The role of miRNA‑155 in monocrotaline‑induced pulmonary arterial hypertension through c‑Fos/NLRP3/caspase‑1

Shou‑Dong Chai,Zhen‑Kun Li,Rui Liu,Tao Liu,Ming‑Feng Dong,Pei‑Zhe Tang,Jian‑Tang Wang,Sheng‑Jun Ma 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3

Background Nisoldipine can effectively suppress pulmonary arterial smooth muscle cell proliferation and c-Fos expression. Objective To identify the mechanism of the anti-inflammatory effects in monocrotaline-induced pulmonary arterial hypertension (PAH), focusing on the c-Fos/NLRP3/caspase-1 pathway. Results In a mice model of monocrotaline-induced PAH, miRNA-155 expression was increased. In an in vitro model, overexpression of miRNA-155 promoted inflammation and induced c-Fos, NLRP3, and caspase-1 protein expression. The inhibition of c-Fos reduced the effects of miRNA-155 on inflammation in an in vitro model of monocrotaline-induced PAH. The inhibition of NLRP3 reduced the effects of miRNA-155 on inflammation in an in vitro model of monocrotaline-induced PAH. Conclusions miRNA-155 increased inflammation in monocrotaline-induced PAH through c-Fos/NLRP3/caspase-1.

PacCAF: a Grid Portal in Pacific Asia for the CDF Experiment

S. Hou,T. L. Hsieh,P. K. Teng 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.5

We present the PacCAF (Pacific CDF Analysis Farm) computing model for the CDF (Collider Detector at Fermilab) experiment. The PacCAF is a portal for job submission to a pool of computing nodes collected from the LCG (LHC Computing Grid) and the OSG (Open Science Grid) sites in the Pacific Asia region. It has a suit of services for user authentication, software distribution, and network connection to worker nodes. It also provides a web-based online monitoring system for the status of batch jobs and the processes running on worker nodes. The PacCAF architecture is modular and is easy to modify. We discuss the upgrade from being a dedicated local cluster to joining shared resources in a Grid computing environment. We present the PacCAF (Pacific CDF Analysis Farm) computing model for the CDF (Collider Detector at Fermilab) experiment. The PacCAF is a portal for job submission to a pool of computing nodes collected from the LCG (LHC Computing Grid) and the OSG (Open Science Grid) sites in the Pacific Asia region. It has a suit of services for user authentication, software distribution, and network connection to worker nodes. It also provides a web-based online monitoring system for the status of batch jobs and the processes running on worker nodes. The PacCAF architecture is modular and is easy to modify. We discuss the upgrade from being a dedicated local cluster to joining shared resources in a Grid computing environment.

論中國傳統企業效率問題

康 埈 荣,张守鑫 韓國外國語大學校 外國學綜合硏究센터 中國硏究所 2005 中國硏究 Vol.35 No.-

1997~2000년에 발생된 황사에 관한 연구

정용승,김학성,낫짜가도르지 엘,적데어 디,첸 수잰 한국교원대학교 환경과학연구소 2002 환경연구논문집 Vol.- No.7

Joint monitoring of yellow sand (YS) phenomena occurred from 1997 to 2000 was carried out. It was found that the YS in source regions occurred in any time during the year, while the severe dust storms occurred frequently from March to May after the spring thaw. Wind erosion occurred usually with wind greater than about 8 ms^-1 in the source region in any seasons. However, severe YS phenomenon found to occur with wind greater than 15 ms^-1 at least for 3 hours or more. In source regions, YS occurred over 60∼120 days per year. In Korea, YS was found to occur 8∼12 cases per year with 12-22 YS days. It was recorded that maximum concentrations of TSP were 989∼1396 ㎍ m^-3 with PM10 values of 861∼996 ㎍ m^-3 and with the lowest visibility of 1.4∼1.6km. In Mongolia, however, it was observed that the number of dusty days decreased due to the increase in rainy days.

