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      • An Application of Machine Vision on Identification of Sugarcane Nodes

        ( Shao-yuan Zhao ),( Suming Chen ),( Chao-yin Tsai ),( I-chen Liu ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1

        Due to labor shortage, modern agriculture goes up on automation gradually, the planting of sugarcane is no exception. If the automatic planting machine is used, sugarcane seedlings should be prepared in advance. A sugarcane node is the main place where bud is grown from. The existing sugarcane node cutting machines rely on human judgement to determine the node locations. There are time-consuming and laborious to collect the sugarcane nodes. This study intends to use machine vision to identify sugarcane nodes for developing automatic machine. The two algorithms of R-CNN and FASTER R-CNN were used to identify sugarcane node and to compare their performance. The R-CNN algorithm is usually used for the identification of multiple targets, and its accuracy is less than FASTER R-CNN, but the processing speed is faster. In this study, 530 sugarcane photos (1300 nodes) were analyzed, 400 and 130 sugarcane photos were selected as the calibration and validation groups, respectively. The experimental results show that the processing time of the R-CNN can be completed within 0.02 sec with the identification rate of 97.9%, and the processing time and identification rate of the FASTER R-CNN are similar to those of the R-CNN. The both algorithms have good results, and can be applied to the development of automated sugarcane node cutting machines.

      • Expression of β-tubulin III and Survivin in Advance Stage Breast Cancer Correlates with Chemotheraputic Effects of Docetaxel

        Yuan, Shao-Fei,Zhu, Lin-Jia,Zheng, Wei-E,Chen, Hua,Wu, Li-Li,Zhang, Wu,Sun, Hong-Yu,Chen, Wen-Jun Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1

        Aims: To investigate the relationship between the expression of ${\beta}$-tubulin III and survivin in advanced breast cancers and chemotherapeutic effects of docetaxel. Methods: Clinical pathological data of 74 patients with advanced breast cancer were retrospectively analyzed after docetaxel chemotherapy. Expression of ${\beta}$-tubulin III and survivin was assessed by immunohistochemistry and analyzed with reference to therapeutical and adverse effects of docetaxel. Results: The positive expression rate of ${\beta}$-tubulin III was 38.1% (32/84), while that of survivin was 76.2% (64/84). The effective rate (complete response + partial response) was 52.4%. That for patients with the positive expression of ${\beta}$-tubulin III or/and survivin was significantly lower than for those with negative expression (P<0.05). There were significant differences in the non-progression of median diseases, 1-year and 2-year survival rates of between the patients with positive and negative expression (P<0.05). The main side effects were myelosuppression, alimentary canal response and alopecie, no differences being observed between groups. Conclusions: The combined detection of ${\beta}$-tubulin III and survivin is a predictive index for chemotherapy effects of docetaxel in metastatic breast cancer.

      • Phase II Clinical Study on the GEMOX Regimen as Second-line Therapy for Advanced Ovarian Cancer

        Yuan, Shao-Fei,Zhang, Lian-Ping,Zhu, Lin-Jia,Chen, Wen-Jun,Zheng, Wei-E,Xiong, Jian-Ping Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6

        Aim: To investigate the effectiveness and adverse effects of gemcitabine by fixed-dose rate infusion plus oxaliplatin (GEMOX regimen) as second-line therapy for advanced ovarian cancer. Methods: 64 patients with advanced ovarian cancer were divided into an experimental group (44 cases) and a control group (20 cases). The experimental group was treated with continuous intravenous infusion of gemcitabine at 1000 $mg/m^2$ with a fixed-dose rate of 10 $mg/m^2/min$, on days 1 and 8 and oxaliplatin at 100 $mg/m^2$ on day 1, IVGTT, repeated every 3 weeks. The control group was treated with intravenous infusion of gemcitabine at 1000 $mg/m^2$ within 30 min on days 1 and and oxaliplatin at 100 $mg/m^2$ on day 1, IVGTT, again repeated every 3 weeks. CT scans or MRI were used for review every 1-2 cycles. Results: The effective rate in the experimental group was significantly high than control group (43.2% vs 35.0%; P < 0.05), with no obvious difference of hematologic or non-hematologic toxicity between the two groups (P > 0.05). Conclusion: GEMOX regimen is very effective to treat advanced ovarian cancer, with low toxicity, good tolerance and improved life quality in patients.

      • COMMENTS : Special Aspect of Marine Insurance Law in China -Direct Action and Warranty

        ( Shao Chun Yuan ) 고려대학교 법학연구원 2014 The Asian Business Lawyer Vol.13 No.-

        The annoying obstacle set by the principle of privity of contract on the direct action has not been thoroughly solved under China marine insurance law. Based the Insurance Law2009, the China Maritime Code and relevant judicial explanations, this paper focuses on the substantive conditions in China marine insurance law concerning to direction action. Further, the fundamental provisions about warranty in China law will also be introduced correspondingly.

