Kinetic and 2D reactor modeling for simulation of the adsorption of SO₂ in the activated carbon bed

( Shaojun Liu ),( Xiang Gao ),( Feifei Cao ),( Zhongyang Luo ),( Kefa Cen ) 한국폐기물자원순환학회 2023 I-CIPEC Vol.2012 No.0

Identification and characterization of scirr1, a novel geneup-regulated after spinal cord injury

Tao Liu,Zhenlian Ma,Haiping Que,Xin Li,Yanli Ni,Shuqian Jing,Shaojun Liu 생화학분자생물학회 2007 Experimental and molecular medicine Vol.39 No.3

Spinal cord injury and regeneration involves trans-criptional activity of many genes, of which many remain unknown. Using the rat spinal cord full- transection model, bioinformatics, cloning, expres-sion assays, fusion proteins, and transfection techniques, we identified and characterized one such differentially expressed gene, termed scirr1 (spinal cord injury and/or regeneration related gene 1). Fourteen orthologs were found in 13 species from echinoderm to insect and human by Blast search of NCBI protein reference sequence database. However, no further information is available for these homo-logues. Using whole-mount in situ hybridization, mouse scirr1 mRNA was expressed temporally and spatially in accordance with the early development sequence of the central nervous system. In adult rat spinal cord, expression of scirr1 mRNA was localized to neurons of gray matter by in situ hybridization. Using immunohistochemistry, SCIRR1 protein was found to be up-regulated and expressed more highly in spinal cord neurons farther from the epicenter of injury. Although the precise function of SCIRR1 is unknown, its unique pattern of expression during CNS early development and up-regulation after spinal cord injury sugges t that SCIRR1 should be involved in the succeeding injury and/or repair processes of the injured spinal cord. Also, the typical F-box and leucine-rich repeat (LRR) architecture of substrate recruiting role in the pleiotropic ubiquitin/ proteasome pathway. All these make scirr1 a new interesting start to study the spinal cord injury and regeneration mechanism.

Characterization of zinc sulfide species on smithsonite surfaces during sulfidation processing: Effect of ammonia liquor

Shaojun Bai,Chunlong Li,Xiangyu Fu,Jian Liu,Shuming Wen 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.61 No.-

The interaction between sulfide-ion species and smithsonite surfaces in the absence with and without ammonia liquor was investigated. The results of zeta potential and sulfide ion adsorption indicated that NH3·H2O addition promoted the transfer of sulfur in the pulp solutions onto the smithsonite surfaces. Time-of-flight secondary ion mass spectrometry and X-ray photo-electron spectroscopy analysis indicated that the zinc sulfide species was composed of zinc monosulfide and zinc polysulfide and was reinforced by NH3·H2O addition. The distribution ratio of polysulfide in the whole S species increased. The results shed light on reinforcement of the smithsonite sulfidation mechanism with ammonia liquor addition.

Effect of Thermal Aging on Microstructure and Mechanical Properties of China Low-Activation Martensitic Steel at 550℃

Wang, Wei,Liu, Shaojun,Xu, Gang,Zhang, Baoren,Huang, Qunying Korean Nuclear Society 2016 Nuclear Engineering and Technology Vol.48 No.2

The thermal aging effects on mechanical properties and microstructures in China low-activation martensitic steel have been tested by aging at $550^{\circ}C$ for 2,000 hours, 4,000 hours, and 10,000 hours. The microstructure was analyzed by scanning and transmission electron microscopy. The results showed that the grain size and martensitic lath increased by about $4{\mu}m$ and $0.3{\mu}m$, respectively, after thermal exposure at $550^{\circ}C$ for 10,000 hours. MX type particles such as TaC precipitated on the matrix and Laves-phase was found on the martensitic lath boundary and grain boundary on aged specimens. The mechanical properties were investigated with tensile and Charpy impact tests. Tensile properties were not seriously affected by aging. Neither yield strength nor ultimate tensile strength changed significantly. However, the ductile-brittle transition temperature of China low-activation martensitic steel increased by $46^{\circ}C$ after aging for 10,000 hours due to precipitation and grain coarsening.