Comparative Analysis of Logistic Regression, Support Vector Machine and Artificial Neural Network for the Differential Diagnosis of Benign and Malignant Solid Breast Tumors by the Use of Three-Dimensional Power Doppler Imaging

Shou-Tung Chen,Yi-Hsuan Hsiao,Yu-Len Huang,Shou-Jen Kuo,Hsin-Shun Tseng,Hwa-Koon Wu,Dar-Ren Chen 대한영상의학회 2009 Korean Journal of Radiology Vol.10 No.5

Objective: Logistic regression analysis (LRA), Support Vector Machine (SVM) and a neural network (NN) are commonly used statistical models in computeraided diagnostic (CAD) systems for breast ultrasonography (US). The aim of this study was to clarify the diagnostic ability of the use of these statistical models for future applications of CAD systems, such as three-dimensional (3D) power Doppler imaging, vascularity evaluation and the differentiation of a solid mass. Materials and Methods: A database that contained 3D power Doppler imaging pairs of non-harmonic and tissue harmonic images for 97 benign and 86 malignant solid tumors was utilized. The virtual organ computer-aided analysis-imaging program was used to analyze the stored volumes of the 183 solid breast tumors. LRA, an SVM and NN were employed in comparative analyses for the characterization of benign and malignant solid breast masses from the database. Results: The values of area under receiver operating characteristic (ROC) curve, referred to as Az values for the use of non-harmonic 3D power Doppler US with LRA, SVM and NN were 0.9341, 0.9185 and 0.9086, respectively. The Az values for the use of harmonic 3D power Doppler US with LRA, SVM and NN were 0.9286, 0.8979 and 0.9009, respectively. The Az values of six ROC curves for the use of LRA, SVM and NN for non-harmonic or harmonic 3D power Doppler imaging were similar. Conclusion: The diagnostic performances of these three models (LRA, SVM and NN) are not different as demonstrated by ROC curve analysis. Depending on user emphasis for the use of ROC curve findings, the use of LRA appears to provide better sensitivity as compared to the other statistical models. Objective: Logistic regression analysis (LRA), Support Vector Machine (SVM) and a neural network (NN) are commonly used statistical models in computeraided diagnostic (CAD) systems for breast ultrasonography (US). The aim of this study was to clarify the diagnostic ability of the use of these statistical models for future applications of CAD systems, such as three-dimensional (3D) power Doppler imaging, vascularity evaluation and the differentiation of a solid mass. Materials and Methods: A database that contained 3D power Doppler imaging pairs of non-harmonic and tissue harmonic images for 97 benign and 86 malignant solid tumors was utilized. The virtual organ computer-aided analysis-imaging program was used to analyze the stored volumes of the 183 solid breast tumors. LRA, an SVM and NN were employed in comparative analyses for the characterization of benign and malignant solid breast masses from the database. Results: The values of area under receiver operating characteristic (ROC) curve, referred to as Az values for the use of non-harmonic 3D power Doppler US with LRA, SVM and NN were 0.9341, 0.9185 and 0.9086, respectively. The Az values for the use of harmonic 3D power Doppler US with LRA, SVM and NN were 0.9286, 0.8979 and 0.9009, respectively. The Az values of six ROC curves for the use of LRA, SVM and NN for non-harmonic or harmonic 3D power Doppler imaging were similar. Conclusion: The diagnostic performances of these three models (LRA, SVM and NN) are not different as demonstrated by ROC curve analysis. Depending on user emphasis for the use of ROC curve findings, the use of LRA appears to provide better sensitivity as compared to the other statistical models.

Quantum Squeezing effect of Mesoscopic Capacitance Coupled Circuit with Mutual Inductance

Shou ZHANG,Ai-Dong ZHU,Chung-In UM,Kyu-Hwang YEON,Zhe JIN 한국물리학회 2003 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.43 No.51

For a mesoscopic coupled circuit with mutual inductance, we calculate the quantum uncertainty relations for the electric charges and currents, and we investigate the squeezed eect using the methods of canonical transformation and unitary transformation. We conrm that the quantum uctuations in two loops are connected with each other because of the existence of the mutual inductance. The existence of the mutual inductance cause the capacitances in the two loops to become important factors in uencing the squeezed eect.?Co_W

Impact of Overlapping Functional Gastrointestinal Disorders on the Quality of Life in Patients With Gastroesophageal Reflux Disease

( Shou-wu Lee ),( Chi-sen Chang ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2021 Journal of Neurogastroenterology and Motility (JNM Vol.27 No.2