      • Effects of Monoclonal Antibodies against Human Stathmin Combined with Paclitaxel on Proliferation of the QG-56 Human Lung Carcinoma Cell Line

        Yuan, Shao-Fei,Chen, Wen-Jun,Zhu, Lin-Jia,Zheng, Wei-E.,Chen, Hua,Xiong, Jian-Ping Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6

        Objective: To explore whether monoclonal antibodies against stathmin and the chemotherapuetic agent paclitaxel have synergenic effects in inhibiting growth and inducing apoptosis in human QG-56 cells. Methods: QG-56 cells were treated with monoclonal antibodies against stathmin or paclitaxel alone or in combination, with untreated cells used as controls. After 24, 48, 72 and 96 hours the cell growth condition was observed under an inverted microscope and inhibition was studied by MTT assay; apoptosis was analyzed by flow cytometry. Results: The populations decreased and cell shape and size changed after the various treatments. Monoclonal antibodies against stathmin and paclitaxel used alone or incombination inhibited the proliferation of QG-56 cells, especially in combination with synergism (P<0.05). Combined treatment also resulted in a significantly higher apoptosis rate than in the other groups (P<0.05). Conclusions: Monoclonal antibodies against stathmin and paclitaxel used alone or in combination can inhibit proliferation of QG-56 cells and induce apoptosis when applied together. The observed synergistic effects may have important implications for clinical application.

      • Impact effect analysis for hangers of half-through arch bridge by vehicle-bridge coupling

        Shao, Yuan,Sun, Zong-Guang,Chen, Yi-Fei,Li, Huan-Lan Techno-Press 2015 Structural monitoring and maintenance Vol.2 No.1

        Among the destruction instances of half-through arch bridges, the shorter hangers are more likely to be ruined. For a thorough investigation of the hanger system durability, we have studied vehicle impact effect on hangers with vehicle-bridge coupling method for a half-through concrete-filled-steel-tube arch bridge. A numerical method has been applied to simulate the variation of dynamic internal force (stress) in hangers under different vehicle speeds and road surface roughness. The characteristics and differences in impact effect among hangers with different length (position) are compared. The impact effect is further analyzed comprehensively based on the vehicle speed distribution model. Our results show that the dynamic internal force induced by moving vehicles inside the shorter hangers is significantly greater than that inside the longer ones. The largest difference of dynamic internal force among the hangers could be as high as 28%. Our results well explained a common phenomenon in several hanger damage accidents occurred in China. This work forms a basis for hanger system's fatigue analysis and service life evaluation. It also provides a reference to the design, management, maintenance, monitoring, and evaluation for this kind of bridge.

      • KCI등재

        Differences in the biological properties of mesenchymal stromal cells from traumatic temporomandibular joint fibrous and bony ankylosis: a comparative study

        Zhang Pei-Pei,Liang Su-Xia,Wang Hua-Lun,Yang Kun,Nie Shao-Chen,Zhang Tong-Mei,Tian Yuan-Yuan,Xu Zhao-Yuan,Chen Wei,Yan Ying-Bin 한국통합생물학회 2021 Animal cells and systems Vol.25 No.5

        The aim of this study was to compare the functional characteristics of mesenchymal stromal cells (MSCs) from a sheep model of traumatic temporomandibular joint (TMJ) fibrous and bony ankylosis. A sheep model of bilateral TMJ trauma-induced fibrous ankylosis on one side and bony ankylosis on the contralateral side was used. MSCs from fibrous ankylosed callus (FAMSCs) or bony ankylosed callus (BA-MSCs) at weeks 1, 2, 4, and 8 after surgery were isolated and cultured. MSCs derived from the bone marrow of the mandibular condyle (BM-MSCs) were used as controls. The MSCs from the different sources were characterized morphologically, phenotypically, and functionally. Adherence and trilineage differentiation potential were presented in the ovine MSCs. These cell populations highly positively expressed MSC-associated specific markers, namely CD29, CD44, and CD166, but lacked CD31 and CD45 expressions. The BA-MSCs had higher clonogenic and proliferative potentials than the FA-MSCs. The BA-MSCs also showed higher osteogenic and chondrogenic potentials, but lower adipogenic capacity than the FA-MSCs. In addition, the BA-MSCs demonstrated higher chondrogenic, but lower osteogenic capacity than the BM-MSCs. Our study suggests that inhibition of the osteogenic and chondrogenic differentiations of MSCs might be a promising strategy for preventing bony ankylosis in the future.

      • Research Trend of Creatine in Sport Using Social Network Analysis

        ( Yuan Wang ),( Kyungsik Kim ),( Wang Songjia ),( Ding Pan ),( Shao Qingyang ) 한국융합과학회 2022 한국융합과학회 국제학술대회자료집 Vol.2022 No.0

