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자가면역 췌장염의 동반증상 없이 발생한 IgG4 연관 경화성 담관염
천송욱 ( Song Wook Chun ),최자성 ( Ja Sung Choi ),강버들 ( Beo Deul Kang ),김유진 ( Yu Jin Kim ),한기준 ( Ki Jun Han ),조현근 ( Hyeon Geun Cho ),오화은 ( Hwa Eun Oh1 ),조재희 ( Jae Hee Cho ) 대한소화기학회 2013 대한소화기학회지 Vol.62 No.1
IgG4-related systemic diseases are characterized by a diffuse or mass forming inflammatory reaction rich in lymphocytes and IgG4-positive plasma cells (lymphoplasmacytic infiltration), fibrosclerosis of variable organs and obliterative phlebitis. They usually involve various organs including the pancreas, bile duct, gallbladder, salivary gland, retroperitoneum, kidney, lung, and prostate. However, most of them are accompanied by autoimmune pancreatitis, and good response to steroid treatment is one of the hallmarks of this disease. We report a case of an 67-year-old man with IgG4 associated sclerosing cholangitis, who was diagnosed by endoscopic retrograde cholangiopancreatography and successfully treated with steroid therapy. (Korean J Gastroenterol 2013; 62:69-74)
Yum, Woo Sung,Jeong, Yeonung,Song, Heamin,Oh, Jae Eun Elsevier 2018 Construction and Building Materials Vol.185 No.-
<P><B>Abstract</B></P> <P>This study explored the possibility of using limestone fines (LF) as a supplementary material in activated slag binder systems using two types of activators (i.e., 10 wt% of Ca(OH)<SUB>2</SUB> or 10 wt% of Ba(OH)<SUB>2</SUB>) and investigated the interactions of the activators with LF in each binder system through strength testing, powder X-ray diffraction, thermogravimetry, and mercury intrusion porosimetry. Using these binders, concrete brick samples containing LF were also made and examined for possible industrial applications. Although the influences of the LF addition on the strength, dissolution degree of the slag, reaction products, and pore-size distribution depended on the type and dosage of the activator, the addition was generally advantageous for all these aspects in both types of activations. The concrete brick made of 20 wt% LF using the Ba(OH)<SUB>2</SUB> activation fulfilled the Korean standard requirements of strength and water absorption for concrete bricks, and it also satisfied the criteria of the leaching test for possible toxic elements.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Limestone fines (LF) was studied as a supplementary material in activated slags. </LI> <LI> Main activators for slag were Ca(OH)<SUB>2</SUB> or Ba(OH)<SUB>2</SUB>. </LI> <LI> At early ages, the use of LF significantly improved strength in both activations. </LI> <LI> The use of LF significantly changed reaction products of Ba(OH)<SUB>2</SUB> activation. </LI> <LI> However, the use LF did not alter reaction products of Ca(OH)<SUB>2</SUB> activation. </LI> </UL> </P>
만성 콩팥병 환자에서 추정 사구체 여과율에 따른 25-Hydroxyvitamin D의 특성
고정희 ( Jung Hee Koh ),곽임수 ( Ihm Soo Kwak ),송상헌 ( Sang Heon Song ),이수봉 ( Soo Bong Lee ),이하린 ( Harin Rhee ),성은영 ( Eun Young Seong ),박창준 ( Chang Jun Park ),김태균 ( Tae Kyun Kim ),오상보 ( Sang Bo Oh ) 대한내과학회 2012 대한내과학회지 Vol.83 No.6
Background/Aims: Accumulating data suggest that vitamin D deficiency is prevalent in patients with chronic kidney disease (CKD). However, comprehensive data are lacking for Koreans. The aim of this study was to survey vitamin D deficiency among patients with CKD in Korea and to identify the relationships among various factors. Methods: We conducted a retrospective cohort study of 444 patients who were divided into four subgroups by estimated glomerular filtration rate (eGFR) for comparisons of mean 25-hydroxyvitamin D [25(OH)D] level and other parameters. In addition, non-dialyzed patients were