Gastroesophageal reflux disease (GERD) and functional gastrointestinal disorders (FGIDs), including irritable bowel syndrome and functional dyspepsia, are common afflictions within the general population. Both conditions have a considerable impact on the daily health related quality of life (HRQoL) of affected individuals. Risk factors surrounding any impaired HRQoL in patients with GERD involve those of younger age, obesity, an increase in reflux symptom frequency, and overlapping FGIDs. The risk factors for subjects experiencing an overlap in FGIDs and GERD involve those who are female, younger age, cigarette smoking, non-erosive reflux disease, more GERD symptoms, and psychological performances including anxiety, somatization, and more frequent healthcare-seeking behavior. The overlap of GERD and FGIDs is associated with a worsening of both physical and mental health, an increase in bothersome symptoms, impaired functional capacity, and a higher likelihood of consulting a physician. Acid secretion suppressors could offer therapeutic efficacy to some patients experiencing overlapping GERD and FGIDs. (J Neurogastroenterol Motil 2021;27:176-184)

20-30대 중국여성들의 외모효능인식, 이상적 외모추구행동과 의복이미지 선호도 간의 관련성 연구

( Shou Bo Bi ),구인숙 ( In Sook Koo ) 한국패션비즈니스학회 2013 패션 비즈니스 Vol.17 No.5

This study conducts a survey based on 425 Chinese females in their twenties to thirties in order to examine the relevance between the cognitions of appearance effectiveness, ideal appearance seeking behavior and clothing image preference which have effects on their self-identity and interpersonal relations. The results of this study are as follows ;First, from the factor analysis for cognition of appearance effectiveness, and ideal appearance seeking behavior, a total of 4 factors such as psychological benefits, social benefits factors, pursuit of plastic surgery and pursuit of beauty treatment are being were drawn. As a result, there are significant correlations between heights of demographic variables and the cognition of appearance effectiveness, together with the ideal appearance seeking behavior. Respondents with higher heights represent the higher cognitions of appearance effectiveness, while the respondents with lower heights show more pursuits of beauty treatment behavior to reach the ideal image. Second, factor analysis of the clothing images are 4 factors such as classic-trendy, natural-dynamic, casual-formal, and masculine-feminine images. There are significant correlations between the four factors from clothing preference images and four factors from the cognition of appearance effectiveness, and ideal appearance seeking behavior. This suggests that higher social status such as job, income, residential district, and age among the demographic factors has greater effects on the clothing image preference.

Trajectory Redundancy Iterative Learning Control

Shou-Han Zhou,Ying Tan,Bai, Zhao,Denny Oetomo 제어로봇시스템학회 2013 제어로봇시스템학회 국제학술대회 논문집 Vol.2013 No.10

For tasks which require a robot to track some particular points along a trajectory (instead of the whole trajectory), there exists redundancy. This redundancy results in an increase in the feasibility in the controller design, enabling the possibility of the robot to obtain better performance by satisfying secondary objectives whilst performing the primary objective of tracking the target points. This paper addresses the task redundancy by using point-to-point learning control. It is shown to be an effective tool to accommodate trajectory redundancy since it has the ability to fully explore the increased feasibility resulting from such redundancy. Following the similar idea widely used in kinematic redundancy, a decomposition technique is used. This leads to a simplification of constrained optimization and provides a suboptimal performance in terms of secondary task while the primary task is always achieved. As an example, the formulation is implemented in an on-line fashion to enable a non-redundant robot to track a target point whilst avoiding an obstacle. Simulation results shows good performance from the proposed online algorithms.

Graphene nanosheets encapsulated poorly soluble drugs with an enhanced dissolution rate

Shou-Cang Shen,Wai Kiong Ng,Kumaran Letchmanan,Ron Tau Yee Lim,Reginald Beng Hee Tan 한국탄소학회 2018 Carbon Letters Vol.27 No.-

In this study, graphene oxide(GO) was used as drug carriers to amorphize poorly watersoluble drugs via a co-spray drying process. Two poorly water-soluble drugs, fenofibrate and ibuprofen, were investigated. It was found that the drug molecules could be in the graphene nanosheets in amorphous or nano crystalline forms and thus have a significantly enhanced dissolution rate compared with the counterpart crystalline form. In addition, the dissolution of the amorphous drug enwrapped with the graphene oxide was higher than that of the amorphous drug in activated carbon (AC) even though the AC possessed a larger specific surface area than that of the graphene oxide. The amorphous formulations also remained stable under accelerated storage conditions (40°C and 75% relative humidity) for a study period of 14 months. Therefore, graphene oxide could be a potential drug carrier and amorphization agent for poorly water-soluble drugs to enhance their bioavailability.