Large-scale microwave-assisted ring-opening polymerization of e-caprolactone

Qi Xu,Chuanjie Zhang,Shaojun Cai,Lijian Liu,Ping Zhu 한국공업화학회 2010 Journal of Industrial and Engineering Chemistry Vol.16 No.5

To probe into the industrialization possibility of microwave-assisted ring-opening polymerization (ROP)of e-caprolactone (e-CL), it was performed with monomer mass from 750 to 2450 g using a self-designed industrial microwave oven (6000W) catalyzed by stannous octanoate (Sn(Oct)2) (M/Cat = 1000). The large-scale ROP of e-CL proceeded smoothly at various microwave power levels (850, 1700, and 2550 W)and produced poly(e-caprolactone) (PCL) with weight-average molar mass (Mw) from 66,000 to 12,2000 g/mol within 40 min in a yield over 93%. The structure of PCL was characterized by 1H and 13C NMR, FT-IR, DSC and WAXD. We propose that the microwave ROP of e-CL is a potential technology to prepare PCL commercially. 2010 Published by Elsevier B.V. on behalf of The Korean Society of Industrial and Engineering Chemistry.

A Novel 5’-Uncoding Region -1248 A>G Variation of Mitofusin-2 Gene Is Associated with Hypertension in Chinese

Zuoguang Wang,Ya Liu,Jieling Liu,Qiuli Niu,Jie Wen,Shaojun Wen,Zhaosu Wu 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.3

Purpose: Mitofusin2 gene (Mfn2, also named Hyperplasia suppressive gene, HSG) is very important in the origin and development of hypertension. However, the mechanism of Mfn2/HSG expression regulation was not uncovered. This study was designed to explore the association of a novel 5’-uncoding region (UCR) -1248 A>G variation of HSG/Mfn2 gene and hypertension. Materials and Methods: 472 healthy, normotensive subjects [normotension (NT) group], 454 prehypertensive subjects [prehypertension (PH) group] and 978 hypertensive patients [essential hypertension (EH) group] were screened for an association study between 5’-UCR -1248 A>G of Mfn2/HSG and hypertension by polymerase chain reaction and DNA sequencing after venous blood was drawn and DNA was extracted. Results: When comparing the A and G frequency in EH, PH and NT groups, in total, NT group significantly had higher A frequency than in PH group [odds ratio (OR)=1.605, confidence interval (CI) 95%=1.063-2.242, p=0.025] and EH group (OR=5.395, CI 95%=3.783-7.695, p<0.01). When subgrouped by gender, A frequency in NT group was still significantly higher than in EH group (male: OR= 4.264, CI 95%=2.780-6.543, p<0.01; female: OR=8.897, CI 95%=4.686-16.891, p<0.01), but not from PH group, either in male group or in female group. Ordinal Logistic Regression analysis showed that A>G variation was significantly related with blood pressure level (B=-1.271, Wald=40.914, CI 95%=-1.660 - -0.881, p<0.01). Conclusion: 5’-UCR -1248 A>G variation of Mfn2/HSG gene was a novel variation and may be associated with hypertension in Chinese.

Factors governing dynamic response of steel-foam ceramic protected RC slabs under blast loads

Xiaomeng Hou,Kunyu Liu,Shaojun Cao,Qin Rong 국제구조공학회 2019 Steel and Composite Structures, An International J Vol.33 No.3

Foam ceramic materials contribute to the explosion effect weakening on concrete structures, due to the corresponding excellent energy absorption ability. The blast resistance of concrete members could be improved through steel-foam ceramics as protective cladding layers. An approach for the modeling of dynamic response of steel-foam ceramic protected reinforced concrete (Steel-FC-RC) slabs under blast loading was presented with the LS-DYNA software. The orthogonal analysis (five factors with five levels) under three degrees of blast loads was conducted. The influence rankings and trend laws were further analyzed. The dynamic displacement of the slab bottom was significantly reduced by increasing the thickness of steel plate, foam ceramic and RC slab, while the displacement decreased slightly as the steel yield strength and the compressive strength of concrete increased. However, the optimized efficiency of blast resistance decreases with factors increase to higher level. Moreover, an efficient design method was reported based on the orthogonal analysis.

Numerical Study of Anisotropic Weakening Mechanism and Degree of Non-persistent Open Joint Set on Rock Strength with Particle Flow Code

Jie Cui,Quan Jiang,Shaojun Liu,Xiating Feng,Youliang Zhang,Ying-en Shi 대한토목학회 2020 KSCE Journal of Civil Engineering Vol.24 No.3