        Since Michel Eugène Chevreul(1786-1889) firstly discovered Creatine in skeletal muscle in 1832[(Volek JS et al., 2012), Research on creatine has caught scholars' attention. Research results showed that Creatine was consumed in the diet and synthesized in the body and is widely utilized as an ergogenic aid for strength and performance gains(Wax B et al.,2021). In addition, a large body of compelling evidence demonstrated high-intensity exercise capacity and lean body mass would be improved by creatine supplementation(Cooper R et al.,2012).When used appropriately, creatine has very few adverse effects and has repeatedly proven to be safe for clinical use with similar beneficial applications across all age groups. In addition, Creatine supplementation has always been considered as a feasible way to treat muscular, neuromuscular or neuromuscular diseases. Including the treatment of arthritis, chronic congestive heart failure, disuse atrophy, circular atrophy, muscle phosphorylase deficiency, Huntington's disease, diversified neuromuscular diseases, mitochondrial diseases, muscular dystrophy and neuroprotection, B. Willer(2000) analyzed effects of creatine supplementation on muscle weakness in patients with rheumatoid arthritis, results of which showed that creatine may be beneficial to neuromuscular disorders. Also, M. Flint(1999 )’ research results indicated that Creatine was twice as effective as the current prescription drug riluzole in prolonging the liver life of rats with amyotrophic lateral sclerosis, which may be on account that available energy of injured nerve cells increased and chemical pathways causing cell death are blocked. Although many qualitative studies on creatine have been conducted, few studies on quantitative analysis of creatine were found. Therefore, three questions arouse the author's thinking as following, How is Research Trend of Creatine in Sport? What are hot topics on creatine research in recent years? In order to respond to these questions, it is necessary to analyze the changes in Creatine research over past years. Recently, social network analysis, which focuses on analyzing the degree centrality and betweenness centrality of keywords in a social network composed of core keywords, has been widely utilized in various research fields to identify research trends and assess sub-research fields. Researchers describe that the research trends can bee derived in a given field by observing the changes of core keywords in networks(Kim & Yim, 2017). In this paper, centrality and frequency changes of top keywords on Creatine by periods were conducted to identify research trends and assess detailed study areas. Methods In this study, detailed bibliographic information of 513 articles on Creatine was collected through searching the Web of Science. The bibliographic information includes journal title, article title, authors, abstract, keyword, and year of publication. To analyze the trends of Yoga therapy by specific periods, we divided the analyzed period into four parts (2000-2005, 2006-2010, 2011-2015, 2016-2020). When identifying research trends using social network analysis, the main element used was the abstract of articles, with the keywords in abstracts being extracted through textmining. To identify research trends, centralities and cohesion group analysis were performed using python and Netminer. First, degree centrality analysis and betweenness analysis were performed to identify keywords with influence within quantified abstract data to identify the development trends of Yoga therapy research. Second, cohesion group analysis was conducted to identify detailed sub-research areas within the network (Kim, 2018;Kim et al., 2020). Findings and applications The findings for the quantitative abstract data and visual network analyses are as follows. By counting, combining, and analyzing the keywords in Creatine research across the four different analyzed periods. The analysis results are as follows, degree centrality of top keywords, such as supplementation, effect, muscle, exercise, increase, placebo was high in four periods, which implied that the similar hot topics on effect of Creatine as supplementation on muscle in the four periods. Maybe the difference between Creatine and placebo during exercise also was the top topics during the four periods. Besides, keywords with high degree centrality also showed a high tendency in betweenness centrality. By contrary, compared the keywords of 4 periods, Differences can be noticed in research topics involving period, man and weight during 2006 and 2010y, and during 2016 and 2020y, keywords ck, player, supplement, serum and measure were covered, which indicated that new topics on ck, player, supplement, serum and measure were conducted, but the other two periods of research didn’t involve. In addition, four specific areas centered on creatine and CK, Creatine and effect, creatine and placebo effect, and Creatine and performance, were derived through cohesion group analysis. o it can be said that the results of keyword network analysis clearly show the sub-research fields of Creantine, which allow future researchers to make more well-informed decisions as to which detailed study areas to focus on. On the other hand, the overall research trend of Yoga therapy is confirmed through keyword network analysis, which will play a supplementary role in the further sub-research on Creatine.

      • SCIESCOPUSKCI등재

        Improvement of Fermentation and Nutritive Quality of Straw-grass Silage by Inclusion of Wet Hulless-barley Distillers' Grains in Tibet

        Yuan, Xianjun,Yu, Chengqun,Shimojo, M.,Shao, Tao Asian Australasian Association of Animal Productio 2012 Animal Bioscience Vol.25 No.4

        In order to develop methods that would enlarge the feed resources in Tibet, mixtures of hulless-barley straw and tall fescue were ensiled with four levels (0, 10%, 20%, and 30% of fresh weight) of wet hulless-barley distillers' grains (WHDG). The silos were opened after 7, 14 or 30 d of ensiling, and the fermentation characteristics and nutritive quality of the silages were analyzed. WHDG addition significantly improved fermentation quality, as indicated by the faster decline of pH, rapid accumulation of lactic acid (LA) (p<0.05), and lower butyric acid content and ammonia-N/total N (p<0.05) as compared with the control. These results indicated that WHDG additions not only effectively inhibited the activity of aerobic bacteria, but also resulted in faster and greatly enhanced LA production and pH value decline, which restricted activity of undesirable bacteria, resulting in more residual water soluble carbohydrates (WSC) in the silages. The protein content of WHDG-containing silages were significantly higher (p<0.05) higher than that of the control. In conclusion, the addition of WHDG increased the fermentation and nutritive quality of straw-grass silage, and this effect was more marked when the inclusion rate of WHDG was greater than 20%.

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