categorized into four groups based on 25(OH)D levels (<10, 10-19, 20-29, and ≥ 30 ng/mL), and risk factors for severe vitamin D deficiency (<10 ng/mL) were investigated. Results: Of patients with an eGFR ≥ 60 mL/min/1.73 m2, 43% (34/79) showed severe 25(OH)D deficiency, and the mean 25(OH)D level was 11.7±5.3 ng/mL. In CKD3 group, 53.2% (41/77) showed severe 25(OH)D deficiency, with a mean level of 11.3±7.2 ng/mL. In CKD4 group, 53.3% (49/92) had severe 25(OH)D deficiency, with a mean level of 11.0±6.2 ng/mL. Approximately 71% (139/196) of patients in CKD5 group showed severe deficiency, and the mean level was 9.2±5.9 ng/mL. Severe 25(OH)D deficiency was affected by winter season, renal function, diabetes, and low-density lipoprotein cholesterol. The serum parathyroid hormone level was inversely correlated with the 25(OH)D level, such that 25(OH)D < 20 ng/mL were associated with a steep increase in parathyroid hormone. Conclusions: Vitamin D deficiency is highly prevalent in the Korean population. Few patients met a sufficient 25(OH)D concentration, even in the early stages of CKD. Our data suggest that 25(OH)D level of 20 ng/mL is a threshold for a rapid increase in parathyroid hormone levels. (Korean J Med 2012;83:740-751)
The Improvement of Learning and Memory Ability of Normal Persons by BF-7
Sang Hyung Lee,Yong Sik Kim,Yong Koo Kang,Oh Sang Kwon,Yong Kyoo Shin,Jin Ho Song,Moo Yeol Lee,Kwang-Gill Lee,Joo-Hong Yeo,Won Bok Lee,Tae Jin Lee,Sung Su Kim 대한생리학회-대한약리학회 2004 The Korean Journal of Physiology & Pharmacology Vol.8 No.6
To investigate whether BF-7, extracted from Bombyx mori, improved learning and memory of ordinary people, Rey-Kim Memory Test was performed with placebo group (32 persons), 200 mg BF-7 treated group (33 persons) and 400 mg BF-7 treated group (34 persons). BF-7 enhanced significantly learning and memory function in a dose-dependent manner. To know how BF-7 plays such a positive role, we measured the concentration of acetylcholine in the brain from memory impairment animal model. Treatment of BF-7 significantly increased the concentration of acetylcholine. So, it is supposed that the protection of cholinergic neuron and/or keeping proper concentration of acetylcholine might be one of the mechanisms by which BF-7 improve brain function. So, our results suggest that the BF-7 is effective material for improving learning and memory ability.
OH, Jae-Hee,YANG, Chul-Su,NOH, Yeon-Kyeong,KWEON, Yu-Mi,JUNG, Sung-Soo,SON, Ji Woong,KONG, Suck-Jun,YOON, Jang Uk,LEE, Ji-Sook,KIM, Hwa-Jung,PARK, Jeong-Kyu,JO, Eun-Kyeong,SONG, Chang-Hwa Blackwell Publishing Asia 2007 RESPIROLOGY Vol.12 No.4
<P>Background and objectives: </P><P>The genetic determinants for developing TB or having recurrent TB are unknown. The present study investigated the relationship between susceptibility to tuberculosis and human tumour necrosis factor-&agr; (TNF-&agr;) and interleukin-10 genes (IL-10).</P><P>Methods: </P><P>A case–control study was conducted using two groups of cases—newly diagnosed TB (N-TB) and recurrent TB (R-TB)—and a control group.</P><P>Results: </P><P>One hundred and seventeen healthy controls, 80 newly diagnosed TB patients and 65 patients with recurrent TB were enrolled. There was no significant difference in the TNF-&agr;−308 G/A genotype between the TB patient groups and the controls. The IL-10 −1082A alleles were markedly over-represented among the TB patient groups compared with the control subjects, however, there was no significant difference in the IL-10 genotype frequency between the N-TB and R-TB patient groups.</P><P>Conclusion: </P><P>The −1082A allele of the IL-10 gene may be important in determining susceptibility to TB, however, the −308 allele of the TNF-&agr; gene does not affect differential TB susceptibility.</P>