The strength of a rock cut by non-persistent open joint set is controlled by complex interactions of the joint network and intact rock bridges. An extensive series of uniaxial numerical tests of the particle models are carried out under different joint fabrics and rock compression-tension strength ratios. The test results show joint dip angle is the main factor controlling the overall anisotropic strength characteristics. With joint dip angle increasing, the main failure modes successively appear as splitting failure, block rotation failure, step-path failure, planar failure, and splitting failure. Accordingly, the strength generally shows a trend of decreasing first and then increasing, and the joint dip angle corresponding to the minimum strength is biased towards 0°, usually at 15° − 30°. The damage of rock bridges is mainly controlled by tensile failure, except in planar failure mode. Joint spacing has an impact on the local anisotropic strength characteristics. The joint spacing and persistence ratio jointly control the degree of penetration difficulty of the rock bridges. The compression-tension strength ratio of intact rock uniformly affects the absolute magnitude of the jointed rock strength and does not affect its anisotropic characteristics. Based on the weakening mechanism, an empirical strength formula is established to realize the practical equivalent characterization of the anisotropic weakening degrees of the non-persistent open joint set on the rock strength.

Sparse Polynomial Chaotic Expansion for Uncertainty Analysis of Tunnel Stability

Hongbo Zhao,Meng Wang,Bingrui Chen,Shaojun Liu 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.9

Uncertainty is an intrinsic property of rock engineering because of the complicated geology conditions, rock failure mechanism ambiguity, and the nonlinear mechanical behavior of surrounding rock mass. We developed a novel framework to handle the uncertainty by combing the Sparse polynomial chaotic expansion (SPCE), numerical model, and reliability method. The SPCE model was used to map the complex relationship between the response of the surrounding rock mass and its uncertainty. The first-order reliability method (FORM) evaluated the reliability index and failure probability. Based on the SPCE model and FORM, a simple global optimization algorithm (SHGO) seeks design points and corresponding reliability indexes. A circular tunnel verified the developed framework with a close-form solution. The reliability index, design point, and failure probability were in excellent agreement with the FORM and Monte Carlo simulation. This indicated that the SPCE model could be used as a surrogate model for the analytical solution to approximate the tunnel response (including deformation and size of the plastic zone). Then, the developed framework was employed in a horseshoe tunnel by combing with the numerical model. The results further proved that the developed framework is feasible and effective for handling uncertainty in rock engineering. Furthermore, the developed framework is effective, efficient, and accurate for reliability analysis and provides a helpful tool to approximate the response of rock structure to avoid the time-consuming numerical model in practical rock engineering.

MicroRNA-130a Increases and Predicts Cardiotoxicity during Adjuvant Chemotherapy in Human Epidermal Growth Factor Receptor-2-Positive Breast Cancer

Qiang Feng,Yanbin Ren,Aijun Hou,Jing Guo,Zhezhe Mao,Shaojun Liu,Boya Wang,Zhichao Bai,Xiaoying Hou 한국유방암학회 2021 Journal of breast cancer Vol.24 No.2

Purpose: This study aimed to investigate the changes in microRNA-130a (miR-130a) and its correlation with cardiotoxicity during epirubicin/cyclophosphamide followed by docetaxel plus trastuzumab (EC-D+T) adjuvant chemotherapy in human epidermal growth factor receptor-2-positive (HER2+ ) breast cancer patients. Methods: A total of 72 HER2+ breast cancer patients who underwent resection and were scheduled to receive EC-D+T adjuvant therapy were consecutively enrolled. The expression of miR-130a and cardiotoxicity (defined as any of the following situations: 1) absolute decline of left ventricular ejection fraction (LVEF) ≥ 10% and LVEF < 53%; 2) heart failure; 3) acute coronary artery syndromes; and 4) fatal arrhythmia) were assessed every 3 months throughout the 15-month EC-D+T treatment. Results: The accumulating cardiotoxicity rate was 12 (16.7%), of which the incidence of heart failure, acute coronary syndrome, life-threatening arrhythmias, ΔLVEF ≥ 10%, and LVEF < 53% was 0 (0.0%), 1 (1.4%), 0 (0.0%), and 12 (16.7%), respectively. Baseline miR-130a expression was negatively correlated with LVEF (%) and positively correlated with cardiac troponin I. The expression of miR-130a gradually increased in both cardiotoxicity and noncardiotoxicity patients during EC-D+T treatment, while the increment of miR-130a was more obvious in cardiotoxicity patients compared with non-cardiotoxicity patients. Further logistic regression and receiver operating characteristic curve analysis indicated that miR-130a was an independent predictive factor for increased cardiotoxicity risk. Conclusion: MiR-130a increases constantly and predicts high cardiotoxicity risk during ECD+T adjuvant chemotherapy in HER2+ breast cancer patients.