jung Tak Park ),( Jin Gu Lee ),( Hyo Chae Paik ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Acute kidney injury(AKI) is a common complication after lung transplantation(LT), increasing morbidity and mortality. If AKI persists, maintaining tacrolimus is in a dilemma due to undesirable nephrotoxic side effect. Basiliximab, chimeric anti-IL- 2R monoclonal antibody, saturates the receptor more than 2 weeks, it comes up with replacing tacrolimus in AKI status. We investigated efficacy of basiliximab using in AKI developed within 6 months after lung transplantation. Method In this single-center study, we retrospectively reviewed 161 consecutive LT patients from October 2012 to September 2017 at Severance hospital, Seoul, Korea. 81 patients developed AKI within 6 months after LT. Excluding 11 patients with Basiliximab use after HD or CRRT, 22 recipients were used Basiliximab as replacement of tacrolimus, 48 were in conservative care. Student t-test, Mann-Whitney test were used for comparing variables. Results Twenty-two (27.1%) were in conservative care with basiliximab for AKI treatment, and forty-eight (59.2%) got only conservative care for AKI. The median age of basiliximab group was 59.5±6.9 years, and 59.1% of population was male. There were no significant differences between two groups with respect to age, sex, comorbidities, primary lung disease. At baseline basiliximab group showed more severe AKI stage, representing 63.6% of AKI stage 3 group. Comparison of delta creatinine at day after 7, 14 showed basiliximab have lowering effect of creatinine in AKI stage 2. More than 50% of AKI stage 2 and AKI stage 3 group have down staging effect in basiliximab group, but it was not statistically significant difference in control group. Although higher severity of AKI stage in basiliximab group at baseline, proportion of HD, CRRT, 6-month mortality was not inferior than that of conservative care group. Conclusion Using basiliximab in AKI after LT could be effective in early timing of AKI stage 2, by reducing exposure of nephrotoxicity of tacrolimus.
Song, Eun Jeong,Kim, Nam Yee,Heo, Moon Young The Korean Society of Food Hygiene and Safety 2017 한국식품위생안전성학회지 Vol.32 No.3
청국장추출물과 청국장의 주요한 플라보노이드의 하나인 genistein의 HepG2 세포에서 Trp-P-1 유도 세포독성과 DNA손상에 대한 보호효과를 평가하였다. 청국장추출물과 주요 플라보노이드성분 genistein은 Trp-P-1 유도 세포독성에 대하여 세포독성보호효과를 나타내었다. 청국장추출물은 Trp-P-1 유도 DNA single strand breaks를 억제하였다. 한편, 청국장추출물은 HepG2 세포에서 Trp-P-1 유도에 의한 CYP1A1와 CYP1A2 발현의 억제를 나타내었다. 청국장추출물과 genistein은 Trp-P-1에 의한 유도 세포독성과 DNA손상에 대하여 CYP1A1, CYP1A2 발현억제에 의하여 보호효과가 나타나는 것으로 판단된다. 한국의 전통 콩발효식품인 청국장은 게놈 불안정성(genomic instability)을 일으키는 heterocyclic amines (HCAs)과 같은 식품의 가열조리로부터 올 수 있는 발암물질에 대한 유전독성을 예방할 수 있는 유망한 기능성물질로서 활용가능성이 있을 것으로 판단된다. This study evaluated the protective effect of Chungkookjang (CKJ) extract, a Korean traditional fermented soybean product made from Bacillus species in rice straw and boiled soybean, and one of its main flavonoids, genistein, against Trp-P-1 induced cytotoxicity and DNA damage in HepG2 cells. CKJ and genistein exhibited protective effect against Trp-P-1 induced cytotoxicity and Trp-P-1 induced DNA single strand breaks. CKJ and genistein inhibited Trp-P-1 induced CYP1A1 and CYP1A2 transcription in HepG2 cells. Our results indicated that CKJ and genistein have the protective effect against Trp-P-1 induced cytotoxicity and DNA damage. Via inhibiting expression of CYP1A1 and CYP1A2. CKJ can be used as a promising functional food material that prevents the genotoxicity induced by carcinogens produced by the heat treatment of foods such as heterocyclic amines (HCAs) that cause genomic instability.