Isolation of CONSTANS as a TGA4/OBF4 Interacting Protein
Song, Young Hun,Song, Na Young,Shin, Su Young,Kim, Hye Jin,Yun, Dae-Jin,Lim, Chae Oh,Lee, Sang Yeol,Kang, Kyu Young,Hong, Jong Chan Korean Society for Molecular Biology 2008 Molecules and cells Vol.25 No.4
Members of the TGA family of basic domain/leucine zipper transcription factors regulate defense genes through physical interaction with NON-EXPRESSOR OF PR1 (NPR1). Of the seven TGA family members, TGA4/octopine synthase (ocs)-element-binding factor 4 (OBF4) is the least understood. Here we present evidence for a novel function of OBF4 as a regulator of flowering. We identified CONSTANS (CO), a positive regulator of floral induction, as an OBF4-interacting protein, in a yeast two-hybrid library screen. OBF4 interacts with the B-box region of CO. The abundance of OBF4 mRNA cycles with a 24 h rhythm under both long-day (LD) and short-day (SD) conditions, with significantly higher levels during the night than during the day. Electrophoretic mobility shift assays revealed that OBF4 binds to the promoter of the FLOWERING LOCUS T (FT) gene, a direct target of CO. We also found that, like CO and FT, an OBF4:GUS construct was prominently expressed in the vascular tissues of leaf, indicating that OBF4 can regulate FT expression through the formation of a protein complex with CO. Taken together, our results suggest that OBF4 may act as a link between defense responses and flowering.
A New Rice Variety Adaptable to Late Planting with High Quality, "Mananbyeo"
Sang Jong Lim,Jong Rae Kang,Byong Geun Oh,No Bong Park,Un Sang Yeo,Sae Jun Yang,Ho Yeong Kim,Hung Goo Hwang,Yon Cheon Song,Do Yeon Kwark,Woon Goo Ha,Jae Ki Chang,Jeom Sig Lee 한국육종학회 2003 한국육종학회지 Vol.35 No.1
Mananbyeo was developed from a three way cross ilyang110/Yeongdeog7//Milyang110 in 1999. It has short growing duration about 71 days from seeding to heading and short culm length of 75 cm. It has almost similar number of panicles per hill , spikelets per
Pancreatic metastasis from papillary thyroid cancer: a case report and literature review
Song Sang Hwa,Hur Young Hoe,Cho Chol Kyoon,Koh Yang Seok,Park Eun Kyu,Kim Hee Joon,Shin Sang Hoon,Yu Sung Yeol,Oh Chae Yung 대한종양외과학회 2023 Korean Journal of Clinical Oncology Vol.19 No.1
Pancreatic metastasis from papillary thyroid cancer (PTC) is extremely rare; only 18 cases have been reported in the literature. However, several reviews have highlighted similar characteristics between metastatic and primary pancreatic tumors. The patient was a 51-year-old male with a history of total thyroidectomy, modified radical neck dissection, and radioactive iodine ablation for PTC in 2014. Nodules suspected of metastasis were found in both lungs on chest computed tomography (CT). However, after 6 months, a follow-up chest CT showed no increase in size; thus, a follow-up observation was planned. Six years after his initial diagnosis, abdominal CT and pancreas magnetic resonance imaging revealed a 4.7 cm cystic mass with a 2.5 cm enhancing mural nodule in the pancreas tail. We diagnosed the pancreatic lesion as either metastatic cancer or primary pancreas cancer. The patient underwent distal pancreato-splenectomy. After surgery, the pathological report revealed that the mass was metastatic PTC. Pancreatic metastasis from PTC indicates an advanced tumor stage and poor prognosis. However, pancreatectomy can increase the survival rate when the lesion is completely resectable. Therefore, surgical resection should be considered as a treatment for pancreatic metastasis from PTC.